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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ

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Angiopoietin-1 Regulates Endothelial Cell Survival Through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

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Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

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mTOR Signaling in Growth Control and Disease

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mTOR Signaling in Growth, Metabolism, and Disease

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AKT/PKB signaling: navigating downstream

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mTOR: from growth signal integration to cancer, diabetes and ageing

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AKT/PKB Signaling: Navigating the Network

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Mechanisms of Insulin Action and Insulin Resistance

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Defining the role of mTOR in cancer

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mTOR at the nexus of nutrition, growth, ageing and disease

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Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

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An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

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mTOR is a key modulator of ageing and age-related disease

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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The nuts and bolts of AGC protein kinases

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

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mTOR signaling: At the crossroads of plasticity, memory and disease

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

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The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

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Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

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Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

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Regulation of Immune Responses by mTOR

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The mTOR Signalling Pathway in Human Cancer

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AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

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Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

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The two TORCs and Akt

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NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

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Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

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A complex interplay between Akt, TSC2 and the two mTOR complexes

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Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

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Novel metabolic and physiological functions of branched chain amino acids: a review

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Signaling pathways controlling skeletal muscle mass

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Rapalogs and mTOR inhibitors as anti-aging therapeutics

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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

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mTOR as a key regulator in maintaining skeletal muscle mass

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Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

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mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer

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Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

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Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

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mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

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mTOR , metabolism, and the regulation of T‐cell differentiation and function

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mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

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Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

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Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

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WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

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mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

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FOXO transcription factors throughout T cell biology

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Role of mTOR in physiology and pathology of the nervous system

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FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System

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Mechanisms that Regulate Stem Cell Aging and Life Span

Signer, R. A. J., & Morrison, S. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.001 · Cited by 320

mTOR signaling and its roles in normal and abnormal brain development

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Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

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mTORC2 controls actin polymerization required for consolidation of long-term memory

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Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

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mTORC1 promotes survival through translational control of Mcl-1

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Inhibition of mTOR induces a paused pluripotent state

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Live strong and prosper: the importance of skeletal muscle strength for healthy ageing

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Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

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Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth

Jossin, Y., & Goffinet, A. M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00928-07 · Cited by 235

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

Perl, A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12756 · Cited by 218

Roles of mTOR complexes in the kidney: implications for renal disease and transplantation

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The coordination of nuclear and mitochondrial communication during aging and calorie restriction

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Human Cytomegalovirus Protein UL38 Inhibits Host Cell Stress Responses by Antagonizing the Tuberous Sclerosis Protein Complex

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Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration

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Skeletal muscle autophagy: a new metabolic regulator

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Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR

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Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin

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Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle

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Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis Complex

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Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model: Diet-induced obesity and skeletal muscle

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Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy

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Regulation of AKT Phosphorylation at Ser473 and Thr308 by Endoplasmic Reticulum Stress Modulates Substrate Specificity in a Severity Dependent Manner

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Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia

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The cunning little vixen: Foxo and the cycle of life and death

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The broken “Off” switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance

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The immunobiology of mTOR in autoimmunity

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Amino Acid Signaling to MTOR Mediated by Inositol Polyphosphate Multikinase

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Role of mTORC1 in mechanically induced increases in translation and skeletal muscle mass

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TOR‐mediated regulation of metabolism in aging

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Downregulation of Akt/Mammalian Target of Rapamycin Pathway in Skeletal Muscle Is Associated with Increased REDD1 Expression in Response to Chronic Hypoxia

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Role of PI3K in the generation and survival of B cells

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Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

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Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated -Catenin Signaling

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Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage

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Depletion of Rictor, an essential protein component of m TORC 2, decreases male lifespan

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mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

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