AMPK in skeletal muscle function and metabolism

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Inflammatory Mechanisms in Obesity

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Identification of ubiquitin ligases required for skeletal muscle atrophy.

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Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases

Pedersen, B. K., & Saltin, B. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12581 · Cited by 3,514

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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The pro- and anti-inflammatory properties of the cytokine interleukin-6

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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Diet, lifestyle, and the risk of type 2 diabetes mellitus in women.

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

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Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

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Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

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ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

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Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis

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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

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Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration

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Free radicals and tissue damage produced by exercise

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

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Biochemical Adaptations in Muscle

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FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

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Autophagy is required to maintain muscle mass.

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Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans

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AMPK and PPARδ Agonists Are Exercise Mimetics

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The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

Simsek, T., Kocabas, F., Zheng, J., DeBerardinis, R. J., Mahmoud, A. I., Olson, E. N., Schneider, J. W., Zhang, C. C., & Sadek, H. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.011 · Cited by 1,101

Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6

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AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

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SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

Nemoto, S., Fergusson, M. M., & Finkel, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501485200 · Cited by 1,047

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

Zong, H., Ren, J. M., Young, L. H., Pypaert, M., Mu, J., Birnbaum, M. J., & Shulman, G. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252625599 · Cited by 1,036

The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

Revollo, J. R., Grimm, A. A., & Imai, S.-I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408388200 · Cited by 1,010

Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

Bitterman, K. J., Anderson, R. M., Cohen, H. Y., Latorre-Esteves, M., & Sinclair, D. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205670200 · Cited by 1,002

Structure of mammalian AMPK and its regulation by ADP

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AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling

Bolster, D. R., Crozier, S. J., Kimball, S. R., & Jefferson, L. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200171200 · Cited by 851

Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise

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Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.001 · Cited by 773

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

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Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D., Mauvais-Jarvis, F., Lowell, B. B., Wojtaszewski, J. F. P., Hirshman, M. F., Virkamaki, A., Goodyear, L. J., et al. (2000) · Nature Medicine · doi:10.1038/78693 · Cited by 743

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

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Mammalian AMP-activated protein kinase subfamily

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Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

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Mitochondrial fission and remodelling contributes to muscle atrophy

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5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2C α and native bovine protein phosphatase‐2A c

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Structural basis for AMP binding to mammalian AMP-activated protein kinase

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The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

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Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle

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Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise

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Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle

Jørgensen, S. B., Viollet, B., Andreelli, F., Frøsig, C., Birk, J. B., Schjerling, P., Vaulont, S., Richter, E. A., & Wojtaszewski, J. F. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306205200 · Cited by 553

Muscle Glucose Metabolism following Exercise in the Rat

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The Association of AMPK with ULK1 Regulates Autophagy

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Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

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Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase

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Isoform‐specific and exercise intensity‐dependent activation of 5′‐AMP‐activated protein kinase in human skeletal muscle

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The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

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Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates

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Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

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AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise

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Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans

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AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity.

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Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation

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Effect of exercise on insulin action in human skeletal muscle

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Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease.

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Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle

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Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family

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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

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A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias

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The 5′-AMP-activated Protein Kinase γ3 Isoform Has a Key Role in Carbohydrate and Lipid Metabolism in Glycolytic Skeletal Muscle

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AMPK: Lessons from transgenic and knockout animals

Viollet, B. (2009) · Frontiers in bioscience · doi:10.2741/3229 · Cited by 314

Calcium Induces Increases in Peroxisome Proliferator-activated Receptor γ Coactivator-1α and Mitochondrial Biogenesis by a Pathway Leading to p38 Mitogen-activated Protein Kinase Activation

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Effect of Acute Exercise on AMPK Signaling in Skeletal Muscle of Subjects with Type 2 Diabetes

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Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

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The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase

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AMPK and Exercise: Glucose Uptake and Insulin Sensitivity

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Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle

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AICAR Administration Causes an Apparent Enhancement of Muscle and Liver Insulin Action in Insulin-Resistant High-Fat-Fed Rats

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AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels

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Interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration

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The Ever-Expanding Myokinome: Discovery Challenges and Therapeutic Implications

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Effects of α‐AMPK knockout on exercise‐induced gene activation in mouse skeletal muscle

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Increased Phosphorylation of Akt Substrate of 160 kDa (AS160) in Rat Skeletal Muscle in Response to Insulin or Contractile Activity

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Molecular Mechanism by Which AMP-Activated Protein Kinase Activation Promotes Glycogen Accumulation in Muscle

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AMPK‐independent pathways regulate skeletal muscle fatty acid oxidation

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Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice.

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Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism

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Skeletal Muscle AMP-activated Protein Kinase Is Essential for the Metabolic Response to Exercise in Vivo

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Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity

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Upregulation of circulating IL-15 by treadmill running in healthy individuals: Is IL-15 an endocrine mediator of the beneficial effects of endurance exercise?

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Exercise induces expression of leukaemia inhibitory factor in human skeletal muscle

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Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK

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Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

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Increased AS160 phosphorylation, but not TBC1D1 phosphorylation, with increased postexercise insulin sensitivity in rat skeletal muscle

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Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle

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Pronounced Effects of Acute Endurance Exercise on Gene Expression in Resting and Exercising Human Skeletal Muscle

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IL-15 activates the Jak3/STAT3 signaling pathway to mediate glucose uptake in skeletal muscle cells

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Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle

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Aerobic Exercise Alters Skeletal Muscle Molecular Responses to Resistance Exercise

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Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3

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The α-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro

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Skeletal Muscle as Potential Central Link between Sarcopenia and Immune Senescence

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