Neurological mechanism-based analysis of the role and characteristics of physical activity in the improvement of depressive symptoms

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425

The biology of VEGF and its receptors

Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810

Metabolic regulation of gene expression by histone lactylation

Zhang, D., Tang, Z., Huang, H., Zhou, G., Cui, C., Weng, Y., Liu, W., Kim, S., Lee, S., Perez-Neut, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1678-1 · Cited by 4,371

AMPK: guardian of metabolism and mitochondrial homeostasis

Herzig, S., & Shaw, R. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.95 · Cited by 4,192

Depression

Malhi, G. S., & Mann, J. J. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31948-2 · Cited by 4,099

Antidepressant effects of ketamine in depressed patients

Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856

Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

Cipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y., Leucht, S., Ruhe, H. G., Turner, E. H., Higgins, J. P. T., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)32802-7 · Cited by 3,541

A Neurotrophic Model for Stress-Related Mood Disorders

Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

eQTLGen, Wray, N. R., 23andMe, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0090-3 · Cited by 3,005

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,261

A molecular and cellular theory of depression

Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments

Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109

The expanded biology of serotonin

Berger, M., Gray, J. A., & Roth, B. L. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.60.042307.110802 · Cited by 2,100

cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)

Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., & Matsubara, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0587 · Cited by 2,081

Epidemiology of anxiety disorders in the 21st century

Bandelow, B., & Michaelis, S. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.3/bbandelow · Cited by 2,079

Neurotrophin regulation of neural circuit development and function

Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060

Purification of a new neurotrophic factor from mammalian brain.

Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822

Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies

Schuch, F. B., Vancampfort, D., Firth, J., Rosenbaum, S., Ward, P. B., Silva, E. S., Hallgren, M., Ponce De Leon, A., Dunn, A. L., Deslandes, A. C., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17111194 · Cited by 1,763

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711

Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression

Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654

Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis

Cipriani, A., Furukawa, T. A., Salanti, G., Geddes, J. R., Higgins, J. P., Churchill, R., Watanabe, N., Nakagawa, A., Omori, I. M., McGuire, H., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60046-5 · Cited by 1,654

Trophic factors and neuronal survival

Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Zanos, P., Moaddel, R., Morris, P. J., Georgiou, P., Fischell, J., Elmer, G. I., Alkondon, M., Yuan, P., Pribut, H. J., Singh, N. S., et al. (2016) · Nature · doi:10.1038/nature17998 · Cited by 1,609

Exercise as a treatment for depression: a meta-analysis adjusting for publication bias

Schuch, F. B., Vancampfort, D., Richards, J., Rosenbaum, S., Ward, P. B., & Stubbs, B. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.02.023 · Cited by 1,529

Global prevalence of depression and elevated depressive symptoms among adolescents: a systematic review and meta-analysis

Shorey, S., Ng, E. D., & Wong, C. H. J. (2022) · British Journal of Clinical Psychology · doi:10.1111/bjc.12333 · Cited by 1,511

IL-6 in inflammation, autoimmunity and cancer

Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453

Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

Yamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Okada-Iwabu, M., Kawamoto, S., Kubota, N., Kubota, T., et al. (2007) · Nature Medicine · doi:10.1038/nm1557 · Cited by 1,396

Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

Cervenka, I., Agudelo, L. Z., & Ruas, J. L. (2017) · Science · doi:10.1126/science.aaf9794 · Cited by 1,382

Association Between Physical Activity and Risk of Depression: A Systematic Review and Meta-analysis

Pearce, M., Garcia, L., Abbas, A., Strain, T., Schuch, F. B., Golubic, R., Kelly, P., Khan, S., Utukuri, M., Laird, Y., et al. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.0609 · Cited by 1,332

Major depressive disorder: hypothesis, mechanism, prevention and treatment

Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,244

The Biochemistry of Affective Disorders

Coppen, A. (1967) · British Journal of Psychiatry · doi:10.1192/bjp.113.504.1237 · Cited by 1,230

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 3. Pharmacological Treatments

Kennedy, S. H., Lam, R. W., McIntyre, R. S., Tourjman, S. V., Bhat, V., Blier, P., Hasnain, M., Jollant, F., Levitt, A. J., MacQueen, G. M., et al. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716659417 · Cited by 1,181

Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study

Chekroud, S. R., Gueorguieva, R., Zheutlin, A. B., Paulus, M., Krumholz, H. M., Krystal, J. H., & Chekroud, A. M. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30227-x · Cited by 1,172

Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication

Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164

Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis

Campbell, S., Marriott, M., Nahmias, C., & MacQueen, G. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.598 · Cited by 1,156

Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T., Sakata, K., Zhen, S., Teng, K. K., Yung, W.-H., Hempstead, B. L., & Lu, B. (2004) · Science · doi:10.1126/science.1100135 · Cited by 1,136

FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise

Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

Yang, Y., Cui, Y., Sang, K., Dong, Y., Ni, Z., Ma, S., & Hu, H. (2018) · Nature · doi:10.1038/nature25509 · Cited by 1,036

Tryptophan metabolism in health and disease

Chen, X., Li, G., Zheng, Q., Gu, X., Shi, Q., Su, Y., Chu, Q., Yuan, X., Bao, Z., Lu, J., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.004 · Cited by 1,035

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1

Baar, K., Wende, A. R., Jones, T. E., Marison, M., Nolte, L. A., Chen, M., Kelly, D. P., & Holloszy, J. O. (2002) · The FASEB Journal · doi:10.1096/fj.02-0367com · Cited by 1,020

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000

Adiponectin and AdipoR1 Regulate PGC-1α and Mitochondria by Ca2+ and AMPK/SIRT1

Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., et al. (2010) · Nature · doi:10.1038/nature08991 · Cited by 971

The serotonin theory of depression: a systematic umbrella review of the evidence

Moncrieff, J., Cooper, R. E., Stockmann, T., Amendola, S., Hengartner, M. P., & Horowitz, M. A. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01661-0 · Cited by 960

BDNF - a key transducer of antidepressant effects

Björkholm, C., & Monteggia, L. M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.034 · Cited by 958

A pathophysiological framework of hippocampal dysfunction in ageing and disease

Small, S. A., Schobel, S., Buxton, R. B., Witter, M. P., & Barnes, C. A. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3085 · Cited by 955

Exerkines in health, resilience and disease

Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927

Prevalence of depression in cancer patients: a meta‐analysis of diagnostic interviews and self‐report instruments

Krebber, A. M. H., Buffart, L. M., Kleijn, G., Riepma, I. C., de Bree, R., Leemans, C. R., Becker, A., Brug, J., van Straten, A., Cuijpers, P., et al. (2014) · Psycho-Oncology · doi:10.1002/pon.3409 · Cited by 908

CYTOKINE TARGETS IN THE BRAIN: IMPACT ON NEUROTRANSMITTERS AND NEUROCIRCUITS: Review: Cytokine Targets in the Brain

Miller, A. H., Haroon, E., Raison, C. L., & Felger, J. C. (2013) · Depression and Anxiety · doi:10.1002/da.22084 · Cited by 892

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

Pan, R.-Y., He, L., Zhang, J., Liu, X., Liao, Y., Gao, J., Liao, Y., Yan, Y., Li, Q., Zhou, X., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.02.013 · Cited by 862

Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

Kubota, N., Yano, W., Kubota, T., Yamauchi, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Okamoto, S., Shiuchi, T., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.003 · Cited by 844

Role of Myokines in Exercise and Metabolism

Pedersen, B. K., Åkerström, T. C. A., Nielsen, A. R., & Fischer, C. P. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00080.2007 · Cited by 841

Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)

Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00169-4 · Cited by 841

Exercise as a treatment for depression: A meta-analysis

Kvam, S., Kleppe, C. L., Nordhus, I. H., & Hovland, A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.03.063 · Cited by 837

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis

Yang, K., Fan, M., Wang, X., Xu, J., Wang, Y., Tu, F., Gill, P. S., Ha, T., Liu, L., Williams, D. L., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00841-9 · Cited by 836

The Semantics of Microglia Activation: Neuroinflammation, Homeostasis, and Stress

Woodburn, S. C., Bollinger, J. L., & Wohleb, E. S. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02309-6 · Cited by 783

Gray matter abnormalities in major depressive disorder: A meta-analysis of voxel based morphometry studies

Bora, E., Fornito, A., Pantelis, C., & Yücel, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.049 · Cited by 763

Physical Exercise and Psychological Well-Being: A Population Study in Finland

Hassmén, P., Koivula, N., & Uutela, A. K. (2000) · Preventive Medicine · doi:10.1006/pmed.1999.0597 · Cited by 736

Neuroinflammation and psychiatric illness

Najjar, S., Pearlman, D. M., Alper, K., Najjar, A., & Devinsky, O. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-43 · Cited by 733

Mental health interventions in schools in high-income countries

Fazel, M., Hoagwood, K., Stephan, S., & Ford, T. (2014) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)70312-8 · Cited by 730

Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity

Gómez-Pinilla, F., Ying, Z., Roy, R. R., Molteni, R., & Edgerton, V. R. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00152.2002 · Cited by 724

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

Matthews, V. B., Åström, M.-B., Chan, M. H. S., Bruce, C. R., Krabbe, K. S., Prelovsek, O., Åkerström, T., Yfanti, C., Broholm, C., Mortensen, O. H., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1364-1 · Cited by 722

Prevalence of depression and anxiety in Multiple Sclerosis: A systematic review and meta-analysis

Boeschoten, R. E., Braamse, A. M. J., Beekman, A. T. F., Cuijpers, P., van Oppen, P., Dekker, J., & Uitdehaag, B. M. J. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.11.067 · Cited by 713

Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section

Sendtner, M., Holtmann, B., Kolbeck, R., Thoenen, H., & Barde, Y. (1992) · Nature · doi:10.1038/360757a0 · Cited by 706

Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects

Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.050 · Cited by 677

Monoamine neurocircuitry in depression and strategies for new treatments

Hamon, M., & Blier, P. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.04.009 · Cited by 674

PGC-1 α , Inflammation, and Oxidative Stress: An Integrative View in Metabolism

Rius‐Pérez, S., Torres-Cuevas, I., Millán, I., Ortega, Á., & Pérez, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1452696 · Cited by 671

Physical Activity and Depression: Evidence from the Alameda County Study

Camacho, T. C., ROBERTS, R. E., LAZARUS, N. B., Kaplan, G. A., & Cohen, R. D. (1991) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116074 · Cited by 654

Neuronal plasticity and survival in mood disorders

Duman, R. S., Malberg, J., Nakagawa, S., & D’Sa, C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00935-5 · Cited by 652

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643

The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk

Pedersen, B. K. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179515 · Cited by 631

Impact of Aerobic Exercise Training on Age-Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity

Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., Rizza, R. A., Coenen-Schimke, J. M., & Nair, K. S. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1888 · Cited by 631

Running-induced systemic cathepsin B secretion is associated with memory function

Moon, H. Y., Becke, A., Berron, D., Becker, B., Sah, N., Benoni, G., Janke, E., Lubejko, S. T., Greig, N. H., Mattison, J. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.025 · Cited by 628

Novel and emerging treatments for major depression

Marwaha, S., Palmer, E. R., Suppes, T. M., Cons, E., Young, A. H., & Upthegrove, R. (2022) · The Lancet · doi:10.1016/s0140-6736(22)02080-3 · Cited by 618

Markers of central inflammation in major depressive disorder: a systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue

Enache, D., Pariante, C. M., & Mondelli, V. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.06.015 · Cited by 615

FNDC5/irisin is not only a myokine but also an adipokine

Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

Morland, C., Andersson, K. A., Haugen, Ø. P., Hadzic, A., Kleppa, L., Gille, A., Rinholm, J. E., Palibrk, V., Diget, E. H., Kennedy, L. H., et al. (2017) · Nature Communications · doi:10.1038/ncomms15557 · Cited by 559

Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action

Castrén, E., & Monteggia, L. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.05.008 · Cited by 540

Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)

El Hayek, L., Khalifeh, M., Zibara, V., Abi Assaad, R., Emmanuel, N., Karnib, N., El-Ghandour, R., Nasrallah, P., Bilen, M., Ibrahim, P., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1661-18.2019 · Cited by 539

Exercise-Mediated Neurogenesis in the Hippocampus via BDNF

Liu, P. Z., & Nusslock, R. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00052 · Cited by 533

Prevalence of Depression in Patients With Mild Cognitive Impairment: A Systematic Review and Meta-analysis

Ismail, Z., Elbayoumi, H., Fischer, C. E., Hogan, D. B., Millikin, C. P., Schweizer, T., Mortby, M. E., Smith, E. E., Patten, S. B., & Fiest, K. M. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.3162 · Cited by 532

Tryptophan metabolism and gut-brain homeostasis

Roth, W., Zadeh, K., Vekariya, R., Ge, Y., & Mohamadzadeh, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062973 · Cited by 519

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Yang, J., Ruchti, E., Petit, J.-M., Jourdain, P., Grenningloh, G., Allaman, I., & Magistretti, P. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322912111 · Cited by 504

Physical activity and memory functions: An interventional study

Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., Völker, K., Ho, H. V., Mooren, F., Knecht, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.001 · Cited by 499

The potential of endurance exercise-derived exosomes to treat metabolic diseases

Safdar, A., Saleem, A., & Tarnopolsky, M. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.76 · Cited by 463

Exercise‐induced increase in serum interleukin‐6 in humans is related to muscle damage.

Brüünsgaard, H., Galbo, H., Halkjær-Kristensen, J., Johansen, T., MacLean, D. A., & Pedersen, B. K. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp021972 · Cited by 455

PGC-1α as a Pivotal Factor in Lipid and Metabolic Regulation

Cheng, C., Ku, H., & Lin, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113447 · Cited by 450

Defining treatment‐resistant depression

Gaynes, B. N., Lux, L., Gartlehner, G., Asher, G., Forman‐Hoffman, V., Green, J., Boland, E., Weber, R. P., Randolph, C., Bann, C., et al. (2020) · Depression and Anxiety · doi:10.1002/da.22968 · Cited by 447

Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3α,5α-THP

Frye, C. A., Petralia, S. M., & Rhodes, M. E. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00392-0 · Cited by 446

Anxiety and depressive disorders in people with epilepsy: A meta‐analysis

Scott, A. J., Sharpe, L., Hunt, C., & Gandy, M. (2017) · Epilepsia · doi:10.1111/epi.13769 · Cited by 441

Serotonin neurons in the dorsal raphe nucleus encode reward signals

Li, Y., Zhong, W., Wang, D., Feng, Q., Liu, Z., Zhou, J., Jia, C., Hu, F., Zeng, J., Guo, Q., et al. (2016) · Nature Communications · doi:10.1038/ncomms10503 · Cited by 440

Exercise plasma boosts memory and dampens brain inflammation via clusterin

De Miguel, Z., Khoury, N., Betley, M. J., Lehallier, B., Willoughby, D., Olsson, N., Yang, A. C., Hahn, O., Lu, N., Vest, R. T., et al. (2021) · Nature · doi:10.1038/s41586-021-04183-x · Cited by 422

Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex

Hinwood, M., Morandini, J., Day, T. A., & Walker, F. R. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr229 · Cited by 420

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

Schnyder, S., & Handschin, C. (2015) · Bone · doi:10.1016/j.bone.2015.02.008 · Cited by 419

Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation

Mao, Y.-Z., Zhang, J., Zhou, Q., He, X., Zheng, Z., Wei, Y., Zhou, K., Lin, Y., Yu, H., Zhang, H., et al. (2024) · Cell Research · doi:10.1038/s41422-023-00864-6 · Cited by 412

Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications

Tartt, A. N., Mariani, M. B., Hen, R., Mann, J. J., & Boldrini, M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01520-y · Cited by 408

Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation

Vaccarino, V., Badimon, L., Bremner, J. D., Cenko, E., Cubedo, J., Dorobantu, M., Duncker, D. J., Koller, A., Manfrini, O., Milicic, D., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehy913 · Cited by 404

Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions

Fogaça, M. V., & Duman, R. S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00087 · Cited by 396

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

Early, J. O., Menon, D., Wyse, C. A., Cervantes-Silva, M. P., Zaslona, Z., Carroll, R. G., Palsson-McDermott, E. M., Angiari, S., Ryan, D. G., Corcoran, S. E., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800431115 · Cited by 389

The role of proteases in transforming growth factor-β activation

Jenkins, G. R. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.11.026 · Cited by 374

Exercise-induced myokines and their role in chronic diseases

Pedersen, B. K. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.02.010 · Cited by 370

Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain

Deng, Y., Zhou, M., Wang, J., Yao, J., Yu, J., Liu, W., Wu, L., Wang, J., & Gao, R. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1869501 · Cited by 362

Physical activity and plasma interleukin-6 in humans - effect of intensity of exercise

Ostrowski, K., Schjerling, P., & Pedersen, B. K. (2000) · European Journal of Applied Physiology · doi:10.1007/s004210000312 · Cited by 355

Wearable-device-measured physical activity and future health risk

Strain, T., Wijndaele, K., Dempsey, P. C., Sharp, S. J., Pearce, M., Jeon, J., Lindsay, T., Wareham, N., & Brage, S. (2020) · Nature Medicine · doi:10.1038/s41591-020-1012-3 · Cited by 355

Protein lactylation induced by neural excitation

Hagihara, H., Shoji, H., Otabi, H., Toyoda, A., Katoh, K., Namihira, M., & Miyakawa, T. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109820 · Cited by 349

Hippocampal Angiogenesis and Progenitor Cell Proliferation Are Increased with Antidepressant Use in Major Depression

Boldrini, M., Hen, R., Underwood, M. D., Rosoklija, G. B., Dwork, A. J., Mann, J. J., & Arango, V. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.024 · Cited by 348

Efficacy of Pharmacotherapy and Psychotherapy for Adult Psychiatric Disorders: A Systematic Overview of Meta-analyses

Huhn, M., Tardy, M., Spineli, L. M., Kissling, W., Förstl, H., Pitschel-Walz, G., Leucht, C., Samara, M., Dold, M., Davis, J. M., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.112 · Cited by 333

Lactic Acid: No Longer an Inert and End-Product of Glycolysis

Sun, S., Li, H., Chen, J., & Qian, Q. (2017) · Physiology · doi:10.1152/physiol.00016.2017 · Cited by 331

Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives

Fee, C., Banasr, M., & Sibille, E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.024 · Cited by 329

Meta-review of depressive subtyping models

Harald, B., & Gordon, P. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.07.015 · Cited by 328

Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin

Yau, S. Y., Li, A., Hoo, R. L. C., Ching, Y. P., Christie, B. R., Lee, T. M. C., Xu, A., & So, K.-F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415219111 · Cited by 326

Neurobiology of local and intercellular BDNF signaling

Sasi, M., Vignoli, B., Canossa, M., & Blum, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1964-4 · Cited by 324

Association of high-sensitivity C-reactive protein with de novo major depression

Pasco, J. A., Nicholson, G. C., Williams, L. J., Jacka, F. N., Henry, M. J., Kotowicz, M. A., Schneider, H. G., Leonard, B. E., & Berk, M. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.076430 · Cited by 321

Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression

Albert, P. R., Vahid-Ansari, F., & Luckhart, C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00199 · Cited by 321

Pro- and anti-inflammatory cytokines expression in rat's brain and spleen exposed to chronic mild stress: Involvement in depression

You, Z., Luo, C., Zhang, W., Chen, Y., He, J., Zhao, Q., Zuo, R. M., & Wu, Y. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.006 · Cited by 312

Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression

Anand, A., Mathew, S. J., Sanacora, G., Murrough, J. W., Goes, F. S., Altinay, M. I., Aloysi, A. S., Asghar‐Ali, A. A., Barnett, B. S., Chang, L. C., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2302399 · Cited by 294

Prevalence of depression, anxiety, and apathy symptoms across dementia stages: A systematic review and meta‐analysis

Leung, D. K. Y., Chan, W. C., Spector, A. E., & Wong, G. H. Y. (2021) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5556 · Cited by 282

Lactate Transport and Signaling in the Brain: Potential Therapeutic Targets and Roles in Body—Brain Interaction

Bergersen, L. H. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.206 · Cited by 266

Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface

Miller, A. H. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.08.006 · Cited by 261

An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder

Pu, J., Liu, Y., Zhang, H., Tian, L., Gui, S., Yu, Y., Chen, X., Chen, Y., Yang, L., Ran, Y., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0645-4 · Cited by 252

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

Schumacher, M. A., Chinnam, N. B., Ohashi, T., Shah, R., & Erickson, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.516641 · Cited by 244

Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease

Chen, L.-M., Bao, C., Wu, Y. H., Liang, S.-H., Wang, D., Wu, L.-Y., Huang, Y., Liu, H.-R., & Wu, H.-G. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02175-2 · Cited by 243

Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?

Müller, P., Duderstadt, Y., Lessmann, V., & Müller, N. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041136 · Cited by 241

Irisin-immunoreactivity in neural and non-neural cells of the rodent

Dun, S. L., Lyu, R., Chen, Y., Chang, J. K., Luo, J. J., & Dun, N. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.050 · Cited by 240

Neurotrophin-Mediated Rapid Signaling in the Central Nervous System: Mechanisms and Functions

Blum, R., & Konnerth, A. (2005) · Physiology · doi:10.1152/physiol.00042.2004 · Cited by 239

Physiological roles of muscle-derived interleukin-6 in response to exercise

Pedersen, B. K., & Fischer, C. P. (2007) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3280ebb5b3 · Cited by 227

Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients

Lucassen, P. J., Stumpel, M. W., Wang, Q., & Aronica, E. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.01.012 · Cited by 223

Pro-inflammatory cytokines as predictors of antidepressant effects of exercise in major depressive disorder

Rethorst, C. D., Toups, M. S. P., GREER, T. L., Nakonezny, P. A., Carmody, T. J., Grannemann, B. D., Huebinger, R. M., Barber, R. C., & Trivedi, M. H. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.125 · Cited by 219

β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

Kitase, Y., Vallejo, J. A., Gutheil, W., Vemula, H., Jähn, K., Yi, J., Zhou, J., Brotto, M., & Bonewald, L. F. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.041 · Cited by 219

Adverse effects of electroconvulsive therapy

Andrade, C., Arumugham, S. S., & Thirthalli, J. (2016) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2016.04.004 · Cited by 216

Prefrontal cortex GABAergic deficits and circuit dysfunction in the pathophysiology and treatment of chronic stress and depression

Ghosal, S., Hare, B. D., & Duman, R. S. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.09.012 · Cited by 213

Brain-Derived Neurotrophic Factor and Major Depressive Disorder: Evidence from Meta-Analyses

Kishi, T., Yoshimura, R., Ikuta, T., & Iwata, N. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00308 · Cited by 213

Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study

Miyaoka, T., Wake, R., Furuya, M., Liaury, K., Ieda, M., Kawakami, K., Tsuchie, K., Taki, M., Ishihara, K., Araki, T., et al. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.002 · Cited by 212

Effectiveness of and dropout from outpatient cognitive behavioral therapy for adult unipolar depression: A meta-analysis of nonrandomized effectiveness studies.

Hans, E., & Hiller, W. (2013) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0031080 · Cited by 211

Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines

Moon, H., Dincer, F., & Mantzoros, C. S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.04.007 · Cited by 208

Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection

Sas, K., Szabó, E., & Vécsei, L. (2018) · Molecules · doi:10.3390/molecules23010191 · Cited by 206

TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism

Takahashi, H., Alves, C. R. R., Stanford, K. I., Middelbeek, R. J. W., Nigro, P., Ryan, R. E., Xue, R., Sakaguchi, M., Lynes, M. D., So, K., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0030-7 · Cited by 204

Bicycle exercise enhances plasma IL-6 but does not change IL-1 alpha, IL-1 beta, IL-6, or TNF-alpha pre-mRNA in BMNC

Ullum, H., Haahr, P., Diamant, M., Palmo, J., Halkjær-Kristensen, J., & Pedersen, B. K. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.1.93 · Cited by 197

Effects of SSRIs on peripheral inflammatory markers in patients with major depressive disorder: A systematic review and meta-analysis

Wang, L., Wang, R., Liu, L., Qiao, D., Baldwin, D. S., & Hou, R. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.02.021 · Cited by 192

Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity

Liu, J., Guo, M., Zhang, D., Cheng, S.-Y., Liu, M., Ding, J., Scherer, P. E., Liu, F., & Lu, X. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202835109 · Cited by 188

Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders

Mor, A., Tankiewicz‐Kwedlo, A., Krupa, A., & Pawlak, D. (2021) · Cells · doi:10.3390/cells10071603 · Cited by 188

Immunologic Mediators as Parameters of the Reaction to Strenuous Exercise

Northoff, H., & Berg, A. (1991) · International Journal of Sports Medicine · doi:10.1055/s-2007-1024743 · Cited by 186

IL‐6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance

Nash, D., Hughes, M. G., Butcher, L., Aicheler, R., Smith, P., Cullen, T., & Webb, R. (2023) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.14241 · Cited by 182

Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis

Jin, Y. T., Kang, Y., Wang, M., Wu, B., Su, B., Yin, H., Tang, Y., Li, Q., Wei, W., Mei, Q., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00872-9 · Cited by 176

Forced treadmill exercise can induce stress and increase neuronal damage in a mouse model of global cerebral ischemia

Svensson, M., Rosvall, P., Boza‐Serrano, A., Andersson, E., Lexell, J. E., & Deierborg, T. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.09.002 · Cited by 174

Peripheral administration of lactate produces antidepressant-like effects

Carrard, A., Elsayed, M. G. A., Margineanu, M. B., Boury‐Jamot, B., Fragnière, L., Meylan, E. M., Petit, J.-M., Fiumelli, H., Magistretti, P. J., & Martin, J.-L. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.179 · Cited by 172

Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity

Matsui, T., Omuro, H., Liu, Y.-F., Soya, M., Shima, T., McEwen, B. S., & Soya, H. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702739114 · Cited by 172

C-Reactive protein as a biomarker for major depressive disorder?

Orsolini, L., Pompili, S., Tempia Valenta, S., Salvi, V., & Volpe, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031616 · Cited by 171

The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes

Piya, M. K., Harte, A. L., Sivakumar, K., Tripathi, G., Voyias, P. D., James, S. G., Sabico, S., Al‐Daghri, N. M., Saravanan, P., Barber, T. M., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00308.2013 · Cited by 168

Emerging roles for TGF‐β1 in nervous system development

Gomes, F. C. A., Sousa, V. D. O., & Romão, L. F. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.04.001 · Cited by 161

Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia

Yuan, P., Zhou, R., Wang, Y., Li, X., Li, J., Chen, G., Guitart, X., & Manji, H. K. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.10.017 · Cited by 160

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

Gaitán, J. M., Moon, H. Y., Stremlau, M., Dubal, D. B., Cook, D. B., Okonkwo, O. C., & van Praag, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.660181 · Cited by 160

IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling

Hoge, J., Yan, I., Jänner, N., Schumacher, V., Chalaris, A., Steinmetz, O. M., Engel, D. R., Scheller, J., Rose‐John, S., & Mittrücker, H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201044 · Cited by 158

Long-Term Mild, rather than Intense, Exercise Enhances Adult Hippocampal Neurogenesis and Greatly Changes the Transcriptomic Profile of the Hippocampus

Inoue, K., Okamoto, M., Shibato, J., Lee, M. C., Matsui, T., Rakwal, R., & Soya, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128720 · Cited by 154

Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise

Thomas, A. G., Dennis, A., Rawlings, N. B., Stagg, C. J., Matthews, L., Morris, M., Kolind, S. H., Foxley, S., Jenkinson, M., Nichols, T. E., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.090 · Cited by 152

BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids

Revest, J., Roux, A. L., Roullot, V., Kaouane, N., Vallée, M., Kasanetz, F., Rougé‐Pont, F., Tronche, F., Desmedt, A., & Piazza, P. V. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.134 · Cited by 152

Activation of AMP-Activated Protein Kinase by Interleukin-6 in Rat Skeletal Muscle

Kelly, M., Gauthier, M., Saha, A. K., & Ruderman, N. B. (2009) · Diabetes · doi:10.2337/db08-1293 · Cited by 151

GABAergic Control of Depression-Related Brain States

Luscher, B., & Fuchs, T. (2015) · Advances in Pharmacology · doi:10.1016/bs.apha.2014.11.003 · Cited by 149

BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice

Jung, T. W., Hwang, H.-J., Hong, H. C., Yoo, H. J., Baik, S. H., & Choi, K. M. (2015) · Diabetologia · doi:10.1007/s00125-015-3663-z · Cited by 145

Regulation of Innate and Adaptive Immunity by TGFβ

Kelly, A., Houston, S. A., Sherwood, E., Casulli, J., & Travis, M. A. (2017) · Advances in immunology · doi:10.1016/bs.ai.2017.01.001 · Cited by 145

Exercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors

Alizadeh Pahlavani, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.811751 · Cited by 145

Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

Yao, S., Xu, M.-D., Wang, Y., Zhao, S., Wang, J., Chen, G.-F., Chen, W., Liu, J., Huang, G., Sun, W.-J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36209-5 · Cited by 144

Physical activity and exercise attenuate neuroinflammation in neurological diseases

Spielman, L. J., Little, J. P., & Klegeris, A. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.03.012 · Cited by 142

Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode: A Systematic Review and Meta-analysis

Rhee, T. G., Shim, S. R., Forester, B. P., Nierenberg, A. A., McIntyre, R. S., Papakostas, G. I., Krystal, J. H., Sanacora, G., & Wilkinson, S. T. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.3352 · Cited by 141

Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice

Leiter, O., Brici, D., Fletcher, S. J., Yong, X. L. H., Widagdo, J., Matigian, N., Schroer, A. B., Bieri, G., Blackmore, D. G., Bartlett, P. F., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39873-9 · Cited by 139

Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures

Fu, X., Zunich, S. M., O’Connor, J. C., Kavelaars, A., Dantzer, R., & Kelley, K. W. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-43 · Cited by 137

β-aminoisobutyric acid attenuates LPS-induced inflammation and insulin resistance in adipocytes through AMPK-mediated pathway

Jung, T. W., Park, H. S., Choi, G. H., Kim, D., & Lee, T. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0431-7 · Cited by 137

Tetrahydrobioterin (BH4) pathway: from metabolism to neuropsychiatry

Fanet, H., Capuron, L., Castanon, N., Calon, F., & Vancassel, S. (2021) · Current Neuropharmacology · doi:10.2174/1570159x18666200729103529 · Cited by 134

Peripheral and central kynurenine pathway abnormalities in major depression

Paul, E. R., Schwieler, L., Erhardt, S., Boda, S., Trepci, A., Kämpe, R., Asratian, A., Holm, L., Yngve, A., Dantzer, R., et al. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.01.002 · Cited by 134

Adiponectin Stimulates Proliferation of Adult Hippocampal Neural Stem/Progenitor Cells through Activation of p38 Mitogen-activated Protein Kinase (p38MAPK)/Glycogen Synthase Kinase 3β (GSK-3β)/β-Catenin Signaling Cascade

Zhang, D., Guo, M., Zhang, W., & Lu, X. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.310052 · Cited by 133

Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time

Bus, B. A. A., Molendijk, M. L., Tendolkar, I., Penninx, B. W. J. H., Prickaerts, J., Elzinga, B. M., & Voshaar, R. C. O. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.83 · Cited by 133

A key role for TGF-β1 in hippocampal synaptic plasticity and memory

Caraci, F., Gulisano, W., Guida, C. A., Impellizzeri, A. A. R., Drago, F., Puzzo, D., & Palmeri, A. (2015) · Scientific Reports · doi:10.1038/srep11252 · Cited by 133

Prenatal inflammation impairs adult neurogenesis and memory related behavior through persistent hippocampal TGFβ1 downregulation

Graciarena, M., Depino, A. M., & Pitossi, F. J. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.06.005 · Cited by 131

Physiology of Microglia

Garaschuk, O., & Verkhratsky, A. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9658-2_3 · Cited by 129

Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN

Sun, N., Qin, Y., Chu, X., Xia, T., Du, Z., Zheng, L., Li, A., Meng, F. J., Zhang, Y., Zhang, J., et al. (2022) · Science · doi:10.1126/science.abo3566 · Cited by 124

Electroconvulsive therapy and structural neuroplasticity in neocortical, limbic and paralimbic cortex

Pirnia, T., Joshi, S. H., Leaver, A. M., Vasavada, M., Njau, S., Woods, R. P., Espinoza, R., & Narr, K. L. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.102 · Cited by 122

Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia

Han, H., Zhao, Y., Du, J., Wang, S., Yang, X., Li, W., Song, J., Zhang, S., Zhang, Z., Tan, Y., et al. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00390-4 · Cited by 122

Astrocytic cAMP modulates memory via synaptic plasticity

Zhou, Z., Okamoto, K., Onodera, J., Hiragi, T., Andoh, M., Ikawa, M., Tanaka, K. F., Ikegaya, Y., & Koyama, R. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016584118 · Cited by 120

Effects of a 9-month resistance training intervention on quality of life, sense of coherence, and depressive symptoms in older adults: randomized controlled trial

Kekäläinen, T., Kokko, K., Sipilä, S., & Walker, S. (2017) · Quality of Life Research · doi:10.1007/s11136-017-1733-z · Cited by 119

Regular exercise cures depression-like behavior via VEGF-Flk-1 signaling in chronically stressed mice

Kiuchi, T., Lee, H., & Mikami, T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.023 · Cited by 116

Acute Interleukin-6 Administration Impairs Athletic Performance in Healthy, Trained Male Runners

Robson-Ansley, P. J., de Milander, L., Collins, M., & Noakes, T. D. (2004) · Canadian Journal of Applied Physiology · doi:10.1139/h04-026 · Cited by 116

Diagnostic and Statistical Manual of Mental Disorders

Bogduk, N. (2013) · Springer eBooks · doi:10.1007/978-3-642-28753-4_1094 · Cited by 116

Effectiveness of relaxation techniques ‘as an active ingredient of psychological interventions’ to reduce distress, anxiety and depression in adolescents: a systematic review and meta-analysis

Hamdani, S. U., Huma, Z., Zafar, S. W., Suleman, N., Baneen, U.-U., Waqas, A., & Rahman, A. (2022) · International Journal of Mental Health Systems · doi:10.1186/s13033-022-00541-y · Cited by 116

Synaptic regulation of affective behaviors; role of BDNF

Ninan, I. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.011 · Cited by 114

Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1/M2 polarization through adiponectin/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress

Liu, L., Tang, J., Liang, X., Li, Y., Zhu, P., Zhou, M., Lu, Q., Deng, Y., Li, J., Wang, Y., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02464-1 · Cited by 114

Racemic Ketamine as an Alternative to Electroconvulsive Therapy for Unipolar Depression: A Randomized, Open-Label, Non-Inferiority Trial (KetECT)

Ekstrand, J., Fattah, C., Persson, M., Cheng, T., Nordanskog, P., Åkeson, J., Tingström, A., Lindström, M. B., Nordenskjöld, A., & Movahed Rad, P. (2022) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab088 · Cited by 113

The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects

Kondo, M., Nakamura, Y., Ishida, Y., & Shimada, S. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.153 · Cited by 112

Irisin ameliorates depressive-like behaviors in rats by regulating energy metabolism

Wang, S., & Pan, J. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.04.047 · Cited by 110

Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience

Yan, L., Wang, Y., Hu, H., Yang, D., Wang, W., Luo, Z., Wang, Y., Yang, F., So, K., & Zhang, L. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.07.018 · Cited by 109

Brain region–specific action of ketamine as a rapid antidepressant

Chen, M., Ma, S., Liu, H., Dong, Y., Tang, J., Ni, Z., Tan, Y. J., Duan, C.-C., Li, H., Huang, H., et al. (2024) · Science · doi:10.1126/science.ado7010 · Cited by 105

Therapeutic options in treatment-resistant depression

Vieta, E., & Colom, F. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.583675 · Cited by 101

Antidepressants act on glial cells: SSRIs and serotonin elicit astrocyte calcium signaling in the mouse prefrontal cortex

Schipke, C. G., Heuser, I., & Peters, O. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.06.005 · Cited by 98

The neuroscience of depressive disorders: A brief review of the past and some considerations about the future

Kaltenboeck, A., & Harmer, C. J. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818799269 · Cited by 98

Expression of extracellular matrix components and related growth factors in human tendon and muscle after acute exercise

Heinemeier, K. M., Bjerrum, S., Schjerling, P., & Kjær, M. (2011) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2011.01414.x · Cited by 94

GABA concentration in sensorimotor cortex following high‐intensity exercise and relationship to lactate levels

Coxon, J. P., Cash, R. F. H., Hendrikse, J. J., Rogasch, N. C., Stavrinos, E. L., Suo, C., & Yücel, M. (2017) · The Journal of Physiology · doi:10.1113/jp274660 · Cited by 94

Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook

Lv, L.-Z., Wang, Z.-D., Ren, J.-J., Li, L.-H., Liu, X.-B., Li, J.-L., Zhu, H., Jiang, B., Han, Y.-P., Zhou, X.-M., et al. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2025.1722453 · Cited by 7

Protective effect of naoyikang on D-gal-induced injury in cultured hippocampal neurons

Hu, Y.-E. (2006) · Journal of Nantong University

Effection of polychlorinated biphenyls in cultured hippocampal neuronic cells of rats

Yuhong, W. (2002) · Medical Journal of National Defending Forces in Northwest China

Protective effect of brain-derived neurotrophic factor on Aβ25-35-induced hippocampal neuron injury

Tian, Y. (2011)

Effects of hippocampal PGC-1α on depression-like behaviors and number of astrocytes in hippocampal subregions in mice

Yuhu, D., Yuhu, D., Yanmin, L., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.16016/j.2097-0927.202110068

Morphofunctional Changes in Pyramidal Neurons in Various Hippocampal Fields in Ischemic Postconditioning

Щербак, Н. С., Galagudza, M. M., Yukina, G. Y., et al. (2014) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-014-9957-7