The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows
Abstract
The second near-infrared wavelength window (NIR-II, 1,000-1,700 nm) enables fluorescence imaging of tissue with enhanced contrast at depths of millimetres and at micrometre-scale resolution. However, the lack of clinically viable NIR-II equipment has hindered the clinical translation of NIR-II imaging. Here, we describe an optical-imaging instrument that integrates a visible multispectral imaging system with the detection of NIR-II and NIR-I (700-900 nm in wavelength) fluorescence (by using the dye indocyanine green) for aiding the fluorescence-guided surgical resection of primary and metastatic liver tumours in 23 patients. We found that, compared with NIR-I imaging, intraoperative NIR-II imaging provided a higher tumour-detection sensitivity (100% versus 90.6%; with 95% confidence intervals of 89.1%-100% and 75.0%-98.0%, respectively), a higher tumour-to-normal-liver-tissue signal ratio (5.33 versus 1.45) and an enhanced tumour-detection rate (56.41% versus 46.15%). We infer that combining the NIR-I/II spectral windows and suitable fluorescence probes might improve image-guided surgery in the clinic.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Compounding this issue, significant liver accumulation of these dyes generates intense background fluorescence, further compromising imaging accuracy66.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [66]
Citations
Cites
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,048
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Self-citationvan Dam, G. M., Themelis, G., Crane, L. M. A., Harlaar, N. J., Pleijhuis, R. G., Kelder, W., Sarantopoulos, A., de Jong, J. S., Arts, H. J. G., van der Zee, A. G. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2472 · Cited by 1,585
Image-guided cancer surgery using near-infrared fluorescence
Vahrmeijer, A. L., Hutteman, M., van der Vorst, J. R., van de Velde, C. J. �., & Frangioni, J. V. (2013) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2013.123 · Cited by 1,507
A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications
James, M. L., & Gambhir, S. S. (2012) · Physiological Reviews · doi:10.1152/physrev.00049.2010 · Cited by 1,199
Self-citationHe, S., Song, J., Qu, J., & Cheng, Z. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00234g · Cited by 1,021
Self-citationMultifunctional in vivo vascular imaging using near-infrared II fluorescence
Hong, G., Lee, J. C., Robinson, J. T., Raaz, U., Xie, L., Huang, N. F., Cooke, J. P., & Dai, H. (2012) · Nature Medicine · doi:10.1038/nm.2995 · Cited by 995
Real‐time identification of liver cancers by using indocyanine green fluorescent imaging
Ishizawa, T., Fukushima, N., Shibahara, J., Masuda, K., Tamura, S., Aoki, T., Hasegawa, K., Beck, Y., Fukayama, M., & Kokudo, N. (2009) · Cancer · doi:10.1002/cncr.24291 · Cited by 857
Carr, J. A., Franke, D., Caram, J. R., Perkinson, C. F., Saif, M., Askoxylakis, V., Datta, M., Fukumura, D., Jain, R. K., Bawendi, M. G., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718917115 · Cited by 721
A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging
Antaris, A. L., Chen, H., Diao, S., Ma, Z., Zhang, Z., Zhu, S., Wang, J., Lozano, A. X., Fan, Q., Chew, L., et al. (2017) · Nature Communications · doi:10.1038/ncomms15269 · Cited by 623
Self-citation
Cited by
Sorted by citations
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037
Self-citationX-ray-activated persistent luminescence nanomaterials for NIR-II imaging
Pei, P., Chen, Y., Sun, C., Fan, Y., Yang, Y., Liu, X., Lu, L., Zhao, M., Zhang, H., Zhao, D., et al. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00922-3 · Cited by 718
Self-citationMolecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection
Lei, Z., & Zhang, F. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202007040 · Cited by 699
Near-infrared luminescence high-contrast in vivo biomedical imaging
Chen, Y., Wang, S., & Zhang, F. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-022-00002-8 · Cited by 615
Self-citationIn vivo NIR-II fluorescence imaging for biology and medicine
Wang, F., Zhong, Y., Bruns, O., Liang, Y., & Dai, H. (2024) · Nature Photonics · doi:10.1038/s41566-024-01391-5 · Cited by 564
Liu, Y., Li, Y., Koo, S., Sun, Y., Liu, Y., Liu, X., Pan, Y., Zhang, Z., Du, M., Lu, S., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00553 · Cited by 547
Self-citationLi, H., Kim, H., Xu, F., Han, J., Yao, Q., Wang, J., Pu, K., Peng, X., & Yoon, J. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00307k · Cited by 507
Fundamentals and developments in fluorescence-guided cancer surgery
Mieog, J. S. D., Achterberg, F. B., Zlitni, A., Hutteman, M., Burggraaf, J., Swijnenburg, R., Gioux, S., & Vahrmeijer, A. L. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00548-3 · Cited by 415
Perfecting and extending the near-infrared imaging window
Feng, Z., Tang, T., Wu, T., Yu, X., Zhang, Y., Wang, M., Zheng, J., Ying, Y., Chen, S., Zhou, J., et al. (2021) · Light: Science & Applications · doi:10.1038/s41377-021-00628-0 · Cited by 394
Self-citationAggregation-Induced Emission (AIE), Life and Health
Wang, H., Li, Q., Alam, P., Bai, H., Bhalla, V., Bryce, M. R., Cao, M., Chen, C., Chen, S., Chen, X., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c03925 · Cited by 404
Self-citationNIR-II light in clinical oncology: opportunities and challenges
Zhang, Z., Du, Y., Shi, X., Wang, K., Qu, Q., Liang, Q. Y., Ma, X., He, K., Chi, C., Tang, J., et al. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00892-0 · Cited by 397
Self-citationNear-infrared II fluorescence imaging
Schmidt, E. L., Ou, Z., Ximendes, E. C., Cui, H., Keck, C. H. C., Jaque, D., & Hong, G. (2024) · Nature Reviews Methods Primers · doi:10.1038/s43586-024-00301-x · Cited by 392
A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging
Wang, T., Wang, S., Liu, Z., He, Z., Yu, P., Zhao, M., Zhang, H., Lu, L., Wang, Z., Wang, Z., et al. (2021) · Nature Materials · doi:10.1038/s41563-021-01063-7 · Cited by 308
Gathering brings strength: How organic aggregates boost disease phototheranostics
Qi, J., Ou, H., Liu, Q., & Ding, D. (2021) · Aggregate · doi:10.1002/agt2.25 · Cited by 284
NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing
Lu, L., Li, B., Ding, S., Fan, Y., Wang, S., Sun, C., Zhao, M., Zhao, C.-X., & Zhang, F. (2020) · Nature Communications · doi:10.1038/s41467-020-18051-1 · Cited by 274
Self-citationMolecular Fluorophores for Deep-Tissue Bioimaging
Wang, S., Li, B., & Zhang, F. (2020) · ACS Central Science · doi:10.1021/acscentsci.0c00544 · Cited by 271
Self-citationFluorescent probes for the detection of disease-associated biomarkers
Dou, W., Han, H., Sedgwick, A. C., Zhu, G.-B., Zang, Y., Yang, X., Yoon, J., James, T. D., Li, J. X., & He, X. (2022) · 中国科学通报:英文版 · doi:10.1016/j.scib.2022.01.014 · Cited by 267
A New Class of NIR‐II Gold Nanocluster‐Based Protein Biolabels for In Vivo Tumor‐Targeted Imaging
Song, X., Zhu, W., Ge, X., Li, R., Li, S., Chen, X., Song, J., Xie, J., Chen, X., & Yang, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202010870 · Cited by 266
Fluorescence image-guided tumour surgery
Wang, K., Du, Y., Zhang, Z., He, K., Cheng, Z., Yin, L., Dong, D., Li, C., Li, W., Hu, Z., et al. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-022-00017-1 · Cited by 265
Self-citationActivatable molecular probes for fluorescence-guided surgery, endoscopy and tissue biopsy
Zhang, Y., Zhang, G., Zeng, Z., & Pu, K. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00525a · Cited by 237
Self-citationLu, C., Zhang, C., Wang, P., Zhao, Y., Yang, Y., Wang, Y., Yuan, H., Qu, S., Zhang, X., Song, G., et al. (2020) · Chem · doi:10.1016/j.chempr.2020.06.024 · Cited by 220
Liu, J., Zhang, W., Zhou, C., Li, M., Wang, X., Zhang, W., Liu, Z., Wu, L., James, T. D., Li, P., et al. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03832 · Cited by 208
Rational Design of Near-Infrared-II Organic Molecular Dyes for Bioimaging and Biosensing
Li, B., Zhao, M., & Zhang, F. (2020) · ACS Materials Letters · doi:10.1021/acsmaterialslett.0c00157 · Cited by 207
Self-citationWang, S., Su, B., Wang, X., Wei, Y., Kuo, K., Wang, C., Liu, S., Liao, L., Hung, W., Fu, L., et al. (2022) · Nature Photonics · doi:10.1038/s41566-022-01079-8 · Cited by 207
A phosphorescent probe for in vivo imaging in the second near-infrared window
Chang, B., Li, D., Ren, Y., Qu, C., Shi, X., Liu, R., Liu, H., Tian, J., Hu, Z., Sun, T., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00773-2 · Cited by 195
Self-citationLiu, G., Wang, Z., Wan, S., Lin, X., Wang, R., Li, C., Zong, L., Fu, Z., Liu, H., & Xu, S. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.139504 · Cited by 196
Self-citationNanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment
Xiong, Y., Rao, Y., Hu, J., Luo, Z., & Chen, C. (2023) · Advanced Materials · doi:10.1002/adma.202305140 · Cited by 190
Targeted multicolor in vivo imaging over 1,000 nm enabled by nonamethine cyanines
Bandi, V., Luciano, M., Saccomano, M., Patel, N. L., Bischof, T. S., Lingg, J. G. P., Tsrunchev, P., Nix, M. N., Ruehle, B., Sanders, C., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01394-6 · Cited by 187
Cosco, E. D., Arús, B. A., Spearman, A. L., Atallah, T. L., Lim, I., Leland, O. S., Caram, J. R., Bischof, T. S., Bruns, O. T., & Sletten, E. M. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.0c11599 · Cited by 183
Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance
Ji, A., Lou, H., Qu, C., Lu, W., Hao, Y., Li, J., Wu, Y., Chang, T., Chen, H., & Cheng, Z. (2022) · Nature Communications · doi:10.1038/s41467-022-31521-y · Cited by 183
Self-citationLee, K., Gao, Y., Wei, W., Tan, J., Wan, Y., Feng, Z., Zhang, Y., Liu, Y., Zheng, X., Cao, C., et al. (2023) · Advanced Materials · doi:10.1002/adma.202211632 · Cited by 182
Self-citationJ‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores
Hu, X., Zhu, C., Sun, F., Chen, Z., Zou, J., Chen, X. S., & Yáng, Z. (2023) · Advanced Materials · doi:10.1002/adma.202304848 · Cited by 182
Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm
Li, Y., Liu, Y., Li, Q., Zeng, X., Tian, T., Zhou, W., Cui, Y., Wang, X., Cheng, X., Ding, Q., et al. (2020) · Chemical Science · doi:10.1039/c9sc06567a · Cited by 177
Near‐Infrared‐II Quantum Dots for In Vivo Imaging and Cancer Therapy
Chen, L., Zhao, L., Wang, Z., Liu, S., & Pang, D. (2021) · Small · doi:10.1002/smll.202104567 · Cited by 164
Gold Nanoclusters for NIR‐II Fluorescence Imaging of Bones
Li, D., Liu, Q., Qi, Q., Shi, H., Hsu, E., Chen, W., Yuan, W., Wu, Y., Lin, S., Zeng, Y., et al. (2020) · Small · doi:10.1002/smll.202003851 · Cited by 162
Self-citationNear-infrared-II activated inorganic photothermal nanomedicines
Yu, Z., Chan, W. K., Zhang, Y., & Tan, T. T. Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120459 · Cited by 160
Self-citationNanobody—A versatile tool for cancer diagnosis and therapeutics
Liu, M., Li, L., Jin, D., & Liu, Y. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1697 · Cited by 160
Li, C., Pang, Y., Xu, Y., Lu, M., Tu, L., Li, Q., Sharma, A., Guo, Z., Li, X., & Sun, Y. (2023) · Chemical Society Reviews · doi:10.1039/d3cs00227f · Cited by 157
Self-citationNear-infrared fluorescence imaging in immunotherapy
Ji, Y., Jones, C., Baek, Y., Park, G. K., Kashiwagi, S., & Choi, H. S. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.012 · Cited by 161
Liu, X., Yu, B., Shen, Y., & Cong, H. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214609 · Cited by 151
Tang, D., Yu, Y., Zhang, J., Dong, X., Liu, C., & Xiao, H. (2022) · Advanced Materials · doi:10.1002/adma.202203820 · Cited by 151
Carbon Nanoparticles and Their Biomedical Applications
Holmannová, D., Borský, P., Švadláková, T., Borská, L., & Fiala, Z. (2022) · Applied Sciences · doi:10.3390/app12157865 · Cited by 151
Surgical Navigation for Malignancies Guided by Near‐Infrared‐II Fluorescence Imaging
Yang, R., Lou, K., Wang, P., Gao, Y., Zhang, Y., Chen, M., Huang, W., & Zhang, G. (2021) · Small Methods · doi:10.1002/smtd.202001066 · Cited by 152
Self-citationSmall Molecular NIR-II Fluorophores for Cancer Phototheranostics
Dai, H., Shen, Q., Shao, J., Wang, W., Gao, F., & Dong, X. (2021) · The Innovation · doi:10.1016/j.xinn.2021.100082 · Cited by 150
Владимирович, Д. В., Marcinkevičs, Z., Zherebtsov, E., Popov, A., Grabovskis, A., Kronberga, H., Geldnere, K., Doronin, A. A., Meglinski, I. V., & Bykov, A. V. (2021) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2021.3049591 · Cited by 144
Zhao, X., Zhang, F., & Lei, Z. (2022) · Chemical Science · doi:10.1039/d2sc03136a · Cited by 140
Deep learning for in vivo near-infrared imaging
Ma, Z., Wang, F., Wang, W., Zhong, Y., & Dai, H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021446118 · Cited by 135
Meng, X., Pang, X., Zhang, K., Gong, C., Yang, J., Dong, H., & Zhang, X. (2022) · Small · doi:10.1002/smll.202202035 · Cited by 135
Song, S., Wang, Y., Zhao, Y., Huang, W., Zhang, F., Zhu, S., Wu, Q., Fu, S., Tang, B. Z., & Wang, D. (2022) · Matter · doi:10.1016/j.matt.2022.06.030 · Cited by 133
Wang, S., Shi, H., Wang, L., Loredo, A., Bachilo, S. M., Wu, W., Tian, Z., Chen, Y., Weisman, R. B., Zhang, X., et al. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c11223 · Cited by 134
Self-citationFluorescent Probes for Imaging in Humans: Where Are We Now?
Seah, D., Cheng, Z., & Vendrell, M. (2023) · ACS Nano · doi:10.1021/acsnano.3c03564 · Cited by 132
Self-citationChang, Y., Chen, H., Xie, X., Wan, Y., Li, Q., Wu, F., Yang, R., Wang, W., & Kong, X. (2023) · Nature Communications · doi:10.1038/s41467-023-36813-5 · Cited by 131
Luo, H., & Gao, S. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.056 · Cited by 139
Organic Optoelectronic Materials: A Rising Star of Bioimaging and Phototherapy
Lee, K., Wan, Y., Huang, Z., Zhao, Q., Li, S., & Lee, C. (2023) · Advanced Materials · doi:10.1002/adma.202306492 · Cited by 128
Wang, L., Li, N., Wang, W., Mei, A., Shao, J., Wang, W., & Dong, X. (2024) · ACS Nano · doi:10.1021/acsnano.3c12316 · Cited by 127
Nanochemistry advancing photon conversion in rare-earth nanostructures for theranostics
Lv, R., Raab, M. E., Wang, Y., Tian, J., Lin, J., & Prasad, P. N. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214486 · Cited by 128
Self-citationThe Design and Bioimaging Applications of NIR Fluorescent Organic Dyes with High Brightness
Wu, J., Shi, Z., Zhu, L., Li, J., Xu, H., Xu, M., Hao, S., Fan, Y., Shao, T., Bai, H., et al. (2022) · Advanced Optical Materials · doi:10.1002/adom.202102514 · Cited by 130
Polymethine Molecular Platform for Ratiometric Fluorescent Probes in the Second near-Infrared Window
Lan, Q., Yu, P., Yan, K., Li, X., Zhang, F., & Lei, Z. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c10041 · Cited by 124
Ma, D., Bian, H., Gu, M., Wang, L., Chen, X., & Peng, X. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215677 · Cited by 124
Functional organic dyes for health‐related applications
Cheng, W., Chen, H., Liu, C., Ji, C., Ma, G., & Yin, M. (2020) · Open Research (University of Surrey) · doi:10.1002/viw.20200055 · Cited by 121
Song, J., Kang, X., Wang, L., Ding, D., Kong, D., Li, W., & Qi, J. (2023) · Nature Communications · doi:10.1038/s41467-023-42691-8 · Cited by 128
Wu, L., Li, Z., Wang, K., Groleau, R. R., Rong, X., Liu, X., Liu, C., Lewis, S. E., Zhu, B., & James, T. D. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.4c17092 · Cited by 115
Wei, D., Yu, Y., Huang, Y. H., Jiang, Y., Zhao, Y., Nie, Z., Wang, F., Ma, W., Yu, Z., Huang, Y., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c00076 · Cited by 116
Nanotechnology for cardiovascular diseases
Hu, Q., Fang, Z., Ge, J., & Li, H. (2022) · The Innovation · doi:10.1016/j.xinn.2022.100214 · Cited by 120
Zhang, Y., Yang, H., An, X., Wang, Z., Yang, X., Yu, M., Zhang, R., Sun, Z., & Wang, Q. (2020) · Small · doi:10.1002/smll.202001003 · Cited by 115
Self-citationLi, Z., Liang, P., Xu, L. J., Zhang, X., Li, K., Wu, Q., Lou, X., Ren, T., Yuan, L., & Zhang, X. (2023) · Nature Communications · doi:10.1038/s41467-023-37586-7 · Cited by 119
NIR‐II Organic Nanotheranostics for Precision Oncotherapy
Dai, H., Wang, X., Shao, J., Wang, W., Mou, X., & Dong, X. (2021) · Small · doi:10.1002/smll.202102646 · Cited by 110
Duan, X., Zhang, G., Ji, S., Zhang, Y., Li, J., Ou, H., Gao, Z., Feng, G., & Ding, D. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202116174 · Cited by 110
Self-citationTeng, C. W., Huang, V., Arguelles, G. R., Zhou, C., Cho, S. S., Harmsen, S., & Lee, J. Y. K. (2021) · Neurosurgical FOCUS · doi:10.3171/2020.10.focus20782 · Cited by 111
Zhan, Y., Ling, S., Huang, H., Zhang, Y., Chen, G., Huang, S., Li, C., Guo, W., & Wang, Q. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202011903 · Cited by 107
Self-citationSecond near-infrared window fluorescence nanoprobes for deep-tissue in vivo multiplexed bioimaging
Yang, Y., Xie, Y., & Zhang, F. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114697 · Cited by 109
Zhang, T., Zhang, J., Wang, F., Cao, H., Zhu, D., Chen, X., Xu, C., Yang, X., Huang, W., Wang, Z., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202110526 · Cited by 107
Wang, F., Qu, L., Ren, F., Baghdasaryan, A., Jiang, Y., Hsu, R., Liang, P., Li, J., Zhu, G., Ma, Z., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2123111119 · Cited by 105
Jin, T., Cheng, D., Jiang, G., Xing, W., Liu, P., Wang, B., Zhu, W. P., Sun, H., Sun, Z., Xu, Y. F., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.12.009 · Cited by 104
Small molecular cyanine dyes for phototheranostics
Zhang, J., Wang, W., Shao, J., Chen, J., & Dong, X. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215986 · Cited by 107
Zhang, T., Chen, X., Yuan, C., Pang, X., Shangguan, P., Liu, Y., Han, L., Sun, J., Lam, J. W. Y., Liu, Y., et al. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202211550 · Cited by 102
Ding, F., Feng, J. C., Zhang, X., Sun, J., Fan, C., & Ge, Z. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.008 · Cited by 100
Li, Y., Zhuang, J., Lü, Y., Li, N., Gu, M., Xia, J., Zhao, N., & Tang, B. Z. (2021) · ACS Nano · doi:10.1021/acsnano.1c08928 · Cited by 98
Activatable Rare Earth Near-Infrared-II Fluorescence Ratiometric Nanoprobes
Sun, Z., Huang, H., Zhang, R., Yang, X., Yang, H., Li, C., Zhang, Y., & Wang, Q. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01962 · Cited by 97
Self-citationOrganic fluorescent nanoprobes with NIR‐IIb characteristics for deep learning
Wanderi, K., & Cui, Z. (2022) · Exploration · doi:10.1002/exp.20210097 · Cited by 96
Tracking tumor heterogeneity and progression with near‐infrared II fluorophores
Qi, X., Ma, H., Wang, H., & Zhang, X. (2023) · Exploration · doi:10.1002/exp.20220011 · Cited by 96
Hu, H., Zhao, J., Ma, K., Wang, J., Wang, X., Mao, T., Xiang, C., Luo, H., Cheng, Y., Yu, M., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.05.041 · Cited by 97
Hu, D., Zha, M., Zheng, H., Gao, D., & Sheng, Z. (2024) · Research · doi:10.34133/research.0583 · Cited by 98
Fan, X., Xia, Q., Zhang, Y., Li, Y., Feng, Z., Zhou, J., Qi, J., Tang, B. Z., Qian, J., & Lin, H. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101043 · Cited by 94
Self-citationPerrigue, P. M., Murray, R. A., Mielcarek, A., Henschke, A., & Moya, S. E. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13060770 · Cited by 99
Zhu, Z., Wang, Q., Chen, X., Wang, Q., Yan, C., Zhao, X., Zhao, W., & Zhu, W. (2021) · Advanced Materials · doi:10.1002/adma.202107444 · Cited by 94
Chen, Y., Sun, B., Jiang, X., Yuan, Z., Chen, S., Sun, P., Fan, Q., & Huang, W. (2021) · Journal of Materials Chemistry B · doi:10.1039/d0tb02499f · Cited by 93
Self-citationLiu, R., Xu, Y., Xu, K., & Dai, Z. (2021) · Aggregate · doi:10.1002/agt2.23 · Cited by 93
Pal, R., Lwin, T. M., Krishnamoorthy, M., Collins, H. R., Chan, C. D., Prilutskiy, A., Nasrallah, M. P., Dijkhuis, T. H., Shukla, S., Kendall, A. L., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01105-2 · Cited by 97
Ultra-photostable small-molecule dyes facilitate near-infrared biophotonics
Yan, K., Hu, Z., Yu, P., He, Z., Chen, Y., Chen, J., Sun, H., Wang, S., & Zhang, F. (2024) · Nature Communications · doi:10.1038/s41467-024-46853-0 · Cited by 101
Self-citationWan, Y., Chen, W., Liu, Y., Lee, K., Gao, Y., Zhang, D., Li, Y., Huang, Z., Luo, J., Lee, C., et al. (2024) · Advanced Materials · doi:10.1002/adma.202405966 · Cited by 90
Pirovano, G., Roberts, S. S., Kossatz, S., & Reiner, T. (2020) · Journal of Nuclear Medicine · doi:10.2967/jnumed.119.238279 · Cited by 90
Delivering metal ions by nanomaterials: Turning metal ions into drug-like cancer theranostic agents
Liu, C., Guo, L., Wang, Y., Zhang, J., & Fu, C. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215332 · Cited by 90
Aggregation-induced emission luminogens for assisted cancer surgery
Dai, J., Xue, H., Chen, D., Lou, X., Xia, F., & Wang, S. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214552 · Cited by 89
Xiao, X., Cai, H., Huang, Q., Wang, B., Wang, X., Luo, Q., Li, Y., Zhang, H., Gong, Q., Ma, X., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.04.026 · Cited by 89
Near-infrared II emissive metal clusters: From atom physics to biomedicine
Ma, H., Wang, J., & Zhang, X. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214184 · Cited by 88
Zhang, X., Gao, J., Tang, Y., Yu, J., Liew, S. S., Qiao, C., Cao, Y., Liu, G., Fan, H., Xia, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31136-3 · Cited by 88
Self-citationMolecular Design of NIR-II Polymethine Fluorophores for Bioimaging and Biosensing
Ou, Y., Ren, T., Yuan, L., & Zhang, X. (2023) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.3c00040 · Cited by 89
A genetic engineering strategy for editing near-infrared-II fluorophores
Tian, R., Feng, X., Long, W., Dai, D., Ma, Y., Pan, H., Ge, S., Bai, L., Ke, C., Liu, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30304-9 · Cited by 91
He, X., Luo, Y., Li, Y., Pan, Y., Kwok, R. T. K., He, L., Duan, X., Zhang, P., Wu, A., Tang, B. Z., et al. (2023) · Aggregate · doi:10.1002/agt2.396 · Cited by 87
Metadata
- Authors
- Hu, Z., Fang, C., Li, B., Zhang, Z., Cao, C., Cai, M., Su, S., Sun, X., Shi, X., Li, C., Zhou, T., Zhang, Y., Chi, C., He, P., Xia, X., Chen, Y., Gambhir, S. S., Cheng, Z., & Tian, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Southwest Medical University (CN)
- Xidian University (CN)
- Stanford Medicine (US)
- Corresponding author
- Gambhir, Sanjiv Sam
- Cheng, Zhen
- Tian, Jie
- ORCID
- Venue
- Nature Biomedical Engineering
- Published
- 2019-12-23
- Volume
- 4
- Issue
- 3
- Pages
- 259-271
- ISSN
- 2157-846X (ISSN-L)
- OpenAlex
- W2995471545
- Cited by
- 1,126
- References
- 38
- Citations by year
- 2026: 120 · 2025: 197 · 2024: 203 · 2023: 206 · 2022: 179 · 2021: 149 · 2020: 72
- FWCI
- 66.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81930053, 61622117, 81671759, 81227901)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- NIR-II fluorescence imaging, multispectral imaging, fluorescence-guided surgery, liver tumors, indocyanine green, cancer detection
- MeSH terms
- Animals, Disease Models, Animal, Female, Fluorescence, Carcinoma, Hepatocellular, Humans, Indocyanine Green, Infrared Rays, Liver, Liver Neoplasms, Male, Surgery, Computer-Assisted, Mice, Hep G2 Cells, Optical Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review