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Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Xia, Zhengui, Dickens, Martin, Raingeaud, Joël, Davis, Roger J., Greenberg, Michael E.·1995·Science
DOI 10.1126/science.270.5240.1326
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Abstract

Apoptosis plays an important role during neuronal development, and defects in apoptosis may underlie various neurodegenerative disorders. To characterize molecular mechanisms that regulate neuronal apoptosis, the contributions to cell death of mitogen-activated protein (MAP) kinase family members, including ERK (extracellular signal-regulated kinase), JNK (c-JUN NH 2 -terminal protein kinase), and p38, were examined after withdrawal of nerve growth factor (NGF) from rat PC-12 pheochromocytoma cells. NGF withdrawal led to sustained activation of the JNK and p38 enzymes and inhibition of ERKs. The effects of dominant-interfering or constitutively activated forms of various components of the JNK-p38 and ERK signaling pathways demonstrated that activation of JNK and p38 and concurrent inhibition of ERK are critical for induction of apoptosis in these cells. Therefore, the dynamic balance between growth factor-activated ERK and stress-activated JNK-p38 pathways may be important in determining whether a cell survives or undergoes apoptosis.

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Research works printed but not linked: 73

  1. AHN N.G., MOL CELL BIOCHEM 127, 201 (1993). · DOI
  2. BARRETT G.L., THE P75 NERVE GROWTH-FACTOR RECEPTOR MEDIATES SURVIVAL OR DEATH DEPENDING ON THE STAGE OF SENSORY NEURON DEVELOPMENT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91, 6501 (1994). · DOI · Paper page
  3. BATISTATOU A, AURINTRICARBOXYLIC ACID RESCUES PC12 CELLS AND SYMPATHETIC NEURONS FROM CELL-DEATH CAUSED BY NERVE GROWTH-FACTOR DEPRIVATION - CORRELATION WITH SUPPRESSION OF ENDONUCLEASE ACTIVITY, JOURNAL OF CELL BIOLOGY 115, 461 (1991). · DOI · Paper page
  4. BATISTATOU A, INTERNUCLEOSOMAL DNA CLEAVAGE AND NEURONAL CELL-SURVIVAL DEATH, JOURNAL OF CELL BIOLOGY 122, 523 (1993). · DOI
  5. BLENIS J, SIGNAL-TRANSDUCTION VIA THE MAP KINASES - PROCEED AT YOUR OWN RSK, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90, 5889 (1993). · DOI · Paper page
  6. BOONSTRA J, IONIC RESPONSES AND GROWTH-STIMULATION INDUCED BY NERVE GROWTH-FACTOR AND EPIDERMAL GROWTH-FACTOR IN RAT PHEOCHROMOCYTOMA (PC12) CELLS, JOURNAL OF CELL BIOLOGY 97, 92 (1983). · DOI
  7. BORASIO G.D., INVOLVEMENT OF RAS P21 IN NEUROTROPHIN-INDUCED RESPONSE OF SENSORY, BUT NOT SYMPATHETIC NEURONS, JOURNAL OF CELL BIOLOGY 121, 665 (1993). · DOI
  8. BORASIO G.D., RAS P21-PROTEIN PROMOTES SURVIVAL AND FIBER OUTGROWTH OF CULTURED EMBRYONIC NEURONS, NEURON 2, 1087 (1989). · DOI
  9. BUCKMASTER E.A., EXPRESSION OF THE CYCLIC-AMP-DEPENDENT PROTEIN-KINASE (PKA) CATALYTIC SUBUNIT FROM A HERPES-SIMPLEX VIRUS VECTOR EXTENDS THE SURVIVAL OF RAT SYMPATHETIC NEURONS IN THE ABSENCE OF NGF, EUROPEAN JOURNAL OF NEUROSCIENCE 6, 1316 (1994). · DOI
  10. CAMPBELL J.S., THE MAP KINASE CASCADE, RECENT PROGRESS IN HORMONE RESEARCH, VOL 50 50, 131 (1995).
  11. COBB M.H., CURR OPIN CELL BIOL 3, 1025 (1991). · DOI
  12. 10.1016/0092-8674(94)90133-3 · DOI · Paper page
  13. DAVIS R.J., THE MITOGEN-ACTIVATED PROTEIN-KINASE SIGNAL-TRANSDUCTION PATHWAY, JOURNAL OF BIOLOGICAL CHEMISTRY 268, 14553 (1993). · DOI · Paper page
  14. DAVIS R.J., MAPKS - NEW JNK EXPANDS THE GROUP, TRENDS IN BIOCHEMICAL SCIENCES 19, 470 (1994). · DOI · Paper page
  15. DERIJARD B, JNK1 - A PROTEIN-KINASE STIMULATED BY UV-LIGHT AND HA-RAS THAT BINDS AND PHOSPHORYLATES THE C-JUN ACTIVATION DOMAIN, CELL 76, 1025 (1994). · DOI · Paper page
  16. DINARELLO C.A., THE BIOLOGICAL PROPERTIES OF INTERLEUKIN-1, EUROPEAN CYTOKINE NETWORK 5, 517 (1994).
  17. 10.1126/science.8079174 · DOI · Paper page
  18. ESTUS S, ALTERED GENE-EXPRESSION IN NEURONS DURING PROGRAMMED CELL-DEATH - IDENTIFICATION OF C-JUN AS NECESSARY FOR NEURONAL APOPTOSIS, JOURNAL OF CELL BIOLOGY 127, 1717 (1994). · DOI · Paper page
  19. FERRARI G, GANGLIOSIDES RESCUE NEURONAL CELLS FROM DEATH AFTER TROPHIC FACTOR DEPRIVATION, JOURNAL OF NEUROSCIENCE 13, 1879 (1993). · DOI
  20. FRESHNEY N.W., INTERLEUKIN-1 ACTIVATES A NOVEL PROTEIN-KINASE CASCADE THAT RESULTS IN THE PHOSPHORYLATION OF HSP27, CELL 78, 1039 (1994). · DOI · Paper page
  21. FRODIN M, CYCLIC-AMP ACTIVATES THE MITOGEN-ACTIVATED PROTEIN-KINASE CASCADE IN PC12 CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 269, 6207 (1994). · DOI · Paper page
  22. GALCHEVAGARGOVA Z, AN OSMOSENSING SIGNAL-TRANSDUCTION PATHWAY IN MAMMALIAN-CELLS, SCIENCE 265, 806 (1994). · DOI · Paper page
  23. GOTOH Y, MICROTUBULE-ASSOCIATED-PROTEIN (MAP) KINASE ACTIVATED BY NERVE GROWTH-FACTOR AND EPIDERMAL GROWTH-FACTOR IN PC12 CELLS - IDENTITY WITH THE MITOGEN-ACTIVATED MAP KINASE OF FIBROBLASTIC CELLS, EUROPEAN JOURNAL OF BIOCHEMISTRY 193, 661 (1990). · DOI · Paper page
  24. GREENBERG M.E., NERVE GROWTH-FACTOR AND EPIDERMAL GROWTH-FACTOR INDUCE RAPID TRANSIENT CHANGES IN PROTO-ONCOGENE TRANSCRIPTION IN PC12 CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 260, 14101 (1985). · DOI · Paper page
  25. GREENE L.A., THE ROLE OF TRANSCRIPTION-DEPENDENT PRIMING IN NERVE GROWTH-FACTOR PROMOTED NEURITE OUTGROWTH, DEVELOPMENTAL BIOLOGY 91, 305 (1982). · DOI
  26. GREENE L.A., NERVE GROWTH-FACTOR PREVENTS DEATH AND STIMULATES NEURONAL DIFFERENTIATION OF CLONAL-PC12 PHEOCHROMOCYTOMA CELLS IN SERUM-FREE MEDIUM, JOURNAL OF CELL BIOLOGY 78, 747 (1978). · DOI · Paper page
  27. GREENE L.A., ESTABLISHMENT OF A NORADRENERGIC CLONAL LINE OF RAT ADRENAL PHEOCHROMOCYTOMA CELLS WHICH RESPOND TO NERVE GROWTH-FACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73, 2424 (1976). · DOI · Paper page
  28. GUERRERO I, ACTIVATED N-RAS GENE INDUCES NEURONAL DIFFERENTIATION OF PC12 RAT PHEOCHROMOCYTOMA CELLS, JOURNAL OF CELLULAR PHYSIOLOGY 129, 71 (1986). · DOI
  29. GUPTA S, TRANSCRIPTION FACTOR ATF2 REGULATION BY THE JNK SIGNAL-TRANSDUCTION PATHWAY, SCIENCE 267, 389 (1995). · DOI · Paper page
  30. HAM J, A C-JUN DOMINANT-NEGATIVE MUTANT PROTECTS SYMPATHETIC NEURONS AGAINST PROGRAMMED CELL-DEATH, NEURON 14, 927 (1995). · DOI · Paper page
  31. 10.1126/science.7914033 · DOI · Paper page
  32. HO S.N., SITE-DIRECTED MUTAGENESIS BY OVERLAP EXTENSION USING THE POLYMERASE CHAIN-REACTION, GENE 77, 51 (1989). · DOI · Paper page
  33. HOCKENBERY D, BCL-2 IS AN INNER MITOCHONDRIAL-MEMBRANE PROTEIN THAT BLOCKS PROGRAMMED CELL-DEATH, NATURE 348, 334 (1990). · DOI · Paper page
  34. HUNTER T, PROTEIN-KINASES AND PHOSPHATASES - THE YIN AND YANG OF PROTEIN-PHOSPHORYLATION AND SIGNALING, CELL 80, 225 (1995). · DOI · Paper page
  35. JACOBSON M.D., PROGRAMMED CELL-DEATH AND BCL-2 PROTECTION IN THE ABSENCE OF A NUCLEUS, EMBO JOURNAL 13, 1899 (1994). · DOI · Paper page
  36. JACOBSON M.D., BCL-2 BLOCKS APOPTOSIS IN CELLS LACKING MITOCHONDRIAL-DNA, NATURE 361, 365 (1993). · DOI · Paper page
  37. JARVIS W.D., INDUCTION OF APOPTOTIC DNA-DAMAGE AND CELL-DEATH BY ACTIVATION OF THE SPHINGOMYELIN PATHWAY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91, 73 (1994). · DOI · Paper page
  38. KOIKE T, PROG NEUROPSYCHOPHAR 16, 65 (1992). · DOI
  39. KOLESNICK R, THE SPHINGOMYELIN PATHWAY IN TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-1 SIGNALING, CELL 77, 325 (1994). · DOI · Paper page
  40. KYRIAKIS J.M., THE STRESS-ACTIVATED PROTEIN-KINASE SUBFAMILY OF C-JUN KINASES, NATURE 369, 156 (1994). · DOI · Paper page
  41. LANGECARTER C.A., A DIVERGENCE IN THE MAP KINASE REGULATORY NETWORK DEFINED BY MEK KINASE AND RAF, SCIENCE 260, 315 (1993). · DOI · Paper page
  42. LEE J.C., A PROTEIN-KINASE INVOLVED IN THE REGULATION OF INFLAMMATORY CYTOKINE BIOSYNTHESIS, NATURE 372, 739 (1994). · DOI · Paper page
  43. LIN A, IDENTIFICATION OF A DUAL-SPECIFICITY KINASE THAT ACTIVATES THE JUN KINASES AND P38-MPK2, SCIENCE 268, 286 (1995). · DOI · Paper page
  44. LIVINGSTONE C, ATF-2 CONTAINS A PHOSPHORYLATION-DEPENDENT TRANSCRIPTIONAL ACTIVATION DOMAIN, EMBO JOURNAL 14, 1785 (1995). · DOI · Paper page
  45. 10.1126/science.8052857 · DOI · Paper page
  46. MARSHALL C.J., SPECIFICITY OF RECEPTOR TYROSINE KINASE SIGNALING - TRANSIENT VERSUS SUSTAINED EXTRACELLULAR SIGNAL-REGULATED KINASE ACTIVATION, CELL 80, 179 (1995). · DOI · Paper page
  47. MESNER P.W., NERVE GROWTH-FACTOR WITHDRAWAL-INDUCED CELL-DEATH IN NEURONAL PC12 CELLS RESEMBLES THAT IN SYMPATHETIC NEURONS, JOURNAL OF CELL BIOLOGY 119, 1669 (1992). · DOI
  48. 10.1126/science.7992057 · DOI · Paper page
  49. MIYASAKA T, NERVE GROWTH-FACTOR STIMULATES A PROTEIN-KINASE IN PC-12 CELLS THAT PHOSPHORYLATES MICROTUBULE-ASSOCIATED PROTEIN-2, JOURNAL OF BIOLOGICAL CHEMISTRY 265, 4730 (1990). · DOI
  50. 10.1126/science.8456305 · DOI · Paper page
  51. 10.1126/science.7652575 · DOI · Paper page
  52. OPPENHEIM R.W., CELL-DEATH DURING DEVELOPMENT OF THE NERVOUS-SYSTEM, ANNUAL REVIEW OF NEUROSCIENCE 14, 453 (1991). · DOI · Paper page
  53. PITTMAN R.N., A SYSTEM FOR CHARACTERIZING CELLULAR AND MOLECULAR EVENTS IN PROGRAMMED NEURONAL CELL-DEATH, JOURNAL OF NEUROSCIENCE 13, 3669 (1993). · DOI · Paper page
  54. QIU M.S., NGF AND EGF RAPIDLY ACTIVATE P21RAS IN PC12 CELLS BY DISTINCT, CONVERGENT PATHWAYS INVOLVING TYROSINE PHOSPHORYLATION, NEURON 7, 937 (1991). · DOI
  55. 10.1126/science.8332899 · DOI · Paper page
  56. RAFF M.C., PROGRAMMED CELL-DEATH AND THE CONTROL OF CELL-SURVIVAL - LESSONS FROM THE NERVOUS-SYSTEM, SCIENCE 262, 695 (1993). · DOI · Paper page
  57. RAINGEAUD J, PRO-INFLAMMATORY CYTOKINES AND ENVIRONMENTAL-STRESS CAUSE P38 MITOGEN-ACTIVATED PROTEIN-KINASE ACTIVATION BY DUAL PHOSPHORYLATION ON TYROSINE AND THREONINE, JOURNAL OF BIOLOGICAL CHEMISTRY 270, 7420 (1995). · DOI · Paper page
  58. RAPP U.R., TRANSFORMATION BY RAF AND OTHER ONCOGENES RENDERS CELLS DIFFERENTIALLY SENSITIVE TO GROWTH-INHIBITION BY A DOMINANT-NEGATIVE C-JUN MUTANT, ONCOGENE 9, 3493 (1994).
  59. RAY L.B., RAPID STIMULATION BY INSULIN OF A SERINE THREONINE KINASE IN 3T3-L1 ADIPOCYTES THAT PHOSPHORYLATES MICROTUBULE-ASSOCIATED PROTEIN-2 INVITRO, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84, 1502 (1987). · DOI · Paper page
  60. 10.1016/0896-6273(94)90438-3 · DOI · Paper page
  61. ROUSE J, A NOVEL KINASE CASCADE TRIGGERED BY STRESS AND HEAT-SHOCK THAT STIMULATES MAPKAP KINASE-2 AND PHOSPHORYLATION OF THE SMALL HEAT-SHOCK PROTEINS, CELL 78, 1027 (1994). · DOI · Paper page
  62. RUKENSTEIN A, MULTIPLE AGENTS RESCUE PC12 CELLS FROM SERUM-FREE CELL-DEATH BY TRANSLATION-INDEPENDENT AND TRANSCRIPTION-INDEPENDENT MECHANISMS, JOURNAL OF NEUROSCIENCE 11, 2552 (1991). · DOI · Paper page
  63. SANCHEZ I, ROLE OF SAPK/ERK KINASE-1 IN THE STRESS-ACTIVATED PATHWAY REGULATING TRANSCRIPTION FACTOR C-JUN, NATURE 372, 794 (1994). · DOI · Paper page
  64. SIUSS H.K., MOL CELL BIOL 14, 8376 (1994).
  65. 10.1126/science.7878463 · DOI · Paper page
  66. STURGILL T.W., RECENT PROGRESS IN CHARACTERIZATION OF PROTEIN-KINASE CASCADES FOR PHOSPHORYLATION OF RIBOSOMAL-PROTEIN S6, BIOCHIMICA ET BIOPHYSICA ACTA 1092, 350 (1991). · DOI · Paper page
  67. SU B, JNK IS INVOLVED IN SIGNAL INTEGRATION DURING COSTIMULATION OF T-LYMPHOCYTES, CELL 77, 727 (1994). · DOI · Paper page
  68. TENG K.K., DEPOLARIZATION MAINTAINS NEURITES AND PRIMING OF PC12 CELLS AFTER NERVE GROWTH-FACTOR WITHDRAWAL, JOURNAL OF NEUROSCIENCE 13, 3124 (1993). · DOI
  69. TOGARI A, THE NEURITE-PROMOTING EFFECT OF FIBROBLAST GROWTH-FACTOR ON PC12 CELLS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 114, 1189 (1983). · DOI
  70. VANDAM H, ATF-2 IS PREFERENTIALLY ACTIVATED BY STRESS-ACTIVATED PROTEIN-KINASES TO MEDIATE C-JUN INDUCTION IN RESPONSE TO GENOTOXIC AGENTS, EMBO JOURNAL 14, 1798 (1995). · DOI · Paper page
  71. 10.1126/science.7618106 · DOI · Paper page
  72. YAN M.H., ACTIVATION OF STRESS-ACTIVATED PROTEIN-KINASE BY MEKK1 PHOSPHORYLATION OF ITS ACTIVATOR SEK1, NATURE 372, 798 (1994). · DOI · Paper page
  73. YOUNG S.W., DIFFERENTIATION OF PC12 CELLS IN RESPONSE TO A CAMP ANALOG IS ACCOMPANIED BY SUSTAINED ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASE - COMPARISON WITH THE EFFECTS OF INSULIN, GROWTH-FACTORS AND PHORBOL ESTERS, FEBS LETTERS 338, 212 (1994). · DOI

Cited by

Metadata

Authors
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1995-11-24
Volume
270
Issue
5240
Pages
1326-1331
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.270.5240.1326
OpenAlex
W1976385326
Cited by
5,287
References
6
FWCI
79.93
Type
journal article
Language
en
Open access
closed

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