The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, Craig L., Christie, Jacinda, Ramsdell, Fred, Brunkow, Mary E., Ferguson, Polly J., Whitesell, Luke, Kelly, Thaddeus E., Saulsbury, Frank T., Chance, Phillip F., Ochs, Hans D.·2001·Nature Genetics

DOI 10.1038/83713

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Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
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Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
How regulatory T cells work
Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Regulatory T cells: mechanisms of differentiation and function
Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669
The PD‐1 pathway in tolerance and autoimmunity
Francisco, L. M., Sage, P. T., & Sharpe, A. H. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00923.x · Cited by 2,300
Immunopathology of multiple sclerosis
Dendrou, C. A., Fugger, L., & Friese, M. A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3871 · Cited by 2,215
Inflammatory bowel disease
Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806
Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells
Thornton, A. M., Korty, P. E., Tran, D. Q., Wohlfert, E. A., Murray, P. E., Belkaid, Y., & Shevach, E. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904028 · Cited by 1,382
Human T cell development, localization, and function throughout life
Kumar, B. V., Connors, T. J., & Farber, D. L. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.007 · Cited by 1,257
Foxp3+ follicular regulatory T cells control the germinal center response
Linterman, M. A., Pierson, W., Lee, S. K., Kallies, A., Kawamoto, S., Rayner, T. F., Srivastava, M., Divekar, D. P., Beaton, L., Hogan, J. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2425 · Cited by 1,292
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
Koch, M. A., Tucker-Heard, G., Perdue, N. R., Killebrew, J. R., Urdahl, K. B., & Campbell, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1731 · Cited by 1,258
THE NOD MOUSE: A Model of Immune Dysregulation
Anderson, M. S., & Bluestone, J. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115643 · Cited by 1,113
Transient expression of FOXP3 in human activated nonregulatory CD4 + T cells
Wang, J., Ioan‐Facsinay, A., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2007) · European Journal of Immunology · doi:10.1002/eji.200636435 · Cited by 1,011
Transcriptional Regulatory Elements in the Human Genome
Maston, G. A., Evans, S. K., & Green, M. R. (2006) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115623 · Cited by 937
Diabetes Mellitus and the β Cell: The Last Ten Years
Ashcroft, F. M., & Rorsman, P. (2012) · Cell · doi:10.1016/j.cell.2012.02.010 · Cited by 902
Enterocolitis in Patients With Cancer After Antibody Blockade of Cytotoxic T-Lymphocyte–Associated Antigen 4
Beck, K. E., Blansfield, J. A., Tran, K. Q., Feldman, A. L., Hughes, M. S., Royal, R. E., Kammula, U. S., Topalian, S. L., Sherry, R. M., Kleiner, D., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.5716 · Cited by 833
Immunosenescence of ageing
Gruver, A., Hudson, L., & Sempowski, G. (2007) · The Journal of Pathology · doi:10.1002/path.2104 · Cited by 834
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
Tone, Y., Furuuchi, K., Kojima, Y., Tykocinski, M. L., Greene, M. I., & Tone, M. (2008) · Nature Immunology · doi:10.1038/ni1549 · Cited by 807
Juvenile idiopathic arthritis
Prakken, B., Albani, S., & Martini, A. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60244-4 · Cited by 771
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
Wing, J. B., Tanaka, A., & Sakaguchi, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.020 · Cited by 726
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724
Regulatory T cells in autoimmune disease
Dominguez-Villar, M., & Hafler, D. A. (2018) · Nature Immunology · doi:10.1038/s41590-018-0120-4 · Cited by 713
Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression
Zamarron, B. F., & Chen, W. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.651 · Cited by 681
Activating Mutations in the ABCC8 Gene in Neonatal Diabetes Mellitus
Babenko, A. P., Polak, M., Cavé, H., Busiah, K., Czernichow, P., Scharfmann, R., Bryan, J., Aguilar-Bryan, L., Vaxillaire, M., & Froguel, P. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055068 · Cited by 655
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
Yadav, M., Louvet, C., Davini, D., Gardner, J. M., Martinez-Llordella, M., Bailey-Bucktrout, S., Anthony, B. A., Sverdrup, F. M., Head, R., Kuster, D. J., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120822 · Cited by 649
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
Weiss, J. M., Bilate, A. M., Gobert, M., Ding, Y., Curotto de Lafaille, M. A., Parkhurst, C. N., Xiong, H., Dolpady, J., Frey, A. B., Ruocco, M. G., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120914 · Cited by 621
The regulation of immune tolerance by FOXP3
Lu, L., Barbi, J., & Pan, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.75 · Cited by 580
Induced CD4+Foxp3+Regulatory T Cells in Immune Tolerance
Bilate, A. M., & Lafaille, J. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075043 · Cited by 569
Development and maintenance of intestinal regulatory T cells
Tanoue, T., Atarashi, K., & Honda, K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.36 · Cited by 553
CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury
D’Alessio, F. R., Tsushima, K., Aggarwal, N. R., West, E. E., Willett, M. H., Britos, M. F., Pipeling, M. R., Brower, R. G., Tuder, R. M., McDyer, J. F., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36498 · Cited by 564
Defective regulatory and effector T cell functions in patients with FOXP3 mutations
Bacchetta, R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25112 · Cited by 511
Genetics of type 1A diabetes
Concannon, P., Rich, S. S., & Nepom, G. T. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0808284 · Cited by 510
Clinical implications of a molecular genetic classification of monogenic β-cell diabetes
Murphy, R., Ellard, S., & Hattersley, A. T. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0778 · Cited by 502
Helper T cell differentiation
Saravia, J., Chapman, N. M., & Chi, H. (2019) · Cellular & Molecular Immunology · doi:10.1038/s41423-019-0220-6 · Cited by 489
Role of the PD-1 pathway in the immune response
Riella, L. V., Paterson, A. M., Sharpe, A. H., & Chandraker, A. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2012.04224.x · Cited by 444
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Background
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo
Read, S., Greenwald, R., Izcue, A., Robinson, N., Mandelbrot, D., Francisco, L., Sharpe, A. H., & Powrie, F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4376 · Cited by 434
Administration of CD4+CD25highCD127-regulatory T cells preserves β-cell function in type 1 diabetes in children
Marek-Trzonkowska, N., Myśliwiec, M., Dobyszuk, A., Grabowska, M., Techmańska, I., Juścińska, J., Wujtewicz, M. A., Witkowski, P., Młynarski, W., Balcerska, A., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0038 · Cited by 431
Cold Urticaria, Immunodeficiency, and Autoimmunity Related to PLCG2 Deletions
Ombrello, M. J., Remmers, E. F., Sun, G., Freeman, A. F., Datta, S., Torabi-Parizi, P., Subramanian, N., Bunney, T. D., Baxendale, R. W., Martins, M. S., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1102140 · Cited by 425
Cell-cell communication: New insights and clinical implications
Su, J., Song, Y., Zhu, Z., Huang, X., Fan, J., Qiao, J., & Mao, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01888-z · Cited by 433
Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target
Sojka, D. K., Huang, Y., & Fowell, D. J. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02813.x · Cited by 393
High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population
Wagner, D. L., Amini, L., Wendering, D. J., Burkhardt, L.-M., Akyüz, L., Reinke, P., Volk, H.-D., & Schmueck-Henneresse, M. (2019) · Nature Medicine · doi:10.1038/s41591-018-0204-6 · Cited by 399
The ‘microflora hypothesis’ of allergic diseases
Noverr, M. C., & Huffnagle, G. B. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02379.x · Cited by 394
Intrinsic and extrinsic control of peripheral T‐cell tolerance by costimulatory molecules of the CD28/ B7 family
Bour‐Jordan, H., Esensten, J. H., Martinez‐Llordella, M., Penaranda, C., Stumpf, M., & Bluestone, J. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01011.x · Cited by 391
Regulation of the Germinal Center Response
Stebegg, M., Kumar, S. D., Silva-Cayetano, A., Fonseca, V. R., Linterman, M. A., & Graca, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02469 · Cited by 349
Immunogenetics of autoimmune thyroid diseases: a comprehensive review
Lee, H. J., Li, C. W., Hammerstad, S. S., Stefan, M., & Tomer, Y. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.07.009 · Cited by 351
The development and function of regulatory T cells
Workman, C. J., Szymczak-Workman, A. L., Collison, L. W., Pillai, M. R., & Vignali, D. A. A. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0026-2 · Cited by 344
The Inherited Basis of Diabetes Mellitus: Implications for the Genetic Analysis of Complex Traits
Florez, J. C., Hirschhorn, J., & Altshuler, D. (2003) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.4.070802.110436 · Cited by 329
Regulatory T Cell Development
Savage, P. A., Klawon, D. E. J., & Miller, C. H. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-100219-020937 · Cited by 321
ISPAD Clinical Practice Consensus Guidelines 2018: The diagnosis and management of monogenic diabetes in children and adolescents
Hattersley, A. T., Greeley, S. A. W., Polak, M., Rubio-Cabezas, O., Njølstad, P. R., Mlynarski, W., Castano, L., Carlsson, A., Raile, K., Chi, D. V., et al. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12772 · Cited by 319
Regulatory T Cells and the Immune Aging Process: A Mini-Review
Jagger, A., Shimojima, Y., Goronzy, J. J., & Weyand, C. M. (2014) · Gerontology · doi:10.1159/000355303 · Cited by 301
Tumor-infiltrating T lymphocytes: Friends or foes?
Yu, P., & Fu, Y.-X. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700389 · Cited by 299
FOXP3+ regulatory T cells and their functional regulation
Li, Z., Li, D., Tsun, A., & Li, B. (2015) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.10 · Cited by 290
The diagnosis and management of monogenic diabetes in children and adolescents
Hattersley, A., Bruining, J., Shield, J., Njolstad, P., & Donaghue, K. C. (2009) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2009.00571.x · Cited by 255
Phosphatase PP2A is requisite for the function of regulatory T cells
Apostolidis, S. A., Rodríguez-Rodríguez, N., Suárez-Fueyo, A., Dioufa, N., Ozcan, E., Crispín, J. C., Tsokos, M. G., & Tsokos, G. C. (2016) · Nature Immunology · doi:10.1038/ni.3390 · Cited by 238
Canonical Wnt signaling negatively modulates regulatory T cell function.
van Loosdregt, J., Fleskens, V., Tiemessen, M. M., Mokry, M., van Boxtel, R., Meerding, J., Pals, C. E. G. M., Kurek, D., Baert, M. R. M., Delemarre, E. M., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.019 · Cited by 238
De Novo Mutations in FOXP1 in Cases with Intellectual Disability, Autism, and Language Impairment
Hamdan, F. F., Daoud, H., Rochefort, D., Piton, A., Gauthier, J., Langlois, M., Foomani, G., Dobrzeniecka, S., Krebs, M.-O., Joober, R., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.09.017 · Cited by 235
ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of monogenic diabetes in children and adolescents
Greeley, S. A. W., Polak, M., Njølstad, P. R., Barbetti, F., Williams, R., Castano, L., Raile, K., Chi, D. V., Habeb, A., Hattersley, A. T., et al. (2022) · Pediatric Diabetes · doi:10.1111/pedi.13426 · Cited by 211
Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma
Sayour, E. J., McLendon, P., McLendon, R., De Leon, G., Reynolds, R., Kresak, J., Sampson, J. H., & Mitchell, D. A. (2015) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-014-1651-7 · Cited by 196
The diagnosis and management of monogenic diabetes in children and adolescents
Rubio-Cabezas, O., Hattersley, A. T., Njølstad, P. R., Mlynarski, W., Ellard, S., White, N., Chi, D. V., & Craig, M. E. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12192 · Cited by 196
Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency–induced autoimmunity via adenosine A2A receptors
He, B., Hoang, T. K., Wang, T., Ferris, M., Taylor, C. M., Tian, X., Luo, M., Tran, D. Q., Zhou, J., Tatevian, N., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20160961 · Cited by 196
Control of regulatory T‐cell differentiation and function by T‐cell receptor signalling and Foxp3 transcription factor complexes
Ono, M. (2020) · Immunology · doi:10.1111/imm.13178 · Cited by 187
Type 1 regulatory T cells (Tr1) in autoimmunity
Pot, C., Apetoh, L., & Kuchroo, V. K. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.07.005 · Cited by 171
T cells in the control of organ-specific autoimmunity
Bluestone, J. A., Bour-Jordan, H., Cheng, M., & Anderson, M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78089 · Cited by 155
Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism
Campbell, C., & Rudensky, A. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.010 · Cited by 154
Intratumoral regulatory T cells: markers, subsets and their impact on anti-tumor immunity
Yano, H., Andrews, L. P., Workman, C. J., & Vignali, D. A. A. (2019) · Immunology · doi:10.1111/imm.13067 · Cited by 116
Helios Induces Epigenetic Silencing of Il2 Gene Expression in Regulatory T Cells
Baine, I., Basu, S., Ames, R., Sellers, R. S., & Macian, F. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200792 · Cited by 116
PD-1 regulates extrathymic regulatory T-cell differentiation
Chen, X., Fosco, D., Kline, D. E., Meng, L., Nishi, S., Savage, P. A., & Kline, J. (2014) · European Journal of Immunology · doi:10.1002/eji.201344423 · Cited by 107
FOXP1 mutations cause intellectual disability and a recognizable phenotype
Le Fevre, A. K., Taylor, S., Malek, N. H., Horn, D., Carr, C. W., Abdul‐Rahman, O. A., O'Donnell, S., Burgess, T., Shaw, M., Gecz, J., et al. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36174 · Cited by 98
A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells
Van Gool, F., Nguyen, M. L. T., Mumbach, M. R., Satpathy, A. T., Rosenthal, W. L., Giacometti, S., Le, D. T., Liu, W., Brusko, T. M., Anderson, M. S., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.016 · Cited by 102
GP96 is a GARP chaperone and controls regulatory T cell functions
Zhang, Y., Wu, B. X., Metelli, A., Thaxton, J. E., Hong, F., Rachidi, S., Ansa-Addo, E., Sun, S., Vasu, C., Yang, Y., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79014 · Cited by 95
Can blocking inflammation enhance immunity during aging?
Chambers, E. S., & Akbar, A. N. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.03.016 · Cited by 92
The Impact of Aging on Regulatory T-Cells
Fessler, J., Ficjan, A., Duftner, C., & Dejaco, C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00231 · Cited by 88
Redox remodeling as an immunoregulatory strategy
Yan, Z., & Banerjee, R. (2010) · Biochemistry · doi:10.1021/bi902022n · Cited by 82
Harnessing FOXP3+ regulatory T cells for transplantation tolerance
Waldmann, H., Hilbrands, R., Howie, D., & Cobbold, S. (2014) · Journal of Clinical Investigation · doi:10.1172/jci67226 · Cited by 69
Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis
Di Giovangiulio, M., Rizzo, A., Franzè, E., Caprioli, F., Facciotti, F., Onali, S., Favale, A., Stolfi, C., Fehling, H.-J., Monteleone, G., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02158 · Cited by 63
Patients with posttraumatic stress disorder exhibit an altered phenotype of regulatory T cells
Jergović, M., Bendelja, K., Vidović, A., Savić, A., Vojvoda, V., Aberle, N., Rabatić, S., Jovanovic, T., & Sabioncello, A. (2014) · Allergy, Asthma & Clinical Immunology · doi:10.1186/1710-1492-10-43 · Cited by 49
Antigen exposure shapes the ratio between antigen-specific Tregs and conventional T cells in human peripheral blood
Su, L. F., del Alcazar, D., Stelekati, E., Wherry, E. J., & Davis, M. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611723113 · Cited by 51
Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells
Fleskens, V., Minutti, C. M., Wu, X., Wei, P., Pals, C. E. G. M., McCrae, J., Hemmers, S., Groenewold, V., Vos, H.-J., Rudensky, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.087 · Cited by 49
Characterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells—Identification of Foxp3Δ7 in human regulatory T cells
Kaur, G., Goodall, J. C., Jarvis, L. B., & Hill Gaston, J. S. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.07.008 · Cited by 45
Th2 Cells: Orchestrating Barrier Immunity
(2004) · Advances in Immunology · doi:10.1016/s0065-2776(04)83005-0 · Cited by 44
FOXP3 recognizes microsatellites and bridges DNA through multimerization
Zhang, W., Leng, F., Wang, X., Ramirez, R. N., Park, J., Benoist, C., & Hur, S. (2023) · Nature · doi:10.1038/s41586-023-06793-z · Cited by 42
Tumor Infiltrating Regulatory T Cells in Sporadic and Colitis-Associated Colorectal Cancer: The Red Little Riding Hood and the Wolf
Fantini, M. C., Favale, A., Onali, S., & Facciotti, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186744 · Cited by 40
T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases
McKinney, E. F., & Smith, K. G. (2016) · Immunology & Cell Biology · doi:10.1038/icb.2016.81 · Cited by 36
Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells
Shan, F., Cillo, A. R., Cardello, C., Yuan, D. Y., Kunning, S. R., Cui, J., Lampenfeld, C., Williams, A. M., McDonough, A. P., Pennathur, A., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.adf6717 · Cited by 38
Consecutive low doses of cyclophosphamide preferentially target Tregs and potentiate T cell responses induced by DNA PLG microparticle immunization
Barbon, C. M., Yang, M., Wands, G. D., Ramesh, R., Slusher, B. S., Hedley, M. L., & Luby, T. M. (2010) · Cellular Immunology · doi:10.1016/j.cellimm.2010.02.007 · Cited by 36
Learning from the nexus of autoimmunity and cancer
Mangani, D., Yang, D., & Anderson, A. C. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.022 · Cited by 33
Gut Microbiota–Host Interactions in Inborn Errors of Immunity
Castagnoli, R., Pala, F., Bosticardo, M., Licari, A., Delmonte, O. M., Villa, A., Marseglia, G. L., & Notarangelo, L. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031416 · Cited by 34
“The gene encodes an essential transcriptional regulator that plays a pivotal role in the development and function of regulatory T cells (Tregs) [69,70].”
Background
Treatment of uveitis by in situ administration of ex vivo–activated polyclonal regulatory T cells
Grégoire, S., Terrada, C., Martin, G. H., Fourcade, G., Baeyens, A., Marodon, G., Fisson, S., Billiard, F., Lucas, B., Tadayoni, R., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501723 · Cited by 33
The imbalance between regulatory and IL-17-secreting CD4+T cells in multiple-trauma rat
Dai, H., Sun, T., Liu, Z., Zhang, J., & Zhou, M. (2013) · Injury · doi:10.1016/j.injury.2013.03.015 · Cited by 31
Cutting Edge: Dab2 Is a FOXP3 Target Gene Required for Regulatory T Cell Function
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Authors: Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E., Saulsbury, F. T., Chance, P. F., & Ochs, H. D.
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 2001-01
Volume: 27
Issue: 1
Pages: 20-21
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/83713
OpenAlex: W1486722793
Cited by: 3,402
References: 0
FWCI: 12.65
Type: journal article
Language: en
Open access: closed

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