Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase

Zimmermann, Robert, Strauss, Juliane G., Haemmerle, Guenter, Schoiswohl, Gabriele, Birner-Gruenberger, Ruth, Riederer, Monika, Lass, Achim, Neuberger, Georg, Eisenhaber, Frank, Hermetter, Albin, Zechner, Rudolf·2004·Science

DOI 10.1126/science.1100747

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Abstract

Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of obesity and insulin resistance. Until now, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. Here, we report that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. It is interesting that ATGL contains a “patatin domain” common to plant acyl-hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.

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Amino acid starvation-induced autophagy is involved in reduced subcutaneous fat deposition in weaning piglets derived from sows fed low-protein diet during gestation and lactation: Autophagy is involved in reduced fat deposition in maternal low-protein piglets
Pan, S., Jia, Y., Yang, X., Cai, D., Liu, Z., Song, H., & Zhao, R. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1383-5 · Cited by 7
DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chains
(2025) · doi:10.1073/pnas.2500527122 · Cited by 3

Authors: Zimmermann, R., Strauss, J. G., Haemmerle, G., Schoiswohl, G., Birner-Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., & Zechner, R.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2004-11-19
Volume: 306
Issue: 5700
Pages: 1383-1386
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1100747
OpenAlex: W2110839026
Cited by: 2,116
References: 0
FWCI: 25.77
Type: journal article
Language: en
Open access: closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase

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