Cited by 347Muscle metabolism and nutritionSports Performance and TrainingCardiovascular and exercise physiology

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Interference between Concurrent Resistance and Endurance Exercise: Molecular Bases and the Role of Individual Training Variables

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Fyfe, Jackson J., Bishop, David J., Stepto, Nigel K.·2014·Sports Medicine

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Abstract

Concurrent training is defined as simultaneously incorporating both resistance and endurance exercise within a periodized training regime. Despite the potential additive benefits of combining these divergent exercise modes with regards to disease prevention and athletic performance, current evidence suggests that this approach may attenuate gains in muscle mass, strength, and power compared with undertaking resistance training alone. This has been variously described as the interference effect or concurrent training effect. In recent years, understanding of the molecular mechanisms mediating training adaptation in skeletal muscle has emerged and provided potential mechanistic insight into the concurrent training effect. Although it appears that various molecular signaling responses induced in skeletal muscle by endurance exercise can inhibit pathways regulating protein synthesis and stimulate protein breakdown, human studies to date have not observed such molecular 'interference' following acute concurrent exercise that might explain compromised muscle hypertrophy following concurrent training. However, given the multitude of potential concurrent training variables and the limitations of existing evidence, the potential roles of individual training variables in acute and chronic interference are not fully elucidated. The present review explores current evidence for the molecular basis of the specificity of training adaptation and the concurrent interference phenomenon. Additionally, insights provided by molecular and performance-based concurrent training studies regarding the role of individual training variables (i.e., within-session exercise order, between-mode recovery, endurance training volume, intensity, and modality) in the concurrent interference effect are discussed, along with the limitations of our current understanding of this complex paradigm.

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Authors: Fyfe, J. J., Bishop, D. J., & Stepto, N. K.
Affiliations: Victoria University (AU)
Corresponding author: Fyfe, Jackson J.
ORCID: Fyfe, Jackson J.
Bishop, David J.
Stepto, Nigel K.
Venue: Sports Medicine
Publisher: Springer Science and Business Media LLC
Published: 2014-04-12
Volume: 44
Issue: 6
Pages: 743-762
ISSN: 0112-1642 (ISSN-L)
1179-2035
DOI: 10.1007/s40279-014-0162-1
OpenAlex: W2076115872
Cited by: 347
References: 192
Citations by year: 2026: 42 · 2025: 28 · 2024: 22 · 2023: 36 · 2022: 31 · 2021: 34 · 2020: 27 · 2019: 27 · 2018: 38 · 2017: 24 · 2016: 18 · 2015: 16 · 2014: 4
FWCI: 2.07
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
www.springer.com/tdm (tdm)
Locations: Sports Medicine (publishedVersion)
PubMed (publishedVersion)
Victoria University Research Repository (Victoria University) (submittedVersion)
Figshare (submittedVersion, cc-by)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: concurrent training, interference effects, resistance training, endurance exercise, muscle hypertrophy, skeletal muscle protein synthesis, protein degradation, training specificity, exercise order, exercise intensity, exercise modalities, muscle strength and power
MeSH terms: Adaptation, Physiological, Energy Metabolism, Humans, Hypertrophy, Muscle Proteins, Physical Education and Training, Physical Endurance, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Strength, Resistance Training

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Interference between Concurrent Resistance and Endurance Exercise: Molecular Bases and the Role of Individual Training Variables

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