Exercise metabolism and adaptation in skeletal muscle

Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr

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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

D’Hulst, G., Soro-Arnaiz, I., Masschelein, E., Veys, K., Fitzgerald, G., Smeuninx, B., Kim, S., Deldicque, L., Blaauw, B., Carmeliet, P., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13889-6 · Cited by 2,310

What is the cause of the ageing atrophy?

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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Baughman, J. M., Perocchi, F., Girgis, H. S., Plovanich, M., Belcher-Timme, C. A., Sancak, Y., Bao, X. R., Strittmatter, L., Goldberger, O., Bogorad, R. L., et al. (2011) · Nature · doi:10.1038/nature10234 · Cited by 1,953

Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration

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Antioxidants prevent health-promoting effects of physical exercise in humans

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Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency

Cogliati, S., Frezza, C., Soriano, M. E., Varanita, T., Quintana-Cabrera, R., Corrado, M., Cipolat, S., Costa, V., Casarin, A., Gomes, L. C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.032 · Cited by 1,265

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yin, Y., Morgunova, E., Jolma, A., Kaasinen, E., Sahu, B., Khund-Sayeed, S., Das, P. K., Kivioja, T., Dave, K., Zhong, F., et al. (2017) · Science · doi:10.1126/science.aaj2239 · Cited by 1,257

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance

Anderson, D. M., Anderson, K. M., Chang, C.-L., Makarewich, C. A., Nelson, B. R., McAnally, J. R., Kasaragod, P., Shelton, J. M., Liou, J., Bassel-Duby, R., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.009 · Cited by 1,216

Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes

Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194

Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6

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AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

Toyama, E. Q., Herzig, S., Courchet, J., Lewis, T. L., Losón, O. C., Hellberg, K., Young, N. P., Chen, H., Polleux, F., Chan, D. C., et al. (2016) · Science · doi:10.1126/science.aab4138 · Cited by 1,085

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

Arany, Z., Foo, S.-Y., Ma, Y., Ruas, J. L., Bommi-Reddy, A., Girnun, G., Cooper, M., Laznik, D., Chinsomboon, J., Rangwala, S. M., et al. (2008) · Nature · doi:10.1038/nature06613 · Cited by 1,054

Human muscle metabolism during intermittent maximal exercise

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Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle

Barrès, R., Yan, J., Egan, B., Treebak, J. T., Rasmussen, M., Fritz, T., Caidahl, K., Krook, A., O'Gorman, D. J., & Zierath, J. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.001 · Cited by 965

Exerkines in health, resilience and disease

Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927

Effectiveness of High-Intensity Interval Training (HIT) and Continuous Endurance Training for VO2max Improvements: A Systematic Review and Meta-Analysis of Controlled Trials

Milanović, Z., Sporiš, G., & Weston, M. (2015) · Sports Medicine · doi:10.1007/s40279-015-0365-0 · Cited by 923

The effects of increasing exercise intensity on muscle fuel utilisation in humans

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Familial aggregation ofV˙ o 2 max response to exercise training: results from the HERITAGE Family Study

Bouchard, C., An, P., Rice, T., Skinner, J. S., Wilmore, J. H., Gagnon, J., Pérusse, L., Leon, A. S., & Rao, D. C. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.3.1003 · Cited by 875

Balance of carbohydrate and lipid utilization during exercise: the "crossover" concept

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Muscle creatine loading in men

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Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

Agudelo, L. Z., Femenía, T., Orhan, F., Porsmyr-Palmertz, M., Goiny, M., Martinez-Redondo, V., Correia, J. C., Izadi, M., Bhat, M., Schuppe-Koistinen, I., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.051 · Cited by 739

A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle

Nelson, B. R., Makarewich, C. A., Anderson, D. M., Winders, B. R., Troupes, C. D., Wu, F.-F., Reese, A. L., McAnally, J. R., Chen, X.-W., Kavalali, E., et al. (2016) · Science · doi:10.1126/science.aad4076 · Cited by 730

Circadian misalignment increases cardiovascular disease risk factors in humans

Morris, C. J., Purvis, T. E., Hu, K., & Scheer, F. A. J. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516953113 · Cited by 691

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.050 · Cited by 677

Dose-response relationship between weekly resistance training volume and increases in muscle mass: a systematic review and meta-analysis.

Schoenfeld, B. J., Ogborn, D., & Krieger, J. W. (2017) · Journal of Sports Sciences · doi:10.1080/02640414.2016.1210197 · Cited by 671

Rapid Determination of Myosin Heavy Chain Expression in Rat, Mouse, and Human Skeletal Muscle Using Multicolor Immunofluorescence Analysis

Bloemberg, D., & Quadrilatero, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035273 · Cited by 629

Muscular Strength as A Predictor of All-Cause Mortality in an Apparently Healthy Population: A Systematic Review and Meta-Analysis of Data From Approximately 2 Million Men and Women

García-Hermoso, A., Cavero-Redondo, I., Ramírez-Vélez, R., Ruiz, J. R., Ortega, F. B., Lee, D.-C., & Martínez-Vizcaíno, V. (2018) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2018.01.008 · Cited by 609

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

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Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans

Robinson, M. M., Dasari, S., Konopka, A. R., Johnson, M. L., Manjunatha, S., Esponda, R. R., Carter, R. E., Lanza, I. R., & Nair, K. S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.009 · Cited by 539

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

Laker, R. C., Drake, J. C., Wilson, R. J., Lira, V. A., Lewellen, B. M., Ryall, K. A., Fisher, C. C., Zhang, M., Saucerman, J. J., Goodyear, L. J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00520-9 · Cited by 529

CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy

Backs, J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27438 · Cited by 514

Chronotypes in the US–influence of age and sex

Fischer, D., Lombardi, D. A., Marucci-Wellman, H., & Roenneberg, T. (2017) · PLOS ONE · doi:10.1371/journal.pone.0178782 · Cited by 502

Molecular Choreography of Acute Exercise

Contrepois, K., Wu, S., Moneghetti, K. J., Hornburg, D., Ahadi, S., Tsai, M.-S., Metwally, A. A., Wei, E., Lee-McMullen, B., Quijada, J. V., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.043 · Cited by 502

Exercise-stimulated glucose uptake — regulation and implications for glycaemic control

Sylow, L., Kleinert, M., Richter, E. A., & Jensen, T. E. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.162 · Cited by 498

Lactate metabolism: historical context, prior misinterpretations, and current understanding

Ferguson, B. S., Rogatzki, M. J., Goodwin, M. L., Kane, D. A., Rightmire, Z. B., & Gladden, L. B. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3795-6 · Cited by 485

Human variation in skeletal muscle fiber-type proportion and enzyme activities

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Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling

Wu, X. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27374 · Cited by 479

Human tendon adaptation in response to mechanical loading: a systematic review and meta-analysis of exercise intervention studies on healthy adults

Böhm, S., Mersmann, F., & Arampatzis, A. (2015) · Sports Medicine - Open · doi:10.1186/s40798-015-0009-9 · Cited by 465

Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity

Tarnopolsky, M. A., Rennie, C. D., Robertshaw, H. A., Fedak-Tarnopolsky, S. N., Devries, M. C., & Hamadeh, M. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00472.2006 · Cited by 457

Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity

Pillon, N. J., Gabriel, B. M., Dollet, L., Smith, J. A. B., Sardón Puig, L., Botella, J., Bishop, D. J., Krook, A., & Zierath, J. R. (2020) · Nature Communications · doi:10.1038/s41467-019-13869-w · Cited by 457

Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock

Dyar, K. A., Ciciliot, S., Wright, L. E., Biensø, R. S., Tagliazucchi, G. M., Patel, V. R., Forcato, M., Paz, M. I. P., Gudiksen, A., Solagna, F., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2013.10.005 · Cited by 454

Mitochondrial reticulum for cellular energy distribution in muscle

Glancy, B., Hartnell, L. M., Malide, D., Yu, Z.-X., Combs, C. A., Connelly, P. S., Subramaniam, S., & Balaban, R. S. (2015) · Nature · doi:10.1038/nature14614 · Cited by 450

Lactate is always the end product of glycolysis

Rogatzki, M. J., Ferguson, B. S., Goodwin, M. L., & Gladden, L. B. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00022 · Cited by 428

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates

Hoffman, N. J., Parker, B. L., Chaudhuri, R., Fisher-Wellman, K. H., Kleinert, M., Humphrey, S. J., Yang, P., Holliday, M., Trefely, S., Fazakerley, D. J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.001 · Cited by 426

An Examination and Critique of Current Methods to Determine Exercise Intensity

Jamnick, N. A., Pettitt, R. W., Granata, C., Pyne, D. B., & Bishop, D. J. (2020) · Sports Medicine · doi:10.1007/s40279-020-01322-8 · Cited by 424

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

Moiseeva, V., Cisneros, A., Sica, V., Deryagin, O., Lai, Y., Jung, S., Andrés, E., An, J., Segalés, J., Ortet, L., et al. (2023) · Nature · doi:10.1038/s41586-022-05535-x · Cited by 423

Lateral transmission of tension in frog myofibers: A myofibrillar network and transverse cytoskeletal connections are possible transmitters

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The exerkine apelin reverses age-associated sarcopenia

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Circadian rhythms and exercise — re-setting the clock in metabolic disease

Gabriel, B. M., & Zierath, J. R. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0150-x · Cited by 382

Myogenic progenitor cells control extracellular matrix production by fibroblasts during skeletal muscle hypertrophy

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Untitled work

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Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage

Damas, F., Phillips, S. M., Libardi, C. A., Vechin, F. C., Lixandrão, M. E., Jannig, P. R., Costa, L. A. R., Bacurau, A. V., Snijders, T., Parise, G., et al. (2016) · The Journal of Physiology · doi:10.1113/jp272472 · Cited by 353

Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise

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Human skeletal muscle possesses an epigenetic memory of hypertrophy

Seaborne, R. A., Strauss, J., Cocks, M., Shepherd, S., O’Brien, T. D., van Someren, K. A., Bell, P. G., Murgatroyd, C., Morton, J. P., Stewart, C. E., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-20287-3 · Cited by 334

An exercise-inducible metabolite that suppresses feeding and obesity

Li, V. L., He, Y., Contrepois, K., Liu, H., Kim, J. T., Wiggenhorn, A. L., Tanzo, J. T., Tung, A. S.-H., Lyu, X., Zushin, P.-J. H., et al. (2022) · Nature · doi:10.1038/s41586-022-04828-5 · Cited by 331

Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise

Goncalves, R. L. S., Quinlan, C. L., Perevoshchikova, I. V., Hey-Mogensen, M., & Brand, M. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.619072 · Cited by 329

Refuting the myth of non‐response to exercise training: ‘non‐responders’ do respond to higher dose of training

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Enhanced Amino Acid Sensitivity of Myofibrillar Protein Synthesis Persists for up to 24 h after Resistance Exercise in Young Men1–3

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ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis

Balsa, E., Soustek, M. S., Thomas, A. J., Cogliati, S., García‐Poyatos, C., Martín-García, E., Jedrychowski, M. P., Gygi, S. P., Enrı́quez, J. A., & Puigserver, P. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.03.031 · Cited by 322

Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging

Murgia, M., Toniolo, L., Nagaraj, N., Ciciliot, S., Vindigni, V., Schiaffino, S., Reggiani, C., & Mann, M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.054 · Cited by 315

Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments

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Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis

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Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

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Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria

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Time of exercise specifies the impact on muscle metabolic pathways and systemic energy homeostasis

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Exercise-induced histone modifications in human skeletal muscle

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Interleukin 6 as an Energy Allocator in Muscle Tissue

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Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells

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Resistance exercise training alters mitochondrial function in human skeletal muscle

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Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle

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Stretch-shortening cycle exercises: an effective training paradigm to enhance power output of human single muscle fibers

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Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults

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Heterodimerization between Members of the Nur Subfamily of Orphan Nuclear Receptors as a Novel Mechanism for Gene Activation

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pH-gated succinate secretion regulates muscle remodeling in response to exercise

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Myofibrillar ATPase activity in skinned human skeletal muscle fibres: fibre type and temperature dependence.

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Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: A randomised crossover trial

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Studies of Mitochondrial and Nonmitochondrial Sources Implicate Nicotinamide Adenine Dinucleotide Phosphate Oxidase(s) in the Increased Skeletal Muscle Superoxide Generation That Occurs During Contractile Activity

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MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells

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An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training

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