Protein Complexes in the Gas Phase: Technology for Structural Genomics and Proteomics

Mass spectrometry-based proteomics

Aebersold, R., & Mann, M. (2003) · Nature · doi:10.1038/nature01511 · Cited by 6,955

Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons

Karas, M., & Hillenkamp, F. (1988) · Analytical Chemistry · doi:10.1021/ac00171a028 · Cited by 5,637

Functional organization of the yeast proteome by systematic analysis of protein complexes

Gavin, A.-C., Bösche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J. M., Michon, A.-M., Cruciat, C.-M., et al. (2002) · Nature · doi:10.1038/415141a · Cited by 4,759

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

Ho, Y., Gruhler, A., Heilbut, A., Bader, G. D., Moore, L., Adams, S.-L., Millar, A., Taylor, P., Bennett, K., Boutilier, K., et al. (2002) · Nature · doi:10.1038/415180a · Cited by 3,601

Protein and polymer analyses up to m/z 100 000 by laser ionization time‐of‐flight mass spectrometry

Tanaka, K., Waki, H., Ido, Y., Akita, S., Yoshida, Y., Yoshida, T., & Matsuo, T. (1988) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1290020802 · Cited by 3,175

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

Krogan, N. J., Cagney, G., Yu, H., Zhong, G., Guo, X., Ignatchenko, A., Li, J., Pu, S., Datta, N., Tikuisis, A. P., et al. (2006) · Nature · doi:10.1038/nature04670 · Cited by 2,952

A generic protein purification method for protein complex characterization and proteome exploration

Rigaut, G., Shevchenko, A., Rutz, B., Wilm, M., Mann, M., & Séraphin, B. (1999) · Nature Biotechnology · doi:10.1038/13732 · Cited by 2,707

Proteome survey reveals modularity of the yeast cell machinery

Gavin, A.-C., Aloy, P., Grandi, P., Krause, R., Boesche, M., Marzioch, M., Rau, C., Jensen, L. J., Bastuck, S., Dümpelfeld, B., et al. (2006) · Nature · doi:10.1038/nature04532 · Cited by 2,575

Electrospray ion source. Another variation on the free-jet theme

Yamashita, M., & Fenn, J. B. (1984) · The Journal of Physical Chemistry · doi:10.1021/j150664a002 · Cited by 2,082

Analytical Properties of the Nanoelectrospray Ion Source

Wilm, M., & Mann, M. (1996) · Analytical Chemistry · doi:10.1021/ac9509519 · Cited by 1,868

XX. On the equilibrium of liquid conducting masses charged with electricity

Rayleigh, L. (1882) · The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science · doi:10.1080/14786448208628425 · Cited by 1,825

Transport Properties of Ions in Gases

Mason, E. A., & McDaniel, E. W. (1988) · Wiley eBooks · doi:10.1002/3527602852 · Cited by 1,797

The Tandem Affinity Purification (TAP) Method: A General Procedure of Protein Complex Purification

Puig, O., Caspary, F., Rigaut, G., Rutz, B., Bouveret, E., Bragado-Nilsson, E., Wilm, M., & Séraphin, B. (2001) · Methods · doi:10.1006/meth.2001.1183 · Cited by 1,783

Molecular Beams of Macroions

Dole, M., Mack, L. L., Hines, R. L., Mobley, R. C., Ferguson, L. D., & Alice, M. B. (1968) · The Journal of Chemical Physics · doi:10.1063/1.1670391 · Cited by 1,613

The Orbitrap: a new mass spectrometer

Hu, Q., Noll, R. J., Li, H., Makarov, A., Hardman, M., & Graham Cooks, R. (2005) · Journal of Mass Spectrometry · doi:10.1002/jms.856 · Cited by 1,333

On the evaporation of small ions from charged droplets

Iribarne, J. V., & Thomson, B. A. (1976) · The Journal of Chemical Physics · doi:10.1063/1.432536 · Cited by 1,281

Studying noncovalent protein complexes by electrospray ionization mass spectrometry

Loo, J. A. (1997) · Mass Spectrometry Reviews · doi:10.1002/(sici)1098-2787(1997)16:1<1::aid-mas1>3.0.co;2-l · Cited by 1,182

A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

Bouwmeester, T., Bauch, A., Ruffner, H., Angrand, P.-O., Bergamini, G., Croughton, K., Cruciat, C., Eberhard, D., Gagneur, J., Ghidelli, S., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1086 · Cited by 1,029

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

Zhang, Z., & Smith, D. L. (1993) · Protein Science · doi:10.1002/pro.5560020404 · Cited by 1,012

Electrospray and Taylor-Cone theory, Dole's beam of macromolecules at last?

Wilm, M. S., & Mann, M. (1994) · International Journal of Mass Spectrometry and Ion Processes · doi:10.1016/0168-1176(94)04024-9 · Cited by 974

The current emitted by highly conducting Taylor cones

De La Mora, J. F., & Loscertales, I. G. (1994) · Journal of Fluid Mechanics · doi:10.1017/s0022112094003472 · Cited by 884

An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument

Pringle, S. D., Giles, K., Wildgoose, J. L., Williams, J. P., Slade, S. E., Thalassinos, K., Bateman, R. H., Bowers, M. T., & Scrivens, J. H. (2007) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2006.07.021 · Cited by 808

Applications of a travelling wave‐based radio‐frequency‐only stacked ring ion guide

Giles, K., Pringle, S. D., Worthington, K. R., Little, D., Wildgoose, J. L., & Bateman, R. H. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1641 · Cited by 727

Crystal structure and assembly of a eukaryotic small heat shock protein.

van Montfort, R. L. M., Basha, E., Friedrich, K. L., Slingsby, C., & Vierling, E. (2001) · Nature Structural Biology · doi:10.1038/nsb722 · Cited by 718

The Desorption Process in MALDI

Dreisewerd, K. (2003) · Chemical Reviews · doi:10.1021/cr010375i · Cited by 709

An introduction to quadrupole–time‐of‐flight mass spectrometry

Chernushevich, I. V., Loboda, A. V., & Thomson, B. A. (2001) · Journal of Mass Spectrometry · doi:10.1002/jms.207 · Cited by 705

A brief overview of the present status of the mechanisms involved in electrospray mass spectrometry

Kebarle, P. (2000) · Journal of Mass Spectrometry · doi:10.1002/1096-9888(200007)35:7<804::aid-jms22>3.0.co;2-q · Cited by 675

Charge and fission of droplets in electrostatic sprays

Gomez, A., & Tang, K. (1994) · Physics of Fluids · doi:10.1063/1.868037 · Cited by 654

Ion Formation in MALDI: The Cluster Ionization Mechanism

Karas, M., & Krüger, R. (2003) · Chemical Reviews · doi:10.1021/cr010376a · Cited by 651

Chemical cross‐linking and mass spectrometry to map three‐dimensional protein structures and protein–protein interactions

Sinz, A. (2006) · Mass Spectrometry Reviews · doi:10.1002/mas.20082 · Cited by 648

Probing conformational changes in proteins by mass spectrometry

Chowdhury, S. K., Katta, V., & Chait, B. T. (1990) · Journal of the American Chemical Society · doi:10.1021/ja00180a074 · Cited by 646

Evidence for Macromolecular Protein Rings in the Absence of Bulk Water

Ruotolo, B. T., Giles, K., Campuzano, I., Sandercock, A. M., Bateman, R. H., & Robinson, C. V. (2005) · Science · doi:10.1126/science.1120177 · Cited by 596

Investigation of intact protein complexes by mass spectrometry

Heck, A. J. R., & van den Heuvel, R. H. H. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.10081 · Cited by 583

Electrospray ionization of large multiply charged species proceeds via Dole’s charged residue mechanism

Fernandez de la Mora, J. (2000) · Analytica Chimica Acta · doi:10.1016/s0003-2670(99)00601-7 · Cited by 528

MALDI Ionization: The Role of In-Plume Processes

Knochenmuss, R., & Zenobi, R. (2003) · Chemical Reviews · doi:10.1021/cr0103773 · Cited by 520

A Tandem Mass Spectrometer for Improved Transmission and Analysis of Large Macromolecular Assemblies

Sobott, F., Hernández, H., McCammon, M. G., Tito, M. A., & Robinson, C. V. (2002) · Analytical Chemistry · doi:10.1021/ac0110552 · Cited by 511

Detection of noncovalent receptor-ligand complexes by mass spectrometry

Ganem, B., Li, Y. T., & Henion, J. D. (1991) · Journal of the American Chemical Society · doi:10.1021/ja00016a069 · Cited by 506

Quantitative determination of noncovalent binding interactions using soft ionization mass spectrometry

Daniel, J. M., Friess, S. D., Rajagopalan, S., Wendt, S., & Zenobi, R. (2002) · International Journal of Mass Spectrometry · doi:10.1016/s1387-3806(02)00585-7 · Cited by 475

From words to literature in structural proteomics

Sali, A., Glaeser, R., Earnest, T., & Baumeister, W. (2003) · Nature · doi:10.1038/nature01513 · Cited by 475

Electrospray ionization mass spectrometry: a technology for studying noncovalent macromolecular complexes

Loo, J. A. (2000) · International Journal of Mass Spectrometry · doi:10.1016/s1387-3806(00)00298-0 · Cited by 444

High-field asymmetric waveform ion mobility spectrometry: A new tool for mass spectrometry

Guevremont, R. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.08.119 · Cited by 444

Structure and function of the small heat shock protein/α-crystallin family of molecular chaperones

Montfort, R. V., Slingsby, C., & Vierlingt, E. (2001) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(01)59004-x · Cited by 432

Nanoelectrospray—More than just a minimized-flow electrospray ionization source

Juraschek, R., Dülcks, T., & Karas, M. (1999) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(98)00157-3 · Cited by 415

Conformation of Macromolecules in the Gas Phase: Use of Matrix-Assisted Laser Desorption Methods in Ion Chromatography

von Helden, G., Wyttenbach, T., & Bowers, M. T. (1995) · Science · doi:10.1126/science.267.5203.1483 · Cited by 363

Peptides and Proteins in the Vapor Phase

Jarrold, M. F. (2000) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.51.1.179 · Cited by 361

Electron-capture dissociation tandem mass spectrometry

Zubarev, R. A. (2004) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.12.002 · Cited by 360

On the mechanisms by which the charged droplets produced by electrospray lead to gas phase ions

Kebarle, P., & Peschke, M. (2000) · Analytica Chimica Acta · doi:10.1016/s0003-2670(99)00598-x · Cited by 352

Molecular recycling within amyloid fibrils

Carulla, N., Caddy, G. L., Hall, D. R., Zurdo, J., Gairí, M., Feliz, M., Giralt, E., Robinson, C. V., & Dobson, C. M. (2005) · Nature · doi:10.1038/nature03986 · Cited by 348

Amyloid β-Protein: Monomer Structure and Early Aggregation States of Aβ42 and Its Pro19Alloform

Bernstein, S. L., Wyttenbach, T., Baumketner, A., Shea, J.-E., Bitan, G., Teplow, D. B., & Bowers, M. T. (2005) · Journal of the American Chemical Society · doi:10.1021/ja044531p · Cited by 341

A Tandem Affinity Tag for Two-step Purification under Fully Denaturing Conditions

Tagwerker, C., Flick, K., Cui, M., Guerrero, C., Dou, Y., Auer, B., Baldi, P., Huang, L., & Kaiser, P. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500368-mcp200 · Cited by 336

Observation of noncovalent enzyme-substrate and enzyme-product complexes by ion-spray mass spectrometry

Ganem, B., Li, Y. T., & Henion, J. D. (1991) · Journal of the American Chemical Society · doi:10.1021/ja00020a085 · Cited by 331

Anhydrous Protein Ions

Hoaglund-Hyzer, C. S., Counterman, A. E., & Clemmer, D. E. (1999) · Chemical Reviews · doi:10.1021/cr980139g · Cited by 320

Estimates of Protein Surface Areas in Solution by Electrospray Ionization Mass Spectrometry

Kaltashov, I. A., & Mohimen, A. (2005) · Analytical Chemistry · doi:10.1021/ac050511+ · Cited by 319

Ion mobility–mass spectrometry: a new paradigm for proteomics

McLean, J. A., Ruotolo, B. T., Gillig, K. J., & Russell, D. H. (2005) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2004.10.003 · Cited by 309

Native protein mass spectrometry: from intact oligomers to functional machineries

Heuvel, R. H. V. D., & Heck, A. J. (2004) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2004.08.006 · Cited by 303

High-resolution ion mobility measurements

Dugourd, P., Hudgins, R. R., Clemmer, D. E., & Jarrold, M. F. (1997) · Review of Scientific Instruments · doi:10.1063/1.1147873 · Cited by 299

Computer Simulations of Laser Ablation of Molecular Substrates

Zhigilei, L. V., Leveugle, E., Garrison, B. J., Yingling, Y. G., & Zeifman, M. I. (2003) · Chemical Reviews · doi:10.1021/cr010459r · Cited by 289

A Fully Integrated Monolithic Microchip Electrospray Device for Mass Spectrometry

Schultz, G. A., Corso, T. N., Prosser, S. J., & Zhang, S. (2000) · Analytical Chemistry · doi:10.1021/ac000325y · Cited by 284

Origin of Asymmetric Charge Partitioning in the Dissociation of Gas-Phase Protein Homodimers

Jurchen, J. C., & Williams, E. R. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0211508 · Cited by 284

Preparing Protein Microarrays by Soft-Landing of Mass-Selected Ions

Ouyang, Z., Takáts, Z., Blake, T. A., Gologan, B., Guymon, A. J., Wiseman, J. M., Oliver, J. C., Davisson, V. J., & Cooks, R. G. (2003) · Science · doi:10.1126/science.1088776 · Cited by 277

Design of a new electrospray ion mobility mass spectrometer

Wyttenbach, T., Kemper, P. R., & Bowers, M. T. (2001) · International Journal of Mass Spectrometry · doi:10.1016/s1387-3806(01)00517-6 · Cited by 277

Nano-electrospray ionization mass spectrometry: addressing analytical problems beyond routine

Karas, M., Bahr, U., & Dülcks, T. (2000) · Fresenius' Journal of Analytical Chemistry · doi:10.1007/s002160051561 · Cited by 275

Effect of reducing disulfide-containing proteins on electrospray ionization mass spectra

Loo, J. A., Edmonds, C. G., Udseth, H. R., & Smith, R. D. (1990) · Analytical Chemistry · doi:10.1021/ac00206a009 · Cited by 274

An IMS−IMS Analogue of MS−MS

Koeniger, S. L., Merenbloom, S. I., Valentine, S. J., Jarrold, M. F., Udseth, H. R., Smith, R. D., & Clemmer, D. E. (2006) · Analytical Chemistry · doi:10.1021/ac051060w · Cited by 272

Studies of biomolecular conformations and conformational dynamics by mass spectrometry

Kaltashov, I. A., & Eyles, S. J. (2002) · Mass Spectrometry Reviews · doi:10.1002/mas.10017 · Cited by 270

Observation of the Noncovalent Quaternary Associations of Proteins by Electrospray Ionization Mass Spectrometry

Light-Wahl, K. J., Schwartz, B. L., & Smith, R. D. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00091a035 · Cited by 260

An Integrated Mass Spectrometry-based Proteomic Approach

Guerrero, C., Tagwerker, C., Kaiser, P., & Huang, L. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500303-mcp200 · Cited by 258

Heat-induced conformational changes in proteins studied by electrospray ionization mass spectrometry

Mirza, U. A., Cohen, S. L., & Chait, B. T. (1993) · Analytical Chemistry · doi:10.1021/ac00049a003 · Cited by 256

Collision cross sections for protein ions

Covey, T., & Douglas, D. J. (1993) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(93)85025-s · Cited by 253

Activation of Unimolecular Reactions by Ambient Blackbody Radiation

Dunbar, R. C., & McMahon, T. B. (1998) · Science · doi:10.1126/science.279.5348.194 · Cited by 252

Improving the Performance of a Quadrupole Time-of-Flight Instrument for Macromolecular Mass Spectrometry

van den Heuvel, R. H. H., van Duijn, E., Mazon, H., Synowsky, S. A., Lorenzen, K., Versluis, C., Brouns, S. J. J., Langridge, D., van der Oost, J., Hoyes, J., et al. (2006) · Analytical Chemistry · doi:10.1021/ac061039a · Cited by 252

An assembly landscape for the 30S ribosomal subunit

Talkington, M. W. T., Siuzdak, G., & Williamson, J. R. (2005) · Nature · doi:10.1038/nature04261 · Cited by 250

Ionization enhancement in atmospheric pressure chemical ionization and suppression in electrospray ionization between target drugs and stable‐isotope‐labeled internal standards in quantitative liquid chromatography/tandem mass spectrometry

Liang, H. R., Foltz, R. L., Meng, M., & Bennett, P. (2003) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1268 · Cited by 247

RADIOLYTIC PROTEIN FOOTPRINTING WITH MASS SPECTROMETRY TO PROBE THE STRUCTURE OF MACROMOLECULAR COMPLEXES

Takamoto, K., & Chance, M. R. (2006) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.102050 · Cited by 245

Polydispersity of a mammalian chaperone: Mass spectrometry reveals the population of oligomers in αB-crystallin

Aquilina, J. A., Benesch, J. L. P., Bateman, O. A., Slingsby, C., & Robinson, C. V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1932958100 · Cited by 243

Detection of Multiple Protein Conformational Ensembles in Solution via Deconvolution of Charge-State Distributions in ESI MS

Dobo, A., & Kaltashov, I. A. (2001) · Analytical Chemistry · doi:10.1021/ac010713f · Cited by 237

Collisional Cooling of Large Ions in Electrospray Mass Spectrometry

Chernushevich, I. V., & Thomson, B. A. (2004) · Analytical Chemistry · doi:10.1021/ac035406j · Cited by 235

Aspects of native proteins are retained in vacuum

Ruotolo, B. T., & Robinson, C. V. (2006) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2006.08.020 · Cited by 235

Identification of protein‐protein interactions using in vivo cross‐linking and mass spectrometry

Vasilescu, J., Guo, X., & Kast, J. (2004) · PROTEOMICS · doi:10.1002/pmic.200400856 · Cited by 226

Gas-Phase Conformations: The Ion Mobility/Ion Chromatography Method

Wyttenbach, T., & Bowers, M. T. (2003) · Topics in Current Chemistry · doi:10.1007/3-540-36113-8_6 · Cited by 223

Charge‐reduced nano electrospray ionization combined with differential mobility analysis of peptides, proteins, glycoproteins, noncovalent protein complexes and viruses

Bacher, G., Szymanski, W. W., Kaufman, S. L., Zöllner, P., Blaas, D., & Allmaier, G. (2001) · Journal of Mass Spectrometry · doi:10.1002/jms.208 · Cited by 222

Tandem Mass Spectrometry Reveals the Quaternary Organization of Macromolecular Assemblies

Benesch, J. L. P., Aquilina, J. A., Ruotolo, B. T., Sobott, F., & Robinson, C. V. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.04.006 · Cited by 222

Macromolecule Analysis Based on Electrophoretic Mobility in Air: Globular Proteins

Kaufman, S. L., Skogen, J. W., Dorman, F. D., Zarrin, F., & Lewis, K. C. (1996) · Analytical Chemistry · doi:10.1021/ac951128f · Cited by 218

Mass Spectrometry Identifiable Cross-Linking Strategy for Studying Protein−Protein Interactions

Tang, X., Munske, G. R., Siems, W. F., & Bruce, J. E. (2005) · Analytical Chemistry · doi:10.1021/ac0488762 · Cited by 218

The effect of the source pressure on the abundance of ions of noncovalent protein assemblies in an electrospray ionization orthogonal time‐of‐flight instrument

Tahallah, N., Pinkse, M., Maier, C. S., & Heck, A. J. R. (2001) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.275 · Cited by 210

Structural Organization of the 19S Proteasome Lid: Insights from MS of Intact Complexes

Sharon, M., Taverner, T., Ambroggio, X. I., Deshaies, R. J., & Robinson, C. V. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040267 · Cited by 209

Elucidating Amyloid β-Protein Folding and Assembly: A Multidisciplinary Approach

Teplow, D. B., Lazo, N. D., Bitan, G., Bernstein, S., Wyttenbach, T., Bowers, M. T., Baumketner, A., Shea, J.-E., Urbanc, B., Cruz, L., et al. (2006) · Accounts of Chemical Research · doi:10.1021/ar050063s · Cited by 207

Mass spectrometry and viral analysis

Siuzdak, G., Bothner, B., Yeager, M., Brugidou, C., Fauquet, C. M., Hoey, K., & Change, C.-M. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90083-6 · Cited by 203

Electrospray ionization mass spectrometry and ion mobility analysis of the 20S proteasome complex

Loo, J. A., Berhane, B., Kaddis, C. S., Wooding, K. M., Xie, Y., Kaufman, S. L., & Chernushevich, I. V. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.02.017 · Cited by 203

ESI/Ion Trap/Ion Mobility/Time-of-Flight Mass Spectrometry for Rapid and Sensitive Analysis of Biomolecular Mixtures

Henderson, S. C., Valentine, S. J., Counterman, A. E., & Clemmer, D. E. (1999) · Analytical Chemistry · doi:10.1021/ac9809175 · Cited by 203

Mass spectrometry of macromolecular assemblies: preservation and dissociation

Benesch, J. L., & Robinson, C. V. (2006) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2006.03.009 · Cited by 203

Changes in bulk solution pH caused by the inherent controlled-current electrolytic process of an electrospray ion source

Van Berkel, G. J., Zhou, F., & Aronson, J. T. (1997) · International Journal of Mass Spectrometry and Ion Processes · doi:10.1016/s0168-1176(96)04476-x · Cited by 201

Top-Down ESI-ECD-FT-ICR Mass Spectrometry Localizes Noncovalent Protein-Ligand Binding Sites

Xie, Y., Zhang, J., Yin, S., & Loo, J. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja063197p · Cited by 200

IMS−IMS and IMS−IMS−IMS/MS for Separating Peptide and Protein Fragment Ions

Merenbloom, S. I., Koeniger, S. L., Valentine, S. J., Plasencia, M. D., & Clemmer, D. E. (2006) · Analytical Chemistry · doi:10.1021/ac052208e · Cited by 200

Subunit Exchange of Multimeric Protein Complexes

Sobott, F., Benesch, J. L. P., Vierling, E., & Robinson, C. V. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206060200 · Cited by 199

A Modular Cross-Linking Approach for Exploring Protein Interactions

Trester-Zedlitz, M., Kamada, K., Burley, S. K., Fenyö, D., Chait, B. T., & Muir, T. W. (2003) · Journal of the American Chemical Society · doi:10.1021/ja026917a · Cited by 195

Electrospray Time-of-Flight Mass Spectrometry of the Intact MS2 Virus Capsid

Tito, M. A., Tars, K., Valegard, K., Hajdu, J., & Robinson, C. V. (2000) · Journal of the American Chemical Society · doi:10.1021/ja993740k · Cited by 195

High-Resolution Field Asymmetric Waveform Ion Mobility Spectrometry Using New Planar Geometry Analyzers

Shvartsburg, A. A., Li, F., Tang, K., & Smith, R. D. (2006) · Analytical Chemistry · doi:10.1021/ac052020v · Cited by 191

Unimolecular Reaction Kinetics in the High-Pressure Limit without Collisions

Price, W. D., Schnier, P. D., Jockusch, R. A., Strittmatter, E. F., & Williams, E. R. (1996) · Journal of the American Chemical Society · doi:10.1021/ja961812r · Cited by 189

Collisional damping interface for an electrospray ionization time-of-flight mass spectrometer

Krutchinsky, A. N., Chernushevich, I. V., Spicer, V. L., Ens, W., & Standing, K. G. (1998) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(98)00027-0 · Cited by 187

Matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS) of membrane proteins and non‐covalent complexes

Rosinke, B., Strupat, K., Hillenkamp, F., Rosenbusch, J., Dencher, N., Krüger, U., & Galla, H. (1995) · Journal of Mass Spectrometry · doi:10.1002/jms.1190301012 · Cited by 185

Mass Measurements of Increased Accuracy Resolve Heterogeneous Populations of Intact Ribosomes

McKay, A. R., Ruotolo, B. T., Ilag, L. L., & Robinson, C. V. (2006) · Journal of the American Chemical Society · doi:10.1021/ja061468q · Cited by 178

Subunit architecture of multimeric complexes isolated directly from cells

Hernández, H., Dziembowski, A., Taverner, T., Séraphin, B., & Robinson, C. V. (2006) · EMBO reports · doi:10.1038/sj.embor.7400702 · Cited by 178

Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry

Nettleton, E. J., Sunde, M., Lai, Z., Kelly, J. W., Dobson, C. M., & Robinson, C. V. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.1937 · Cited by 174

Detection of the Intact GroEL Chaperonin Assembly by Mass Spectrometry

Rostom, A. A., & Robinson, C. V. (1999) · Journal of the American Chemical Society · doi:10.1021/ja990238r · Cited by 173

Thermal Decomposition of a Gaseous Multiprotein Complex Studied by Blackbody Infrared Radiative Dissociation. Investigating the Origin of the Asymmetric Dissociation Behavior

Felitsyn, N., Kitova, E. N., & Klassen, J. S. (2001) · Analytical Chemistry · doi:10.1021/ac0103975 · Cited by 173

Thermal Dissociation of Multimeric Protein Complexes by Using Nanoelectrospray Mass Spectrometry

Benesch, J. L. P., Sobott, F., & Robinson, C. V. (2003) · Analytical Chemistry · doi:10.1021/ac034132x · Cited by 170

Efficiency of nano-electrospray ionization

El-Faramawy, A., Siu, K. W. M., & Thomson, B. A. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.06.011 · Cited by 168

Analytical applications of ion-molecule reactions

Brodbelt, J. S. (1997) · Mass Spectrometry Reviews · doi:10.1002/(sici)1098-2787(1997)16:2<91::aid-mas3>3.0.co;2-4 · Cited by 166

Quantitative Determination of Noncovalent Binding Interactions Using Automated Nanoelectrospray Mass Spectrometry

Zhang, S., Van Pelt, C. K., & Wilson, D. B. (2003) · Analytical Chemistry · doi:10.1021/ac034089d · Cited by 164

Coupling High-Pressure MALDI with Ion Mobility/Orthogonal Time-of-Flight Mass Spectrometry

Gillig, K. J., Ruotolo, B., Stone, E. G., Russell, D. H., Fuhrer, K., Gonin, M., & Schultz, A. J. (2000) · Analytical Chemistry · doi:10.1021/ac0005619 · Cited by 162

Mechanisms of electrospray ionization of singly and multiply charged salt clusters

Gamero-Castaño, M., & de la Mora, J. F. (2000) · Analytica Chimica Acta · doi:10.1016/s0003-2670(99)00596-6 · Cited by 162

Intermolecular Interactions in Biomolecular Systems Examined by Mass Spectrometry

Wyttenbach, T., & Bowers, M. T. (2007) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.58.032806.104515 · Cited by 158

Origin and number of charges observed on multiply-protonated native proteins produced by ESI

Felitsyn, N. M., Peschke, M., & Kebarle, P. (2002) · International Journal of Mass Spectrometry · doi:10.1016/s1387-3806(02)00588-2 · Cited by 157

α-Synuclein: Stable compact and extended monomeric structures and pH dependence of dimer formation

Bernstein, S. L., Liu, D., Wyttenbach, T., Bowers, M. T., Lee, J. C., Gray, H. B., & Winkler, J. R. (2004) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2004.08.003 · Cited by 154

Direct Observation of Oligomeric Species formed in the Early Stages of Amyloid Fibril Formation using Electrospray Ionisation Mass Spectrometry

Smith, A. M., Jahn, T. R., Ashcroft, A. E., & Radford, S. E. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.08.081 · Cited by 147

Direct observation of a ternary complex between the dimeric enzyme HIV-1 protease and a substrate-based inhibitor

Baca, M., & Kent, S. B. H. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00036a066 · Cited by 146

Ultrasensitive and Quantitative Analyses from Combined Separations−Mass Spectrometry for the Characterization of Proteomes

Smith, R. D., Shen, Y., & Tang, K. (2004) · Accounts of Chemical Research · doi:10.1021/ar0301330 · Cited by 146

Two-Dimensional Gas-Phase Separations Coupled to Mass Spectrometry for Analysis of Complex Mixtures

Tang, K., Li, F., Shvartsburg, A. A., Strittmatter, E. F., & Smith, R. D. (2005) · Analytical Chemistry · doi:10.1021/ac050871x · Cited by 141

Equilibrium unfolding of proteins monitored by electrospray ionization mass spectrometry: distinguishing two-state from multi-state transitions

Konermann, L., & Douglas, D. J. (1998) · Rapid Communications in Mass Spectrometry · Cited by 140

Heptameric (L12) 6 /L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria

Ilag, L. L., Videler, H., McKay, A. R., Sobott, F., Fucini, P., Nierhaus, K. H., & Robinson, C. V. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502193102 · Cited by 138

A top down approach to protein structural studies using chemical cross‐linking and Fourier transform mass spectrometry

Kruppa, G. H., Schoeniger, J. S., & Young, M. M. (2002) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.885 · Cited by 137

Dissociation of tetrameric ions of noncovalent streptavidin complexes formed by electrospray ionization

Schwartz, B. L., Bruce, J. E., Anderson, G., Hofstadler, S. A., Rockwood, A. L., Smith, R. D., Chilkoti, A., & Stayton, P. S. (1995) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(95)00191-f · Cited by 134

A Capillary Mixer with Adjustable Reaction Chamber Volume for Millisecond Time-Resolved Studies by Electrospray Mass Spectrometry

Wilson, D. J., & Konermann, L. (2003) · Analytical Chemistry · doi:10.1021/ac0346757 · Cited by 132

Protein complexes gain momentum

Sobott, F. (2002) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(02)00400-1 · Cited by 132

Radiolytic Modification of Basic Amino Acid Residues in Peptides: Probes for Examining Protein−Protein Interactions

Xu, G., Takamoto, K., & Chance, M. R. (2003) · Analytical Chemistry · doi:10.1021/ac035104h · Cited by 127

Single‐step Strep‐tag® purification for the isolation and identification of protein complexes from mammalian cells

Junttila, M. R., Saarinen, S., Schmidt, T. G. M., Kast, J., & Westermarck, J. K. (2005) · PROTEOMICS · doi:10.1002/pmic.200400991 · Cited by 122

Characterization of an Antagonist Interleukin-6 Dimer by Stable Isotope Labeling, Cross-linking, and Mass Spectrometry

Taverner, T., Hall, N. E., O’Hair, R. A. J., & Simpson, R. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207370200 · Cited by 121

Cytochrome c Folding Kinetics Studied by Time-Resolved Electrospray Ionization Mass Spectrometry

Konermann, L., Collings, B. A., & Douglas, D. J. (1997) · Biochemistry · doi:10.1021/bi970046d · Cited by 121

Observation and implications of high mass-to-charge ratio ions from electrospray ionization mass spectrometry

Winger, B. E., Light‐Wahl, K. J., Loo, R. R. O., Udseth, H. R., & Smith, R. D. (1993) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(93)85015-p · Cited by 120

Multidimensional separations of ubiquitin conformers in the gas phase: Relating ion cross sections to H/D exchange measurements

Robinson, E. W., & Williams, E. R. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.04.007 · Cited by 120

Protein Cross-Linking Analysis Using Mass Spectrometry, Isotope-Coded Cross-Linkers, and Integrated Computational Data Processing

Seebacher, J., Mallick, P., Zhang, N., Eddes, J. S., Aebersold, R. H., & Gelb, M. H. (2006) · Journal of Proteome Research · doi:10.1021/pr060154z · Cited by 119

Structural proteomics of macromolecular assemblies using oxidative footprinting and mass spectrometry

Guan, J.-Q., & Chance, M. R. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.08.007 · Cited by 117

An Ion Trap Interface for ESI−Ion Mobility Experiments

Hoaglund‐Hyzer, C. S., Valentine, S. J., & Clemmer, D. E. (1997) · Analytical Chemistry · doi:10.1021/ac970526a · Cited by 117

Characterising electrosprayed biomolecules using tandem-MS—the noncovalent GroEL chaperonin assembly

Sobott, F., & Robinson, C. V. (2004) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2004.05.010 · Cited by 112

Isotopically Coded Cleavable Cross-linker for Studying Protein-Protein Interaction and Protein Complexes

Petrotchenko, E. V., Olkhovik, V. K., & Borchers, C. H. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.t400016-mcp200 · Cited by 107

Surface plasmon resonance mass spectrometry: recent progress and outlooks

Nedelkov, D., & Nelson, R. W. (2003) · Trends in biotechnology · doi:10.1016/s0167-7799(03)00141-0 · Cited by 107

Mapping the Topology and Determination of a Low-Resolution Three-Dimensional Structure of the Calmodulin−Melittin Complex by Chemical Cross-Linking and High-Resolution FTICRMS: Direct Demonstration of Multiple Binding Modes

Schulz, D. M., Ihling, C. H., Clore, G. M., & Sinz, A. (2004) · Biochemistry · doi:10.1021/bi036149f · Cited by 106

Conformation of Cytochrome c Studied by Deuterium Exchange-Electrospray Ionization Mass Spectrometry

Wagner, D. S., & Anderegg, R. J. (1994) · Analytical Chemistry · doi:10.1021/ac00077a020 · Cited by 105

Ion-Ion and ion-molecule reactions at the surface of proteins produced by nanospray. Information on the number of acidic residues and control of the number of ionized acidic and basic residues

Verkerk, U. H., & Kebarle, P. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.03.018 · Cited by 105

Characterizing the Structures and Folding of Free Proteins Using 2-D Gas-Phase Separations: Observation of Multiple Unfolded Conformers

Shvartsburg, A. A., Li, F., Tang, K., & Smith, R. D. (2006) · Analytical Chemistry · doi:10.1021/ac060283z · Cited by 104

Factors Affecting Gas-Phase Deuterium Scrambling in Peptide Ions and Their Implications for Protein Structure Determination

Demmers, J., Rijkers, D. T. S., Haverkamp, J., Killian, J. A., & Heck, A. J. R. (2002) · Journal of the American Chemical Society · doi:10.1021/ja0125927 · Cited by 102

Highly Asymmetric Interactions between Globin Chains during Hemoglobin Assembly Revealed by Electrospray Ionization Mass Spectrometry

Griffith, W. P., & Kaltashov, I. A. (2003) · Biochemistry · doi:10.1021/bi034035y · Cited by 101

Effects of pH on the kinetic reaction

Sogbein, O. O., Simmons, D. A., & Konermann, L. (2000) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(99)00149-x · Cited by 100

Observation of the noncovalent assembly and disassembly pathways of the chaperone complex MtGimC by mass spectrometry

Fändrich, M., Tito, M. A., Leroux, M. R., Rostom, A. A., Hartl, F. U., Dobson, C. M., & Robinson, C. V. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240326597 · Cited by 100

A segmented radiofrequency-only quadrupole collision cell for measurements of ion collision cross section on a triple quadrupole mass spectrometer

Javahery, G., & Thomson, B. A. (1997) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(97)00027-5 · Cited by 100

Matrix-Assisted Laser Desorption/Ionization of Noncovalently Bound Compounds

Woods, A. S., Buchsbaum, J. C., Worrall, T. A., Berg, J. M., & Cotter, R. J. (1995) · Analytical Chemistry · doi:10.1021/ac00120a005 · Cited by 95

The role of conformation on electron capture dissociation of ubiquitin

Robinson, E. W., Leib, R. D., & Williams, E. R. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2006.06.027 · Cited by 93

Correlation of the Phosphorylation States of pp60c-src with Tyrosine Kinase Activity: The Intramolecular pY530−SH2 Complex Retains Significant Activity If Y419 Is Phosphorylated

Boerner, R. J., Kassel, D. B., Barker, S. C., Ellis, B., DeLacy, P., & Knight, W. B. (1996) · Biochemistry · doi:10.1021/bi960248u · Cited by 92

Further studies on the origins of asymmetric charge partitioning in protein homodimers

Jurchen, J. C., García, D., & Williams, E. R. (2004) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2004.06.006 · Cited by 92

Detecting equilibrium cytochrome c folding intermediates by electrospray ionisation mass spectrometry: Two partially folded forms populate the molten‐globule state

Grandori, R. (2002) · Protein Science · doi:10.1110/ps.45102 · Cited by 91

Mapping protein interfaces by a trifunctional cross-linker combined with MALDI-TOF and ESI-FTICR mass spectrometry

Sinz, A., Kalkhof, S., & Ihling, C. H. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.07.020 · Cited by 89

Tandem Mass Spectrometry of Intact GroEL−Substrate Complexes Reveals Substrate-Specific Conformational Changes in thetransRing

van Duijn, E., Simmons, D. A., van den Heuvel, R. H. H., Bakkes, P. J., van Heerikhuizen, H., Heeren, R. M. A., Robinson, C. V., van der Vies, S. M., & Heck, A. J. R. (2006) · Journal of the American Chemical Society · doi:10.1021/ja056756l · Cited by 87

Photoaffinity labeling combined with mass spectrometric approaches as a tool for structural proteomics

Robinette, D. W., Neamati, N., Tomer, K. B., & Borchers, C. H. (2006) · Expert Review of Proteomics · doi:10.1586/14789450.3.4.399 · Cited by 87

Charge-Induced Unfolding of Multiply Charged Polyethylene Glycol Ions

Ude, S., de la Mora, J. F., & Thomson, B. A. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0381306 · Cited by 84

Symmetrical gas-phase dissociation of noncovalent protein complexes via surface collisions.

Jones, C. M., Beardsley, R. L., Galhena, A. S., Dagan, S., Cheng, G., & Wysocki, V. (2006) · Journal of the American Chemical Society · doi:10.1021/ja064586m · Cited by 81

Electrospray Ionization of a Whole Virus: Analyzing Mass, Structure, and Viability

Bothner, B. B., & Siuzdak, G. E. (2004) · ChemBioChem · doi:10.1002/cbic.200300754 · Cited by 81

Mapping protein–protein interactions by mass spectrometry

Vasilescu, J., & Figeys, D. (2006) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2006.06.008 · Cited by 80

Mass Spectrometry: Recent Advances and Future Directions

Bowers, M. T., Marshall, A. G., & McLafferty, F. W. (1996) · The Journal of Physical Chemistry · doi:10.1021/jp960154u · Cited by 80

Interpreting conformational effects in protein nano-ESI-MS spectra

Šamalíková, M., Matečko‐Burmann, I., Müller, N., & Grandori, R. (2003) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-003-2339-6 · Cited by 78

V-1, a Protein Expressed Transiently during Murine Cerebellar Development, Regulates Actin Polymerization via Interaction with Capping Protein

Taoka, M., Ichimura, T., Wakamiya, A., Kubota, Y., Araki, T., Obinata, T., & Isobe, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211509200 · Cited by 78

Mapping protein-protein interactions by affinity-directed mass spectrometry.

Zhao, Y., Muir, T. W., Kent, S. B. H., Tischer, E., Scardina, J. M., & Chait, B. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4020 · Cited by 76

A Split-Field Drift Tube for Separation and Efficient Fragmentation of Biomolecular Ions

Valentine, S. J., Koeniger, S. L., & Clemmer, D. E. (2003) · Analytical Chemistry · doi:10.1021/ac030111r · Cited by 75

Protein Charge-State Distributions in Electrospray-Ionization Mass Spectrometry Do Not Appear To Be Limited by the Surface Tension of the Solvent

Šamalíková, M., & Grandori, R. (2003) · Journal of the American Chemical Society · doi:10.1021/ja037000u · Cited by 73

Radiolytic Modification of Acidic Amino Acid Residues in Peptides: Probes for Examining Protein−Protein Interactions

Xu, G., & Chance, M. R. (2004) · Analytical Chemistry · doi:10.1021/ac035422g · Cited by 70

A Study of peptide-peptide interaction by matrix-assisted laser desorption/ionization

Woods, A. S., & Huestis, M. A. (2001) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(00)00197-5 · Cited by 69

Macromolecular assembly of Helicobacter pylori urease investigated by mass spectrometry

Pinkse, M. W. H., Maier, C. S., Kim, J., Oh, B., & Heck, A. J. R. (2003) · Journal of Mass Spectrometry · doi:10.1002/jms.443 · Cited by 68

A modified tandem affinity purification tag technique for the purification of protein complexes in mammalian cells

Drakas, R. A., di Prisco, M., & Baserga, R. (2004) · PROTEOMICS · doi:10.1002/pmic.200400919 · Cited by 68

Electrospray tandem mass spectrometry of poly(3-hydroxybutanoic acid) end groups analysis and fragmentation mechanism

Jedliński, Z., Adamus, G., Kowalczuk, M. M., Schubert, R., Szewczuk, Z., & Stefanowicz, P. (1998) · Rapid Communications in Mass Spectrometry · doi:10.1002/(sici)1097-0231(19980415)12:7<339::aid-rcm163>3.0.co;2-6 · Cited by 66

Folding and assembly of hemoglobin monitored by electrospray mass spectrometry using an on-line dialysis system

Boys, B. L., & Konermann, L. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2006.08.013 · Cited by 66

Testing the role of solvent surface tension in protein ionization by electrospray

Šamalíková, M., & Grandori, R. (2005) · Journal of Mass Spectrometry · doi:10.1002/jms.821 · Cited by 61

Comparative ESI-MS study of ∼2.2 MDa native hemocyanins from deep-sea and shore crabs: from protein oligomeric state to biotope

Cianférani, S., Leize‐Wagner, E., Dorsselaer, A. V., & Zal, F. (2003) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(03)00131-4 · Cited by 60

Observation of the multimeric forms of concanavalin A by electrospray ionization mass spectrometry

Light‐Wahl, K. J., Winger, B. E., & Smith, R. D. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00066a083 · Cited by 60

Immunoassays with Direct Mass Spectrometric Detection

Nazabal, A., Wenzel, R. J., & Zenobi, R. (2006) · Analytical Chemistry · doi:10.1021/ac0519108 · Cited by 59

The observation of multivalent complexes of Shiga-like toxin with globotriaoside and the determination of their stoichiometry by nanoelectrospray Fourier-transform ion cyclotron resonance mass spectrometry

Kitova, E. N., Kitov, P. I., Bundle, D. R., & Klassen, J. S. (2001) · Glycobiology · doi:10.1093/glycob/11.7.605 · Cited by 59

Structural Reorganization of the Transferrin C-Lobe and Transferrin Receptor upon Complex Formation: The C-Lobe Binds to the Receptor Helical Domain

Liu, R., Guan, J.-Q., Zak, O., Aisen, P., & Chance, M. R. (2003) · Biochemistry · doi:10.1021/bi0352973 · Cited by 58

Improved sensitivity of biomolecular interaction analysis mass spectrometry for the identification of interacting molecules

Lopez, F., Pichereaux, C., Burlet‐Schiltz, O., Pradayrol, L., Monsarrat, B., & Estève, J. (2003) · PROTEOMICS · doi:10.1002/pmic.200390055 · Cited by 58

Application of electrospray mass spectrometry in probing protein-protein and protein-ligand noncovalent interactions

Huang, E. C., Pramanik, B. N., Tsarbopoulos, A., Reichert, P., Ganguly, A. K., Trotta, P. P., Nagabhushan, T. L., & Covey, T. R. (1993) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(93)85026-t · Cited by 58

Mass Spectrometry of Macromolecules: Has Its Time Now Come?

Senko, M. W., & McLafferty, F. W. (1994) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.bb.23.060194.003555 · Cited by 56

Isotope-Coded and Affinity-Tagged Cross-Linking (ICATXL): An Efficient Strategy to Probe Protein Interaction Surfaces

Feixia Chu, C., Mahrus, S., Craik, C. S., & Burlingame, A. L. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0614159 · Cited by 55

Determining Protein−Protein Interactions by Oxidative Cross-Linking of a Glycine-Glycine-Histidine Fusion Protein

Brown, K. C., Yu, Z., Burlingame, A. L., & Craik, C. S. (1998) · Biochemistry · doi:10.1021/bi9728046 · Cited by 52

Folding Kinetics of the S100A11 Protein Dimer Studied by Time-Resolved Electrospray Mass Spectrometry and Pulsed Hydrogen−Deuterium Exchange

Pan, J., Rintala‐Dempsey, A. C., Li, Y., Shaw, G. S., & Konermann, L. (2006) · Biochemistry · doi:10.1021/bi052349a · Cited by 51

FAIMS operation for realistic gas flow profile and asymmetric waveforms including electronic noise and ripple

Shvartsburg, A. A., Tang, K., & Smith, R. D. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.04.003 · Cited by 50

Electron Capture Dissociation as Structural Probe for Noncovalent Gas-Phase Protein Assemblies

Geels, R. B. J., van der Vies, S. M., Heck, A. J. R., & Heeren, R. M. A. (2006) · Analytical Chemistry · doi:10.1021/ac060960p · Cited by 49

Protein—Ion Charge-State Distributions in Electrospray Ionization Mass Spectrometry: Distinguishing Conformational Contributions from Masking Effects

Gumerov, D. R., Dobó, A., & Kaltashov, I. A. (2002) · European Journal of Mass Spectrometry · doi:10.1255/ejms.480 · Cited by 48

Analysis of a 3.6-MDa Hexagonal Bilayer Hemoglobin fromLumbricus terrestrisUsing a Gas-Phase Electrophoretic Mobility Molecular Analyzer

Kaufman, S. L., Kuchumov, A. R., Kazakevich, M. Z., & Vinogradov, S. N. (1998) · Analytical Biochemistry · doi:10.1006/abio.1998.2644 · Cited by 44

Automated Nano-Electrospray Mass Spectrometry for Protein-Ligand Screening by Noncovalent Interaction Applied to Human H-FABP and A-FABP

Benkestock, K., Pelt, C. K. V., Åkerud, T., Sterling, A., Edlund, P., & Roeraade, J. (2003) · SLAS DISCOVERY · doi:10.1177/1087057103008003002 · Cited by 44

Identification of the interface of a large protein-protein complex using H/D exchange and Fourier transform ion cyclotron resonance mass spectrometry.

Yamada, N., Suzuki, E., & Hirayama, K. (2002) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.579 · Cited by 42

Infrared Multiphoton Dissociation in Quadrupole Time-of-Flight Mass Spectrometry: Top-Down Characterization of Proteins

Raspopov, S. A., El-Faramawy, A., Thomson, B. A., & Siu, K. W. M. (2006) · Analytical Chemistry · doi:10.1021/ac052248i · Cited by 40

Pulsed Hydrogen/Deuterium Exchange MS/MS for Studying the Relationship between Noncovalent Protein Complexes in Solution and in the Gas Phase after Electrospray Ionization

Hossain, B. M., & Konermann, L. (2006) · Analytical Chemistry · doi:10.1021/ac051687e · Cited by 37

An ion‐storage time‐of‐flight mass spectrometer for analysis of electrospray ions

Boyle, J. G., Whitehouse, C. M., Fenn, J. B., et al. (1991) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1290050906 · Cited by 36

Evaluation of automated nano‐electrospray mass spectrometry in the determination of non‐covalent protein–ligand complexes

Vriendt, K. D., Sandra, K., Desmet, T., Nerinckx, W., BEEUMEN, J. V., & Devreese, B. V. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1728 · Cited by 33

Structural change in response to ligand binding

McCammon, M. G., & Robinson, C. V. (2003) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2003.11.005 · Cited by 33

Introduction: Laser Ablation of Molecular Substrates

Georgiou, S. K., & Hillenkamp, F. (2003) · Chemical Reviews · doi:10.1021/cr030601j · Cited by 32

Detection of bound and free IGF‐1 and IGF‐2 in human plasma via biomolecular interaction analysis mass spectrometry

Nedelkov, D., Nelson, R. W., Kiernan, U. A., Niederkofler, E. E., & Tubbs, K. A. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00042-5 · Cited by 31

Delineation of in vivo assembled multiprotein complexes via biomolecular interaction analysis mass spectrometry

Nedelkov, D., & Nelson, R. W. (2001) · PROTEOMICS · Cited by 31

Mass spectrometry of hydrogen/deuterium exchange in 70S ribosomal proteins from E. coli

Yamamoto, T., Izumi, S., & Gekko, K. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.05.049 · Cited by 30

“Zero‐length” cross‐linking in solid state as an approach for analysis of protein–protein interactions

El‐Shafey, A., Tolić, N., Young, M. M., Sale, K. L., Smith, R. D., & Kéry, V. (2006) · Protein Science · doi:10.1110/ps.051685706 · Cited by 29

Activation of Ubiquitin Ligase SCFSkp2 by Cks1: Insights from Hydrogen Exchange Mass Spectrometry

Yao, Z., Zhou, M., Kelly, S. E., Seeliger, M. A., Robinson, C. V., & Itzhaki, L. S. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.08.032 · Cited by 26

Characterization of the Binding Site for Inhibitors of the HPV11 E1−E2 Protein Interaction on the E2 Transactivation Domain by Photoaffinity Labeling and Mass Spectrometry

Davidson, W. C., McGibbon, G. A., White, P. W., Yoakim, C., Hopkins, J. L., Guse, I., Hambly, D. M., Frego, L., Ogilvie, W. W., Lavallée, P., et al. (2004) · Analytical Chemistry · doi:10.1021/ac035335o · Cited by 22

Native mass spectrometry: a bridge between interactomics and structural biology

Heck, A. J. R. (2008) · Nature Methods · doi:10.1038/nmeth.1265 · Cited by 766

Ion mobility mass spectrometry of proteins and proteinassemblies

Uetrecht, C., Rose, R. J., van Duijn, E., Lorenzen, K., & Heck, A. J. R. (2010) · Chem. Soc. Rev. · doi:10.1039/b914002f · Cited by 462

The beginning of a beautiful friendship: Cross-linking/mass spectrometry and modelling of proteins and multi-protein complexes

Rappsilber, J. (2011) · Journal of Structural Biology · doi:10.1016/j.jsb.2010.10.014 · Cited by 422

Charge-State Dependent Compaction and Dissociation of Protein Complexes: Insights from Ion Mobility and Molecular Dynamics

Hall, Z., Politis, A., Bush, M. F., Smith, L. J., & Robinson, C. V. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2096859 · Cited by 267

Addressing a Common Misconception: Ammonium Acetate as Neutral pH “Buffer” for Native Electrospray Mass Spectrometry

Konermann, L. (2017) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-017-1739-3 · Cited by 243