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Rho GTPases in cell biology

Etienne-Manneville, Sandrine, Hall, Alan·2002·Nature
DOI 10.1038/nature01148
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Abstract

Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells. They are known principally for their pivotal role in regulating the actin cytoskeleton, but their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant. Underlying this biological complexity is a simple biochemical idea, namely that by switching on a single GTPase, several distinct signalling pathways can be coordinately activated. With spatial and temporal activation of multiple switches factored in, it is not surprising to find Rho GTPases having such a prominent role in eukaryotic cell biology.

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Cited by

Metadata

Authors
Etienne-Manneville, S., & Hall, A.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2002-12
Volume
420
Issue
6916
Pages
629-635
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/nature01148
Cited by
4,201
References
3
Language
en
Licence
www.springer.com/tdm (tdm)

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