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Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity
Open accessAbstract
Social relations between humans critically depend on our affective experiences of others. Oxytocin enhances prosocial behavior, but its effect on humans' affective experience of others is not known. We tested whether oxytocin influences affective ratings, and underlying brain activity, of faces that have been aversively conditioned. Using a standard conditioning procedure, we induced differential negative affective ratings in faces exposed to an aversive conditioning compared with nonconditioning manipulation. This differential negative evaluative effect was abolished by treatment with oxytocin, an effect associated with an attenuation of activity in anterior medial temporal and anterior cingulate cortices. In amygdala and fusiform gyrus, this modulation was stronger for faces with direct gaze, relative to averted gaze, consistent with a relative specificity for socially relevant cues. The data suggest that oxytocin modulates the expression of evaluative conditioning for socially relevant faces via influences on amygdala and fusiform gyrus, an effect that may explain its prosocial effects.
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“Previous studies on amygdala responses to fearful faces and fearful/threatening scenes (14 -17, 30) and social risk (31) have also indicated that OXT may induce sex-dependent changes in amygdala activation to emotional stimuli.”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [30]
In the citing paper
“Intranasal OT administration in FXS may work mechanistically by dampening amygdala reactivity toward socially threatening and anxiety-provoking stimuli (Kirsch et al., 2005; Petrovic et al., 2008), decreasing HPA axis activation, and increasing social motivation (Witt et al., 1992).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Petrovic et al., 2008
In the citing paper
“Recent functional neuroimaging studies suggest that these effects are mediated through OXT's effects on amygdala reactivity and/or amygdala-frontal connectivity.”
From Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder (2014) · cites this paper as Petrovic et al, 2008
In the citing paper
“In this context, the insula17 as well as the amygdala seem to be key target regions in the brain, with oxytocin modulating amygdala responsiveness to emotional faces18–22 or social stimuli in general23.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [22]
In the citing paper
“Results indicate that the tested type of intranasal OT delivery -but not peripherally delivered OT that produces similar blood levels -replicates prior findings of reduced right amygdala activation in response to emotional stimuli after OT treatment (Domes et al., 2007;Labuschagne et al., 2010;Petrovic et al., 2008).”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Petrovic et al., 2008
In the citing paper
“Human functional neuroimaging studies have shown that inhaling OT reduces BOLD (blood-oxygen-level dependent) activation in the amygdala when viewing or associating aversive social stimuli (Kirsch, 2005; Petrovic et al., 2008), during trust formation (Baumgartner et al., 2008), in response to pain (Singer et al., 2008), and in response to infant crying (Riem et al., 2011).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Petrovic et al., 2008
In the citing paper
“OT is highly involved in the regulation of social recognition, by facilitating social memory and selective attention to socially-relevant information through action in the medial amygdala (Petrovic et al., 2008; Samuelsen and Meredith, 2011).”
From Oxytocin facilitates fidelity in well-established marmoset pairs by reducing sociosexual behavior toward opposite-sex strangers (2014) · cites this paper as Petrovic et al., 2008
In the citing paper
“Petrovic et al. (2008) found that oxytocin reduced the negative evaluation of a face predicting unpleasant electric shocks.”
From Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions (2013) · cites this paper as Petrovic et al. (2008)
In the citing paper
“possibly through dampening amygdala activation in response to fear-inducing stimuli [16], [17]”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [17]
In the citing paper
“While previous research strongly suggests that intranasal administration of OT can reliably influence socially relevant judgments and ratings, relative to placebo [58], [17], [5]”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [17]
In the citing paper
“its activity here tends to be reduced by OT administration upon exposure to threatening stimuli [18], [16], [17].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [17]
In the citing paper
“This finding is in line with the anxiolytic action of OT via inhibiting amygdala responses to threatening stimuli (Kirsch et al., 2005; Petrovic et al., 2008).”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Petrovic et al., 2008
In the citing paper
“the anxiolytic action of OT via inhibiting amygdala responses to threatening stimuli (Kirsch et al., 2005; Petrovic et al., 2008)”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Petrovic et al., 2008
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Citations
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Items 101–200 of 422
Sex differences in fear extinction
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“Intranasal OXT produces sexdependent activations in the amygdala and changes in its rsFC (Bethlehem et al., 2017; Domes et al., 2010, 2007; Ebner et al., 2016; Eckstein et al., 2017; Kovács and Kéri, 2015; Lischke et al., 2012; Petrovic et al., 2008; Sripada et al., 2013).”
BackgroundIntranasal oxytocin selectively attenuates rhesus monkeys’ attention to negative facial expressions
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“, 2008), and reduces the amygdala’s response to emotional images (Domes et al., 2007b; Kirsch et al., 2005; Petrovic et al., 2008; Striepens et al., 2012).”
BackgroundResultRoles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour
Onaka, T., Takayanagi, Y., & Yoshida, M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02300.x · Cited by 123
Autism and Oxytocin: New Developments in Translational Approaches to Therapeutics
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“[17] On this background, the present study was conducted with the following aims: (1) To study the effect of yoga therapy on FERD, negative symptoms and social-occupational functioning as add on treatment in antipsychotic stabilized schizophrenia patients as compared to a waitlist group.”
Oxytocin-messages via the cerebrospinal fluid: Behavioral effects; a review
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“In addition, OT administered after fear conditioning was found to attenuate amygdala and dACC activity to pre-conditioned faces as well as affective ratings of these faces (Petrovic et al., 2008).”
BackgroundInfluentialGrace, S. A., Rossell, S. L., Heinrichs, M., Kordsachia, C., & Labuschagne, I. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.031 · Cited by 120
“When broken down into task type: 14 studies used tasks that included facial emotion or aversive stimuli (Domes et al., 2013; Domes et al., 2014; Domes et al., 2010; Frijling et al., 2016; Gamer et al., 2010; Gordon et al., 2016; Grimm et al., 2014; Koch et al., 2016a; Lischke et al., 2012; Petrovic et al., 2008; Pincu…”
Oxytocin and the social brain: Neural mechanisms and perspectives in human research
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“Taken together, the studies by Kirsch et al. (2005) and Petrovic et al. (2008) suggest that dampening effects of OT on neural reactivity to threat-related social stimuli might mediate its anxiolytic effects on human social behavior (Acheson et al., 2013; Heinrichs et al., 2003).”
BackgroundMontag, C., Brockmann, E.-M., Lehmann, A. I., Müller, D. J., Rujescu, D., & Gallinat, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051882 · Cited by 128
“Specifically, OXT has been shown to dampen the hypothalamic-pituitary-adrenal-axis (HPA-axis) [37,38] and to reduce amygdala activation in response to social stressors [39–42].”
BackgroundOxytocin in the socioemotional brain: implications for psychiatric disorders
Kirsch, P. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.4/pkirsch · Cited by 123
Overview of human oxytocin research
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Oxytocin indexes relational distress following interpersonal harms in women
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“In contrast to previous studies associating oxytocin administration and attenuated amygdala activity in men (Baumgartner et al., 2008; Domes et al., 2007; Petrovic et al., 2008), Domes et al.”
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“The other way around, that oxytocin modulates prediction especially among individuals high rather than low in attachment avoidance fits the finding that oxytocin reduces amygdala activity and attenuated its coupling to brainstem centers responsible for autonomic and behavioral components of fear (Kirsch et al., 2005;…”
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“In anxiety disorders, OXT attenuated conditioned fear responses and amygdala activity [44] to become similar to the effects observed in psychologically healthy individuals [45].”
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Intranasal Oxytocin as an Adjunct to Risperidone in Patients with Schizophrenia
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“Oxytocin administration to humans increases feeling of empathy and trusting behaviour, and helps with understanding of others’ feelings [5–7].”
BackgroundRDoC-based categorization of amygdala functions and its implications in autism
Hennessey, T., Andari, E., & Rainnie, D. G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.007 · Cited by 107
“Indeed, the amygdala has more connections with distinct parts of the brain than almost any other region (Pessoa, 2014, 2008; Petrovich et al., 2001; Young et al., 1994).”
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“Oxytocin also exerts anxiolytic effects in humans, by dampening activation of the amygdala in response to both threatening and positive facial stimuli (Kirsch et al. 2005; Domes et al. 2007), as well as aversely conditioned emotional responses to social stimuli (Petrovic et al. 2008).”
BackgroundOxytocin Receptor (OXTR) Polymorphisms and Attachment in Human Infants
Chen, F. S., Barth, M. E., Johnson, S. L., Gotlib, I. H., & Johnson, S. C. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00200 · Cited by 106
“…information (Domes et al., 2007), to strengthen their memory for emotional faces (Savaskan et al., 2008), to dampen their negative reactions to aversive faces (Kirsch et al., 2005; Petrovic et al., 2008), and to facilitate their recognition of positive social words (Unkelbach et al., 2008).”
BackgroundQuintana, D. S., Westlye, L. T., Alnæs, D., Rustan, Ø. G., Kaufmann, T., Smerud, K. T., Mahmoud, R. A., Djupesland, P. G., & Andreassen, O. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.010 · Cited by 102
Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders
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“Based upon the data to date, Hall and colleagues hypothesized that in FXS administration of OT may dampen amygdala reactivity towards social stimuli that causes anxiety (Kirsch et al., 2005; Petrovic et al., 2008), decrease HPA axis activation, and increase social motivation (Witt and Insel, 1992; Witt et al.”
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“Researchers have demonstrated a direct link between oxytocin and empathy, emotional processing (and, by extension, a reduction in mood disorders), the lessening of fear responses, and the capacity to infer other people ’ s emotional states (29, 30).”
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
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“Among the plethora of behavioural effects described, intranasal OXT was reported to affect social cognition 162 , fear 163 , empathy 164 , trust 165 , the perception of the attractiveness of a female partner 166 and xenophobia 167 .”
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“This finding is in line with the anxiolytic action of OT via inhibiting amygdala responses to threatening stimuli (Kirsch et al., 2005; Petrovic et al., 2008).”
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“IN OT has also been found to reduce amygdala activation in modulation of autonomic fear(73) and in response to stimuli that were aversively conditioned.(74) Meta-analytic findings suggest that IN OT increases activity in prefrontal cortical areas that mediate emotion regulation and fear inhibition.”
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Oxytocin decreases aversion to angry faces in an associative learning task
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“…to aversive aspects of stimuli, including lack of reciprocity in trust games (Baumgartner et al ., 2008), painful stimulation of one’s own hand (Singer et al ., 2008), images with either intrinsic or conditioned negative valence (Kirsch et al ., 2005, Petrovic et al ., 2008), or faces…”
InfluentialLaterobasal Amygdalar Enlargement in 6- to 7-Year-Old Children With Autism Spectrum Disorder
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Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
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“…that the amygdalamight have a critical role in the mediation of the socio-cognitive effects of oxytocin (Domes et al., 2007; Kirsch et al., 2005; Petrovic et al., 2008), and it is of note that this neural structure is thought to be part of the extended face processing system that acts in…”
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“…and affective processes (Gamer et al., 2010; Rilling et al., 2012,2014; Rupp et al., 2013), whereas the OT-decreased amygdala activity was mainly contributed by contrasts on negative-valenced processes (Petrovic et al., 2008; Labuschagne et al., 2010; Bertsch et al., 2013; Rupp et al., 2014).”
BackgroundSelective influences of oxytocin on the evaluative processing of social stimuli
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“Moreover, oxytocin decreases amygdala activation and modulates the expression of evaluative conditioning selectively for socially relevant faces (Petrovic et al., 2008).”
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“As the amygdala seems to be a potential target of OT (Baumgartner et al, 2008; Domes et al, 2007a; Kirsch et al, 2005; Petrovic et al, 2008), this reduced salience signaling of amygdala to social stimuli could be caused by alterations in the OT system.”
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Attachment and Personality Disorders: A Short Review
Lorenzini, N., & Fonagy, P. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.2.155 · Cited by 107
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Oxytocin’s effect on resting-state functional connectivity varies by age and sex
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“This may then result in increased approach motivation by either reducing negative reactions to social cues and/or reducing (aversive) associative learning in response to socially relevant cues (Petrovic et al., 2008).”
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“In particular, oxytocin enhances facial emotion recognition (Domes et al. 2007) and memory for positive social information (Guastella et al. 2008; Rimmele et al. 2009), reduces negative evaluation of faces ( Petrovic et al. 2008 ), increases perceived facial trustworthiness (Theodoridou et al. 2009), and promotes actu…”
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“Extinction of the fear response improves when intranasal oxytocin is given at the same time as extinction learning, and fear conditioning to faces is nullified if oxytocin is given after conditioning (Petrovic et al., 2008; Acheson et al., 2013).”
BackgroundOxytocin Motivates Non-Cooperation in Intergroup Conflict to Protect Vulnerable In-Group Members
Dreu, C. K. W. D., Shalvi, S., Greer, L. L., Kleef, G. A. V., & Handgraaf, M. J. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046751 · Cited by 87
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Oxytocin Reduces Background Anxiety in a Fear-Potentiated Startle Paradigm
Missig, G., Ayers, L. W., Schulkin, J., & Rosen, J. B. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.155 · Cited by 79
Hormonal contraceptives, menstrual cycle and brain response to faces
Marečková, K., Perrin, J. S., Khan, I. N., Lawrence, C., Dickie, E. W., McQuiggan, D. A., & Paus, T. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss128 · Cited by 78
“Petrovic et al. (2008) showed that during evaluation of conditioned faces oxytocin modulated BOLD response in the fusiform gyrus and amygdala.”
BackgroundOxytocin and socioemotional aging: current knowledge and future trends
Ebner, N. C., Maura, G. M., MacDonald, K., Westberg, L., & Fischer, H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00487 · Cited by 78
Oxytocin attenuates neural reactivity to masked threat cues from the eyes
Kanat, M., Heinrichs, M., Schwarzwald, R., & Domes, G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.183 · Cited by 77
Sex-Related Differences in Plasma Oxytocin Levels in Humans
Marazziti, D., Baroni, S., Mucci, F., Piccinni, A., Moroni, I., Giannaccini, G., Carmassi, C., Massimetti, E., & Dell’Osso, L. (2019) · Clinical Practice and Epidemiology in Mental Health · doi:10.2174/1745017901915010058 · Cited by 80
Oxytocin, sexually dimorphic features of the social brain, and autism
Yamasue, H., Kuwabara, H., Kawakubo, Y., & Kasai, K. (2009) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2009.01944.x · Cited by 78
Sturge‐Apple, M. L., Cicchetti, D., Davies, P. T., & Suor, J. H. (2012) · Journal of Family Psychology · doi:10.1037/a0028302 · Cited by 81
Chang, S. W. C., & Platt, M. L. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.006 · Cited by 71
“…inhaling OT reduces BOLD (bloodoxygen-level dependent) activation in the amygdala when viewing or associating aversive social stimuli (Kirsch, 2005; Petrovic et al., 2008), during trust formation (Baumgartner et al., 2008), in response to pain (Singer et al., 2008), and in response to infant…”
BackgroundOxytocin selectively moderates negative cognitive appraisals in high trait anxious males
Alvares, G. A., Chen, N. T. M., Balleine, B. W., Hickie, I. B., & Guastella, A. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.018 · Cited by 71
Social neuroscience: The social brain, oxytocin, and health
Norman, G. J., Hawkley, L. C., Cole, S. W., Berntson, G. G., & Cacioppo, J. T. (2011) · Social Neuroscience · doi:10.1080/17470919.2011.568702 · Cited by 77
“For example, intranasal oxytocin has been shown to attenuate amygdala–brainstem coupling in response to threatening social stimuli (Kirsch et al, 2005 ), and intranasal delivery of oxytocin modulates the evaluation of socially relevant faces, ostensibly by differentially modulating distinct subregions of the amygdala…”
BackgroundRubin, L. H., Connelly, J. J., Reilly, J. L., Carter, C. S., Drogos, L. L., Pournajafi‐Nazarloo, H., Ruocco, A. C., Keedy, S., Matthew, I., Tandon, N., et al. (2015) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2015.10.003 · Cited by 72
“In healthy humans, some opposite sex-related effects have been seen, as intranasal OT reduces neural activation in the amygdala in response to emotional face processing in men (28, 29) but increases amygdala activity in women (30, 31).”
BackgroundRestoring effects of oxytocin on the attentional preference for faces in autism
Kanat, M., Spenthof, I., Riedel, A., van Elst, L. T., Heinrichs, M., & Domes, G. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.67 · Cited by 70
Cavanaugh, J., Mustoe, A. C., Taylor, J. H., & French, J. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.06.020 · Cited by 72
“OT is highly involved in the regulation of social recognition, by facilitating social memory and selective attention to socially relevant information through action in the medial amygdala (Petrovic et al., 2008; Samuelsen and Meredith, 2011).”
Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia
Shin, N. Y., Park, H. Y., Jung, W. H., Park, J. W., Yun, J., Jang, J. H., Kim, S. N., Han, H. J., Kim, S.-Y., Kang, D., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.41 · Cited by 69
“…neuroimaging studies have shown that intranasal oxytocin attenuated neural activity in the amygdala of healthy subjects viewing fearful faces (Gamer et al, 2010; Kirsch et al, 2005; Petrovic et al, 2008), whereas the results were mixed for happy faces (Domes et al, 2007a; Gamer et al, 2010).”
ResultPawling, R., Trotter, P. D., McGlone, F. P., & Walker, S. C. (2017) · Biological Psychology · doi:10.1016/j.biopsycho.2017.08.057 · Cited by 69
“With 4 different CSs for each of our two USs, the relationship is likely to have been harder for participants to learn explicitly than other studies with half the number of conditioned stimuli (eg Andreatta & Pauli, 2015; Petrovic et al., 2008).”
BackgroundResultInfluentialWhen Two Become One: The Role of Oxytocin in Interpersonal Coordination and Cooperation
Arueti, M., Perach-Barzilay, N., Tsoory, M. M., Berger, B., Getter, N., & Shamay-Tsoory, S. G. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00400 · Cited by 67
Oxytocin modulates fMRI responses to facial expression in macaques
Liu, N., Hadj-Bouziane, F., Jones, K. B., Turchi, J. N., Averbeck, B. B., & Ungerleider, L. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508097112 · Cited by 65
“Subsequently, a series of studies examined the effects of OT on responses to facial expressions (3, 16), to conditioned facial expressions (17), and to threatening scenes (18).”
BackgroundDistress of ostracism: oxytocin receptor gene polymorphism confers sensitivity to social exclusion
McQuaid, R. J., McInnis, O. A., Matheson, K., & Anisman, H. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu166 · Cited by 67
“…so that the rewarding attributes of particular stimuli take on greater salience (Love, 2014), and oxytocin also influences amygdala activity (Kirsch et al., 2005; Petrovic et al., 2008), possibly through actions on -aminobutyric acid, so that fear reactions are altered (Huber et al., 2005).”
BackgroundOxytocin reduces amygdala responses during threat approach
Radke, S., Volman, I., Kokal, I., Roelofs, K., de Bruijn, E. R. A., & Toni, I. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.02.028 · Cited by 67
“While the effects of oxytocin likely involve ther brain regions and hormone systems, most human studies on he neuromodulatory effects of oxytocin on face processing have ocused on the amygdala, showing reduced activation to threatning scenes and faces in males (Domes et al., 2007; Gamer et al., 010; Kirsch et al., 200…”
BackgroundResultInfluentialNeurobiology of human affiliative behaviour: implications for psychiatric disorders
Bora, E., Yücel, M., & Allen, N. B. (2009) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328329e970 · Cited by 75
Campbell-Smith, E. J., Holmes, N. M., Lingawi, N. W., Panayi, M. C., & Westbrook, R. F. (2015) · Learning & Memory · doi:10.1101/lm.036962.114 · Cited by 66
“Two of its nuclei, the basolateral amygdala (BLA) and central amygdala (CeA), play dissociable roles in fear conditioning in rats (Sah et al. 2008; Pape and Pare 2010; Lee et al. 2013).”
BackgroundGender moderates the effect of oxytocin on social judgments
Hoge, E. A., Anderson, E., Lawson, E. A., Bui, E., Fischer, L. E., Khadge, S. D., Barrett, L. F., & Simon, N. M. (2014) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.2402 · Cited by 64
“Copyright © 2014 John Wiley & Sons, Ltd. key words—oxytocin; visual perception; affective learning; facial expression; social learning; neuropeptide”
BackgroundMethodOxytocin: Parallel Processing in the Social Brain?
Dölen, G. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12284 · Cited by 65
Loth, E., Poline, J.-B., Thyreau, B., Jia, T., Tao, C., Lourdusamy, A., Stacey, D., Cattrell, A., Desrivières, S., Ruggeri, B., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.043 · Cited by 65
“They reported that OT-inhalation significantly attenuated amygdala response to angry, fearful (17), and happy faces (18) and during fear conditioning (19).”
Oxytocin's Fingerprint in Personality Traits and Regional Brain Volume
Andari, E., Schneider, F. C., Mottolese, R., Vindras, P., & Sirigu, A. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs328 · Cited by 63
“2005), during prosocial behaviors or perception of emotional faces (Kirsch et al. 2005; Domes, Heinrichs, Glascher, et al. 2007; Domes, Heinrichs, Michel et al. 2007; Baumgartner et al. 2008; Petrovic et al. 2008).”
BackgroundOxytocin and the salience of social cues
Averbeck, B. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004892107 · Cited by 64
“hypothesis that OT decreases the aversive aspects of negative social interactions, work has also shown that OT can decrease affective evaluations of faces that have been negatively conditioned with shock (20).”
BackgroundOxytocin modulates amygdala reactivity to masked fearful eyes
Kanat, M., Heinrichs, M., Mader, I., van Elst, L. T., & Domes, G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.111 · Cited by 65
“…studies reported dampening oxytocin effects on amygdala reactivity to facial threat in men (Domes et al, 2007a; Kanat et al, 2015; Kirsch et al, 2005; Petrovic et al, 2008), we expected decreased amygdala responses to fearful eye whites following oxytocin as compared with placebo administration.”
BackgroundResultFrijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv116 · Cited by 62
“, 2013) Additionally, in healthy men participating in a fear-conditioning paradigm it was observed that OT administration decreased right amygdala reactivity to fearful faces previously associated with an electric shock (Petrovic et al., 2008).”
Sparapani, S., Millet-Boureima, C., Oliver, J., Mu, K., Hadavi, P., Kalostian, T., Ali, N., Avelar, C. M., Bardies, M., Barrow, B., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9010089 · Cited by 64
Kurth, F., Narr, K. L., Woods, R. P., O’Neill, J., Alger, J. R., Caplan, R., McCracken, J. T., Toga, A. W., & Levitt, J. G. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.026 · Cited by 62
Janeček, M., & Dabrowska, J. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2889-8 · Cited by 63
“Furthermore, a stronger effect was observed toward CS+ paired faces with direct gaze, relative to averted gaze, suggesting specificity of OT effects toward socially relevant cues (Petrovic et al. 2008).”
InfluentialFrijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.278 · Cited by 60
“Similarly, OT dampened amygdala and dACC reactivity to fear-conditioned faces, while reducing negative ratings of these faces (Petrovic et al, 2008).”
BackgroundEbert, A., & Brüne, M. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_21 · Cited by 66
The effect of oxytocin on biological motion perception in dogs (Canis familiaris)
Kovács, K., Kis, A., Kanizsàr, O., Hernádi, A., Gácsi, M., & Topál, J. (2016) · Animal Cognition · doi:10.1007/s10071-015-0951-4 · Cited by 59
Oxytocin Mediates a Calming Effect on Postpartum Mood in Primiparous Mothers
Niwayama, R., Nishitani, S., Takamura, T., Shinohara, K., Honda, S., Miyamura, T., Nakao, Y., Oishi, K., & 永橋, 美. (2017) · Breastfeeding Medicine · doi:10.1089/bfm.2016.0052 · Cited by 59
Oxytocin and anxiety disorders
Gottschalk, M. G., & Domschke, K. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_25 · Cited by 61
Current findings on the role of oxytocin in the regulation of food intake
Spetter, M. S., & Hallschmid, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.007 · Cited by 61
The impact of oxytocin on stress: the role of sex
Love, T. M. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.06.018 · Cited by 56
Laursen, H. R., Siebner, H. R., Haren, T., Madsen, K., Grønlund, R., Hulme, O., & Henningsson, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00423 · Cited by 56
Opposing Oxytocin Effects on Intergroup Cooperative Behavior in Intuitive and Reflective Minds
Ma, Y., Liu, Y., Rand, D. G., Heatherton, T. F., & Han, S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.87 · Cited by 55
Oxytocin sharpens self-other perceptual boundary
Colonnello, V., Chen, F. S., Panksepp, J., & Heinrichs, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.08.010 · Cited by 58
“Oxytocin also dampens amygdala reactivity to threatening faces (Kirsch et al., 2005; Domes et al., 2007; Petrovic et al., 2008; Gamer et al., 2010) and modulates social memory (Heinrichs et al.”
BackgroundOxytocin effects on neural correlates of self-referential processing
Liu, Y., Sheng, F., Woodcock, K. A., & Han, S. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.08.003 · Cited by 55
Ellenbogen, M. A., Linnen, A.-M., Cardoso, C., & Joober, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.06.016 · Cited by 53
“Changes in brain activation in the anterior cingulate and frontal cortex have also been found following intranasal oxytocin administration (Baumgartner et al., 2008; Petrovic et al., 2008; Domes et al., 2010), consistent with our speculation that oxytocin alters inhibition in dysphoric participants through its effects…”
BackgroundEffects of Oxytocin and Vasopressin on Preferential Brain Responses to Negative Social Feedback
Gozzi, M., Dashow, E. M., Thurm, A. E., Swedo, S. E., & Zink, C. F. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.248 · Cited by 54
Mothers' amygdala response to positive or negative infant affect is modulated by personal relevance
Strathearn, L., & Kim, S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00176 · Cited by 59
“Oxytocin is a neuropeptide with a localized effect within the amygdala (Kirsch et al., 2005; Baumgartner et al., 2008; Petrovic et al., 2008; Domes et al., 2010).”
BackgroundAssociation between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards
Damiano, C. R., Aloi, J. M., Dunlap, K., Burrus, C. J., Mosner, M. G., Kozink, R. V., McLaurin, R. E., Mullette-Gillman, O. A., Carter, R., Huettel, S. A., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-7 · Cited by 56
“[44,45,86-91] and plasma OXT levels are associated with striatal responses to a social reward (that is, reciprocated cooperation) [45,46].”
BackgroundZoratto, F., Sbriccoli, M., Martinelli, A., Glennon, J. C., Macrı̀, S., & Laviola, G. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.010 · Cited by 53
“The remaining mice were excluded from further analyses (Ferreira et al., 2016; Piazza et al., 1993, 1991).”
Metadata
- Authors
- Petrovic, P., Kalisch, R., Singer, T., & Dolan, R. J.
- Affiliations
- Max Planck Society (DE)
- University College London (GB)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-06-25
- Volume
- 28
- Issue
- 26
- Pages
- 6607-6615
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2647078
- OpenAlex
- W1993130604
- Cited by
- 424
- References
- 80
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 8 · 2021: 17 · 2020: 22 · 2019: 13 · 2018: 25 · 2017: 23 · 2016: 22 · 2015: 44 · 2014: 47 · 2013: 45 · 2012: 38
- FWCI
- 43.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Wellcome Trust (078865)
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- oxytocin, evaluative conditioning, amygdala, fusiform gyrus, gaze direction, anterior cingulate cortex, prosocial behavior, social cognition
- MeSH terms
- Adult, Affect, Amygdala, Conditioning, Psychological, Facial Expression, Fixation, Ocular, Humans, Male, Neuropsychological Tests, Oxytocin, Pattern Recognition, Visual, Photic Stimulation, Social Behavior, Temporal Lobe, Visual Cortex
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