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Calcium and Arrhythmogenesis

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ter Keurs, Henk E. D. J., Boyden, Penelope A.·2007·Physiological Reviews

DOI 10.1152/physrev.00011.2006

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Abstract

Triggered activity in cardiac muscle and intracellular Ca 2+have been linked in the past. However, today not only are there a number of cellular proteins that show clear Ca 2+dependence but also there are a number of arrhythmias whose mechanism appears to be linked to Ca 2+-dependent processes. Thus we present a systematic review of the mechanisms of Ca 2+transport (forward excitation-contraction coupling) in the ventricular cell as well as what is known for other cardiac cell types. Second, we review the molecular nature of the proteins that are involved in this process as well as the functional consequences of both normal and abnormal Ca 2+cycling (e.g., Ca 2+waves). Finally, we review what we understand to be the role of Ca 2+cycling in various forms of arrhythmias, that is, those associated with inherited mutations and those that are acquired and resulting from reentrant excitation and/or abnormal impulse generation (e.g., triggered activity). Further solving the nature of these intricate and dynamic interactions promises to be an important area of research for a better recognition and understanding of the nature of Ca 2+and arrhythmias. Our solutions will provide a more complete understanding of the molecular basis for the targeted control of cellular calcium in the treatment and prevention of such.

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1 retracted

Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
Dzhura, I., Wu, Y., Colbran, R. J., Balser, J. R., & Anderson, M. E. (2000) · Nature Cell Biology · doi:10.1038/35004052 · Cited by 335
Retracted
Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+
Bootman, M. D., Missiaen, L., Parys, J. B., De Smedt, H., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,120
INTRACELLULAR CALCIUM HOMEOSTASIS
Carafoli, E. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.002143 · Cited by 2,190
PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor)
Marx, S. O., Reiken, S., Hisamatsu, Y., Jayaraman, T., Burkhoff, D., Rosemblit, N., & Marks, A. R. (2000) · Cell · doi:10.1016/s0092-8674(00)80847-8 · Cited by 1,978
Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle
Cheng, H., Lederer, W. J., & Cannell, M. B. (1993) · Science · doi:10.1126/science.8235594 · Cited by 1,935
Mechanisms by which mitochondria transport calcium
Gunter, T. E., & Pfeiffer, D. R. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.5.c755 · Cited by 1,640
Excitation-Contraction Coupling and Cardiac Contractile Force
Bers, D. M., & Zhu, Y. (2010) · Journal of Cardiovascular Disease Research · doi:10.1016/s0975-3583(10)11011-0 · Cited by 1,603
CaV1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism
Splawski, I., Timothy, K. W., Sharpe, L. M., Decher, N., Kumar, P., Bloise, R., Napolitano, C., Schwartz, P. J., Joseph, R. M., Condouris, K., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.011 · Cited by 1,586
Nomenclature of Voltage-Gated Sodium Channels
Goldin, A. L., Barchi, R. L., Caldwell, J. H., Hofmann, F., Howe, J. R., Hunter, J. C., Kallen, R. G., Mandel, G., Meisler, M. H., Netter, Y. B., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)00116-1 · Cited by 1,481
Mutations in the Cardiac Ryanodine Receptor Gene ( hRyR2 ) Underlie Catecholaminergic Polymorphic Ventricular Tachycardia
Priori, S. G., Napolitano, C., Tiso, N., Memmi, M., Vignati, G., Bloise, R., Sorrentino, V., & Danieli, G. A. (2001) · Circulation · doi:10.1161/01.cir.103.2.196 · Cited by 1,378
Sensitivity of CaM Kinase II to the Frequency of Ca 2+ Oscillations
De Koninck, P., & Schulman, H. (1998) · Science · doi:10.1126/science.279.5348.227 · Cited by 1,269
Clinical and Molecular Characterization of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
Priori, S. G., Napolitano, C., Memmi, M., Colombi, B., Drago, F., Gasparini, M., DeSimone, L., Coltorti, F., Bloise, R., Keegan, R., et al. (2002) · Circulation · doi:10.1161/01.cir.0000020013.73106.d8 · Cited by 1,173
Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor
Takeshima, H., Nishimura, S., Matsumoto, T., Ishida, H., Kangawa, K., Minamino, N., Matsuo, H., Ueda, M., Hanaoka, M., Hirose, T., et al. (1989) · Nature · doi:10.1038/339439a0 · Cited by 1,146
Electrical Alternans and Vulnerability to Ventricular Arrhythmias
Rosenbaum, D. S., Jackson, L. E., Smith, J. M., Garan, H., Ruskin, J. N., & Cohen, R. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199401273300402 · Cited by 1,143
Catecholaminergic Polymorphic Ventricular Tachycardia in Children: A 7-Year Follow-up of 21 Patients
Leenhardt, A., Lucet, V., Denjoy, I., Grau, F., Ngoc, D. D., & Coumel, P. (1995) · Circulation · doi:10.1161/01.cir.91.5.1512 · Cited by 1,010
Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells
McDonald, T. F., Pelzer, S., Trautwein, W., & Pelzer, D. J. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.2.365 · Cited by 995
Modulation of A-type potassium channels by a family of calcium sensors
An, W. F., Bowlby, M. R., Betty, M., Cao, J., Ling, H.-P., Mendoza, G., Hinson, J. W., Mattsson, K. I., Strassle, B. W., Trimmer, J. S., et al. (2000) · Nature · doi:10.1038/35000592 · Cited by 958
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death
Mohler, P. J., Schott, J.-J., Gramolini, A. O., Dilly, K. W., Guatimosim, S., duBell, W. H., Song, L.-S., Haurogné, K., Kyndt, F., Ali, M. E., et al. (2003) · Nature · doi:10.1038/nature01335 · Cited by 957
Purification and reconstitution of the calcium release channel from skeletal muscle
Anthony Lai, F., Erickson, H. P., Rousseau, E., Liu, Q.-Y., & Meissner, G. (1988) · Nature · doi:10.1038/331315a0 · Cited by 941
Congenital Deafness and Sinoatrial Node Dysfunction in Mice Lacking Class D L-Type Ca2+ Channels
Platzer, J., Engel, J., Schrott-Fischer, A., Stephan, K., Bova, S., Chen, H., Zheng, H., & Striessnig, J. (2000) · Cell · doi:10.1016/s0092-8674(00)00013-1 · Cited by 932
Calmodulin supports both inactivation and facilitation of L-type calcium channels
Zühlke, R. D., Pitt, G. S., Deisseroth, K., Tsien, R. W., & Reuter, H. (1999) · Nature · doi:10.1038/20200 · Cited by 899
Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.
Fabiato, A. (1985) · The Journal of general physiology · doi:10.1085/jgp.85.2.247 · Cited by 892
Nomenclature of Voltage-Gated Calcium Channels
Ertel, E. A., Campbell, K. P., Harpold, M. M., Hofmann, F., Mori, Y., Perez-Reyes, E., Schwartz, A., Snutch, T. P., Tanabe, T., Birnbaumer, L., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)81057-0 · Cited by 885
Calmodulin Is the Ca2+ Sensor for Ca2+-Dependent Inactivation of L-Type Calcium Channels
Peterson, B. Z., DeMaria, C. D., & Yue, D. T. (1999) · Neuron · doi:10.1016/s0896-6273(00)80709-6 · Cited by 856
Mechanism Linking T-Wave Alternans to the Genesis of Cardiac Fibrillation
Pastore, J. M., Girouard, S. D., Laurita, K. R., Akar, F. G., & Rosenbaum, D. S. (1999) · Circulation · doi:10.1161/01.cir.99.10.1385 · Cited by 817
Two Ca2+ ATPase genes: Homologies and mechanistic implications of deduced amino acid sequences
Brandl, C. J., Green, N. M., Korczak, B., & MacLennan, D. H. (1986) · Cell · doi:10.1016/0092-8674(86)90269-2 · Cited by 817
Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)
Tiso, N. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.3.189 · Cited by 806
Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino‐atrial node cells.
Hagiwara, N., Irisawa, H., & Kameyama, M. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp016916 · Cited by 786
Calcium channel characteristics conferred on the sodium channel by single mutations
Heinemann, S. H., Terlau, H., Stühmer, W., Imoto, K., & Numa, S. (1992) · Nature · doi:10.1038/356441a0 · Cited by 784
Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle.
Block, B. A., Imagawa, T., Campbell, K. P., & Franzini-Armstrong, C. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.6.2587 · Cited by 783
Excitation-Contraction Coupling and Cardiac Contractile Force
Bers, D. M. (1993) · Developments in Cardiovascular Medicine · doi:10.1007/978-94-017-1512-6 · Cited by 772
FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death
Wehrens, X. H. T., Lehnart, S. E., Huang, F., Vest, J. A., Reiken, S. R., Mohler, P. J., Sun, J., Guatimosim, S., Song, L.-S., Rosemblit, N., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00434-3 · Cited by 764
Molecular characterization of a neuronal low-voltage-activated T-type calcium channel
Perez-Reyes, E., Cribbs, L. L., Daud, A., Lacerda, A. E., Barclay, J., Williamson, M. P., Fox, M., Rees, M., & Lee, J.-H. (1998) · Nature · doi:10.1038/36110 · Cited by 736
Mutations of the Cardiac Ryanodine Receptor (RyR2) Gene in Familial Polymorphic Ventricular Tachycardia
Laitinen, P. J., Brown, K. M., Piippo, K., Swan, H., Devaney, J. M., Brahmbhatt, B., Donarum, E. A., Marino, M., Tiso, N., Viitasalo, M., et al. (2001) · Circulation · doi:10.1161/01.cir.103.4.485 · Cited by 726
Energy Interconversion by the Ca2+-Dependent ATPase of the Sarcoplasmic Reticulum
Meis, L., & Vianna, A. L. (1979) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.48.070179.001423 · Cited by 723
Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.
Bean, B. P. (1985) · The Journal of general physiology · doi:10.1085/jgp.86.1.1 · Cited by 717
Inward current channels activated by intracellular Ca in cultured cardiac cells
Colquhoun, D., Neher, E., Reuter, H., & Stevens, C. F. (1981) · Nature · doi:10.1038/294752a0 · Cited by 678
Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current.
January, C. T., & Riddle, J. M. (1989) · Circulation Research · doi:10.1161/01.res.64.5.977 · Cited by 673
Ionic Mechanisms of Propagation in Cardiac Tissue: Roles of the Sodium and L-type Calcium Currents During Reduced Excitability and Decreased Gap Junction Coupling
Shaw, R. M., & Rudy, Y. (1997) · Circulation Research · doi:10.1161/01.res.81.5.727 · Cited by 670
Cardiac pacemaking in the sinoatrial node
Irisawa, H., Brown, H. F., & Giles, W. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.1.197 · Cited by 667
Calcium channel β-subunit binds to a conserved motif in the I–II cytoplasmic linker of the α1-subunit
Pragnell, M., De Waard, M., Mori, Y., Tanabe, T., Snutch, T. P., & Campbell, K. P. (1994) · Nature · doi:10.1038/368067a0 · Cited by 662
Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure.
JBeuckelmann, D., MNäbauer, & EErdmann (1992) · Circulation · Cited by 662
A Missense Mutation in a Highly Conserved Region of CASQ2 Is Associated with Autosomal Recessive Catecholamine-Induced Polymorphic Ventricular Tachycardia in Bedouin Families from Israel
Lahat, H., Pras, E., Olender, T., Avidan, N., Ben-Asher, E., Man, O., Levy-Nissenbaum, E., Khoury, A., Lorber, A., Goldman, B., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/324565 · Cited by 655
Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.
Otsu, K., Willard, H. F., Khanna, V. K., Zorzato, F., Green, N. M., & MacLennan, D. H. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77371-7 · Cited by 631
Identification of sodium‐calcium exchange current in single ventricular cells of guinea‐pig.
Kimura, J., Miyamae, S., & Noma, A. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016450 · Cited by 628
Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations
Splawski, I., Timothy, K. W., Decher, N., Kumar, P., Sachse, F. B., Beggs, A. H., Sanguinetti, M. C., & Keating, M. T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502506102 · Cited by 624
Purification of the ryanodine receptor and identity with feet structures of junctional terminal cisternae of sarcoplasmic reticulum from fast skeletal muscle.
Inui, M., Saito, A., & Fleischer, S. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75701-9 · Cited by 618
Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels
Yang, J., Elllnor, P. T., Sather, W. A., Zhang, J.-F., & Tsien, R. W. (1993) · Nature · doi:10.1038/366158a0 · Cited by 617
Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure.
Beuckelmann, D. J., Näbauer, M., & Erdmann, E. (1992) · Circulation · doi:10.1161/01.cir.85.3.1046 · Cited by 600
Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.
Sáez, J. C., Connor, J. A., Spray, D. C., & Bennett, M. V. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2708 · Cited by 595
Molecular mechanism of active calcium transport by sarcoplasmic reticulum.
Tada, M., Yamamoto, T., & Tonomura, Y. (1978) · Physiological Reviews · doi:10.1152/physrev.1978.58.1.1 · Cited by 588
Ionic mechanisms of electrical remodeling in human atrial fibrillation
Bosch, R. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00178-9 · Cited by 580
Calcium Fluxes Involved in Control of Cardiac Myocyte Contraction
Bers, D. M. (2000) · Circulation Research · doi:10.1161/01.res.87.4.275 · Cited by 580
Atrial L-Type Ca 2+ Currents and Human Atrial Fibrillation
Van Wagoner, D. R., Pond, A. L., Lamorgese, M., Rossie, S. S., McCarthy, P. M., & Nerbonne, J. M. (1999) · Circulation Research · doi:10.1161/01.res.85.5.428 · Cited by 575
Cloning and Characterization of α1H From Human Heart, a Member of the T-Type Ca2+Channel Gene Family
Cribbs, L. L., Lee, J.-H., Yang, J., Satin, J., Zhang, Y., Daud, A., Barclay, J., Williamson, M. P., Fox, M., Rees, M., et al. (1998) · Circulation Research · doi:10.1161/01.res.83.1.103 · Cited by 575
Location of high affinity Ca2 +-binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca2+-ATPase
Clarke, D. M., Loo, T. W., Inesi, G., & MacLennan, D. H. (1989) · Nature · doi:10.1038/339476a0 · Cited by 569
Auxiliary subunits of voltage-gated ion channels
Isom, L. (1994) · Neuron · doi:10.1016/0896-6273(94)90436-7 · Cited by 564
The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle.
Allen, D. G., & Kurihara, S. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014221 · Cited by 556
The Roles of the Subunits in the Function of the Calcium Channel
Singer, D., Biel, M., Lotan, I., Flockerzi, V., Hofmann, F., & Dascal, N. (1991) · Science · doi:10.1126/science.1716787 · Cited by 553
Ryanodine modifies conductance and gating behavior of single Ca2+ release channel
Rousseau, E., Smith, J. S., & Meissner, G. (1987) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1987.253.3.c364 · Cited by 551
The control of calcium release in heart muscle
Cannell, M., Cheng, H., & Lederer, W. (1995) · Science · doi:10.1126/science.7754384 · Cited by 550
Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes
Bassani, J. W., Yuan, W., & Bers, D. M. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.268.5.c1313 · Cited by 547
Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase
Denton, R. M., Randle, P. J., & Martin, B. R. (1972) · Biochemical Journal · doi:10.1042/bj1280161 · Cited by 540
Calcium sparks and [Ca2+]i waves in cardiac myocytes
Cheng, H., Lederer, M. R., Lederer, W. J., & Cannell, M. B. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.270.1.c148 · Cited by 533
FK506 binding protein associated with the calcium release channel (ryanodine receptor).
Jayaraman, T., Brillantes, A. M., Timerman, A. P., Fleischer, S., Erdjument-Bromage, H., Tempst, P., & Marks, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50114-4 · Cited by 526
Intercellular Propagation of Calcium Waves Mediated by Inositol Trisphosphate
Boitano, S., Dirksen, E. R., & Sanderson, M. J. (1992) · Science · doi:10.1126/science.1411526 · Cited by 519
Purified ryanodine receptor from skeletal muscle sarcoplasmic reticulum is the Ca2+-permeable pore of the calcium release channel.
Imagawa, T., Smith, J., Coronado, R., & Campbell, K. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)49303-9 · Cited by 506
Auxiliary subunits: essential components of the voltage-gated calcium channel complex
Arikkath, J., & Campbell, K. P. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00066-7 · Cited by 505
Electrical alternans and cardiac electrical instability.
Smith, J. M., Clancy, E. A., Valeri, C. R., Ruskin, J. N., & Cohen, R. J. (1988) · Circulation · doi:10.1161/01.cir.77.1.110 · Cited by 504
Purified ryanodine receptor from rabbit skeletal muscle is the calcium-release channel of sarcoplasmic reticulum.
Smith, J. S., Imagawa, T., Ma, J., Fill, M., Campbell, K. P., & Coronado, R. (1988) · The Journal of general physiology · doi:10.1085/jgp.92.1.1 · Cited by 480
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling
Wu, X. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27374 · Cited by 478
Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium.
Lee, K. S., Marban, E., & Tsien, R. W. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015752 · Cited by 478
Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules
Curtis, B. M., & Catterall, W. A. (1984) · Biochemistry · doi:10.1021/bi00305a001 · Cited by 477
Functional role of L-type Ca v 1.3 Ca 2+ channels in cardiac pacemaker activity
Mangoni, M. E., Couette, B., Bourinet, E., Platzer, J., Reimer, D., Striessnig, J., & Nargeot, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0935295100 · Cited by 467
The regulation of the calcium conductance of cardiac muscle by adrenaline.
Reuter, H., & Scholz, H. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp011657 · Cited by 466
Preassociation of Calmodulin with Voltage-Gated Ca2+ Channels Revealed by FRET in Single Living Cells
Erickson, M. G., Alseikhan, B. A., Peterson, B. Z., & Yue, D. T. (2001) · Neuron · doi:10.1016/s0896-6273(01)00438-x · Cited by 465
CALCIUM‐INDUCED RELEASE OF CALCIUM FROM THE SARCOPLASMIC RETICULUM OF SKINNED CELLS FROM ADULT HUMAN, DOG, CAT, RABBIT, RAT, AND FROG HEARTS AND FROM FETAL AND NEW‐BORN RAT VENTRICLES*
Fabiato, A., & Fabiato, F. (1978) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1978.tb41979.x · Cited by 463
Local calcium transients triggered by single L-type calcium channel currents in cardiac cells
Lopez-Lopez, Shacklock, P., Balke, C., & Wier, W. (1995) · Science · doi:10.1126/science.7754383 · Cited by 454
The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex
McCormack, J. G., & Denton, R. M. (1979) · Biochemical Journal · doi:10.1042/bj1800533 · Cited by 453
Nature and site of phospholamban regulation of the Ca2+ pump of sarcoplasmic reticulum
James, P., Inui, M., Tada, M., Chiesi, M., & Carafoli, E. (1989) · Nature · doi:10.1038/342090a0 · Cited by 453
α1D (Cav1.3) Subunits Can Form L-type Ca2+ Channels Activating at Negative Voltages
Koschak, A., Reimer, D., Huber, I., Grabner, M., Glossmann, H., Engel, J., & Striessnig, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101469200 · Cited by 453
TRPV4 Forms a Novel Ca 2+ Signaling Complex With Ryanodine Receptors and BK Ca Channels
Earley, S., Heppner, T. J., Nelson, M. T., & Brayden, J. E. (2005) · Circulation Research · doi:10.1161/01.res.0000194321.60300.d6 · Cited by 452
The Role of Calsequestrin, Triadin, and Junctin in Conferring Cardiac Ryanodine Receptor Responsiveness to Luminal Calcium
Györke, I., Hester, N., Jones, L. R., & Györke, S. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74271-x · Cited by 442
RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca 2+ release (SOICR)
Jiang, D., Xiao, B., Yang, D., Wang, R., Choi, P., Zhang, L., Cheng, H., & Chen, S. R. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402388101 · Cited by 440
Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12
Shou, W., Aghdasi, B., Armstrong, D. L., Guo, Q., Bao, S., Charng, M.-J., Mathews, L. M., Schneider, M. D., Hamilton, S. L., & Matzuk, M. M. (1998) · Nature · doi:10.1038/35146 · Cited by 431
Structure of a complex between a voltage-gated calcium channel β-subunit and an α-subunit domain
Van Petegem, F., Clark, K. A., Chatelain, F. C., & Minor, D. L. (2004) · Nature · doi:10.1038/nature02588 · Cited by 426
Absence of Calsequestrin 2 Causes Severe Forms of Catecholaminergic Polymorphic Ventricular Tachycardia
Postma, A. V., Denjoy, I., Hoorntje, T. M., Lupoglazoff, J.-M., Da Costa, A., Sebillon, P., Mannens, M. M. A. M., Wilde, A. A. M., & Guicheney, P. (2002) · Circulation Research · doi:10.1161/01.res.0000038886.18992.6b · Cited by 410
The time-course of Ca2+ exchange with calmodulin, troponin, parvalbumin, and myosin in response to transient increases in Ca2+
Robertson, S. P., Johnson, J. D., & Potter, J. D. (1981) · Biophysical Journal · doi:10.1016/s0006-3495(81)84868-0 · Cited by 409
Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels
DeMaria, C. D., Soong, T. W., Alseikhan, B. A., Alvania, R. S., & Yue, D. T. (2001) · Nature · doi:10.1038/35078091 · Cited by 407
Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells
Wang, S.-Q., Song, L.-S., Lakatta, E. G., & Cheng, H. (2001) · Nature · doi:10.1038/35069083 · Cited by 407
Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres.
Lederer, W. J., & Tsien, R. W. (1976) · The Journal of Physiology · doi:10.1113/jphysiol.1976.sp011622 · Cited by 407
The Stimulation of Calcium Transport in Cardiac Sarcoplasmic Reticulum by Adenosine 3′:5′-Monophosphate-dependent Protein Kinase
Tada, M., Kirchberger, M. A., Repke, D. I., & Katz, A. M. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42237-0 · Cited by 406
Upregulation of Na+/Ca2+Exchanger Expression and Function in an Arrhythmogenic Rabbit Model of Heart Failure
Pogwizd, S. M., Qi, M., Yuan, W., Samarel, A. M., & Bers, D. M. (1999) · Circulation Research · doi:10.1161/01.res.85.11.1009 · Cited by 399
Comparison between the sarcomere length-force relations of intact and skinned trabeculae from rat right ventricle. Influence of calcium concentrations on these relations.
Kentish, J. C., ter Keurs, H. E., Ricciardi, L., Bucx, J. J., & Noble, M. I. (1986) · Circulation Research · doi:10.1161/01.res.58.6.755 · Cited by 396
Self-citation
Mechano‐electrical transduction currents in isolated vestibular hair cells of the chick.
Ohmori, H. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015581 · Cited by 394
Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres.
Kass, R. S., Tsien, R. W., & Weingart, R. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012417 · Cited by 390
T-Tubule Function in Mammalian Cardiac Myocytes
Brette, F., & Orchard, C. (2003) · Circulation Research · doi:10.1161/01.res.0000074908.17214.fd · Cited by 387
Adult forms of the Ca2+ATPase of sarcoplasmic reticulum. Expression in developing skeletal muscle.
Brandl, C. J., deLeon, S., Martin, D. R., & MacLennan, D. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61421-8 · Cited by 375
Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues
Denton, R. M., Richards, D. A., & Chin, J. G. (1978) · Biochemical Journal · doi:10.1042/bj1760899 · Cited by 373
Sinoatrial Nodal Cell Ryanodine Receptor and Na + -Ca 2+ Exchanger: Molecular Partners in Pacemaker Regulation
Bogdanov, K. Y., Vinogradova, T. M., & Lakatta, E. G. (2001) · Circulation Research · doi:10.1161/hh1201.092095 · Cited by 368
Spatial non-uniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes
Cannell, M. B., Cheng, H., & Lederer, W. J. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80677-0 · Cited by 361
Na v 1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Na v 1.5 on the surface of cardiomyocytes
Mohler, P. J., Rivolta, I., Napolitano, C., LeMaillet, G., Lambert, S., Priori, S. G., & Bennett, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403711101 · Cited by 360
Enhanced Store Overload–Induced Ca 2+ Release and Channel Sensitivity to Luminal Ca 2+ Activation Are Common Defects of RyR2 Mutations Linked to Ventricular Tachycardia and Sudden Death
Jiang, D., Wang, R., Xiao, B., Kong, H., Hunt, D. J., Choi, P., Zhang, L., & Chen, S. R. W. (2005) · Circulation Research · doi:10.1161/01.res.0000192146.85173.4b · Cited by 359
Atrial Fibrillation Is Associated With Increased Spontaneous Calcium Release From the Sarcoplasmic Reticulum in Human Atrial Myocytes
Hove-Madsen, L., Llach, A., Bayes-Genís, A., Roura, S., Font, E. R., Arís, A., & Cinca, J. (2004) · Circulation · doi:10.1161/01.cir.0000141296.59876.87 · Cited by 357
Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation
Vest, J. A., Wehrens, X. H. T., Reiken, S. R., Lehnart, S. E., Dobrev, D., Chandra, P., Danilo, P., Ravens, U., Rosen, M. R., & Marks, A. R. (2005) · Circulation · doi:10.1161/01.cir.0000162461.67140.4c · Cited by 356
Mapping of a gene for long QT syndrome to chromosome 4q25-27.
Schott, J., Charpentier, F., Peltier, S., Foley, P., Drouin, E., Bouhour, J. B., Donnelly, P., Vergnaud, G., Bachner, L., & Moisan, J. (1995) · Europe PMC (PubMed Central) · Cited by 353
Arrhythmic disorder mapped to chromosome 1q42–q43 causes malignant polymorphic ventricular tachycardia in structurally normal hearts
Swan, H., Piippo, K., Viitasalo, M., Heikkilä, P., Paavonen, T., Kainulainen, K., Kere, J., Keto, P., Kontula, K., & Toivonen, L. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00461-1 · Cited by 348
Cellular and Subcellular Heterogeneity of [Ca 2+ ] i in Single Heart Cells Revealed by Fura-2
Wier, W. G., Cannell, M. B., Berlin, J. R., Marban, E., & Lederer, W. J. (1987) · Science · doi:10.1126/science.3798114 · Cited by 347
The effects of inorganic phosphate and creatine phosphate on force production in skinned muscles from rat ventricle.
Kentish, J. C. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp015952 · Cited by 345
CaMKII tethers to L-type Ca2 + channels, establishing a local and dedicated integrator of Ca2 + signals for facilitation
Hudmon, A., Schulman, H., Kim, J., Maltez, J. M., Tsien, R. W., & Pitt, G. S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505155 · Cited by 344
Sudden Death in Familial Polymorphic Ventricular Tachycardia Associated With Calcium Release Channel (Ryanodine Receptor) Leak
Lehnart, S. E., Wehrens, X. H. T., Laitinen, P. J., Reiken, S. R., Deng, S.-X., Cheng, Z., Landry, D. W., Kontula, K., Swan, H., & Marks, A. R. (2004) · Circulation · doi:10.1161/01.cir.0000132472.98675.ec · Cited by 338
Sodium-Calcium Exchange Initiated by the Ca2+Transient
Patterson, E., Lazzara, R., Szabo, B., Liu, H., Tang, D., Li, Y.-H., Scherlag, B. J., & Po, S. S. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.12.023 · Cited by 336
CARDIAC MUSCLE
Sommer, J. R., & Johnson, E. A. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.36.3.497 · Cited by 336
Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts
Volders, P. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00022-5 · Cited by 333
Endothelin-1–Induced Arrhythmogenic Ca 2+ Signaling Is Abolished in Atrial Myocytes of Inositol-1,4,5-Trisphosphate(IP 3 )–Receptor Type 2–Deficient Mice
Li, X., Zima, A. V., Sheikh, F., Blatter, L. A., & Chen, J. (2005) · Circulation Research · doi:10.1161/01.res.0000172556.05576.4c · Cited by 332
Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes
Petroff, M. G. V., Kim, S. H., Pepe, S., Dessy, C., Marbán, E., Balligand, J.-L., & Sollott, S. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1001-867 · Cited by 329
Intracellular Ca2+ Dynamics and the Stability of Ventricular Tachycardia
Chudin, E., Goldhaber, J., Garfinkel, A., Weiss, J., & Kogan, B. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77126-2 · Cited by 322
Regulation and deregulation of cardiac Na+–Ca2+ exchange in giant excised sarcolemmal membrane patches
Hilgemann, D. W. (1990) · Nature · doi:10.1038/344242a0 · Cited by 320
Isolation of the ryanodine receptor from cardiac sarcoplasmic reticulum and identity with the feet structures.
Inui, M., Saito, A., & Fleischer, S. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47774-5 · Cited by 313
Reinduction of Atrial Fibrillation Immediately After Termination of the Arrhythmia Is Mediated by Late Phase 3 Early Afterdepolarization–Induced Triggered Activity
Burashnikov, A., & Antzelevitch, C. (2003) · Circulation · doi:10.1161/01.cir.0000065578.00869.7c · Cited by 310
Elevated Sarcoplasmic Reticulum Ca 2+ Leak in Intact Ventricular Myocytes From Rabbits in Heart Failure
Shannon, T. R., Pogwizd, S. M., & Bers, D. M. (2003) · Circulation Research · doi:10.1161/01.res.0000093399.11734.b3 · Cited by 310
Calcium, Calmodulin, and Calcium-Calmodulin Kinase II: Heartbeat to Heartbeat and Beyond
Maier, L. S., & Bers, D. M. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.2038 · Cited by 309
Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes.
Yue, D. T., Herzig, S., & Marban, E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.753 · Cited by 309
Sarcoplasmic Reticulum Ca 2+ Release Causes Myocyte Depolarization: Underlying Mechanism and Threshold for Triggered Action Potentials
Schlotthauer, K., & Bers, D. M. (2000) · Circulation Research · doi:10.1161/01.res.87.9.774 · Cited by 309
Macromolecular complexes regulating cardiac ryanodine receptor function
BERS, D. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.05.026 · Cited by 308
Unified Mechanisms of Ca2+ Regulation across the Ca2+ Channel Family
Liang, H., DeMaria, C. D., Erickson, M. G., Mori, M. X., Alseikhan, B. A., & Yue, D. T. (2003) · Neuron · doi:10.1016/s0896-6273(03)00560-9 · Cited by 305
Structural basis of the α1–β subunit interaction of voltage-gated Ca2+ channels
Chen, Y.-H., Li, M.-H., Zhang, Y., He, L.-L., Yamada, Y., Fitzmaurice, A., Shen, Y., Zhang, H., Tong, L., & Yang, J. (2004) · Nature · doi:10.1038/nature02641 · Cited by 304
Calcium‐ and length‐dependent force production in rat ventricular muscle
Hibberd, M. G., & Jewell, B. R. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014317 · Cited by 302
Three-dimensional architecture of the calcium channel/foot structure of sarcoplasmic reticulum
Wagenknecht, T., Grassucci, R., Frank, J., Saito, A., Inui, M., & Fleischer, S. (1989) · Nature · doi:10.1038/338167a0 · Cited by 301
Phospholamban Phosphorylation in Intact Ventricles
Wegener, A. D., Simmerman, H. K., Lindemann, J. P., & Jones, L. R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60487-9 · Cited by 300
Intracellular Ca2+ release contributes to automaticity in cat atrial pacemaker cells
Hüser, J., Blatter, L. A., & Lipsius, S. L. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00415.x · Cited by 296
Molecular Basis of Calmodulin Tethering and Ca2+-dependent Inactivation of L-type Ca2+ Channels
Pitt, G. S., Zühlke, R. D., Hudmon, A., Schulman, H., Reuter, H., & Tsien, R. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104959200 · Cited by 294
Targeted Mutational Analysis of the RyR2-Encoded Cardiac Ryanodine Receptor in Sudden Unexplained Death: A Molecular Autopsy of 49 Medical Examiner/Coroner's Cases
Tester, D. J., Spoon, D. B., Valdivia, H. H., Makielski, J. C., & Ackerman, M. J. (2004) · Mayo Clinic Proceedings · doi:10.4065/79.11.1380 · Cited by 294
High Basal Protein Kinase A–Dependent Phosphorylation Drives Rhythmic Internal Ca 2+ Store Oscillations and Spontaneous Beating of Cardiac Pacemaker Cells
Vinogradova, T. M., Lyashkov, A. E., Zhu, W., Ruknudin, A. M., Sirenko, S., Yang, D., Deo, S., Barlow, M., Johnson, S., Caffrey, J. L., et al. (2006) · Circulation Research · doi:10.1161/01.res.0000204575.94040.d1 · Cited by 292
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem
Béguin, P., Nagashima, K., Gonoi, T., Shibasaki, T., Takahashi, K., Kashima, Y., Ozaki, N., Geering, K., Iwanaga, T., & Seino, S. (2001) · Nature · doi:10.1038/35079621 · Cited by 291
Normalization of current kinetics by interaction between the α1and β subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel
Lacerda, A. E., Kim, H. S., Ruth, P., Perez-Reyes, E., Flockerzi, V., Hofmann, F., Birnbaumer, L., & Brown, A. M. (1991) · Nature · doi:10.1038/352527a0 · Cited by 291
Single cardiac sarcoplasmic reticulum Ca2+-release channel: activation by caffeine
Rousseau, E., & Meissner, G. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.256.2.h328 · Cited by 287
Role of Calcium Cycling Versus Restitution in the Mechanism of Repolarization Alternans
Pruvot, E. J., Katra, R. P., ROSENBAUM, D. S., & Laurita, K. R. (2004) · Circulation Research · doi:10.1161/01.res.0000125629.72053.95 · Cited by 287
Molecular Diversity of the Calcium Channel α2δ Subunit
Klugbauer, N., Lacinová, L., Marais, E., Hobom, M., & Hofmann, F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00684.1999 · Cited by 286
Stretch-Activated Ion Channels in the Heart
Hu, H., & Sachs, F. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1997.0392 · Cited by 286
Specific Phosphorylation of a Site in the Full-Length Form of the α1 Subunit of the Cardiac L-Type Calcium Channel by Adenosine 3‘,5‘-Cyclic Monophosphate- Dependent Protein Kinase
De Jongh, K. S., Murphy, B. J., Colvin, A. A., Hell, J. W., Takahashi, M., & Catterall, W. A. (1996) · Biochemistry · doi:10.1021/bi953023c · Cited by 284
Bidirectional Ventricular Tachycardia and Fibrillation Elicited in a Knock-In Mouse Model Carrier of a Mutation in the Cardiac Ryanodine Receptor
Cerrone, M., Colombi, B., Santoro, M., di Barletta, M. R., Scelsi, M., Villani, L., Napolitano, C., & Priori, S. G. (2005) · Circulation Research · doi:10.1161/01.res.0000169067.51055.72 · Cited by 283
Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions
Ellinor, P. T., Yang, J., Sather, W. A., Zhang, J.-F., & Tsien, R. W. (1995) · Neuron · doi:10.1016/0896-6273(95)90100-0 · Cited by 283
Sarcoplasmic Reticulum Ca 2+ and Heart Failure: Roles of Diastolic Leak and Ca 2+ Transport
Bers, D. M., Eisner, D. A., & Valdivia, H. H. (2003) · Circulation Research · doi:10.1161/01.res.0000091871.54907.6b · Cited by 282
Essential Ca 2+ -Binding Motif for Ca 2+ -Sensitive Inactivation of L-Type Ca 2+ Channels
de Leon, M., Wang, Y., Jones, L., Perez-Reyes, E., Wei, X., Soong, T. W., Snutch, T. P., & Yue, D. T. (1995) · Science · doi:10.1126/science.270.5241.1502 · Cited by 280
Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes
Miyata, H., Silverman, H. S., Sollott, S. J., Lakatta, E. G., Stern, M. D., & Hansford, R. G. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.261.4.h1123 · Cited by 276
Spectrum and Frequency of Cardiac Channel Defects in Swimming-Triggered Arrhythmia Syndromes
Choi, G., Kopplin, L. J., Tester, D. J., Will, M. L., Haglund, C. M., & Ackerman, M. J. (2004) · Circulation · doi:10.1161/01.cir.0000144471.98080.ca · Cited by 274
Calcium-activated chloride current in rabbit ventricular myocytes.
Zygmunt, A. C., & Gibbons, W. R. (1991) · Circulation Research · doi:10.1161/01.res.68.2.424 · Cited by 273
Structural Analysis of the Voltage-Dependent Calcium Channel β Subunit Functional Core and Its Complex with the α1 Interaction Domain
Opatowsky, Y., Chen, C.-C., Campbell, K. P., & Hirsch, J. A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00250-8 · Cited by 269
Immunolocalization of sarcolemmal dihydropyridine receptor and sarcoplasmic reticular triadin and ryanodine receptor in rabbit ventricle and atrium.
Carl, S. L., Felix, K., Caswell, A. H., Brandt, N. R., Ball, W. J., Vaghy, P. L., Meissner, G., & Ferguson, D. G. (1995) · The Journal of cell biology · doi:10.1083/jcb.129.3.673 · Cited by 267
Intracellular calcium transients underlying the short‐term force‐interval relationship in ferret ventricular myocardium.
Wier, W. G., & Yue, D. T. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016167 · Cited by 267
Enhanced Ca 2+ Release and Na/Ca Exchange Activity in Hypertrophied Canine Ventricular Myocytes: Potential Link Between Contractile Adaptation and Arrhythmogenesis
Sipido, K. R., Volders, P. G. A., de Groot, S. H. M., Verdonck, F., Van de Werf, F., Wellens, H. J. J., & Vos, M. A. (2000) · Circulation · doi:10.1161/01.cir.102.17.2137 · Cited by 263
Calcium Channel α2δ Subunits—Structure and Gabapentin Binding
Marais, E., Klugbauer, N., & Hofmann, F. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.5.1243 · Cited by 262
Genetics of acquired long QT syndrome
Roden, D. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25539 · Cited by 256
Calsequestrin determines the functional size and stability of cardiac intracellular calcium stores: Mechanism for hereditary arrhythmia
Terentyev, D., Viatchenko-Karpinski, S., Györke, I., Volpe, P., Williams, S. C., & Györke, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1932318100 · Cited by 256
Effects of pacing on triggered activity induced by early afterdepolarizations.
Damiano, B. P., & Rosen, M. R. (1984) · Circulation · doi:10.1161/01.cir.69.5.1013 · Cited by 253
Ca 2+ /Calmodulin-Dependent Protein Kinase II Phosphorylation of Ryanodine Receptor Does Affect Calcium Sparks in Mouse Ventricular Myocytes
Guo, T., Zhang, T., Mestril, R., & Bers, D. M. (2006) · Circulation Research · doi:10.1161/01.res.0000236756.06252.13 · Cited by 253
Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome
Nuyens, D., Stengl, M., Dugarmaa, S., Rossenbacker, T., Compernolle, V., Rudy, Y., Smits, J. F., Flameng, W., Clancy, C. E., Moons, L., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1021 · Cited by 251
Potentiation by the β Subunit of the Ratio of the Ionic Current to the Charge Movement in the Cardiac Calcium Channel
Neely, A., Wei, X., Olcese, R., Birnbaumer, L., & Stefani, E. (1993) · Science · doi:10.1126/science.8211185 · Cited by 250
Functional InsP3 receptors that may modulate excitation–contraction coupling in the heart
Lipp, P., Laine, M., Tovey, S. C., Burrell, K. M., Berridge, M. J., Li, W., & Bootman, M. D. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00624-2 · Cited by 247
Ankyrin-B Coordinates the Na/K ATPase, Na/Ca Exchanger, and InsP3 Receptor in a Cardiac T-Tubule/SR Microdomain
Mohler, P. J., Davis, J. Q., & Bennett, V. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030423 · Cited by 245
Catecholamine-induced severe ventricular arrhythmias with Adams-Stokes syndrome in children : report of four cases
Coumel, P. (1978) · Medical Entomology and Zoology · Cited by 244
Crystal structure of calsequestrin from rabbit skeletal muscle sarcoplasmic reticulum
Wang, S., Trumble, W. R., Liao, H., Wesson, C. R., Dunker, A. K., & Kang, C. (1998) · Nature Structural Biology · doi:10.1038/nsb0698-476 · Cited by 242
Differences between outward currents of human atrial and subepicardial ventricular myocytes.
Amos, G. J., Wettwer, E., Metzger, F., Li, Q., Himmel, H. M., & Ravens, U. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021194 · Cited by 241
Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase
Yuan, W., & Bers, D. M. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.267.3.h982 · Cited by 237
A calcium sensor in the sodium channel modulates cardiac excitability
Tan, H. L., Kupershmidt, S., Zhang, R., Stepanovic, S., Roden, D. M., Wilde, A. A. M., Anderson, M. E., & Balser, J. R. (2002) · Nature · doi:10.1038/415442a · Cited by 236
Calcium‐activated transient outward current in calf cardiac Purkinje fibres.
Siegelbaum, S. A., & Tsien, R. W. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013138 · Cited by 235
Action Potential Duration Restitution and Alternans in Rabbit Ventricular Myocytes: The Key Role of Intracellular Calcium Cycling
Goldhaber, J. I., Xie, L.-H., Duong, T., Motter, C., Khuu, K., & Weiss, J. N. (2005) · Circulation Research · doi:10.1161/01.res.0000156891.66893.83 · Cited by 235
Calreticulin inhibits repetitive intracellular Ca2+ waves
Camacho, P., & Lechleiter, J. D. (1995) · Cell · doi:10.1016/0092-8674(95)90473-5 · Cited by 234
Screening for ryanodine receptor type 2 mutations in families with effort-induced polymorphic ventricular arrhythmias and sudden death
Bauce, B., Rampazzo, A., Basso, C., Bagattin, A., Daliento, L., Tiso, N., Turrini, P., Thiene, G., Danieli, G. A., & Nava, A. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01946-0 · Cited by 232
Structures and Functions of Calcium Channel β Subunits
Birnbaumer, L., Qin, N., Olcese, R., Tareilus, E., Platano, D., Costantin, J., & Stefani, E. (1998) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1021989622656 · Cited by 228
Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes.
Anderson, M. E., Braun, A. P., Schulman, H., & Premack, B. A. (1994) · Circulation Research · doi:10.1161/01.res.75.5.854 · Cited by 227
Charge movement during Na+ translocation by native and cloned cardiac Na+/Ca2+ exchanger
Hilgemann, D. W., Nicoll, D. A., & Philipson, K. D. (1991) · Nature · doi:10.1038/352715a0 · Cited by 226
Cellular origins of the transient inward current in cardiac myocytes. Role of fluctuations and waves of elevated intracellular calcium.
Berlin, J. R., Cannell, M. B., & Lederer, W. J. (1989) · Circulation Research · doi:10.1161/01.res.65.1.115 · Cited by 226
Altered intracellular Ca2+ handling in heart failure
Yano, M., Ikeda, Y., & Matsuzaki, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524159 · Cited by 219
Calcium gradients during excitation‐contraction coupling in cat atrial myocytes.
Hüser, J., Lipsius, S. L., & Blatter, L. A. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021521 · Cited by 219
Two components of transient outward current in canine ventricular myocytes.
Tseng, G. N., & Hoffman, B. F. (1989) · Circulation Research · doi:10.1161/01.res.64.4.633 · Cited by 218
Triggered activity and automaticity in ventricular trabeculae of failing human and rabbit hearts
Vermeulen, J. T., Mcguire, M. A., Opthof, T., Coronel, R., De Bakker, J. M. T., Klopping, C., & Janse, M. J. (1994) · Cardiovascular Research · doi:10.1093/cvr/28.10.1547 · Cited by 218
Novel functional properties of Ca2+ channel β subunits revealed by their expression in adult rat heart cells
Colecraft, H. M., Alseikhan, B., Takahashi, S. X., Chaudhuri, D., Mittman, S., Yegnasubramanian, V., Alvania, R. S., Johns, D. C., Marbán, E., & Yue, D. T. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.018515 · Cited by 218
Ca2+ binding effects on protein conformation and protein interactions of canine cardiac calsequestrin.
Mitchell, R. D., Simmerman, H. K., & Jones, L. R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57313-6 · Cited by 217
The role of inositol 1,4,5‐trisphosphate receptors in Ca2+ signalling and the generation of arrhythmias in rat atrial myocytes
Mackenzie, L., Bootman, M. D., Laine, M., Berridge, M. J., Thuring, J., Holmes, A., Li, W., & Lipp, P. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013411 · Cited by 217
Effects of Action Potential Duration on Excitation-Contraction Coupling in Rat Ventricular Myocytes: Action Potential Voltage-Clamp Measurements
Bouchard, R. A., Clark, R. B., & Giles, W. R. (1995) · Circulation Research · doi:10.1161/01.res.76.5.790 · Cited by 216
KN-93, an Inhibitor of Multifunctional Ca++/Calmodulin-Dependent Protein Kinase, Decreases Early Afterdepolarizations in Rabbit Heart
Anderson, M. E., Braun, A. P., Wu, Y., Lu, T., Wu, Y., Schulman, H., & Sung, R. J. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37893-0 · Cited by 216
Ratio of ryanodine to dihydropyridine receptors in cardiac and skeletal muscle and implications for E-C coupling
Bers, D. M., & Stiffel, V. M. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.6.c1587 · Cited by 216
β-Adrenergic Stimulation Modulates Ryanodine Receptor Ca 2+ Release During Diastolic Depolarization to Accelerate Pacemaker Activity in Rabbit Sinoatrial Nodal Cells
Vinogradova, T. M., Bogdanov, K. Y., & Lakatta, E. G. (2002) · Circulation Research · doi:10.1161/hh0102.102271 · Cited by 215
Functional Roles of Ca v 1.3 (α 1D ) Calcium Channel in Sinoatrial Nodes: Insight Gained Using Gene-Targeted Null Mutant Mice
Zhang, Z., Xu, Y., Song, H., Rodriguez, J., Tuteja, D., Namkung, Y., Shin, H.-S., & Chiamvimonvat, N. (2002) · Circulation Research · doi:10.1161/01.res.0000018003.14304.e2 · Cited by 213
Molecular determinants of voltage-dependent inactivation in calcium channels
Zhang, J.-F., Ellinor, P. T., Aldrich, R. W., & Tsien, R. W. (1994) · Nature · doi:10.1038/372097a0 · Cited by 208
Clinical Phenotype and Functional Characterization of CASQ2 Mutations Associated With Catecholaminergic Polymorphic Ventricular Tachycardia
di Barletta, M. R., Viatchenko-Karpinski, S., Nori, A., Memmi, M., Terentyev, D., Turcato, F., Valle, G., Rizzi, N., Napolitano, C., Gyorke, S., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.623793 · Cited by 207
Functional coupling between glycolysis and excitation—contraction coupling underlies alternans in cat heart cells
Hüser, J., Wang, Y. G., Sheehan, K. A., Cifuentes, F., Lipsius, S. L., & Blatter, L. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00795.x · Cited by 206
Critical Determinants of Ca2+-Dependent Inactivation within an EF-Hand Motif of L-Type Ca2+ Channels
Peterson, B. Z., Lee, J. S., Mulle, J. G., Wang, Y., de Leon, M., & Yue, D. T. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76739-7 · Cited by 203
The Identification and Characterization of a Noncontinuous Calmodulin-binding Site in Noninactivating Voltage-dependent KCNQ Potassium Channels
Yus-Nájera, E., Santana-Castro, I., & Villarroel, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204130200 · Cited by 203
Calmodulin Is Essential for Cardiac I KS Channel Gating and Assembly: Impaired Function in Long-QT Mutations
Shamgar, L., Ma, L., Schmitt, N., Haitin, Y., Peretz, A., Wiener, R., Hirsch, J., Pongs, O., & Attali, B. (2006) · Circulation Research · doi:10.1161/01.res.0000218979.40770.69 · Cited by 203
Regulation of calcium release by calcium inside the sarcoplasmic reticulum in ventricular myocytes
Lukyanenko, V., Györke, I., & Györke, S. (1996) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050233 · Cited by 201
N-methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons.
Hell, J. W., Westenbroek, R. E., Breeze, L. J., Wang, K. K., Chavkin, C., & Catterall, W. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3362 · Cited by 198
Calcium‐activated non‐selective cation channel in ventricular cells isolated from adult guinea‐pig hearts.
Ehara, T., Noma, A., & Ono, K. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017242 · Cited by 195
Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM
Samsó, M., Wagenknecht, T., & Allen, P. D. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb938 · Cited by 195
Regulation of Cardiac Ca 2+ Release Channel (Ryanodine Receptor) by Ca 2+ , H + , Mg 2+ , and Adenine Nucleotides Under Normal and Simulated Ischemic Conditions
Xu, L., Mann, G., & Meissner, G. (1996) · Circulation Research · doi:10.1161/01.res.79.6.1100 · Cited by 195
Functional Regulation of L-type Calcium Channels via Protein Kinase A-mediated Phosphorylation of the β2 Subunit
Bünemann, M., Gerhardstein, B. L., Gao, T., & Hosey, M. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.33851 · Cited by 194
Na + -Ca 2+ Exchange Current and Submembrane [Ca 2+ ] During the Cardiac Action Potential
Weber, C. R., Piacentino, V., Ginsburg, K. S., Houser, S. R., & Bers, D. M. (2002) · Circulation Research · doi:10.1161/hh0202.103940 · Cited by 194
Functional Stoichiometry and Local Enrichment of Calmodulin Interacting with Ca 2+ Channels
Mori, M. X., Erickson, M. G., & Yue, D. T. (2004) · Science · doi:10.1126/science.1093490 · Cited by 193

STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca2+ Levels
Brandman, O., Liou, J., Park, W. S., & Meyer, T. (2007) · Cell · doi:10.1016/j.cell.2007.11.039 · Cited by 698
Association of Vitamin D Deficiency with Heart Failure and Sudden Cardiac Death in a Large Cross-Sectional Study of Patients Referred for Coronary Angiography
Pilz, S., März, W., Wellnitz, B., Seelhorst, U., Fahrleitner-Pammer, A., Dimai, H. P., Boehm, B. O., & Dobnig, H. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0784 · Cited by 607
The mechanisms of air pollution and particulate matter in cardiovascular diseases
Fiordelisi, A., Piscitelli, P., Trimarco, B., Coscioni, E., Iaccarino, G., & Sorriento, D. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9606-7 · Cited by 485
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Lei, M., Wu, L., Terrar, D. A., & Huang, C. L.-H. (2018) · Circulation · doi:10.1161/circulationaha.118.035455 · Cited by 319
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Cerrone, M., Montnach, J., Lin, X., Zhao, Y.-T., Zhang, M., Agullo-Pascual, E., Leo-Macias, A., Alvarado, F. J., Dolgalev, I., Karathanos, T. V., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00127-0 · Cited by 210

See all 356

Authors: ter Keurs, H. E. D. J., & Boyden, P. A.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2007-04
Volume: 87
Issue: 2
Pages: 457-506
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00011.2006
OpenAlex: W2123374731
Cited by: 356
References: 441
FWCI: 4.19
Type: journal article
Language: en
Open access: green

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Calcium and Arrhythmogenesis

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