Autophagy: from phenomenology to molecular understanding in less than a decade

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

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Functions of Lysosomes

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The role of autophagy during the early neonatal starvation period

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

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Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

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Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996

Regulation mechanisms and signaling pathways of autophagy

He, C., & Klionsky, D. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102808-114910 · Cited by 3,609

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

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Targeting Autophagy in Cancer

Levy, J. M. M., Towers, C. G., & Thorburn, A. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.53 · Cited by 2,526

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy · doi:10.4161/auto.5338 · Cited by 2,230

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076

Role of autophagy in cancer

Mathew, R., Karantza-Wadsworth, V., & White, E. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2254 · Cited by 1,798

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

Lee, J.-H., Yu, W. H., Kumar, A., Lee, S., Mohan, P. S., Peterhoff, C. M., Wolfe, D. M., Martinez-Vicente, M., Massey, A. C., Sovak, G., et al. (2010) · Cell · doi:10.1016/j.cell.2010.05.008 · Cited by 1,212

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

Itakura, E., Kishi, C., Inoue, K., & Mizushima, N. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-01-0080 · Cited by 1,176

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.010 · Cited by 1,057

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

Cárdenas, C., Miller, R. A., Smith, I., Bui, T., Molgó, J., Müller, M., Vais, H., Cheung, K.-H., Yang, J., Parker, I., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.007 · Cited by 1,026

Lysosomal positioning coordinates cellular nutrient responses

Korolchuk, V. I., Saiki, S., Lichtenberg, M., Siddiqi, F. H., Roberts, E. A., Imarisio, S., Jahreiss, L., Sarkar, S., Futter, M., Menzies, F. M., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2204 · Cited by 891

Autophagy gone awry in neurodegenerative diseases

Wong, E., & Cuervo, A. M. (2010) · Nature Neuroscience · doi:10.1038/nn.2575 · Cited by 815

Senescence and aging: the critical roles of p53

Rufini, A., Tucci, P., Celardo, I., & Melino, G. (2013) · Oncogene · doi:10.1038/onc.2012.640 · Cited by 798

History and progress of hypotheses and clinical trials for Alzheimer’s disease

Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

Huang, R., Xu, Y., Wan, W., Shou, X., Qian, J., You, Z., Liu, B., Chang, C., Zhou, T., Lippincott-Schwartz, J., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2014.12.013 · Cited by 662

Atg9 vesicles are an important membrane source during early steps of autophagosome formation

Yamamoto, H., Kakuta, S., Watanabe, T. M., Kitamura, A., Sekito, T., Kondo-Kakuta, C., Ichikawa, R., Kinjo, M., & Ohsumi, Y. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201202061 · Cited by 659

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

Mortensen, M., Soilleux, E. J., Djordjevic, G., Tripp, R., Lutteropp, M., Sadighi-Akha, E., Stranks, A. J., Glanville, J., Knight, S., W. Jacobsen, S.-E., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101145 · Cited by 657

Adipose-specific deletion of autophagy-related gene 7 ( atg7 ) in mice reveals a role in adipogenesis

Zhang, Y., Goldman, S., Baerga, R., Zhao, Y., Komatsu, M., & Jin, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906048106 · Cited by 634

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

Kyei, G. B., Dinkins, C., Davis, A. S., Roberts, E., Singh, S. B., Dong, C., Wu, L., Kominami, E., Ueno, T., Yamamoto, A., et al. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903070 · Cited by 509

Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging

Terman, A., Kurz, T., Navratil, M., Arriaga, E. A., & Brunk, U. T. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2598 · Cited by 490

The endoplasmic reticulum–mitochondria connection: One touch, multiple functions

Marchi, S., Patergnani, S., & Pinton, P. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.10.015 · Cited by 475

MAPK/JNK signalling: a potential autophagy regulation pathway

Zhou, Y.-Y., Li, Y., Jiang, W.-Q., & Zhou, L.-F. (2015) · Bioscience Reports · doi:10.1042/bsr20140141 · Cited by 444

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

Shin, H.-J. R., Kim, H., Oh, S., Lee, J.-G., Kee, M., Ko, H.-J., Kweon, M.-N., Won, K.-J., & Baek, S. H. (2016) · Nature · doi:10.1038/nature18014 · Cited by 417

Mitochondria removal by autophagy

Wang, K., & Klionsky, D. J. (2011) · Autophagy · doi:10.4161/auto.7.3.14502 · Cited by 380

Neurodegenerative lysosomal disorders: A continuum from development to late age

Nixon, R. A., Yang, D.-S., & Lee, J.-H. (2008) · Autophagy · doi:10.4161/auto.6259 · Cited by 362

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease.

Raben, N., Hill, V., Shea, L., Takikita, S., Baum, R., Mizushima, N., Ralston, E., & Plotz, P. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn292 · Cited by 352

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M. N., & Madeo, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.031 · Cited by 345

Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family

Lu, K., Psakhye, I., & Jentsch, S. (2014) · Cell · doi:10.1016/j.cell.2014.05.048 · Cited by 346

Mitophagy in Yeast Occurs through a Selective Mechanism

Kanki, T., & Klionsky, D. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802403200 · Cited by 335

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L

Papandreou, I., Lim, A. L., Laderoute, K., & Denko, N. C. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.84 · Cited by 334

The Cvt pathway as a model for selective autophagy

Lynch-Day, M. A., & Klionsky, D. J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.013 · Cited by 329

Exosomes derived from mesenchymal stem cells repair a Parkinson’s disease model by inducing autophagy

Chen, H.-X., Liang, F.-C., Gu, P., Xu, B.-L., Xu, H.-J., Wang, W.-T., Hou, J.-Y., Xie, D.-X., Chai, X.-Q., & An, S.-J. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2473-5 · Cited by 319

Targeted deletion of autophagy-related 5(atg5) impairs adipogenesis in a cellular model and in mice

Baerga, R., Zhang, Y., Chen, P.-H., Goldman, S., & Jin, S. V. (2009) · Autophagy · doi:10.4161/auto.5.8.9991 · Cited by 304

Lysosomes in iron metabolism, ageing and apoptosis

Kurz, T., Terman, A., Gustafsson, B., & Brunk, U. T. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0394-y · Cited by 302

Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation

Rong, Y., Liu, M., Ma, L., Du, W., Zhang, H., Tian, Y., Cao, Z., Li, Y., Ren, H., Zhang, C., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2557 · Cited by 297

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

Vicencio, J. M., Ortiz, C., Criollo, A., Jones, A. W. E., Kepp, O., Galluzzi, L., Joza, N., Vitale, I., Morselli, E., Tailler, M., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2009.34 · Cited by 289

Lysosomes and oxidative stress in aging and apoptosis

Kurz, T., Terman, A., Gustafsson, B., & Brunk, U. T. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.01.009 · Cited by 287

ATG8 lipidation and ATG8-mediated autophagy in Arabidopsis require ATG12 expressed from the differentially controlled ATG12A AND ATG12B loci: Arabidopsis autophagy requires ATG12

Chung, T., Phillips, A. R., & Vierstra, R. D. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04166.x · Cited by 285

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

Löffler, A. S., Alers, S., Dieterle, A. M., Keppeler, H., Franz-Wachtel, M., Kundu, M., Campbell, D. G., Wesselborg, S., Alessi, D. R., & Stork, B. (2011) · Autophagy · doi:10.4161/auto.7.7.15451 · Cited by 258

Autophagy in bone homeostasis and the onset of osteoporosis

Yin, X., Zhou, C., Li, J., Liu, R., Shi, B., Yuan, Q., & Zou, S. (2019) · Bone Research · doi:10.1038/s41413-019-0058-7 · Cited by 235

Insufficient Activation of Autophagy Allows Cellular Damage to Accumulate in Critically Ill Patients

Vanhorebeek, I., Gunst, J., Derde, S., Derese, I., Boussemaere, M., Güiza, F., Martinet, W., Timmermans, J.-P., D'Hoore, A., Wouters, P. J., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2563 · Cited by 241

Molecular mechanisms of renal aging

Schmitt, R., & Melk, A. (2017) · Kidney International · doi:10.1016/j.kint.2017.02.036 · Cited by 235

IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation

Hu, F., Song, D., Yan, Y., Huang, C., Shen, C., Lan, J., Chen, Y., Liu, A., Wu, Q., Sun, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23923-1 · Cited by 235

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

Bach, M., Larance, M., James, D. E., & Ramm, G. (2011) · Biochemical Journal · doi:10.1042/bj20101894 · Cited by 233

Quantitation of "autophagic flux" in mature skeletal muscle

Ju, J.-S., Varadhachary, A. S., Miller, S. E., & Weihl, C. C. (2010) · Autophagy · doi:10.4161/auto.6.7.12785 · Cited by 229

Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection

Ishida, Y., Yamamoto, A., Kitamura, A., Lamandé, S. R., Yoshimori, T., Bateman, J. F., Kubota, H., & Nagata, K. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-11-1092 · Cited by 221

The ATG Autophagic Conjugation System in Maize: ATG Transcripts and Abundance of the ATG8-Lipid Adduct Are Regulated by Development and Nutrient Availability

Chung, T., Suttangkakul, A., & Vierstra, R. D. (2009) · Plant Physiology · doi:10.1104/pp.108.126714 · Cited by 221

Human TBK1: A Gatekeeper of Neuroinflammation

Ahmad, L., Zhang, S.-Y., Casanova, J.-L., & Sancho-Shimizu, V. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.04.006 · Cited by 208

New Autophagy Reporter Mice Reveal Dynamics of Proximal Tubular Autophagy

Li, L., Wang, Z. V., Hill, J. A., & Lin, F. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013040374 · Cited by 206

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2

Ferguson, C. J., Lenk, G. M., & Meisler, M. H. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp460 · Cited by 202

The Autophagy Lysosomal Pathway and Neurodegeneration

Finkbeiner, S. (2020) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033993 · Cited by 196

Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications

Banerjee, R., Beal, M. F., & Thomas, B. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.09.001 · Cited by 199

Autophagy Is a Component of Epithelial Cell Fate in Obstructive Uropathy

Li, L., Zepeda-Orozco, D., Black, R., & Lin, F. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090345 · Cited by 195

Antigen processing and presentation

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The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies

Nahimana, A., Attinger, A., Aubry, D., Greaney, P., Ireson, C., Thougaard, A. V., Tjørnelund, J., Dawson, K. M., Dupuis, M., & Duchosal, M. A. (2009) · Blood · doi:10.1182/blood-2008-08-173369 · Cited by 190

Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis

Hou, Y.-C. C., Chittaranjan, S., Barbosa, S. G., McCall, K., & Gorski, S. M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712091 · Cited by 180

Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation

Coupé, B., Ishii, Y., Dietrich, M. O., Komatsu, M., Horvath, T. L., & Bouret, S. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.016 · Cited by 174

Genetic Control of Programmed Cell Death During Animal Development

Conradt, B. (2009) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091533 · Cited by 173

Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling

Shrivastava, S., Bhanja Chowdhury, J., Steele, R., Ray, R., & Ray, R. B. (2012) · Journal of Virology · doi:10.1128/jvi.00616-12 · Cited by 163

Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase

Bowles, T. L., Kim, R., Galante, J., Parsons, C. M., Virudachalam, S., Kung, H., & Bold, R. J. (2008) · International Journal of Cancer · doi:10.1002/ijc.23723 · Cited by 153

The Decline of Autophagy Contributes to Proximal Tubular Dysfunction During Sepsis

Hsiao, H.-W., Tsai, K.-L., Wang, L.-F., Chen, Y.-H., Chiang, P.-C., Chuang, S.-M., & Hsu, C. (2012) · Shock · doi:10.1097/shk.0b013e318240b52a · Cited by 151

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis

Osonoi, Y., Mita, T., Azuma, K., Nakajima, K., Masuyama, A., Goto, H., Nishida, Y., Miyatsuka, T., Fujitani, Y., Koike, M., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1501132 · Cited by 149

Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state

Jamart, C., Naslain, D., Gilson, H., & Francaux, M. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00270.2013 · Cited by 148

Calcium signaling alterations, oxidative stress, and autophagy in aging

Ureshino, R. P., Rocha, K. K., Lopes, G. S., Bincoletto, C., & Smaili, S. S. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5777 · Cited by 143

Toll-like receptor signaling in the lysosomal pathways

Sanjuan, M. A., Milasta, S., & Green, D. R. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00732.x · Cited by 137

Berberine as a potential autophagy modulator

Mohammadinejad, R., Ahmadi, Z., Tavakol, S., & Ashrafizadeh, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28325 · Cited by 132

Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease

Nemazanyy, I., Blaauw, B., Paolini, C., Caillaud, C., Protasi, F., Mueller, A., Proikas‐Cezanne, T., Russell, R. C., Guan, K., Nishino, I., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202057 · Cited by 126

The role of autophagy in unilateral ureteral obstruction rat model

KIM, W., NAM, S. A., SONG, H. C., KO, J. S., PARK, S. H., KIM, H. L., CHOI, E. J., KIM, Y., KIM, J., & KIM, Y. K. (2012) · Nephrology · doi:10.1111/j.1440-1797.2011.01541.x · Cited by 108

The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells

Padman, B. S., Bach, M., Lucarelli, G., Prescott, M., & Ramm, G. (2013) · Autophagy · doi:10.4161/auto.26557 · Cited by 106

Sequential formation of different layers of dystrophic neurites in Alzheimer’s brains

Sharoar, M. G., Hu, X., Ma, X.-M., Zhu, X., & Yan, R. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0396-2 · Cited by 87

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway

Nam, S. A., Kim, W.-Y., Kim, J. W., Park, S. H., Kim, H. L., Lee, M.-S., Komatsu, M., Ha, H., Lim, J. H., Park, C. W., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1356-0 · Cited by 92

MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy

Ma, X., Zhang, S., He, L., Rong, Y., Brier, L. W., Sun, Q., Liu, R., Fan, W., Chen, S., Yue, Z., et al. (2017) · Autophagy · doi:10.1080/15548627.2016.1269988 · Cited by 92

Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes

Jänen, S. B., Chaachouay, H., & Richter‐Landsberg, C. (2010) · Glia · doi:10.1002/glia.21047 · Cited by 87

17-AAG Induces Cytoplasmic α-Synuclein Aggregate Clearance by Induction of Autophagy

Riedel, M., Goldbaum, O., Schwarz, L., Schmitt, S., & Richter-Landsberg, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008753 · Cited by 87

Repurposing quinacrine for treatment-refractory cancer

Oien, D. B., Pathoulas, C. L., Ray, U., Thirusangu, P., Kalogera, E., & Shridhar, V. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.021 · Cited by 87

Autophagy in Pulmonary Diseases

Nakahira, K., Pabon Porras, M. A., & Choi, A. M. K. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201512-2468so · Cited by 78

Co-targeting of EGFR and autophagy signaling is an emerging treatment strategy in metastatic colorectal cancer

Koustas, E., Karamouzis, M. V., Mihailidou, C., Schizas, D., & Papavassiliou, A. G. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.03.023 · Cited by 79

Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy

Wang, J., Zhou, J.-Y., Kho, D., Reiners, J. J., & Wu, G. S. (2016) · Autophagy · doi:10.1080/15548627.2016.1203483 · Cited by 82

zVAD-fmk prevents cisplatin-induced cleavage of autophagy proteins but impairs autophagic flux and worsens renal function

Herzog, C., Yang, C., Holmes, A., & Kaushal, G. P. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00659.2011 · Cited by 82

Delayed treatment with fenofibrate protects against high-fat diet-induced kidney injury in mice: the possible role of AMPK autophagy

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Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress

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