The DOI matches its Crossref record; 254 of the 254 references it cites were found in a registry or an index.
Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery
Abstract
Gene therapy is a promising strategy for the treatment of monogenic disorders. Non-viral gene delivery systems including lipid-based DNA therapeutics offer the opportunity to deliver an encoding gene sequence specifically to the target tissue and thus enable the expression of therapeutic proteins in diseased cells. Currently, available gene delivery approaches based on DNA are inefficient and require improvements to achieve clinical utility. In this Review, we discuss state-of-the-art lipid-based DNA delivery systems that have been investigated in a preclinical setting. We emphasize factors influencing the delivery and subsequent gene expression in vitro, ex vivo, and in vivo. In addition, we cover aspects of nanoparticle engineering and optimization for DNA therapeutics. Finally, we highlight achievements of lipid-based DNA therapies in clinical trials.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A new technique for the assay of infectivity of human adenovirus 5 DNA
Graham, F. L., & van der Eb, A. J. (1973) · Virology · doi:10.1016/0042-6822(73)90341-3 · Cited by 9,451
The new frontier of genome engineering with CRISPR-Cas9
Doudna, J. A., & Charpentier, E. (2014) · Science · doi:10.1126/science.1258096 · Cited by 7,062
Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002
Development and Applications of CRISPR-Cas9 for Genome Engineering
Hsu, P. D., Lander, E. S., & Zhang, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.010 · Cited by 5,762
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.
Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., Ringold, G. M., & Danielsen, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7413 · Cited by 4,978
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
OWENSIII, D., & PEPPAS, N. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.010 · Cited by 3,637
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,515
Block copolymer micelles for drug delivery: design, characterization and biological significance
Kataoka, K., Harada, A., & Nagasaki, Y. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00124-1 · Cited by 3,506
Delivering nanomedicine to solid tumors
Jain, R. K., & Stylianopoulos, T. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.139 · Cited by 3,180
Non-viral vectors for gene-based therapy
Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123
Knocking down barriers: advances in siRNA delivery
Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115
Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
Adams, D., Gonzalez-Duarte, A., O’Riordan, W. D., Yang, C.-C., Ueda, M., Kristen, A. V., Tournev, I., Schmidt, H. H., Coelho, T., Berk, J. L., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1716153 · Cited by 3,047
REJMAN, J., OBERLE, V., ZUHORN, I. S., & HOEKSTRA, D. (2004) · Biochemical Journal · doi:10.1042/bj20031253 · Cited by 2,864
Bertrand, N., Wu, J., Xu, X., Kamaly, N., & Farokhzad, O. C. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.009 · Cited by 2,824
Many roads to maturity: microRNA biogenesis pathways and their regulation
Winter, J., Jung, S., Keller, S., Gregory, R. I., & Diederichs, S. (2009) · Nature Cell Biology · doi:10.1038/ncb0309-228 · Cited by 2,656
Design and development of polymers for gene delivery
Pack, D. W., Hoffman, A. S., Pun, S., & Stayton, P. S. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1775 · Cited by 2,568
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Cabral, H., Matsumoto, Y., Mizuno, K., Chen, Q., Murakami, M., Kimura, M., Terada, Y., Kano, M. R., Miyazono, K., Uesaka, M., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.166 · Cited by 2,429
Toxicity of cationic lipids and cationic polymers in gene delivery
Lv, H., Zhang, S., Wang, B., Cui, S., & Yan, J. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.014 · Cited by 2,286
Longmire, M., Choyke, P. L., & Kobayashi, H. (2008) · Nanomedicine · doi:10.2217/17435889.3.5.703 · Cited by 2,149
New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?
Feng, S.-S. (2006) · Nanomedicine · doi:10.2217/17435889.1.3.297 · Cited by 1,951
Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications
Wicki, A., Witzigmann, D., Balasubramanian, V., & Huwyler, J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.030 · Cited by 1,901
Self-citationRational design of cationic lipids for siRNA delivery
Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. Y., Stebbing, D., Crosley, E. J., Yaworski, E., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1602 · Cited by 1,822
Self-citationSystemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
Kranz, L. M., Diken, M., Haas, H., Kreiter, S., Loquai, C., Reuter, K. C., Meng, M., Fritz, D., Vascotto, F., Hefesha, H., et al. (2016) · Nature · doi:10.1038/nature18300 · Cited by 1,819
Self-citationDelivery materials for siRNA therapeutics
Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D. (2013) · Nature Materials · doi:10.1038/nmat3765 · Cited by 1,800
The Basic Science of Gene Therapy
Mulligan, R. C. (1993) · Science · doi:10.1126/science.8493530 · Cited by 1,741
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
Liu, F., Song, Y. K., & Liu, D. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300947 · Cited by 1,727
Diehl, K., Hull, R., Morton, D., Pfister, R., Rabemampianina, Y., Smith, D., Vidal, J., & Vorstenbosch, C. V. D. (2001) · Journal of Applied Toxicology · doi:10.1002/jat.727 · Cited by 1,562
Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid
Zabner, J., Fasbender, A. J., Moninger, T., Poellinger, K. A., & Welsh, M. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18997 · Cited by 1,410
Role of collagenous matrices in the adhesion and growth of cells.
Kleinman, H. K., Klebe, R. J., & Martin, G. R. (1981) · The Journal of cell biology · doi:10.1083/jcb.88.3.473 · Cited by 1,361
Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations.
Felgner, J. H., Kumar, R., Sridhar, C. N., Wheeler, C. J., Tsai, Y. J., Border, R., Ramsey, P., Martin, M., & Felgner, P. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41980-6 · Cited by 1,312
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo
Jayaraman, M., Ansell, S. M., Mui, B. L., Tam, Y. K., Chen, J., Du, X., Butler, D., Eltepu, L., Matsuda, S., Narayanannair, J. K., et al. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201203263 · Cited by 1,267
Self-citationTargeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
Akinc, A., Querbes, W., De, S., Qin, J., Frank-Kamenetsky, M., Jayaprakash, K. N., Jayaraman, M., Rajeev, K. G., Cantley, W. L., Dorkin, J. R., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.85 · Cited by 1,261
Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency
Mao, H.-Q., Roy, K., Troung-Le, V. L., Janes, K. A., Lin, K. Y., Wang, Y., August, J. T., & Leong, K. W. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00361-8 · Cited by 1,228
Lipid Nanoparticle Systems for Enabling Gene Therapies
Cullis, P. R., & Hope, M. J. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.013 · Cited by 1,208
Self-citationA combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Akinc, A., Zumbuehl, A., Goldberg, M., Leshchiner, E. S., Busini, V., Hossain, N., Bacallado, S. A., Nguyen, D. N., Fuller, J., Alvarez, R., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1402 · Cited by 1,150
Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 1)
Honary, S., & Zahir, F. (2013) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v12i2.19 · Cited by 1,138
Mechanism of DNA Release from Cationic Liposome/DNA Complexes Used in Cell Transfection,
Xu, Y., & Szoka, F. C. (1996) · Biochemistry · doi:10.1021/bi9602019 · Cited by 1,134
Xiao, K., Li, Y., Luo, J., Lee, J. S., Xiao, W., Gonik, A. M., Agarwal, R. G., & Lam, K. S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.021 · Cited by 1,039
Ernsting, M. J., Murakami, M., Roy, A., & Li, S.-D. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.09.013 · Cited by 1,012
Lipid-like materials for low-dose, in vivo gene silencing
Love, K. T., Mahon, K. P., Levins, C. G., Whitehead, K. A., Querbes, W., Dorkin, J. R., Qin, J., Cantley, W., Qin, L. L., Racie, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910603106 · Cited by 969
Gene Therapy Progress and Prospects: Nonviral vectors
Niidome, T., & Huang, L. (2002) · Gene Therapy · doi:10.1038/sj.gt.3301923 · Cited by 963
RNAi therapeutics: Principles, prospects and challenges
Aagaard, L., & Rossi, J. J. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.005 · Cited by 895
Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
Pardi, N., Hogan, M. J., Pelc, R. S., Muramatsu, H., Andersen, H., DeMaso, C. R., Dowd, K. A., Sutherland, L. L., Scearce, R. M., Parks, R., et al. (2017) · Nature · doi:10.1038/nature21428 · Cited by 884
Nabel, G. J., Nabel, E. G., Yang, Z. Y., Fox, B. A., Plautz, G. E., Gao, X., Huang, L., Shu, S., Gordon, D., & Chang, A. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11307 · Cited by 882
Finn, J. D., Smith, A. R., Patel, M. C., Shaw, L., Youniss, M. R., van Heteren, J., Dirstine, T., Ciullo, C., Lescarbeau, R., Seitzer, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.014 · Cited by 878
Viral and nonviral delivery systems for gene delivery
Nayerossadat, N., Maedeh, T., & Ali, P. (2012) · Advanced Biomedical Research · doi:10.4103/2277-9175.98152 · Cited by 858
A novel cationic liposome reagent for efficient transfection of mammalian cells
Gao, X., & Huang, L. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91366-k · Cited by 847
Sabnis, S., Kumarasinghe, E. S., Salerno, T., Mihai, C., Ketova, T., Senn, J. J., Lynn, A., Bulychev, A., McFadyen, I., Chan, J., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.03.010 · Cited by 820
Kunath, K. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00076-2 · Cited by 809
Tools for translation: non-viral materials for therapeutic mRNA delivery
Hajj, K. A., & Whitehead, K. A. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.56 · Cited by 799
The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer
Farhood, H., Serbina, N., & Huang, L. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)80016-9 · Cited by 798
Kauffman, K. J., Dorkin, J. R., Yang, J. H., Heartlein, M. W., DeRosa, F., Mir, F. F., Fenton, O. S., & Anderson, D. G. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b02497 · Cited by 796
Progress in developing cationic vectors for non-viral systemic gene therapy against cancer
Morille, M., Passirani, C., Vonarbourg, A., Clavreul, A., & Benoit, J.-P. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.036 · Cited by 769
Size-dependent DNA Mobility in Cytoplasm and Nucleus
Lukacs, G. L., Haggie, P., Seksek, O., Lechardeur, D., Freedman, N., & Verkman, A. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1625 · Cited by 752
Improved DNA: liposome complexes for increased systemic delivery and gene expression
Templeton, N. S., Lasic, D. D., Frederik, P. M., Strey, H. H., Roberts, D. D., & Pavlakis, G. N. (1997) · Nature Biotechnology · doi:10.1038/nbt0797-647 · Cited by 740
Shin, S. I., Freedman, V. H., Risser, R., & Pollack, R. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.11.4435 · Cited by 738
Wisse, E., de Zanger, R. B., Charels, K., van der Smissen, P., & McCuskey, R. S. (1985) · Hepatology · doi:10.1002/hep.1840050427 · Cited by 712
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis
Caplen, N. J., Alton, E. W. F. W., Mddleton, P. G., Dorin, J. R., Stevenson, B. J., Gao, X., Durham, S. R., Jeffery, P. K., Hodson, M. E., Coutelle, C., et al. (1995) · Nature Medicine · doi:10.1038/nm0195-39 · Cited by 711
The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery
Cheng, X., & Lee, R. J. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.01.022 · Cited by 703
Different behavior of branched and linear polyethylenimine for gene deliveryin vitro andin vivo
Wightman, L., Kircheis, R., R�ssler, V., Carotta, S., Ruzicka, R., Kursa, M., & Wagner, E. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.187 · Cited by 697
Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
Belliveau, N. M., Huft, J., Lin, P. J., Chen, S., Leung, A. K., Leaver, T. J., Wild, A. W., Lee, J. B., Taylor, R. J., Tam, Y. K., et al. (2012) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2012.28 · Cited by 685
Self-citationMetabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer
Lechardeur, D., Sohn, K.-J., Haardt, M., Joshi, P. B., Monck, M., Graham, R. W., Beatty, B., Squire, J., O’Brodovich, H., & Lukacs, G. L. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300867 · Cited by 633
Maier, M. A., Jayaraman, M., Matsuda, S., Liu, J., Barros, S., Querbes, W., Tam, Y. K., Ansell, S. M., Kumar, V., Qin, J., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.124 · Cited by 625
Self-citationEfficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
Wang, M., Zuris, J. A., Meng, F., Rees, H., Sun, S., Deng, P., Han, Y., Gao, X., Pouli, D., Wu, Q., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520244113 · Cited by 624
Dalby, B. (2004) · Methods · doi:10.1016/j.ymeth.2003.11.023 · Cited by 619
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
Whitehead, K. A., Dorkin, J. R., Vegas, A. J., Chang, P. H., Veiseh, O., Matthews, J., Fenton, O. S., Zhang, Y., Olejnik, K. T., Yesilyurt, V., et al. (2014) · Nature Communications · doi:10.1038/ncomms5277 · Cited by 615
Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications
Liu, C., Zhang, L., Liu, H., & Cheng, K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.012 · Cited by 607
Lipid nanoparticles enabling gene therapies: from concepts to clinical utility
Kulkarni, J. A., Cullis, P. R., & van der Meel, R. (2018) · Nucleic Acid Therapeutics · doi:10.1089/nat.2018.0721 · Cited by 592
Self-citationIn Vivo Biodistribution of Nanoparticles
Almeida, J. P. M., Chen, A. L., Foster, A., & Drezek, R. (2011) · Nanomedicine · doi:10.2217/nnm.11.79 · Cited by 583
Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids
Heyes, J., Palmer, L., Bremner, K., & MacLachlan, I. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.06.014 · Cited by 572
Ogris, M., Steinlein, P., Kursa, M., Mechtler, K., Kircheis, R., & Wagner, E. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300745 · Cited by 571
Sarin, H. (2010) · Journal of Angiogenesis Research · doi:10.1186/2040-2384-2-14 · Cited by 562
Kurzchalia, T. V., Dupree, P., Parton, R. G., Kellner, R., Virta, H., Lehnert, M., & Simons, K. (1992) · The Journal of cell biology · doi:10.1083/jcb.118.5.1003 · Cited by 559
Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles
Prabha, S., Zhou, W.-Z., Panyam, J., & Labhasetwar, V. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00315-0 · Cited by 553
GENETICS OF HUMAN CELL LINES, IV. DNA-MEDIATED HERITABLE TRANSFORMATION OF A BIOCHEMICAL TRAIT
Szybalska, E. H., & Szybalski, W. (1962) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.48.12.2026 · Cited by 502
Nanomedicine in pulmonary delivery
Mansour, H., Haemosu, & Wu, X. (2009) · International Journal of Nanomedicine · doi:10.2147/ijn.s4937 · Cited by 485
Biodegradable polymers as non-viral carriers for plasmid DNA delivery
Luten, J., van Nostrum, C. F., De Smedt, S. C., & Hennink, W. E. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.10.028 · Cited by 471
Yavin, E., & Yavin, Z. (1974) · The Journal of Cell Biology · doi:10.1083/jcb.62.2.540 · Cited by 463
Formation and Intracellular Trafficking of Lipoplexes and Polyplexes
Elouahabi, A., & Ruysschaert, J.-M. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2004.12.006 · Cited by 462
Szebeni, J. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.06.038 · Cited by 457
Effect of cholesterol on the structure of a phospholipid bilayer
de Meyer, F., & Smit, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809959106 · Cited by 453
Possible roles for cell-to-substratum adhesion in neuronal morphogenesis
Letourneau, P. C. (1975) · Developmental Biology · doi:10.1016/0012-1606(75)90378-4 · Cited by 444
Lee, E. R., Marshall, J., Siegel, C. S., Jiang, C., Yew, N. S., Nichols, M. R., Nietupski, J. B., Ziegler, R. J., Lane, M. B., Wang, K. X., et al. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.14-1701 · Cited by 443
Cornerstones of CRISPR–Cas in drug discovery and therapy
Fellmann, C., Gowen, B. G., Lin, P.-C., Doudna, J. A., & Corn, J. E. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.238 · Cited by 443
Alton, E., Stern, M., Farley, R., Jaffe, A., Chadwick, S., Phillips, J., Davies, J., Smith, S., Browning, J., Davies, M., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)06532-5 · Cited by 435
Alton, E. W. F. W., Armstrong, D. K., Ashby, D., Bayfield, K. J., Bilton, D., Bloomfield, E. V., Boyd, A. C., Brand, J., Buchan, R., Calcedo, R., et al. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00245-3 · Cited by 428
Introduction of liposome-encapsulated SV40 DNA into cells.
Fraley, R., Subramani, S., Berg, P., & Papahadjopoulos, D. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70482-7 · Cited by 420
Ligand-targeted particulate nanomedicines undergoing clinical evaluation: Current status
van der Meel, R., Vehmeijer, L. J. C., Kok, R. J., Storm, G., & van Gaal, E. V. B. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.012 · Cited by 398
Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-Carriers
Jin, L., Zeng, X., Liu, M., Deng, Y., & He, N. (2014) · Theranostics · doi:10.7150/thno.6914 · Cited by 388
Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane
Zuckerman, J. E., Choi, C. H. J., Han, H., & Davis, M. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200718109 · Cited by 372
Characterization of cationic lipid-protamine–DNA (LPD) complexes for intravenous gene delivery
Li, S., Rizzo, M., Bhattacharya, S., & Huang, L. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300683 · Cited by 369
Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA
Chen, S., Tam, Y. Y. C., Lin, P. J. C., Sung, M. M. H., Tam, Y. K., & Cullis, P. R. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.059 · Cited by 366
Self-citationPardi, N., Secreto, A. J., Shan, X., Debonera, F., Glover, J., Yi, Y., Muramatsu, H., Ni, H., Mui, B. L., Tam, Y. K., et al. (2017) · Nature Communications · doi:10.1038/ncomms14630 · Cited by 352
Oxygen Radical-Mediated Pulmonary Toxicity Induced by Some Cationic Liposomes
Dokka, S., Toledo, D., Shi, X., Castranova, V., & Rojanasakul, Y. (2000) · Pharmaceutical Research · doi:10.1023/a:1007504613351 · Cited by 349
Hydrodynamic Gene Delivery: Its Principles and Applications
Suda, T., & Liu, D. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300314 · Cited by 347
Zuhorn, I. S., Kalicharan, R., & Hoekstra, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111257200 · Cited by 338
Superior Penetration and Retention Behavior of 50 nm Gold Nanoparticles in Tumors
Huo, S., Ma, H., Huang, K., Liu, J., Wei, T., Jin, S., Zhang, J., He, S., & Liang, X.-J. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2071 · Cited by 337
Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers
Scholz, C., & Wagner, E. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.11.014 · Cited by 333
Levchenko, T. S., Rammohan, R., Lukyanov, A. N., Whiteman, K. R., & Torchilin, V. P. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00129-1 · Cited by 332
Ishida, T., Harashima, H., & Kiwada, H. (2002) · Bioscience Reports · doi:10.1023/a:1020134521778 · Cited by 330
Porteous, D., Dorin, Jr., McLachlan, G., Davidson-Smith, H., Davidson, H., Stevenson, B., Carothers, A., Wallace, W., Moralee, S., Hoenes, C., et al. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300390 · Cited by 324
Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver
Akinc, A., Goldberg, M., Qin, J., Dorkin, J. R., Gamba-Vitalo, C., Maier, M., Jayaprakash, K. N., Jayaraman, M., Rajeev, K. G., Manoharan, M., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.36 · Cited by 323
Mao, S., Neu, M., Germershaus, O., Merkel, O., Sitterberg, J., Bakowsky, U., & Kissel, T. (2006) · Bioconjugate Chemistry · doi:10.1021/bc060129j · Cited by 319
Hong, K., Zheng, W., Baker, A., & Papahadjopoulos, D. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01397-x · Cited by 317
Sago, C. D., Lokugamage, M. P., Paunovska, K., Vanover, D. A., Monaco, C. M., Shah, N. N., Gamboa Castro, M., Anderson, S. E., Rudoltz, T. G., Lando, G. N., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811276115 · Cited by 313
Hajj, K. A., Ball, R. L., Deluty, S. B., Singh, S. R., Strelkova, D., Knapp, C. M., & Whitehead, K. A. (2019) · Small · doi:10.1002/smll.201805097 · Cited by 312
Structure and Function of Lipid-DNA Complexes for Gene Delivery
Chesnoy, S., & Huang, L. (2000) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.29.1.27 · Cited by 312
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression
Hyde, S. C., Pringle, I. A., Abdullah, S., Lawton, A. E., Davies, L. A., Varathalingam, A., Nunez-Alonso, G., Green, A.-M., Bazzani, R. P., Sumner-Jones, S. G., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1399 · Cited by 310
Zebrafish: A complete animal model to enumerate the nanoparticle toxicity
Chakraborty, C., Sharma, A. R., Sharma, G., & Lee, S.-S. (2016) · Journal of Nanobiotechnology · doi:10.1186/s12951-016-0217-6 · Cited by 297
Chitosan-graft-polyethylenimine as a gene carrier
Jiang, H.-L., Kim, Y.-K., Arote, R., Nah, J.-W., Cho, M.-H., Choi, Y.-J., Akaike, T., & Cho, C.-S. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.10.025 · Cited by 289
Going beyond the liver: progress and challenges of targeted delivery of siRNA therapeutics
Lorenzer, C., Dirin, M., Winkler, A.-M., Baumann, V., & Winkler, J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.02.003 · Cited by 284
Import of Plasmid DNA into the Nucleus Is Sequence Specific
Dean, D. A. (1997) · Experimental Cell Research · doi:10.1006/excr.1996.3427 · Cited by 283
Judge, A., McClintock, K., Phelps, J. R., & MacLachlan, I. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2005.09.014 · Cited by 280
Synthesis and extrusion of collagen by freshly isolated cells from chick embryo tendon
Dehm, P., & Prockop, D. J. (1971) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(71)90529-6 · Cited by 279
Kreiss, P. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.19.3792 · Cited by 279
Paunovska, K., Sago, C. D., Monaco, C. M., Hudson, W. H., Castro, M. G., Rudoltz, T. G., Kalathoor, S., Vanover, D. A., Santangelo, P. J., Ahmed, R., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00432 · Cited by 277
The Headgroup Evolution of Cationic Lipids for Gene Delivery
Zhi, D., Zhang, S., Cui, S., Zhao, Y., Wang, Y., & Zhao, D. (2013) · Bioconjugate Chemistry · doi:10.1021/bc300381s · Cited by 271
Gill, D., Southern, K., Mofford, K., Seddon, T., Huang, L., Sorgi, F., Thomson, A., MacVinish, L., Ratcliff, R., Bilton, D., et al. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300391 · Cited by 263
A new DNA vehicle for nonviral gene delivery: supercoiled minicircle
Darquet, A.-M., Cameron, B., Wils, P., Scherman, D., & Crouzet, J. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300540 · Cited by 249
Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes.
Xu, L., Huang, C., Huang, W., Tang, W., Rait, A. S., Yin, Y. Z., Cruz, I., Xiang, L., Pirollo, K. F., & Chang, E. H. (2002) · PubMed · Cited by 243
Phase I Study of a Systemically Delivered p53 Nanoparticle in Advanced Solid Tumors
Senzer, N., Nemunaitis, J., Nemunaitis, D., Bedell, C., Edelman, G., Barve, M., Nunan, R., Pirollo, K. F., Rait, A., & Chang, E. H. (2013) · Molecular Therapy · doi:10.1038/mt.2013.32 · Cited by 236
Tousignant, J. D., Gates, A. L., Ingram, L. A., Johnson, C. L., Nietupski, J. B., Cheng, S. H., Eastman, S. J., & Scheule, R. K. (2000) · Human Gene Therapy · doi:10.1089/10430340050207984 · Cited by 236
Campbell, F., Bos, F. L., Sieber, S., Arias-Alpizar, G., Koch, B. E., Huwyler, J., Kros, A., & Bussmann, J. (2018) · ACS Nano · doi:10.1021/acsnano.7b06995 · Cited by 233
Self-citationRepeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis
Hyde, S., Southern, K., Gileadi, U., Fitzjohn, E., Mofford, K., Waddell, B., Gooi, H., Goddard, C., Hannavy, K., Smyth, S., et al. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301212 · Cited by 231
Wu, M., Frieboes, H. B., McDougall, S. R., Chaplain, M. A. J., Cristini, V., & Lowengrub, J. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2012.11.031 · Cited by 229
Song, L. Y., Ahkong, Q. F., Rong, Q., Wang, Z., Ansell, S., Hope, M. J., & Mui, B. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00399-6 · Cited by 228
Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA
Kulkarni, J. A., Myhre, J. L., Chen, S., Tam, Y. Y. C., Danescu, A., Richman, J. M., & Cullis, P. R. (2017) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2016.12.014 · Cited by 225
Self-citationImproved packing of poly(ethylenimine)/DNA complexes increases transfection efficiency
Godbey, W. T., Wu, K. K., Hirasaki, G. J., & Mikos, A. G. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300976 · Cited by 222
Effect of surface properties on liposomal siRNA delivery
Xia, Y., Tian, J., & Chen, X. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.056 · Cited by 220
Use of extracellular matrix components for cell culture
Kleinman, H. K., Luckenbill-Edds, L., Cannon, F. W., & Sephel, G. C. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90538-0 · Cited by 219
Use of polyethyleneimine polymer in cell culture as attachment factor and lipofection enhancer
Vancha, A. R., Govindaraju, S., Parsa, K. V., Jasti, M., González-García, M., & Ballestero, R. P. (2004) · BMC Biotechnology · doi:10.1186/1472-6750-4-23 · Cited by 213
Liposome-mediated DNA vaccination: the effect of vesicle composition
Perrie, Y., Frederik, P. M., & Gregoriadis, G. (2001) · Vaccine · doi:10.1016/s0264-410x(00)00432-1 · Cited by 210
Engineered nanomaterial uptake and tissue distribution: from cell to organism
Huwyler, J., Kettiger, H., Schipanski, A., & Wick, P. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s49770 · Cited by 210
Self-citationZebrafish as a Model to Evaluate Nanoparticle Toxicity
Haque, E., & Ward, A. C. (2018) · Nanomaterials · doi:10.3390/nano8070561 · Cited by 204
Getting across the nuclear pore complex
Talcott, B., & Moore, M. S. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01608-6 · Cited by 202
Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice
McLean, J. W., Fox, E. A., Baluk, P., Bolton, P. B., Haskell, A., Pearlman, R., Thurston, G., Umemoto, E. Y., & McDonald, D. M. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.1.h387 · Cited by 199
Next-Generation Lipids in RNA Interference Therapeutics
Rietwyk, S., & Peer, D. (2017) · ACS Nano · doi:10.1021/acsnano.7b04734 · Cited by 199
Ramesh, R., Saeki, T., Smyth Templeton, N., Ji, L., Stephens, L. C., Ito, I., Wilson, D. R., Wu, Z., Branch, C. D., Minna, J. D., et al. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0266 · Cited by 193
Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier
Suk, J. S., Kim, A. J., Trehan, K., Schneider, C. S., Cebotaru, L., Woodward, O. M., Boylan, N. J., Boyle, M. P., Lai, S. K., Guggino, W. B., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.01.007 · Cited by 192
In Vivo Characteristics of Cationic Liposomes as Delivery Vectors for Gene Therapy
Audouy, S. A. L., de Leij, L. F. M. H., Hoekstra, D., & Molema, G. (2002) · Pharmaceutical Research · doi:10.1023/a:1020989709019 · Cited by 189
Escriou, V., Ciolina, C., Lacroix, F., Byk, G., Scherman, D., & Wils, P. (1998) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(97)00194-6 · Cited by 188
The Mucus Barrier to Inhaled Gene Therapy
Duncan, G. A., Jung, J., Hanes, J., & Suk, J. S. (2016) · Molecular Therapy · doi:10.1038/mt.2016.182 · Cited by 188
Ruiz, F. E., Clancy, J. P., Perricone, M. A., Bebok, Z., Hong, J. S., Cheng, S. H., Meeker, D. P., Young, K. R., Schoumacher, R. A., Weatherly, M. R., et al. (2001) · Human Gene Therapy · doi:10.1089/104303401750148667 · Cited by 185
Lu, C., Stewart, D. J., Lee, J. J., Ji, L., Ramesh, R., Jayachandran, G., Nunez, M. I., Wistuba, I. I., Erasmus, J. J., Hicks, M. E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034833 · Cited by 184
Delivery of oligonucleotides with lipid nanoparticles
Wang, Y., Miao, L., Satterlee, A., & Huang, L. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.02.007 · Cited by 184
Lipid Nanoparticles for Gene Delivery
Zhao, Y., & Huang, L. (2014) · Advances in Genetics · doi:10.1016/b978-0-12-800148-6.00002-x · Cited by 178
Zabner, J., Cheng, S. H., Meeker, D., Launspach, J., Balfour, R., Perricone, M. A., Morris, J. E., Marshall, J., Fasbender, A., Smith, A. E., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119676 · Cited by 176
Sakurai, F., Nishioka, T., Saito, H., Baba, T., Okuda, A., Matsumoto, O., Taga, T., Yamashita, F., Takakura, Y., & Hashida, M. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301460 · Cited by 175
Safety and Short-Term Toxicity of a Novel Cationic Lipid Formulation for Human Gene Therapy
San, H., Yang, Z.-Y., Pompili, V. J., Jaffe, M. L., Plautz, G. E., Xu, L., Felgner, J. H., Wheeler, C. J., Felgner, P. L., Gao, X., et al. (1993) · Human Gene Therapy · doi:10.1089/hum.1993.4.6-781 · Cited by 174
Porter, C. J. H., Moghimi, S. M., Illum, L., & Davis, S. S. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80655-z · Cited by 173
Protein–polymer nanoreactors for medical applications
Palivan, C. G., Fischer-Onaca, O., Delcea, M., Itel, F., & Meier, W. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15240h · Cited by 172
Nicolau, C., Le Pape, A., Soriano, P., Fargette, F., & Juhel, M. F. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.4.1068 · Cited by 169
The role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids
(1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00973-3 · Cited by 165
Paunovska, K., Gil, C. J., Lokugamage, M. P., Sago, C. D., Sato, M., Lando, G. N., Gamboa Castro, M., Bryksin, A. V., & Dahlman, J. E. (2018) · ACS Nano · doi:10.1021/acsnano.8b03640 · Cited by 160
Liposomes as Gene Carriers: Efficient Transformation of Mouse L Cells by Thymidine Kinase Gene
Schaefer-Ridder, M., Wang, Y., & HOFSCHNEIDER, P. H. (1982) · Science · doi:10.1126/science.7053567 · Cited by 159
Zhang, Y., Li, H., Sun, J., Gao, J., Liu, W., Li, B., Guo, Y., & Chen, J. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.01.035 · Cited by 158
Kim, S. S., Rait, A. S., Kim, E. H., Pirollo, K. F., Nishida, M., Farkas, N., Dagata, J. A., & Chang, E. H. (2014) · ACS Nano · doi:10.1021/nn5014484 · Cited by 158
Zebrafish as a preclinical in vivo screening model for nanomedicines
Sieber, S., Grossen, P., Bussmann, J., Campbell, F., Kros, A., Witzigmann, D., & Huwyler, J. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.001 · Cited by 156
Self-citationDamen, J., Regts, J., & Scherphof, G. L. (1981) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(81)90268-x · Cited by 155
Gao, Y., Xu, Z., Chen, S., et al. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.03.037 · Cited by 153
Systemic p53 Gene Therapy of Cancer with Immunolipoplexes Targeted by Anti-Transferrin Receptor scFv
Xu, L., Tang, W., Huang, C., Alexander, W., Xiang, L., Pirollo, K. F., Rait, A. S., & Chang, E. H. (2001) · Molecular Medicine · doi:10.1007/bf03401962 · Cited by 150
Simões, S., Slepushkin, V., Pires, P., Gaspar, R. S., de Lima, M. C. P., & Düzgüneş, N. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00238-2 · Cited by 143
Fink, T. L., Klepcyk, P. J., Oette, S. M., Gedeon, C. R., Hyatt, S. L., Kowalczyk, T. H., Moen, R. C., & Cooper, M. J. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302761 · Cited by 139
Oral delivery of siRNA lipid nanoparticles: Fate in the GI tract
Ball, R. L., Bajaj, P., & Whitehead, K. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-20632-6 · Cited by 138
In Vitro–In Vivo Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery
Whitehead, K. A., Matthews, J., Chang, P., Niroui, F., Dorkin, J. R., Severgnini, M., & Anderson, D. G. (2012) · ACS Nano · doi:10.1021/nn301922x · Cited by 133
Nanoparticles That Deliver RNA to Bone Marrow Identified by in Vivo Directed Evolution
Sago, C. D., Lokugamage, M. P., Islam, F. Z., Krupczak, B. R., Sato, M., & Dahlman, J. E. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b08976 · Cited by 133
Masotti, A., Mossa, G., Cametti, C., Ortaggi, G., Bianco, A., Grosso, N. D., Malizia, D., & Esposito, C. (2008) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2008.09.017 · Cited by 130
Cubic Phases in Phosphatidylcholine-Cholesterol Mixtures: Cholesterol as Membrane “Fusogen”
Tenchov, B., MacDonald, R. C., & Siegel, D. P. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.083766 · Cited by 130
Defenestration of the sinusoidal endothelial cell in a rat model of cirrhosis
Mori, T., Okanoue, T., Sawa, Y., Hori, N., Ohta, M., & Kagawa, K. (1993) · Hepatology · doi:10.1002/hep.1840170520 · Cited by 128
Ciani, L., Ristori, S., Salvati, A. L., Calamai, L., & Martini, G. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.04.003 · Cited by 128
An Early History of Gene Transfer and Therapy
Wolff, J. A., & Lederberg, J. (1994) · Human Gene Therapy · doi:10.1089/hum.1994.5.4-469 · Cited by 127
Zhao, Q., Chen, J., Lv, T.-F., He, C., Tang, G., Liang, W., Tabata, Y., & Gao, J. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.706 · Cited by 127
Stable and monodisperse lipoplex formulations for gene delivery
Zelphati, O., Nguyen, C., Ferrari, M. E., Felgner, J. H., Tsai, Y.-L., & Felgner, P. L. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300707 · Cited by 127
The role of lipid charge density in the serum stability of cationic lipid/DNA complexes
Zhang, Y., & Anchordoquy, T. J. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.03.004 · Cited by 120
Kim, S. S., Rait, A. S., Kim, E. H., Pirollo, K. F., & Chang, E. H. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.09.005 · Cited by 118
Pirollo, K. F., Nemunaitis, J. J., Leung, P. K., Nunan, R., Adams, J., & Chang, E. H. (2016) · Molecular Therapy · doi:10.1038/mt.2016.135 · Cited by 118
Liver as a target for oligonucleotide therapeutics
Sehgal, A., Vaishnaw, A. K., & Fitzgerald, K. J. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.05.045 · Cited by 116
Camp, E. R., Wang, C., Little, E. C., Watson, P. M., Pirollo, K. F., Rait, A. S., Cole, D. J., Chang, E. H., & Watson, D. K. (2013) · Cancer Gene Therapy · doi:10.1038/cgt.2013.9 · Cited by 115
Stopeck, A., Jones, A., Hersh, E. M., Thompson, J. A., Finucane, D., Gutheil, J. C., & Gonzalez, R. C. (2001) · PubMed · Cited by 111
Hattori, Y., Suzuki, S., Kawakami, S., Yamashita, F., & Hashida, M. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.08.012 · Cited by 110
Hsu, C. Y. M., & Uludağ, H. (2012) · Nature Protocols · doi:10.1038/nprot.2012.038 · Cited by 110
Middleton, P. G., Caplen, N. J., Gao, X., Huang, L., Gaya, H., Geddes, D. M., & Alton, E. W. F. W. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07030442 · Cited by 108
Biodistribution of Radiolabeled Lipid–DNA Complexes and DNA in Mice
Niven, R. W., Pearlman, R., Wedeking, T., MacKeigan, J. P., Noker, P. E., Simpson‐Herren, L., & Smith, J. G. (1998) · Journal of Pharmaceutical Sciences · doi:10.1021/js980087a · Cited by 107
Sakurai, F., Nishioka, T., Yamashita, F., Takakura, Y., & Hashida, M. (2001) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(01)00165-5 · Cited by 106
Hao, J., Kós, P., Zhou, K., Miller, J. B., Xue, L., Yan, Y., Xiong, H., Elkassih, S. A., & Siegwart, D. J. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b03429 · Cited by 105
Galanis, E., Hersh, E. M., Stopeck, A., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.10.3313 · Cited by 99
Sieber, S., Grossen, P., Detampel, P., Siegfried, S., Witzigmann, D., & Huwyler, J. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.08.023 · Cited by 99
Self-citationLipoplex size determines lipofection efficiency with or without serum
Almofti, M. R., Harashima, H., Shinohara, Y., Almofti, A., Li, W., & Kiwada, H. (2003) · Molecular Membrane Biology · doi:10.1080/09687680210035104 · Cited by 98
Entrapment of a bacterial plasmid in phospholipid vesicles: potential for gene transfer.
Fraley, R. T., Fornari, C. S., & Kaplan, S. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.7.3348 · Cited by 97
Vaxfectin enhances the humoral immune response to plasmid DNA-encoded antigens
Hartikka, J., Bozoukova, V., Ferrari, M. E., Sukhu, L., Enas, J. D., Sawdey, M., Wloch, M. K., Tonsky, K., Norman, J. A., Manthorpe, M., et al. (2001) · Vaccine · doi:10.1016/s0264-410x(00)00445-x · Cited by 97
Minicircle DNA vectors for gene therapy: advances and applications
Gaspar, V. M., de Melo‐Diogo, D., Costa, E. C., Moreira, A. F., Queiroz, J. A., Pichon, C., Correia, I. J., & de Sousa, F. P. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.996544 · Cited by 97
A phase 2 study of high-dose Allovectin-7 in patients with advanced metastatic melanoma
Bedikian, A. Y., Richards, J. M., Kharkevitch, D. D., Atkins, M. B., Whitman, E. D., & Gonzalez, R. C. (2010) · Melanoma Research · doi:10.1097/cmr.0b013e3283390711 · Cited by 96
Vercauteren, D., Piest, M., van der Aa, L. J., Al-Soraj, M. H., Jones, A. T., Engbersen, J. F. J., Smedt, S. C. D., & Braeckmans, K. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.12.045 · Cited by 96
Entrapment of plasmid DNA by liposomes and their interactions with plant protoplasts
Lurquin, P. F. (1979) · Nucleic Acids Research · doi:10.1093/nar/6.12.3773 · Cited by 91
Cationic lipids for reporter gene and CFTR transfer to rat pulmonary epithelium.
Logan, J. J., Bebők, Z., Walker, L., Peng, S., Felgner, P. L., Siegal, G. P., Frizzell, R. A., Dong, J., Howard, M., & Matalon (1995) · PubMed · Cited by 90
Schenkman, S., Araujo, P. S. D., Dukman, R., Quina, F. H., & Chaimovich, H. (1981) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(81)90168-1 · Cited by 89
Eastman, S. J., Lukason, M., Tousignant, J. D., et al. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.6-765 · Cited by 89
Hui, K. M., Pt, A., Huang, L., et al. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300455 · Cited by 84
Evaluation of lipid-based reagents to mediate intracellular gene delivery
Faneca, H., Simões, S., & de Lima, M. C. P. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00545-x · Cited by 83
Eastman, S. J., Tousignant, J. D., Lukason, M., et al. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.3-313 · Cited by 83
Cited by
Drug delivery systems for RNA therapeutics
Paunovska, K., Loughrey, D., & Dahlman, J. E. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-021-00439-4 · Cited by 1,349
Lipid nanoparticle technology for therapeutic gene regulation in the liver
Witzigmann, D., Kulkarni, J. A., Leung, J., Chen, S., Cullis, P. R., & van der Meel, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.026 · Cited by 376
Self-citationPolymeric Delivery of Therapeutic Nucleic Acids
Kumar, R., Santa Chalarca, C. F., Bockman, M. R., Bruggen, C. V., Grimme, C. J., Dalal, R. J., Hanson, M. G., Hexum, J. K., & Reineke, T. M. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00997 · Cited by 365
Neutral Lipopolyplexes for In Vivo Delivery of Conventional and Replicative RNA Vaccine
Perche, F., Clemençon, R., Schulze, K., Ebensen, T., Guzmán, C. A., & Pichon, C. (2019) · Molecular Therapy - Nucleic Acids · doi:10.1016/j.omtn.2019.07.014 · Cited by 55
An inflammation self-adaptive nanocarrier for highly efficient gene therapy
Jia, H., Yang, Y., Li, M., Li, Y., Han, X., Li, J., Zhang, X., Fan, C., Wu, T., Cui, C., et al. (2020) · Materials Today Chemistry · doi:10.1016/j.mtchem.2020.100287 · Cited by 3
Metadata
- Authors
- Buck, J., Grossen, P., Cullis, P. R., Huwyler, J., & Witzigmann, D.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-03-25
- Volume
- 13
- Issue
- 4
- Pages
- 3754-3782
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2925126737
- Cited by
- 312
- References
- 254
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.