Biosensing with DNAzymes

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

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In vitro selection of RNA molecules that bind specific ligands

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In situ click chemistry generation of cyclooxygenase-2 inhibitors

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Central Dogma of Molecular Biology

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Diagnostics for the Developing World: Microfluidic Paper-Based Analytical Devices

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Functional Nucleic Acid Sensors

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Paper-based microfluidic point-of-care diagnostic devices

Yetisen, A. K., Akram, M. S., & Lowe, C. R. (2013) · Lab on a Chip · doi:10.1039/c3lc50169h · Cited by 1,943

Isothermal Amplification of Nucleic Acids

Zhao, Y., Chen, F., Li, Q., Wang, L., & Fan, C. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00428 · Cited by 1,775

A facile soft-template synthesis of mesoporous polymeric and carbonaceous nanospheres

Liu, J., Yang, T., Wang, D.-W., Lu, G. Q., Zhao, D., & Qiao, S. Z. (2013) · Nature Communications · doi:10.1038/ncomms3798 · Cited by 1,567

A general purpose RNA-cleaving DNA enzyme

Santoro, S. W., & Joyce, G. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4262 · Cited by 1,541

A DNA enzyme that cleaves RNA

Breaker, R. R., & Joyce, G. F. (1994) · Chemistry & Biology · doi:10.1016/1074-5521(94)90014-0 · Cited by 1,476

A Colorimetric Lead Biosensor Using DNAzyme-Directed Assembly of Gold Nanoparticles

Liu, J., & Lu, Y. (2003) · Journal of the American Chemical Society · doi:10.1021/ja034775u · Cited by 1,347

Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

Robertson, D. L., & Joyce, G. F. (1990) · Nature · doi:10.1038/344467a0 · Cited by 1,331

In Vitro Selection of Functional Nucleic Acids

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Advances in paper-based point-of-care diagnostics

Hu, J., Wang, S., Wang, L., Li, F., Pingguan-Murphy, B., Lu, T. J., & Xu, F. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.10.075 · Cited by 956

Control of gene expression by a natural metabolite-responsive ribozyme

Winkler, W. C., Nahvi, A., Roth, A., Collins, J. A., & Breaker, R. R. (2004) · Nature · doi:10.1038/nature02362 · Cited by 951

Metal Sensing by DNA

Zhou, W., Saran, R., & Liu, J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00063 · Cited by 931

Escherichia coli: the best biological drinking water indicator for public health protection

Edberg, S. C., Rice, E. W., Karlin, R. J., & Allen, M. J. (2000) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2000.tb05338.x · Cited by 907

Detection and removal of heavy metal ions: a review

Malik, L. A., Bashir, A., Qureashi, A., & Pandith, A. H. (2019) · Environmental Chemistry Letters · doi:10.1007/s10311-019-00891-z · Cited by 904

Exploration of pyrazine-embedded antiaromatic polycyclic hydrocarbons generated by solution and on-surface azomethine ylide homocoupling

Wang, X.-Y., Richter, M., He, Y., Björk, J., Riss, A., Rajesh, R., Garnica, M., Hennersdorf, F., Weigand, J. J., Narita, A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01934-1 · Cited by 883

A perspective on paper-based microfluidics: Current status and future trends

Li, X., Ballerini, D. R., & Shen, W. (2012) · Biomicrofluidics · doi:10.1063/1.3687398 · Cited by 813

DNAzymes for sensing, nanobiotechnology and logic gate applications

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Isothermal nucleic acid amplification technologies for point-of-care diagnostics: a critical review

Craw, P., & Balachandran, W. (2012) · Lab on a Chip · doi:10.1039/c2lc40100b · Cited by 766

A Highly Sensitive and Selective Catalytic DNA Biosensor for Lead Ions

Li, J., & Lu, Y. (2000) · Journal of the American Chemical Society · doi:10.1021/ja0021316 · Cited by 704

Functional DNA Regulated CRISPR-Cas12a Sensors for Point-of-Care Diagnostics of Non-Nucleic-Acid Targets

Xiong, Y., Zhang, J., Yang, Z., Mou, Q., Ma, Y., Xiong, Y., & Lu, Y. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b09211 · Cited by 689

Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets

Xiang, Y., & Lu, Y. (2011) · Nature Chemistry · doi:10.1038/nchem.1092 · Cited by 677

Recent Advances in Paper-Based Sensors

Liana, D. D., Raguse, B., Gooding, J. J., & Chow, E. (2012) · Sensors · doi:10.3390/s120911505 · Cited by 660

Ultrasensitive and Highly Specific Lateral Flow Assays for Point-of-Care Diagnosis

Liu, Y., Zhan, L., Qin, Z., Sackrison, J., & Bischof, J. C. (2021) · ACS Nano · doi:10.1021/acsnano.0c10035 · Cited by 626

Rational Design of “Turn‐On” Allosteric DNAzyme Catalytic Beacons for Aqueous Mercury Ions with Ultrahigh Sensitivity and Selectivity

Liu, J., & Lu, Y. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200702006 · Cited by 593

A microRNA-initiated DNAzyme motor operating in living cells

Peng, H., Li, X.-F., Zhang, H., & Le, X. C. (2017) · Nature Communications · doi:10.1038/ncomms14378 · Cited by 577

Replacing antibodies with aptamers in lateral flow immunoassay

Chen, A., & Yang, S. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.04.041 · Cited by 551

Paper-based nanobiosensors for diagnostics

Parolo, C., & Merkoçi, A. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35255a · Cited by 550

A catalytic beacon sensor for uranium with parts-per-trillion sensitivity and millionfold selectivity

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Review on microfluidic paper-based analytical devices towards commercialisation

Akyazi, T., Basabe-Desmonts, L., & Benito-Lopez, F. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.11.010 · Cited by 515

Aptamers as therapeutic and diagnostic agents

Brody, E. N., & Gold, L. (2000) · Reviews in Molecular Biotechnology · doi:10.1016/s1389-0352(99)00004-5 · Cited by 494

Advances and Challenges in Small‐Molecule DNA Aptamer Isolation, Characterization, and Sensor Development

Yu, H., Alkhamis, O., Canoura, J., Liu, Y., & Xiao, Y. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202008663 · Cited by 492

Deoxyribozyme-Based Logic Gates

Stojanovic, M. N., Mitchell, T. E., & Stefanovic, D. (2002) · Journal of the American Chemical Society · doi:10.1021/ja016756v · Cited by 485

In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme

Li, J. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.2.481 · Cited by 456

Mechanism and Utility of an RNA-Cleaving DNA Enzyme

Santoro, S. W., & Joyce, G. F. (1998) · Biochemistry · doi:10.1021/bi9812221 · Cited by 455

Isothermal amplified detection of DNA and RNA

Yan, L., Zhou, J., Zheng, Y., Gamson, A. S., Roembke, B. T., Nakayama, S., & Sintim, H. O. (2014) · Molecular BioSystems · doi:10.1039/c3mb70304e · Cited by 446

A DNA metalloenzyme with DNA ligase activity

Cuenoud, B., & Szostak, J. W. (1995) · Nature · doi:10.1038/375611a0 · Cited by 445

Toward practical application of paper-based microfluidics for medical diagnostics: state-of-the-art and challenges

Yamada, K., Shibata, H., Suzuki, K., & Citterio, D. (2017) · Lab on a Chip · doi:10.1039/c6lc01577h · Cited by 437

A DNAzyme-Gold Nanoparticle Probe for Uranyl Ion in Living Cells

Wu, P., Hwang, K., Lan, T., & Lu, Y. (2013) · Journal of the American Chemical Society · doi:10.1021/ja400150v · Cited by 428

A DNA enzyme with Mg2+-dependent RNA phosphoesterase activity

Breaker, R. R., & Joyce, G. F. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90028-4 · Cited by 420

Recent Advances in Electrochemical Sensors for Detecting Toxic Gases: NO2, SO2 and H2S

Khan, M. A. H., Rao, M. V., & Li, Q. (2019) · Sensors · doi:10.3390/s19040905 · Cited by 417

A guide to aid the selection of diagnostic tests

Kosack, C. S., Page, A.-L., & Klatser, P. R. (2017) · Bulletin of the World Health Organization · doi:10.2471/blt.16.187468 · Cited by 415

Nucleic acid aptamers and enzymes as sensors

Navani, N. K., & Li, Y. (2006) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2006.04.003 · Cited by 413

Rational design of allosteric ribozymes

Tang, J., & Breaker, R. R. (1997) · Chemistry & Biology · doi:10.1016/s1074-5521(97)90197-6 · Cited by 383

Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes

Silverman, S. K. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.04.010 · Cited by 364

Natural and engineered nucleic acids as tools to explore biology

Breaker, R. R. (2004) · Nature · doi:10.1038/nature03195 · Cited by 362

RNA Cleavage by a DNA Enzyme with Extended Chemical Functionality

Santoro, S. W., Joyce, G. F., Sakthivel, K., Gramatikova, S., & Barbas, C. F. (2000) · Journal of the American Chemical Society · doi:10.1021/ja993688s · Cited by 357

In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing

Torabi, S.-F., Wu, P., McGhee, C. E., Chen, L., Hwang, K., Zheng, N., Cheng, J., & Lu, Y. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420361112 · Cited by 347

A catalytic DNA for porphyrin metallation

Li, Y., & Sen, D. (1996) · Nature Structural & Molecular Biology · doi:10.1038/nsb0996-743 · Cited by 340

Amplified Analysis of DNA by the Autonomous Assembly of Polymers Consisting of DNAzyme Wires

Wang, F., Elbaz, J., Orbach, R., Magen, N., & Willner, I. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2076789 · Cited by 339

A Smart DNAzyme–MnO 2 Nanosystem for Efficient Gene Silencing

Fan, H., Zhao, Z., Yan, G., Zhang, X., Yang, C., Meng, H., Chen, Z., Liu, H., & Tan, W. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201411417 · Cited by 328

A Highly Selective DNAzyme Sensor for Mercuric Ions

Hollenstein, M., Hipolito, C., Lam, C., Dietrich, D., & Perrin, D. M. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200800960 · Cited by 317

In vitro selection, characterization, and application of deoxyribozymes that cleave RNA

Silverman, S. K. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki930 · Cited by 303

Paper-based analytical devices for environmental analysis

Meredith, N. A., Quinn, C., Cate, D. M., Reilly, T. H., Volckens, J., & Henry, C. S. (2016) · The Analyst · doi:10.1039/c5an02572a · Cited by 299

A Lead-Dependent DNAzyme with a Two-Step Mechanism

Brown, A. K., Li, J., Pavot, C. M.-B., & Lu, Y. (2003) · Biochemistry · doi:10.1021/bi027332w · Cited by 298

Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection

Kang, D.-K., Ali, M. M., Zhang, K., Huang, S. S., Peterson, E., Digman, M. A., Gratton, E., & Zhao, W. (2014) · Nature Communications · doi:10.1038/ncomms6427 · Cited by 297

Discovery and Biosensing Applications of Diverse RNA-Cleaving DNAzymes

Liu, M., Chang, D., & Li, Y. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00262 · Cited by 290

Biologically Inspired Synthetic Enzymes Made from DNA

Schlosser, K., & Li, Y. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.01.008 · Cited by 282

A highly selective lead sensor based on a classic lead DNAzyme

Lan, T., Furuya, K., & Lu, Y. (2010) · Chemical Communications · doi:10.1039/b926910j · Cited by 281

DNAzymes as Activity-Based Sensors for Metal Ions: Recent Applications, Demonstrated Advantages, Current Challenges, and Future Directions

Lake, R. J., Yang, Z., Zhang, J., & Lu, Y. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00419 · Cited by 281

Paper based diagnostics for personalized health care: Emerging technologies and commercial aspects

Mahato, K., Srivastava, A., & Chandra, P. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.05.001 · Cited by 280

A Smart, Autocatalytic, DNAzyme Biocircuit for in Vivo, Amplified, MicroRNA Imaging

Wei, J., Wang, H., Wu, Q., Gong, X., Ma, K., Liu, X., & Wang, F. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201911712 · Cited by 272

Ureases: Historical aspects, catalytic, and non-catalytic properties – A review

Kappaun, K., Piovesan, A. R., Carlini, C. R., & Ligabue-Braun, R. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2018.05.010 · Cited by 269

Engineered allosteric ribozymes as biosensor components

Breaker, R. R. (2002) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(02)00281-1 · Cited by 266

Lateral-flow technology: From visual to instrumental

Mak, W. C., Beni, V., & Turner, A. P. F. (2016) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.10.017 · Cited by 264

Cleaving DNA with DNA

Carmi, N., Balkhi, S. R., & Breaker, R. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2233 · Cited by 262

Fundamental studies of functional nucleic acids: aptamers, riboswitches, ribozymes and DNAzymes

Micura, R., & Höbartner, C. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00617c · Cited by 262

In vitro selection of self-cleaving DNAs

Carmi, N., Shultz, L. A., & Breaker, R. R. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90170-2 · Cited by 254

Optical Control of Metal Ion Probes in Cells and Zebrafish Using Highly Selective DNAzymes Conjugated to Upconversion Nanoparticles

Yang, Z., Loh, K. Y., Chu, Y.-T., Feng, R., Satyavolu, N. S. R., Xiong, M., Nakamata Huynh, S. M., Hwang, K., Li, L., Xing, H., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b09867 · Cited by 252

Theranostic DNAzymes

Zhou, W., Ding, J., & Liu, J. (2017) · Theranostics · doi:10.7150/thno.17736 · Cited by 252

Paper-based analytical devices for clinical diagnosis: recent advances in the fabrication techniques and sensing mechanisms

Sher, M., Zhuang, R., Demirci, U., & Asghar, W. (2017) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2017.1285228 · Cited by 245

In Vitro Selection of Catalytic Polynucleotides

Breaker, R. R. (1997) · Chemical Reviews · doi:10.1021/cr960008k · Cited by 240

An amino acid as a cofactor for a catalytic polynucleotide

Roth, A., & Breaker, R. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6027 · Cited by 238

Fluorogenic DNAzyme Probes as Bacterial Indicators

Ali, M. M., Aguirre, S. D., Lazim, H., & Li, Y. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201100477 · Cited by 234

Imaging Endogenous Metal Ions in Living Cells Using a DNAzyme–Catalytic Hairpin Assembly Probe

Wu, Z., Fan, H., Satyavolu, N. S. R., Wang, W., Lake, R., Jiang, J., & Lu, Y. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201703540 · Cited by 230

DNAzyme-Mediated Assays for Amplified Detection of Nucleic Acids and Proteins

Peng, H., Newbigging, A. M., Wang, Z., Tao, J., Deng, W., Le, X. C., & Zhang, H. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04926 · Cited by 228

Ribozyme speed limits

EMILSSON, G. M., NAKAMURA, S., ROTH, A., & BREAKER, R. R. (2003) · RNA · doi:10.1261/rna.5680603 · Cited by 216

Photocaged DNAzymes as a General Method for Sensing Metal Ions in Living Cells

Hwang, K., Wu, P., Kim, T., Lei, L., Tian, S., Wang, Y., & Lu, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201408333 · Cited by 213

Crystal structure of an RNA-cleaving DNAzyme

Liu, H., Yu, X., Chen, Y., Zhang, J., Wu, B., Zheng, L., Haruehanroengra, P., Wang, R., Li, S., Lin, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02203-x · Cited by 211

Biosensors to support sustainable agriculture and food safety

Griesche, C., & Baeumner, A. J. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.115906 · Cited by 209

Translating Bacterial Detection by DNAzymes into a Litmus Test

Tram, K., Kanda, P., Salena, B. J., Huan, S., & Li, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201407021 · Cited by 203

Near‐Infrared Photothermally Activated DNAzyme–Gold Nanoshells for Imaging Metal Ions in Living Cells

Wang, W., Satyavolu, N. S. R., Wu, Z., Zhang, J., Zhu, J., & Lu, Y. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201701325 · Cited by 202

DNA-catalyzed sequence-specific hydrolysis of DNA

Chandra, M., Sachdeva, A., & Silverman, S. K. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.201 · Cited by 194

Dinucleotide Junction Cleavage Versatility of 8-17 Deoxyribozyme

Cruz, R. P. G., Withers, J. B., & Li, Y. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2003.12.012 · Cited by 194

Microfluidic paper-based analytical devices for environmental analysis of soil, air, ecology and river water

Kung, C.-T., Hou, C.-Y., Wang, Y.-N., & Fu, L.-M. (2019) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2019.126855 · Cited by 194

Sentinel Wraps: Real-Time Monitoring of Food Contamination by Printing DNAzyme Probes on Food Packaging

Yousefi, H., Ali, M. M., Su, H.-M., Filipe, C. D. M., & Didar, T. F. (2018) · ACS Nano · doi:10.1021/acsnano.7b08010 · Cited by 193

A deoxyribozyme that harnesses light to repair thymine dimers in DNA

Chinnapen, D. J.-F., & Sen, D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305943101 · Cited by 190

Fluoride ion encapsulation by Mg2+ ions and phosphates in a fluoride riboswitch

Ren, A., Rajashankar, K. R., & Patel, D. J. (2012) · Nature · doi:10.1038/nature11152 · Cited by 189

Phosphorylating DNA with DNA

Li, Y., & Breaker, R. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2746 · Cited by 189

An Efficient RNA-Cleaving DNA Enzyme that Synchronizes Catalysis with Fluorescence Signaling

Mei, S. H. J., Liu, Z., Brennan, J. D., & Li, Y. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0281232 · Cited by 188

The Ca2+ Ion as a Cofactor for a Novel RNA‐Cleaving Deoxyribozyme

Faulhammer, D., & Famulok, M. (1996) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199628371 · Cited by 186

DNAzymes: From Creation In Vitro to Application In Vivo

Achenbach, J., Chiuman, W., Cruz, R., & Li, Y. (2004) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201043376751 · Cited by 182

Nucleic Acid Catalysis: Metals, Nucleobases, and Other Cofactors

Ward, W. L., Plakos, K., & DeRose, V. J. (2014) · Chemical Reviews · doi:10.1021/cr400476k · Cited by 177

Using Commercially Available Personal Glucose Meters for Portable Quantification of DNA

Xiang, Y., & Lu, Y. (2012) · Analytical Chemistry · doi:10.1021/ac203014s · Cited by 175

Portable and Quantitative Detection of Protein Biomarkers and Small Molecular Toxins Using Antibodies and Ubiquitous Personal Glucose Meters

Xiang, Y., & Lu, Y. (2012) · Analytical Chemistry · doi:10.1021/ac300517n · Cited by 173

DNA Dendrimer: An Efficient Nanocarrier of Functional Nucleic Acids for Intracellular Molecular Sensing

Meng, H.-M., Zhang, X., Lv, Y., Zhao, Z., Wang, N.-N., Fu, T., Fan, H., Liang, H., Qiu, L., Zhu, G., et al. (2014) · ACS Nano · doi:10.1021/nn5015962 · Cited by 170

DNA Catalysis: The Chemical Repertoire of DNAzymes

Hollenstein, M. (2015) · Molecules · doi:10.3390/molecules201119730 · Cited by 169

Cell Membrane-Anchored Biosensors for Real-Time Monitoring of the Cellular Microenvironment

Qiu, L., Zhang, T., Jiang, J., Wu, C., Zhu, G., You, M., Chen, X., Zhang, L., Cui, C., Yu, R., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5047389 · Cited by 169

DNA Aptamer-Based Activatable Probes for Photoacoustic Imaging in Living Mice

Zhang, J., Smaga, L. P., Satyavolu, N. S. R., Chan, J., & Lu, Y. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b07913 · Cited by 169

Exercises in Molecular Computing

Stojanovic, M. N., Stefanovic, D., & Rudchenko, S. (2014) · Accounts of Chemical Research · doi:10.1021/ar5000538 · Cited by 164

Deoxyribozymes with 2‘−5‘ RNA Ligase Activity

Flynn-Charlebois, A., Wang, Y., Prior, T. K., Rashid, I., Hoadley, K. A., Coppins, R. L., Wolf, A. C., & Silverman, S. K. (2003) · Journal of the American Chemical Society · doi:10.1021/ja028774y · Cited by 163

A DNAzyme Feedback Amplification Strategy for Biosensing

Liu, M., Zhang, Q., Chang, D., Gu, J., Brennan, J. D., & Li, Y. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201700054 · Cited by 161

Crystal structure of a DNA catalyst

Ponce-Salvatierra, A., Wawrzyniak-Turek, K., Steuerwald, U., Höbartner, C., & Peña, V. (2016) · Nature · doi:10.1038/nature16471 · Cited by 154

Current and Future Perspectives on Isothermal Nucleic Acid Amplification Technologies for Diagnosing Infections

Obande, G. A., & Singh, K. K. B. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s217571 · Cited by 154

Rational evolution of Cd 2+ -specific DNAzymes with phosphorothioate modified cleavage junction and Cd 2+ sensing

Huang, P. J., & Liu, J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv519 · Cited by 153

Signal amplification strategies for paper-based analytical devices

Liu, L., Yang, D., & Liu, G. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.04.043 · Cited by 153

Ultrasensitive DNAzyme Beacon for Lanthanides and Metal Speciation

Huang, P. J., Lin, J. J., Cao, J., Vazin, M., & Liu, J. (2014) · Analytical Chemistry · doi:10.1021/ac403762s · Cited by 151

Catalytic Molecular Beacons

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Cooperative Multicomponent Self‐Assembly of Nucleic Acid Structures for the Activation of DNAzyme Cascades: A Paradigm for DNA Sensors and Aptasensors

Elbaz, J., Moshe, M., Shlyahovsky, B., & Willner, I. (2009) · Chemistry - A European Journal · doi:10.1002/chem.200802004 · Cited by 150

DNAzyme sensors for detection of metal ions in the environment and imaging them in living cells

McGhee, C. E., Loh, K. Y., & Lu, Y. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.03.002 · Cited by 147

DNAzyme technology and cancer therapy: cleave and let die

Dass, C. R., Choong, P., & Khachigian, L. M. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0510 · Cited by 146

A Versatile Endoribonuclease Mimic Made of DNA: Characteristics and Applications of the 8–17 RNA‐Cleaving DNAzyme

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Nanoporous Au-based chronocoulometric aptasensor for amplified detection of Pb2+ using DNAzyme modified with Au nanoparticles

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A Target-Triggered DNAzyme Motor Enabling Homogeneous, Amplified Detection of Proteins

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An invasive DNA approach toward a general method for portable quantification of metal ions using a personal glucose meter

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An electrochemical impedance biosensor for Hg2+ detection based on DNA hydrogel by coupling with DNAzyme-assisted target recycling and hybridization chain reaction

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An Ultrasensitive Light-up Cu2+ Biosensor Using a New DNAzyme Cleaving a Phosphorothioate-Modified Substrate

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Label-Free Biosensor Detection of Endocrine Disrupting Compounds Using Engineered Estrogen Receptors

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Enzyme‐Mediated Endogenous and Bioorthogonal Control of a DNAzyme Fluorescent Sensor for Imaging Metal Ions in Living Cells

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Sequence-function relationships provide new insight into the cleavage site selectivity of the 8-17 RNA-cleaving deoxyribozyme

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Circular Polarized Light Activated Chiral Satellite Nanoprobes for the Imaging and Analysis of Multiple Metal Ions in Living Cells

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Size-selective molecular recognition based on a confined DNA molecular sieve using cavity-tunable framework nucleic acids

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Dose‐Dependent Response of Personal Glucose Meters to Nicotinamide Coenzymes: Applications to Point‐of‐Care Diagnostics of Many Non‐Glucose Targets in a Single Step

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Pullulan Encapsulation of Labile Biomolecules to Give Stable Bioassay Tablets

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Portable Aptasensor of Aflatoxin B1 in Bread Based on a Personal Glucose Meter and DNA Walking Machine

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Metal Cation Detection in Drinking Water

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The application of personal glucose meters as universal point-of-care diagnostic tools

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Programming a topologically constrained DNA nanostructure into a sensor

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A DNAzyme requiring two different metal ions at two distinct sites

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Translating molecular detections into a simple temperature test using a target-responsive smart thermometer

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In Vitro Selection of a New Lanthanide-Dependent DNAzyme for Ratiometric Sensing Lanthanides

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Dual-color encoded DNAzyme nanostructures for multiplexed detection of intracellular metal ions in living cells

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Diagnosing Antibiotic Resistance Using Nucleic Acid Enzymes and Gold Nanoparticles

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MicroRNA-Initiated and Intracellular Na + -Fueled DNAzyme Motor for Differentiating Molecular Subtypes of Nonsmall Cell Lung Cancer

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Cleavage-based signal amplification of RNA

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A General Strategy for Effector-mediated Control of RNA-cleaving Ribozymes and DNA Enzymes

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Biocomputing for Portable, Resettable, and Quantitative Point‐of‐Care Diagnostics: Making the Glucose Meter a Logic‐Gate Responsive Device for Measuring Many Clinically Relevant Targets

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A new heavy lanthanide-dependent DNAzyme displaying strong metal cooperativity and unrescuable phosphorothioate effect

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ATP-Dependent Allosteric DNA Enzymes

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Biostable L-DNAzyme for Sensing of Metal Ions in Biological Systems

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An Exceptionally Selective DNA Cooperatively Binding Two Ca2+ Ions

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DNAzyme‐Mediated Genetically Encoded Sensors for Ratiometric Imaging of Metal Ions in Living Cells

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Autonomous Replication of Nucleic Acids by Polymerization/Nicking Enzyme/DNAzyme Cascades for the Amplified Detection of DNA and the Aptamer–Cocaine Complex

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Metal-Dependent DNAzymes for the Quantitative Detection of Metal Ions in Living Cells: Recent Progress, Current Challenges, and Latest Results on FRET Ratiometric Sensors

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Printed Paper Sensors for Serum Lactate Dehydrogenase using Pullulan-Based Inks to Immobilize Reagents

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DNA-Catalyzed Amide Hydrolysis

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A Multi‐component All‐DNA Biosensing System Controlled by a DNAzyme

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Label free detection of lead using impedimetric sensor based on ordered mesoporous carbon–gold nanoparticles and DNAzyme catalytic beacons

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Oligonucleotide Cross-Linked Hydrogel for Recognition and Quantitation of MicroRNAs Based on a Portable Glucometer Readout

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A Sensitive DNA Enzyme-Based Fluorescent Assay for Bacterial Detection

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Programming a Target-Initiated Bifunctional DNAzyme Nanodevice for Sensitive Ratiometric Electrochemical Biosensing

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Acid-Switchable DNAzyme Nanodevice for Imaging Multiple Metal Ions in Living Cells

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Low-cost and highly efficient DNA biosensor for heavy metal ion using specific DNAzyme-modified microplate and portable glucometer-based detection mode

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Microfluidic Particle Dam for Visual and Quantitative Detection of Lead Ions

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Hemin on graphene nanosheets functionalized with flower-like MnO2 and hollow AuPd for the electrochemical sensing lead ion based on the specific DNAzyme

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Magnetic beads-based DNA hybridization chain reaction amplification and DNAzyme recognition for colorimetric detection of uranyl ion in seafood

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Distinction of Individual Lanthanide Ions with a DNAzyme Beacon Array

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A facile cascade signal amplification strategy using DNAzyme loop-mediated isothermal amplification for the ultrasensitive colorimetric detection of Salmonella

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DNAzyme-integrated plasmonic nanosensor for bacterial sample-to-answer detection

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An Origami Paper-Based Device Printed with DNAzyme-Containing DNA Superstructures for Escherichia coli Detection

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Selection of a metal ligand modified DNAzyme for detecting Ni2+

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Auto-cleaning paper-based electrochemiluminescence biosensor coupled with binary catalysis of cubic Cu2O-Au and polyethyleneimine for quantification of Ni2+ and Hg2+

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Multiplexed Analysis of Genes and of Metal Ions Using Enzyme/DNAzyme Amplification Machineries

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Fe3+ doped ZnO-Ag photocatalyst for photoelectrochemical sensing platform of ultrasensitive Hg2+ detection using exonuclease III-assisted target recycling and DNAzyme-catalyzed amplification

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Synergetic performance of isothermal amplification techniques and lateral flow approach for nucleic acid diagnostics

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Development of DNA-based signal amplification and microfluidic technology for protein assay: A review

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Ultrasensitive and Portable Assay for Lead(II) Ions by Electronic Balance as a Readout

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“Light-up” Sensing of human 8-oxoguanine DNA glycosylase activity by target-induced autocatalytic DNAzyme-generated rolling circle amplification

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Simple, one-step and amplified Hg2+ detection strategy based on DNAzyme motor

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Biomolecular sensors for advanced physiological monitoring

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Simultaneous Fe 2+ /Fe 3+ imaging shows Fe 3+ over Fe 2+ enrichment in Alzheimer’s disease mouse brain

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