Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

A perivascular origin for mesenchymal stem cells in multiple human organs

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Monocyte recruitment during infection and inflammation

Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015

The bone marrow niche for haematopoietic stem cells

Morrison, S. J., & Scadden, D. T. (2014) · Nature · doi:10.1038/nature12984 · Cited by 2,451

Mesenchymal stem cell perspective: cell biology to clinical progress

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Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

Wang, Y., Chen, X., Cao, W., & Shi, Y. (2014) · Nature Immunology · doi:10.1038/ni.3002 · Cited by 1,452

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., & Morrison, S. J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.008 · Cited by 1,381

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

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Direct measurement of local oxygen concentration in the bone marrow of live animals

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Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

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Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization

Baccin, C., Al-Sabah, J., Velten, L., Helbling, P. M., Grünschläger, F., Hernández-Malmierca, P., Nombela-Arrieta, C., Steinmetz, L. M., Trumpp, A., & Haas, S. (2020) · Nature Cell Biology · doi:10.1038/s41556-019-0439-6 · Cited by 904

Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration

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Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation

Prockop, D. J., & Youn Oh, J. (2012) · Molecular Therapy · doi:10.1038/mt.2011.211 · Cited by 816

Chronic variable stress activates hematopoietic stem cells

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Mesenchymal stromal cells: new directions

Keating, A. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.015 · Cited by 778

The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

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Adult haematopoietic stem cell niches

Crane, G. M., Jeffery, E., & Morrison, S. J. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.53 · Cited by 712

Regulation of macrophage development and function in peripheral tissues

Lavin, Y., Mortha, A., Rahman, A., & Merad, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3920 · Cited by 680

The ageing haematopoietic stem cell compartment

Geiger, H., de Haan, G., & Florian, M. C. (2013) · Nature Reviews Immunology · doi:10.1038/nri3433 · Cited by 604

Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche

Schepers, K., Pietras, E. M., Reynaud, D., Flach, J., Binnewies, M., Garg, T., Wagers, A. J., Hsiao, E. C., & Passegué, E. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.06.009 · Cited by 614

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

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Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine

Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095919 · Cited by 462

CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization

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Sleep modulates haematopoiesis and protects against atherosclerosis

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Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

Arranz, L., Sánchez-Aguilera, A., Martín-Pérez, D., Isern, J., Langa, X., Tzankov, A., Lundberg, P., Muntión, S., Tzeng, Y.-S., Lai, D.-M., et al. (2014) · Nature · doi:10.1038/nature13383 · Cited by 444

Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines

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Mesenchymal stem cells in fibrotic disease

El Agha, E., Kramann, R., Schneider, R. K., Li, X., Seeger, W., Humphreys, B. D., & Bellusci, S. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.011 · Cited by 430

Transforming growth factor‐β in stem cells and tissue homeostasis

Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414

Skeletal stem cells

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Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche

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Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

Giladi, A., Paul, F., Herzog, Y., Lubling, Y., Weiner, A., Yofe, I., Jaitin, D., Cabezas-Wallscheid, N., Dress, R., Ginhoux, F., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0121-4 · Cited by 366

Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis

Vi, L., Baht, G. S., Whetstone, H., Ng, A., Wei, Q., Poon, R., Mylvaganam, S., Grynpas, M., & Alman, B. A. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2422 · Cited by 330

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

Ho, Y.-H., del Toro, R., Rivera-Torres, J., Rak, J., Korn, C., García-García, A., Macías, D., González-Gómez, C., del Monte, A., Wittner, M., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.06.007 · Cited by 315

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

Frodermann, V., Rohde, D., Courties, G., Severe, N., Schloss, M. J., Amatullah, H., McAlpine, C. S., Cremer, S., Hoyer, F. F., Ji, F., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0633-x · Cited by 292

Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging

Bandyopadhyay, S., Duffy, M. P., Ahn, K. J., Sussman, J. H., Pang, M., Smith, D., Duncan, G., Zhang, I., Huang, J., Lin, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.04.013 · Cited by 300

Neural Regulation of Hematopoiesis, Inflammation, and Cancer

Hanoun, M., Maryanovich, M., Arnal-Estapé, A., & Frenette, P. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.026 · Cited by 265

Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts

Kim, S. W., Pajevic, P. D., Selig, M., Barry, K. J., Yang, J.-Y., Shin, C. S., Baek, W.-Y., Kim, J.-E., & Kronenberg, H. M. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1665 · Cited by 266

The hematopoietic stem cell niche: from embryo to adult

Gao, X., Xu, C., Asada, N., & Frenette, P. S. (2018) · Development · doi:10.1242/dev.139691 · Cited by 247

Quiescent tissue stem cells evade immune surveillance

Agudo, J., Park, E. S., Rose, S. A., Alibo, E., Sweeney, R., Dhainaut, M., Kobayashi, K. S., Sachidanandam, R., Baccarini, A., Merad, M., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.02.001 · Cited by 244

The Effect of Hypoxia on Mesenchymal Stem Cell Biology

Ejtehadifar, M., Shamsasenjan, K., Movassaghpour, A., Akbarzadehlaleh, P., Dehdilani, N., Abbasi, P., Molaeipour, Z., & Saleh, M. (2015) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2015.021 · Cited by 235

Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes

Song, L., Liu, M., Ono, N., Bringhurst, F. R., Kronenberg, H. M., & Guo, J. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1694 · Cited by 234

Concise review: two negative feedback loops place mesenchymal stem/stromal cells at the center of early regulators of inflammation

Prockop, D. J. (2013) · Stem Cells · doi:10.1002/stem.1400 · Cited by 230

Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging

Young, K., Eudy, E., Bell, R., Loberg, M. A., Stearns, T., Sharma, D., Velten, L., Haas, S., Filippi, M.-D., & Trowbridge, J. J. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.03.017 · Cited by 216

SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage

Seo, E., Basu-Roy, U., Gunaratne, P. H., Coarfa, C., Lim, D.-S., Basilico, C., & Mansukhani, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.029 · Cited by 216

Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration

Scott, R. W., Arostegui, M., Schweitzer, R., Rossi, F. M. V., & Underhill, T. M. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.004 · Cited by 214

Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood

Matic, I., Matthews, B. G., Wang, X., Dyment, N. A., Worthley, D. L., Rowe, D. W., Grcevic, D., & Kalajzic, I. (2016) · Stem Cells · doi:10.1002/stem.2474 · Cited by 195

Leukemia Propagating Cells Rebuild an Evolving Niche in Response to Therapy

Duan, C.-W., Shi, J., Chen, J., Wang, B., Yu, Y.-H., Qin, X., Zhou, X.-C., Cai, Y.-J., Li, Z.-Q., Zhang, F., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.015 · Cited by 198

Effects of PTH on osteocyte function

Bellido, T., Saini, V., & Pajevic, P. D. (2013) · Bone · doi:10.1016/j.bone.2012.09.016 · Cited by 196

Brain-derived Neurotrophic Factor in Megakaryocytes

Chacón-Fernández, P., Säuberli, K., Colzani, M., Moreau, T., Ghevaert, C., & Barde, Y.-A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.720029 · Cited by 186

Osteoclast-secreted SLIT3 coordinates bone resorption and formation

Kim, B.-J., Lee, Y.-S., Lee, S.-Y., Baek, W.-Y., Choi, Y. J., Moon, S. A., Lee, S. H., Kim, J.-E., Chang, E.-J., Kim, E.-Y., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci91086 · Cited by 174

An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro‐inflammatory program

Gnani, D., Crippa, S., della Volpe, L., Rossella, V., Conti, A., Lettera, E., Rivis, S., Ometti, M., Fraschini, G., Bernardo, M. E., et al. (2019) · Aging Cell · doi:10.1111/acel.12933 · Cited by 188

Long-term cultured mesenchymal stem cells frequently develop genomic mutations but do not undergo malignant transformation

Wang, Y., Zhang, Z., Chi, Y., Zhang, Q., Xu, F., Yang, Z., Meng, L., Yang, S., Yan, S., Mao, A., et al. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.480 · Cited by 185

FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging

Li, H., Liu, P., Xu, S., Li, Y., Dekker, J. D., Li, B., Fan, Y., Zhang, Z., Hong, Y., Yang, G., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89511 · Cited by 180

PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity

Iwayama, T., Steele, C., Yao, L., Dozmorov, M. G., Karamichos, D., Wren, J. D., & Olson, L. E. (2015) · Genes & Development · doi:10.1101/gad.260554.115 · Cited by 164

The perivascular origin of pathological fibroblasts

Di Carlo, S. E., & Peduto, L. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93558 · Cited by 164

Direct In Vivo Evidence for Tumor Propagation by Glioblastoma Cancer Stem Cells

Lathia, J. D., Gallagher, J., Myers, J. T., Li, M., Vasanji, A., McLendon, R. E., Hjelmeland, A. B., Huang, A. Y., & Rich, J. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024807 · Cited by 158

The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis

Tencerova, M., & Kassem, M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00127 · Cited by 149

Multipotent stromal cells: One name, multiple identities

Soliman, H., Theret, M., Scott, W., Hill, L., Underhill, T. M., Hinz, B., & Rossi, F. M. V. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.09.001 · Cited by 147

Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion

Isern, J., Martín-Antonio, B., Ghazanfari, R., Martín, A. M., López, J. A., del Toro, R., Sánchez-Aguilera, A., Arranz, L., Martín-Pérez, D., Suárez-Lledó, M., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.041 · Cited by 141

Haematopoietic stem cells in perisinusoidal niches are protected from ageing

Saçma, M., Pospiech, J., Bogeska, R., de Back, W., Mallm, J.-P., Sakk, V., Soller, K., Marka, G., Vollmer, A., Karns, R., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0418-y · Cited by 133

How does spaceflight affect the acquired immune system?

Akiyama, T., Horie, K., Hinoi, E., Hiraiwa, M., Kato, A., Maekawa, Y., Takahashi, A., & Furukawa, S. (2020) · npj Microgravity · doi:10.1038/s41526-020-0104-1 · Cited by 132

Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping

Severe, N., Karabacak, N. M., Gustafsson, K., Baryawno, N., Courties, G., Kfoury, Y., Kokkaliaris, K. D., Rhee, C., Lee, D., Scadden, E. W., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.06.003 · Cited by 130

IGF-1 enhances cell proliferation and survival during early differentiation of mesenchymal stem cells to neural progenitor-like cells

Huat, T. J., Khan, A. A., Pati, S., Mustafa, Z., Abdullah, J. M., & Jaafar, H. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-91 · Cited by 129

BCR-ABL Independent Mechanisms of Resistance in Chronic Myeloid Leukemia

Loscocco, F., Visani, G., Galimberti, S., Curti, A., & Isidori, A. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00939 · Cited by 120

A short field guide to fibroblast function in immunity

Buechler, M. B., & Turley, S. J. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2017.11.001 · Cited by 121

The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis

Schoedel, K. B., Morcos, M. N. F., Zerjatke, T., Roeder, I., Grinenko, T., Voehringer, D., Göthert, J. R., Waskow, C., Roers, A., & Gerbaulet, A. (2016) · Blood · doi:10.1182/blood-2016-03-706010 · Cited by 120

Neural regulation of bone and bone marrow

Maryanovich, M., Takeishi, S., & Frenette, P. S. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031344 · Cited by 114

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline

Hennrich, M. L., Romanov, N., Horn, P., Jaeger, S., Eckstein, V., Steeples, V., Ye, F., Ding, X., Poisa-Beiro, L., Lai, M. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06353-4 · Cited by 101

Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

Nakahara, F., Borger, D. K., Wei, Q., Pinho, S., Maryanovich, M., Zahalka, A. H., Suzuki, M., Cruz, C. D., Wang, Z., Xu, C., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0308-3 · Cited by 99

Differential temporal effects of sclerostin antibody and parathyroid hormone on cancellous and cortical bone and quantitative differences in effects on the osteoblast lineage in young intact rats

Ominsky, M. S., Brown, D. L., Van, G., Cordover, D., Pacheco, E., Frazier, E., Cherepow, L., Higgins-Garn, M., Aguirre, J. I., Wronski, T. J., et al. (2015) · Bone · doi:10.1016/j.bone.2015.08.007 · Cited by 93

A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis

Rankin, E. B., Giaccia, A. J., & Schipani, E. (2011) · Current Osteoporosis Reports · doi:10.1007/s11914-011-0047-2 · Cited by 93

Programmed cell senescence in skeleton during late puberty

Li, C., Chai, Y., Wang, L., Gao, B., Chen, H., Gao, P., Zhou, F.-Q., Luo, X., Crane, J. L., Yu, B., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01509-0 · Cited by 92

Blood Vessels and the Satellite Cell Niche

Mounier, R., Chrétien, F., & Chazaud, B. (2011) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385940-2.00005-x · Cited by 89

Immune Organs and Immune Cells on a Chip: An Overview of Biomedical Applications

Morsink, M., Willemen, N., Leijten, J., Bansal, R., & Shin, S. (2020) · Micromachines · doi:10.3390/mi11090849 · Cited by 73

Noncanonical NF-κB Signaling Regulates Hematopoietic Stem Cell Self-Renewal and Microenvironment Interactions

Zhao, C., Xiu, Y., Ashton, J., Xing, L., Morita, Y., Jordan, C. T., & Boyce, B. F. (2012) · Stem Cells · doi:10.1002/stem.1050 · Cited by 65

A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise

Gadomski, S., Fielding, C., García-García, A., Korn, C., Kapeni, C., Ashraf, S., Villadiego, J., Toro, R. D., Domingues, O., Skepper, J. N., et al. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.02.008 · Cited by 65

Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis.

Carbonneau, C. L., Despars, G., Rojas-Sutterlin, S., Fortin, A., Le, O., Hoang, T., & Beauséjour, C. M. (2012) · Blood · doi:10.1182/blood-2011-06-361626 · Cited by 59

Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

Doolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D. G., & Khosla, S. (2023) · Nature Communications · doi:10.1038/s41467-023-40393-9 · Cited by 57

Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

Doolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D. G., & Khosla, S. (2023) · doi:10.1101/2023.01.12.523760 · Cited by 57

Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow

Yu, V. W. C., Lymperi, S., Oki, T., Jones, A., Swiatek, P., Vasic, R., Ferraro, F., & Scadden, D. T. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.06.009 · Cited by 52

Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset

Martini, H., Iacovoni, J. S., Maggiorani, D., Dutaur, M., Marsal, D. J., Roncalli, J., Itier, R., Dambrin, C., Pizzinat, N., Mialet‐Perez, J., et al. (2019) · Aging Cell · doi:10.1111/acel.13015 · Cited by 51

Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome

Ribezzo, F., Snoeren, I. A. M., Ziegler, S., Stoelben, J., Olofsen, P. A., Henic, A., Ferreira, M. V., Chen, S., Stalmann, U. S. A., Buesche, G., et al. (2019) · Leukemia · doi:10.1038/s41375-018-0350-3 · Cited by 51

Bone-muscle crosstalk under physiological and pathological conditions

Dong, Y., Yuan, H., Ma, G., & Cao, H. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05331-y · Cited by 52

Nonmyogenic Cells in Skeletal Muscle Regeneration

Paylor, B., Natarajan, A., Zhang, R.-H., & Rossi, F. (2011) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385940-2.00006-1 · Cited by 49

Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations

Scharenberg, C., Giai, V., Pellagatti, A., Saft, L., Dimitriou, M., Jansson, M., Jädersten, M., Grandien, A., Douagi, I., Neuberg, D. S., et al. (2017) · Haematologica · doi:10.3324/haematol.2016.152025 · Cited by 47

Bone marrow niches for hematopoietic stem cells: Life span dynamics and adaptation to acute stress

Hofmann, J., & Kokkaliaris, K. D. (2024) · Blood · doi:10.1182/blood.2023023788 · Cited by 45

Bone circuitry and interorgan skeletal crosstalk

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Inhibition of caMKK2 enhances fracture healing by stimulating Indian hedgehog signaling and accelerating endochondral ossification

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