Stiffness Sensing by Cells

Matrix elasticity directs stem cell lineage specification

Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382

AMPK: a nutrient and energy sensor that maintains energy homeostasis

Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602

Tensional homeostasis and the malignant phenotype

Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941

Cell Movement Is Guided by the Rigidity of the Substrate

Lo, C.-M., Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76279-5 · Cited by 3,289

Cell locomotion and focal adhesions are regulated by substrate flexibility

Pelham, R. J., & Wang, Y.-L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13661 · Cited by 3,027

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

Chaudhuri, O., Gu, L., Klumpers, D., Darnell, M., Bencherif, S. A., Weaver, J. C., Huebsch, N., Lee, H.-P., Lippens, E., Duda, G. N., et al. (2016) · Nature Materials · doi:10.1038/nmat4489 · Cited by 2,443

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20041 · Cited by 2,325

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001

Cells lying on a bed of microneedles: An approach to isolate mechanical force

Tan, J. L., Tien, J., Pirone, D. M., Gray, D. S., Bhadriraju, K., & Chen, C. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0235407100 · Cited by 1,962

Glutamine addiction: a new therapeutic target in cancer

Wise, D. R., & Thompson, C. B. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.003 · Cited by 1,770

Myotubes differentiate optimally on substrates with tissue-like stiffness

Engler, A. J., Griffin, M. A., Sen, S., Bönnemann, C. G., Sweeney, H. L., & Discher, D. E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405004 · Cited by 1,743

Mechanical forces direct stem cell behaviour in development and regeneration

Vining, K. H., & Mooney, D. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.108 · Cited by 1,656

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

Gilbert, P. M., Havenstrite, K. L., Magnusson, K. E. G., Sacco, A., Leonardi, N. A., Kraft, P., Nguyen, N. K., Thrun, S., Lutolf, M. P., & Blau, H. M. (2010) · Science · doi:10.1126/science.1191035 · Cited by 1,587

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478

Silicone Rubber Substrata: A New Wrinkle in the Study of Cell Locomotion

Harris, A. K., Wild, P., & Stopak, D. (1980) · Science · doi:10.1126/science.6987736 · Cited by 1,348

Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity

Hinz, B., Celetta, G., Tomasek, J. J., Gabbiani, G., & Chaponnier, C. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.9.2730 · Cited by 1,288

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., Friedl, A., & Keely, P. J. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.11.076 · Cited by 1,285

Agar suspension culture for the selective assay of cells transformed by polyoma virus

Macpherson, I., & Montagnier, L. (1964) · Virology · doi:10.1016/0042-6822(64)90301-0 · Cited by 1,236

Traction fields, moments, and strain energy that cells exert on their surroundings

Butler, J. P., Tolić-Nørrelykke, I. M., Fabry, B., & Fredberg, J. J. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00270.2001 · Cited by 1,043

Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates

Solon, J., Levental, I., Sengupta, K., Georges, P. C., & Janmey, P. A. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.101386 · Cited by 1,027

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

Ulrich, T. A., de Juan Pardo, E. M., & Kumar, S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4859 · Cited by 901

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Liu, F., Lagares, D., Choi, K. M., Stopfer, L., Marinković, A., Vrbanac, V., Probst, C. K., Hiemer, S. E., Sisson, T. H., Horowitz, J. C., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00300.2014 · Cited by 874

Fibroblast traction as a mechanism for collagen morphogenesis

Harris, A. K., Stopak, D., & Wild, P. (1981) · Nature · doi:10.1038/290249a0 · Cited by 868

Neurite branching on deformable substrates

Flanagan, L. A., Ju, Y.-E., Marg, B., Osterfield, M., & Janmey, P. A. (2002) · NeuroReport · doi:10.1097/00001756-200212200-00007 · Cited by 759

Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro.

Shin, S. I., Freedman, V. H., Risser, R., & Pollack, R. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.11.4435 · Cited by 738

Matrices with Compliance Comparable to that of Brain Tissue Select Neuronal over Glial Growth in Mixed Cortical Cultures

Georges, P. C., Miller, W. J., Meaney, D. F., Sawyer, E. S., & Janmey, P. A. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.073114 · Cited by 724

Agarose-based biomaterials for tissue engineering

Zarrintaj, P., Manouchehri, S., Ahmadi, Z., Saeb, M. R., Urbanska, A. M., Kaplan, D. L., & Mozafari, M. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.01.060 · Cited by 687

A comparison of methods to assess cell mechanical properties

Wu, P.-H., Aroush, D. R.-B., Asnacios, A., Chen, W.-C., Dokukin, M. E., Doss, B. L., Durand-Smet, P., Ekpenyong, A., Guck, J., Guz, N. V., et al. (2018) · Nature Methods · doi:10.1038/s41592-018-0015-1 · Cited by 672

Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion

Peyton, S. R., & Putnam, A. J. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20274 · Cited by 657

Substrate flexibility regulates growth and apoptosis of normal but not transformed cells

Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.5.c1345 · Cited by 655

Mechanosensing is critical for axon growth in the developing brain

Koser, D. E., Thompson, A. J., Foster, S. K., Dwivedy, A., Pillai, E. K., Sheridan, G. K., Svoboda, H., Viana, M., Costa, L. D. F., Guck, J., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4394 · Cited by 649

Mechanoreciprocity in cell migration

van Helvert, S., Storm, C., & Friedl, P. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0012-0 · Cited by 587

Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis

Georges, P. C., Hui, J.-J., Gombos, Z., McCormick, M. E., Wang, A. Y., Uemura, M., Mick, R., Janmey, P. A., Furth, E. E., & Wells, R. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2007 · Cited by 577

Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

Boulant, S., Kural, C., Zeeh, J.-C., Ubelmann, F., & Kirchhausen, T. (2011) · Nature Cell Biology · doi:10.1038/ncb2307 · Cited by 566

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

Houk, A. R., Jilkine, A., Mejean, C. O., Boltyanskiy, R., Dufresne, E. R., Angenent, S. B., Altschuler, S. J., Wu, L. F., & Weiner, O. D. (2012) · Cell · doi:10.1016/j.cell.2011.10.050 · Cited by 565

Targeting extracellular matrix stiffness to attenuate disease: from molecular mechanisms to clinical trials

Lampi, M. C., & Reinhart-King, C. A. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0475 · Cited by 551

Force Microscopy of Nonadherent Cells: A Comparison of Leukemia Cell Deformability

Rosenbluth, M. J., Lam, W. A., & Fletcher, D. A. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.067496 · Cited by 532

Cell volume change through water efflux impacts cell stiffness and stem cell fate

Guo, M., Pegoraro, A. F., Mao, A., Zhou, E. H., Arany, P. R., Han, Y., Burnette, D. T., Jensen, M. H., Kasza, K. E., Moore, J. R., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705179114 · Cited by 529

Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension

Wang, N., & Ingber, D. E. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)81014-8 · Cited by 528

Traction Force Microscopy of Migrating Normal and H-ras Transformed 3T3 Fibroblasts

Munevar, S., Wang, Y.-L., & Dembo, M. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76145-0 · Cited by 527

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression

Schedin, P., & Keely, P. J. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003228 · Cited by 524

Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures

Balgude, A. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00350-1 · Cited by 518

Cell type-specific response to growth on soft materials

Georges, P. C., & Janmey, P. A. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01121.2004 · Cited by 496

Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1–5, 2012: The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)‐based hydrogels

Blakney, A. K., Swartzlander, M. D., & Bryant, S. J. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34104 · Cited by 470

Stimuli-Responsive DNA-Based Hydrogels: From Basic Principles to Applications

Kahn, J. S., Hu, Y., & Willner, I. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6b00542 · Cited by 446

Breakers of advanced glycation end products restore large artery properties in experimental diabetes

Wolffenbuttel, B. H. R., Boulanger, C. M., Crijns, F. R. L., Huijberts, M. S. P., Poitevin, P., Swennen, G. N. M., Vasan, S., Egan, J. J., Ulrich, P., Cerami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4630 · Cited by 434

The influence of substrate creep on mesenchymal stem cell behaviour and phenotype

Cameron, A. R., Frith, J. E., & Cooper-White, J. J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.003 · Cited by 428

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

Klein, E. A., Yin, L., Kothapalli, D., Castagnino, P., Byfield, F. J., Xu, T., Levental, I., Hawthorne, E., Janmey, P. A., & Assoian, R. K. (2009) · Current Biology · doi:10.1016/j.cub.2009.07.069 · Cited by 421

Matrix stiffening promotes a tumor vasculature phenotype

Bordeleau, F., Mason, B. N., Lollis, E. M., Mazzola, M., Zanotelli, M. R., Somasegar, S., Califano, J. P., Montague, C., LaValley, D. J., Huynh, J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613855114 · Cited by 416

Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation

Charrier, E. E., Pogoda, K., Wells, R. G., & Janmey, P. A. (2018) · Nature Communications · doi:10.1038/s41467-018-02906-9 · Cited by 415

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

Wang, X., Zheng, Z., Caviglia, J. M., Corey, K. E., Herfel, T. M., Cai, B., Masia, R., Chung, R. T., Lefkowitch, J. H., Schwabe, R. F., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.016 · Cited by 413

Cell Shape and Substrate Rigidity Both Regulate Cell Stiffness

Tee, S.-Y., Fu, J., Chen, C. S., & Janmey, P. A. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2010.12.3744 · Cited by 402

Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration

Huynh, J., Nishimura, N., Rana, K., Peloquin, J. M., Califano, J. P., Montague, C. R., King, M. R., Schaffer, C. B., & Reinhart-King, C. A. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002761 · Cited by 402

Traction forces and rigidity sensing regulate cell functions

Ghibaudo, M., Saez, A., Trichet, L., Xayaphoummine, A., Browaeys, J., Silberzan, P., Buguin, A., & Ladoux, B. (2008) · Soft Matter · doi:10.1039/b804103b · Cited by 392

Cell-Cell Mechanical Communication through Compliant Substrates

Reinhart-King, C. A., Dembo, M., & Hammer, D. A. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.127662 · Cited by 390

Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties

Ghosh, K., Pan, Z., Guan, E., Ge, S., Liu, Y., Nakamura, T., Ren, X.-D., Rafailovich, M., & Clark, R. A. F. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.038 · Cited by 386

The mechanical memory of lung myofibroblasts

Balestrini, J. L., Chaudhry, S., Sarrazy, V., Koehler, A., & Hinz, B. (2012) · Integrative Biology · doi:10.1039/c2ib00149g · Cited by 386

Compatibility of Mammalian Cells on Surfaces of Poly(dimethylsiloxane)

Lee, J. N., Jiang, X., Ryan, D., & Whitesides, G. M. (2004) · Langmuir · doi:10.1021/la048562+ · Cited by 379

Influence of substrate stiffness on the phenotype of heart cells

Bhana, B., Iyer, R. K., Chen, W. L. K., Zhao, R., Sider, K. L., Likhitpanichkul, M., Simmons, C. A., & Radisic, M. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22647 · Cited by 373

Evaluation of polydimethylsiloxane scaffolds with physiologically-relevant elastic moduli: interplay of substrate mechanics and surface chemistry effects on vascular smooth muscle cell response

Brown, X. Q., Ookawa, K., & Wong, J. Y. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.08.009 · Cited by 372

Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films: Correlations between substrate stiffness and cell adhesion

Engler, A. J., Richert, L., Wong, J. Y., Picart, C., & Discher, D. E. (2004) · Surface Science · doi:10.1016/j.susc.2004.06.179 · Cited by 370

Non-Linear Elasticity of Extracellular Matrices Enables Contractile Cells to Communicate Local Position and Orientation

Winer, J. P., Oake, S., & Janmey, P. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006382 · Cited by 368

Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs

Hall, M. S., Alisafaei, F., Ban, E., Feng, X., Hui, C.-Y., Shenoy, V. B., & Wu, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613058113 · Cited by 360

The use of poly(ethylene glycol) hydrogels to investigate the impact of ECM chemistry and mechanics on smooth muscle cells

Peyton, S. R., Raub, C. B., Keschrumrus, V. P., & Putnam, A. J. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.05.012 · Cited by 357

Cell Membranes Resist Flow

Shi, Z., Graber, Z. T., Baumgart, T., Stone, H. A., & Cohen, A. E. (2018) · Cell · doi:10.1016/j.cell.2018.09.054 · Cited by 355

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

Olsen, A. L., Bloomer, S. A., Chan, E. P., Gaça, M. D. A., Georges, P. C., Sackey, B., Uemura, M., Janmey, P. A., & Wells, R. G. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00412.2010 · Cited by 355

How deeply cells feel: methods for thin gels

Buxboim, A., Rajagopal, K., Brown, A. E. X., & Discher, D. E. (2010) · Journal of Physics: Condensed Matter · doi:10.1088/0953-8984/22/19/194116 · Cited by 355

Liver Stiffness Is Associated With Risk of Decompensation, Liver Cancer, and Death in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis

Singh, S., Fujii, L. L., Murad, M. H., Wang, Z., Asrani, S. K., Ehman, R. L., Kamath, P. S., & Talwalkar, J. A. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.07.034 · Cited by 352

Mechanics and contraction dynamics of single platelets and implications for clot stiffening

Lam, W. A., Chaudhuri, O., Crow, A., Webster, K. D., Li, T.-D., Kita, A., Huang, J., & Fletcher, D. A. (2011) · Nature Materials · doi:10.1038/nmat2903 · Cited by 349

Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform

Ananthanarayanan, B., Kim, Y., & Kumar, S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.07.005 · Cited by 337

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

Li, C. X., Talele, N. P., Boo, S., Koehler, A., Knee-Walden, E., Balestrini, J. L., Speight, P., Kapus, A., & Hinz, B. (2017) · Nature Materials · doi:10.1038/nmat4780 · Cited by 336

Transforming growth factor-β and substrate stiffness regulate portal fibroblast activation in culture

Li, Z., Dranoff, J. A., Chan, E. P., Uemura, M., Sévigny, J., & Wells, R. G. (2007) · Hepatology · doi:10.1002/hep.21792 · Cited by 335

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

Tilghman, R. W., Cowan, C. R., Mih, J. D., Koryakina, Y., Gioeli, D., Slack-Davis, J. K., Blackman, B. R., Tschumperlin, D. J., & Parsons, J. T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012905 · Cited by 331

Integrin-dependent actomyosin contraction regulates epithelial cell scattering

de Rooij, J., Kerstens, A., Danuser, G., Schwartz, M. A., & Waterman-Storer, C. M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200506152 · Cited by 324

Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact

Califano, J. P., & Reinhart-King, C. A. (2010) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-010-0102-6 · Cited by 320

Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity

Weisbrod, R. M., Shiang, T., Al Sayah, L., Fry, J. L., Bajpai, S., Reinhart-King, C. A., Lob, H. E., Santhanam, L., Mitchell, G., Cohen, R. A., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01744 · Cited by 317

Extracellular Matrix Rigidity Promotes Invadopodia Activity

Alexander, N. R., Branch, K. M., Parekh, A., Clark, E. S., Iwueke, I. C., Guelcher, S. A., & Weaver, A. M. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.090 · Cited by 317

Probing cellular mechanobiology in three-dimensional culture with collagen–agarose matrices

Ulrich, T. A., Jain, A., Tanner, K., MacKay, J. L., & Kumar, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.047 · Cited by 310

Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing

Gupta, M., Sarangi, B. R., Deschamps, J., Nematbakhsh, Y., Callan-Jones, A., Margadant, F., Mège, R.-M., Lim, C. T., Voituriez, R., & Ladoux, B. (2015) · Nature Communications · doi:10.1038/ncomms8525 · Cited by 292

Molecular Basis of Arterial Stiffening: Role of Glycation – A Mini-Review

Sell, D. R., & Monnier, V. M. (2012) · Gerontology · doi:10.1159/000334668 · Cited by 282

Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates

Gong, Z., Szczesny, S. E., Caliari, S. R., Charrier, E. E., Chaudhuri, O., Cao, X., Lin, Y., Mauck, R. L., Janmey, P. A., Burdick, J. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716620115 · Cited by 281

Cell orientation determines the alignment of cell-produced collagenous matrix

Wang, J. H.-C., Jia, F., Gilbert, T. W., & Woo, S. L.-Y. (2003) · Journal of Biomechanics · doi:10.1016/s0021-9290(02)00233-6 · Cited by 279

Cell Elasticity Determines Macrophage Function

Patel, N. R., Bole, M., Chen, C., Hardin, C. C., Kho, A. T., Mih, J., Deng, L., Butler, J., Tschumperlin, D., Fredberg, J. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041024 · Cited by 275

Divergent immune responses to synthetic and biological scaffolds

Sadtler, K., Wolf, M. T., Ganguly, S., Moad, C. A., Chung, L., Majumdar, S., Housseau, F., Pardoll, D. M., & Elisseeff, J. H. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.11.002 · Cited by 256

YAP and TAZ Regulate Skin Wound Healing

Lee, M.-J., Byun, M. R., Furutani-Seiki, M., Hong, J.-H., & Jung, H.-S. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.339 · Cited by 253

Polyacrylamide Hydrogels for Cell Mechanics: Steps Toward Optimization and Alternative Uses

Kandow, C. E., Georges, P. C., Janmey, P. A., & Beningo, K. A. (2007) · Methods in Cell Biology · doi:10.1016/s0091-679x(07)83002-0 · Cited by 243

Cancer cells’ ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential

Wullkopf, L., West, A.-K. V., Leijnse, N., Cox, T. R., Madsen, C. D., Oddershede, L. B., & Erler, J. T. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-05-0319 · Cited by 242

Correlation of anchorage-independent growth with tumorigenicity of chemically transformed mouse epidermal cells.

Colburn, N. H., Bruegge, W. F., Bates, J., Gray, R. H., Rossen, J. D., Kelsey, W. H., & Shimada, T. (1978) · PubMed · Cited by 238

Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions

Fraley, S. I., Wu, P.-H., He, L., Feng, Y., Krisnamurthy, R., Longmore, G. D., & Wirtz, D. (2015) · Scientific Reports · doi:10.1038/srep14580 · Cited by 234

Regulating Myoblast Phenotype Through Controlled Gel Stiffness and Degradation

Boontheekul, T., Hill, E. E., Kong, H.-J., & Mooney, D. J. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0356 · Cited by 233

Endothelial actin and cell stiffness is modulated by substrate stiffness in 2D and 3D

Byfield, F. J., Reen, R. K., Shentu, T.-P., Levitan, I., & Gooch, K. J. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.02.012 · Cited by 230

CD44-Mediated Adhesion to Hyaluronic Acid Contributes to Mechanosensing and Invasive Motility

Kim, Y., & Kumar, S. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0629 · Cited by 228

Effect of substrate mechanics on chondrocyte adhesion to modified alginate surfaces

Genes, N. G., Rowley, J. A., Mooney, D. J., & Bonassar, L. J. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.11.023 · Cited by 227

Spatially patterned matrix elasticity directs stem cell fate

Yang, C., DelRio, F. W., Ma, H., Killaars, A. R., Basta, L. P., Kyburz, K. A., & Anseth, K. S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1609731113 · Cited by 217

Compression stiffening of brain and its effect on mechanosensing by glioma cells

Pogoda, K., Chin, L., Georges, P. C., Byfield, F. J., Bucki, R., Kim, R., Weaver, M., Wells, R. G., Marcinkiewicz, C., & Janmey, P. A. (2014) · New Journal of Physics · doi:10.1088/1367-2630/16/7/075002 · Cited by 216

Endothelial cell substrate stiffness influences neutrophil transmigration via myosin light chain kinase-dependent cell contraction

Stroka, K. M., & Aranda-Espinoza, H. (2011) · Blood · doi:10.1182/blood-2010-11-321125 · Cited by 214

Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation

Qiu, Y., Brown, A. C., Myers, D. R., Sakurai, Y., Mannino, R. G., Tran, R., Ahn, B., Hardy, E. T., Kee, M. F., Kumar, S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322917111 · Cited by 213

Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension

Zieman, S. J., Melenovsky, V., Clattenburg, L., Corretti, M. C., Capriotti, A., Gerstenblith, G., & Kass, D. A. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e328013e7dd · Cited by 209

Neutrophil morphology and migration are affected by substrate elasticity

Oakes, P. W., Patel, D. C., Morin, N. A., Zitterbart, D. P., Fabry, B., Reichner, J. S., & Tang, J. X. (2009) · Blood · doi:10.1182/blood-2008-11-191445 · Cited by 208

Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices

Wolfenson, H., Meacci, G., Liu, S., Stachowiak, M. R., Iskratsch, T., Ghassemi, S., Roca-Cusachs, P., O’Shaughnessy, B., Hone, J., & Sheetz, M. P. (2016) · Nature Cell Biology · doi:10.1038/ncb3277 · Cited by 202

Effect of collagen gel stiffness on neurite extension

Willits, R. K., & Skornia, S. L. (2004) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/1568562042459698 · Cited by 201

Statin drugs to reduce breast cancer recurrence and mortality

Beckwitt, C. H., Brufsky, A., Oltvai, Z. N., & Wells, A. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-1066-z · Cited by 197

Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration

Diz-Muñoz, A., Thurley, K., Chintamen, S., Altschuler, S. J., Wu, L. F., Fletcher, D. A., & Weiner, O. D. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002474 · Cited by 187

Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory

Nasrollahi, S., Walter, C., Loza, A. J., Schimizzi, G. V., Longmore, G. D., & Pathak, A. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.09.012 · Cited by 187

Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening

Kothapalli, D., Liu, S.-L., Bae, Y. H., Monslow, J., Xu, T., Hawthorne, E. A., Byfield, F. J., Castagnino, P., Rao, S., Rader, D. J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.018 · Cited by 186

Cell Adhesion as Wetting Transition?

Sackmann, E., & Bruinsma, R. F. (2002) · ChemPhysChem · doi:10.1002/1439-7641(20020315)3:3<262::aid-cphc262>3.0.co;2-u · Cited by 186

The effect of time-dependent deformation of viscoelastic hydrogels on myogenic induction and Rac1 activity in mesenchymal stem cells

Cameron, A. R., Frith, J. E., Gomez, G. A., Yap, A. S., & Cooper-White, J. J. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.023 · Cited by 185

Mechanical phenotype of cancer cells: cell softening and loss of stiffness sensing

Lin, H.-H., Lin, H.-K., Lin, I.-H., Chiou, Y.-W., Chen, H.-W., Liu, C.-Y., Harn, H. I.-C., Chiu, W.-T., Wang, Y.-K., Shen, M.-R., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4173 · Cited by 184

Hydrogel substrate stress-relaxation regulates the spreading and proliferation of mouse myoblasts

Bauer, A., Gu, L., Kwee, B., Li, W. A., Dellacherie, M., Celiz, A. D., & Mooney, D. J. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.08.041 · Cited by 180

Redirecting Valvular Myofibroblasts into Dormant Fibroblasts through Light-mediated Reduction in Substrate Modulus

Wang, H., Haeger, S. M., Kloxin, A. M., Leinwand, L. A., & Anseth, K. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039969 · Cited by 179

Flexible polyacrylamide substrata for the analysis of mechanical interactions at cell-substratum adhesions

Beningo, K. A., Lo, C.-M., & Wang, Y.-L. (2002) · Methods in Cell Biology · doi:10.1016/s0091-679x(02)69021-1 · Cited by 174

Regulation of ATP utilization during metastatic cell migration by collagen architecture

Zanotelli, M. R., Goldblatt, Z. E., Miller, J. P., Bordeleau, F., Li, J., VanderBurgh, J. A., Lampi, M. C., King, M. R., & Reinhart-King, C. A. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-01-0041 · Cited by 174

The motility of normal and cancer cells in response to the combined influence of the substrate rigidity and anisotropic microstructure

Tzvetkova-Chevolleau, T., Stéphanou, A., Fuard, D., Ohayon, J., Schiavone, P., & Tracqui, P. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.12.016 · Cited by 172

Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area

Wong, S., Guo, W.-H., & Wang, Y.-L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412285111 · Cited by 167

Cooperative Effects of Matrix Stiffness and Fluid Shear Stress on Endothelial Cell Behavior

Kohn, J. C., Zhou, D. W., Bordeleau, F., Zhou, A. L., Mason, B. N., Mitchell, M. J., King, M. R., & Reinhart‐King, C. A. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2014.12.023 · Cited by 159

Self-Organized Podosomes Are Dynamic Mechanosensors

Collin, O., Na, S., Chowdhury, F., Hong, M., Shin, M. E., Wang, F., & Wang, N. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.046 · Cited by 154

Active epithelial Hippo signaling in idiopathic pulmonary fibrosis

Gokey, J. J., Sridharan, A., Xu, Y. J., Green, J., Carraro, G., Stripp, B. R., Perl, A. T., & Whitsett, J. A. (2018) · JCI Insight · doi:10.1172/jci.insight.98738 · Cited by 154

Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion

Yahalom-Ronen, Y., Rajchman, D., Sarig, R., Geiger, B., & Tzahor, E. (2015) · eLife · doi:10.7554/elife.07455 · Cited by 151

Mechanosensitivity of astrocytes on optimized polyacrylamide gels analyzed by quantitative morphometry

Moshayedi, P., Costa, L. D. F., Christ, A., Lacour, S. P., Fawcett, J. W., Guck, J. R., & Franze, K. (2010) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/22/19/194114 · Cited by 149

Chemical and Mechanical Requirements for Fibroblast Adhesion

Maroudas, N. G. (1973) · Nature · doi:10.1038/244353a0 · Cited by 143

Membrane tension regulates motility by controlling lamellipodium organization

Batchelder, E. L., Hollopeter, G., Campillo, C. C., Mezanges, X., Jørgensen, E. M., Nassoy, P., Sens, P., & Plastino, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010481108 · Cited by 141

LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

Infante, E., Castagnino, A., Ferrari, R., Monteiro, P., Agüera‐González, S., Paul‐Gilloteaux, P., Domingues, M. J., Maiuri, P., Raab, M., Shanahan, C. M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04865-7 · Cited by 140

Sensitivity of alveolar macrophages to substrate mechanical and adhesive properties

Féréol, S., Fodil, R., Labat, B., Galiacy, S., Laurent, V. M., Louis, B., Isabey, D., & Planus, E. (2006) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20130 · Cited by 139

Extracellular matrix stiffness causes systematic variations in proliferation and chemosensitivity in myeloid leukemias

Shin, J., & Mooney, D. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611338113 · Cited by 138

Absence of Filamin A Prevents Cells from Responding to Stiffness Gradients on Gels Coated with Collagen but not Fibronectin

Byfield, F. J., Wen, Q., Levental, I., Nordstrom, K., Arratia, P. E., Miller, R. T., & Janmey, P. A. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.03.046 · Cited by 133

Membrane tension controls adhesion positioning at the leading edge of cells

Pontes, B., Monzo, P., Golé, L., Roux, A. L., Kosmalska, A. J., Tam, Z. Y., Luo, W., Kan, S., Viasnoff, V., Roca‐Cusachs, P., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201611117 · Cited by 133

Cardiac myocyte remodeling mediated by N-cadherin-dependent mechanosensing

Chopra, A., Tabdanov, E. D., Patel, H., Janmey, P. A., & Kresh, J. Y. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00515.2010 · Cited by 132

Substrate Stiffness Regulates Cellular Uptake of Nanoparticles

Huang, C., Butler, P. J., Tong, S., Muddana, H. S., Bao, G., & Zhang, S. (2013) · Nano Letters · doi:10.1021/nl400033h · Cited by 131

Actomyosin Cortical Mechanical Properties in Nonadherent Cells Determined by Atomic Force Microscopy

Cartagena‐Rivera, A. X., Logue, J. S., Waterman, C. M., & Chadwick, R. S. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2016.04.034 · Cited by 130

Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells

Morris, B., Burkel, B. M., Ponik, S. M., Fan, J., Condeelis, J. S., Aguirre‐Ghiso, J. A., Castracane, J., Denu, J. M., & Keely, P. J. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.10.012 · Cited by 128

Local VE-cadherin mechanotransduction triggers long-ranged remodeling of endothelial monolayers

Barry, A. K., Wang, N., & Leckband, D. E. (2015) · Journal of Cell Science · doi:10.1242/jcs.159954 · Cited by 127

Augmentation of integrin-mediated mechanotransduction by hyaluronic acid

Chopra, A., Murray, M. E., Byfield, F. J., Mendez, M. G., Halleluyan, R., Restle, D. J., Aroush, D. R.-B., Galie, P. A., Pogoda, K., Bucki, R., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.066 · Cited by 121

Engineering hydrogel viscoelasticity

Cacopardo, L., Guazzelli, N., Nossa, R., Mattei, G., & Ahluwalia, A. D. (2018) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2018.09.031 · Cited by 121

Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells

Haage, A., & Schneider, I. C. (2014) · The FASEB Journal · doi:10.1096/fj.13-245613 · Cited by 118

Tensional Homeostasis in Single Fibroblasts

Webster, K. D., Ng, W. P., & Fletcher, D. A. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.04.051 · Cited by 117

Filamin A Is Essential for Active Cell Stiffening but not Passive Stiffening under External Force

Kasza, K. E., Nakamura, F., Hu, S., Kollmannsberger, P., Bonakdar, N., Fabry, B., Stossel, T. P., Wang, N., & Weitz, D. A. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.02.035 · Cited by 115

Extracellular fluid viscosity enhances liver cancer cell mechanosensing and migration

Gonzalez‐Molina, J., Zhang, X., Borghesan, M., da Silva, J. M., Awan, M., Fuller, B. J., Gavara, N., & Selden, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.058 · Cited by 115

AMPK negatively regulates tensin-dependent integrin activity

Georgiadou, M., Lilja, J., Jacquemet, G., Guzmán, C., Rafaeva, M., Alibert, C., Yan, Y., Sahgal, P., Lerche, M., Manneville, J.-B., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201609066 · Cited by 109

TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts

Noguchi, S. F., Saito, A., Mikami, Y., Urushiyama, H., Horie, M., Matsuzaki, H., Takeshima, H., Makita, K., Miyashita, N., Mitani, A., et al. (2017) · Scientific Reports · doi:10.1038/srep42595 · Cited by 109

RPTPα is required for rigidity-dependent inhibition of extension and differentiation of hippocampal neurons

Kostić, A., Sap, J., & Sheetz, M. P. (2007) · Journal of Cell Science · doi:10.1242/jcs.009852 · Cited by 107

Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression

Okamoto, T., Takagi, Y., Kawamoto, E., Park, E. J., Usuda, H., Wada, K., & Shimaoka, M. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.04.005 · Cited by 106

Modulus-dependent macrophage adhesion and behavior

Irwin, E. F., Saha, K., Rosenbluth, M., Gamble, L. J., Castner, D. G., & Healy, K. E. (2008) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856208786052407 · Cited by 105

The role of FAK in tumor metabolism and therapy

Zhang, J., & Hochwald, S. N. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.12.003 · Cited by 104

Mechanical Force Affects Expression of an In Vitro Metastasis-Like Phenotype in HCT-8 Cells

Tang, X., Kuhlenschmidt, T. B., Zhou, J., Bell, P., Wang, F., Kuhlenschmidt, M. S., & Saif, T. A. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.08.034 · Cited by 104

Phenotypic Analysis of Stromal Vascular Fraction after Mechanical Shear Reveals Stress-Induced Progenitor Populations

Banyard, D. A., Sarantopoulos, C. N., Borovikova, A. A., Qiu, X., Wirth, G. A., Paydar, K. Z., Haun, J. B., Evans, G. R. D., & Widgerow, A. D. (2016) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000002356 · Cited by 101

Substrate Viscosity Enhances Correlation in Epithelial Sheet Movement

Murrell, M. P., Kamm, R. D., & Matsudaira, P. T. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.05.048 · Cited by 99

Ras Induces Anchorage-Independent Growth by Subverting Multiple Adhesion-Regulated Cell Cycle Events

Kang, J., & Krauss, R. S. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3370 · Cited by 96

Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity

Eguiluz, R. C. A., Kaylan, K. B., Underhill, G. H., & Leckband, D. E. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.010 · Cited by 96

Mechanosensitivity of Cancer Cells in Contact with Soft Substrates Using AFM

Abidine, Y., Constantinescu, A., Laurent, V. M., Rajan, V. S., Michel, R., Laplaud, V., Duperray, A., & Claude Verdier, A. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2018.01.005 · Cited by 95

Cellular Dynamics

Weiss, P. A. (1959) · Reviews of Modern Physics · doi:10.1103/revmodphys.31.11 · Cited by 95

Cell tension and mechanical regulation of cell volume

Gonzalez, N. P., Tao, J., Rochman, N. D., Vig, D., Chiu, E., Wirtz, D., & Sun, S. X. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-04-0213 · Cited by 93

Force is a signal that cells cannot ignore

Yusko, E., & Asbury, C. L. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-12-0707 · Cited by 92

Controlling Cellular Volume via Mechanical and Physical Properties of Substrate

Xie, K., Yang, Y., & Jiang, H. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2017.11.3785 · Cited by 92

Cellular Volume and Matrix Stiffness Direct Stem Cell Behavior in a 3D Microniche

Bao, M., Xie, J., Katoele, N., Hu, X., Wang, B., Piruska, A., & Huck, W. T. S. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b19396 · Cited by 91

Enhanced neurite growth from mammalian neurons in three-dimensional salmon fibrin gels

Ju, Y.-E., Janmey, P. A., McCormick, M. E., Sawyer, E. S., & Flanagan, L. A. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.01.008 · Cited by 88

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts

Nobis, M., Herrmann, D., Warren, S. C., Kadir, S. R., Leung, W., Killen, M. J., Magenau, A., Stevenson, D., Lucas, M. C., Reischmann, N., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.022 · Cited by 88

Matrix-driven Myosin II Mediates the Pro-fibrotic Fibroblast Phenotype

Southern, B. D., Grove, L. M., Rahaman, S. O., Abraham, S., Scheraga, R. G., Niese, K. A., Sun, H., Herzog, E. L., Liu, F., Tschumperlin, D. J., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.712380 · Cited by 86

Soft Substrates Containing Hyaluronan Mimic the Effects of Increased Stiffness on Morphology, Motility, and Proliferation of Glioma Cells

Pogoda, K., Bucki, R., Byfield, F. J., Cruz, K., Lee, T., Marcinkiewicz, C., & Janmey, P. A. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00324 · Cited by 86

Matrix stiffness regulates vascular integrity through focal adhesion kinase activity

Wang, W., Lollis, E. M., Bordeleau, F., & Reinhart‐King, C. A. (2018) · The FASEB Journal · doi:10.1096/fj.201800841r · Cited by 85

Cells as liquid motors: Mechanosensitivity emerges from collective dynamics of actomyosin cortex

Etienne, J., Fouchard, J., Mitrossilis, D., Bufi, N., Durand-Smet, P., & Asnacios, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417113112 · Cited by 84

Reprogramming cardiomyocyte mechanosensing by crosstalk between integrins and hyaluronic acid receptors

Chopra, A., Lin, V., McCollough, A., Atzet, S. K., Prestwich, G. D., Wechsler, A. S., Murray, M. E., Oake, S. A., Kresh, J. Y., & Janmey, P. A. (2011) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2011.11.023 · Cited by 83

The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to-Mesenchymal Transition of Aortic Valve Endothelial Cells

Zhong, A., Mirzaei, Z., & Simmons, C. A. (2018) · Cardiovascular Engineering and Technology · doi:10.1007/s13239-018-0363-0 · Cited by 83

Behavior of cells at fluid interfaces.

Giæver, I., & Keese, C. R. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.1.219 · Cited by 82

Effect of Dynamic Stiffness of the Substrates on Neurite Outgrowth by Using a DNA-Crosslinked Hydrogel

Jiang, F. X., Yurke, B., Schloss, R. S., Firestein, B. L., & Langrana, N. A. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0574 · Cited by 81

TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression

Jorgenson, A. J., Choi, K. M., Sicard, D., Smith, K. M. J., Hiemer, S. E., Varelas, X., & Tschumperlin, D. J. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00205.2016 · Cited by 81

The role of extracellular matrix stiffness in megakaryocyte and platelet development and function

Leiva, O., Léon, C., Ng, S. K., Mangin, P., Gachet, C., & Ravid, K. (2017) · American Journal of Hematology · doi:10.1002/ajh.25008 · Cited by 80

Stiffness of hyaluronic acid gels containing liver extracellular matrix supports human hepatocyte function and alters cell morphology

Deegan, D. B., Zimmerman, C., Skardal, A., Atala, A., & Shupe, T. D. (2016) · Journal of the Mechanical Behavior of Biomedical Materials · doi:10.1016/j.jmbbm.2015.10.016 · Cited by 79

The relationship between fibroblast growth and the dynamic stiffnesses of a DNA crosslinked hydrogel

Jiang, F. X., Yurke, B., Schloss, R. S., Firestein, B. L., & Langrana, N. A. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.050 · Cited by 77

Mechanosensing of substrate thickness

Lin, Y.-C., Tambe, D. T., Park, C. Y., Wasserman, M. R., Trepat, X., Krishnan, R., Lenormand, G., Fredberg, J. J., & Butler, J. P. (2010) · Physical Review E · doi:10.1103/physreve.82.041918 · Cited by 77

The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis

Seo, E., Kim, W., Hur, J., Kim, H., Nam, S. A., Choi, A., Kim, Y., Park, S. H., Chung, C., Kim, J., et al. (2016) · Scientific Reports · doi:10.1038/srep31931 · Cited by 77

Active Biochemical Regulation of Cell Volume and a Simple Model of Cell Tension Response

Tao, J., & Sun, S. X. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.08.025 · Cited by 76

Initial Fiber Alignment Pattern Alters Extracellular Matrix Synthesis in Fibroblast-Populated Fibrin Gel Cruciforms and Correlates with Predicted Tension

Sander, E. A., Barocas, V. H., & Tranquillo, R. T. (2010) · Annals of Biomedical Engineering · doi:10.1007/s10439-010-0192-2 · Cited by 75

Liposome adhesion generates traction stress

Murrell, M. P., Voituriez, R., Joanny, J., Nassoy, P., Sykes, C., & Gardel, M. L. (2014) · Nature Physics · doi:10.1038/nphys2855 · Cited by 74

Extracellular matrix rigidity controls podosome induction in microvascular endothelial cells

Juin, A., Planus, E., Guillemot, F., Horakova, P., Albigès‐Rizo, C., Genot, E. M., Rosenbaum, J., Moreau, V., & Saltel, F. (2012) · Biology of the Cell · doi:10.1111/boc.201200037 · Cited by 72

The Effect of Substrate Stiffness on Cardiomyocyte Action Potentials

Boothe, S. D., Myers, J. D., Pok, S., Sun, J., Xi, Y. T., Nieto, R., Cheng, J., & Jacot, J. G. (2016) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-016-0758-1 · Cited by 72

Application of multiple levels of fluid shear stress to endothelial cells plated on polyacrylamide gels

Galie, P. A., van Oosten, A., Chen, C. S., & Janmey, P. A. (2015) · Lab on a Chip · doi:10.1039/c4lc01236d · Cited by 69

Soft Hyaluronic Gels Promote Cell Spreading, Stress Fibers, Focal Adhesion, and Membrane Tension by Phosphoinositide Signaling, Not Traction Force

Mandal, K., Aroush, D. R.-B., Graber, Z. T., Wu, B., Park, C. Y., Fredberg, J., Guo, W., Baumgart, T., & Janmey, P. A. (2018) · ACS Nano · doi:10.1021/acsnano.8b05286 · Cited by 68

Bi-Directional Signaling: Extracellular Matrix and Integrin Regulation of Breast Tumor Progression

Gehler, S., Ponik, S. M., Riching, K. M., & Keely, P. J. (2013) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.2013006647 · Cited by 67

Toll-like receptor signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled-coil kinase (ROCK1/2)

Gruber, E. J., Heyward, C., Cameron, J. L., & Leifer, C. A. (2018) · International Immunology · doi:10.1093/intimm/dxy027 · Cited by 67

Fluorescence eXclusion Measurement of volume in live cells

Cadart, C., Zlotek-Zlotkiewicz, E., Venkova, L. S., Thouvenin, O., Racine, V., Berre, M. L., Monnier, S., & Piel, M. (2016) · Methods in cell biology · doi:10.1016/bs.mcb.2016.11.009 · Cited by 65

The effect of substrate modulus on the growth and function of matrix-embedded endothelial cells

Murikipudi, S., Methe, H., & Edelman, E. R. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.09.079 · Cited by 63

Elastic properties of epithelial cells probed by atomic force microscopy

Brückner, B. R., & Janshoff, A. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.07.010 · Cited by 62

Neurite extension and neuronal differentiation of human induced pluripotent stem cell derived neural stem cells on polyethylene glycol hydrogels containing a continuous Young's Modulus gradient

Mosley, M. C., Lim, H. J., Chen, J., Yang, Y.-H. K., Li, S., Liu, Y., & Callahan, L. A. S. (2016) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35955 · Cited by 62

Stiff Substrates Increase Inflammation-Induced Endothelial Monolayer Tension and Permeability

Urbano, R. L., Furia, C. M., Basehore, S. E., & Clyne, A. M. (2017) · Biophysical Journal · doi:10.1016/j.bpj.2017.06.033 · Cited by 60

Glial Tissue Mechanics and Mechanosensing by Glial Cells

Pogoda, K., & Janmey, P. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00025 · Cited by 60

Basement membrane stiffening promotes retinal endothelial activation associated with diabetes

Yang, X. Q., Scott, H. A., Monickaraj, F., Xu, J. C., Ardekani, S., Nitta, C. F., Cabrera, A. P., McGuire, P. G., Mohideen, U., Das, A., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-277962 · Cited by 57

Cellular mechanoadaptation to substrate mechanical properties: contributions of substrate stiffness and thickness to cell stiffness measurements using AFM

Vichare, S., Sen, S., & Inamdar, M. M. (2013) · Soft Matter · doi:10.1039/c3sm51786a · Cited by 54

Dynamic measurement of the height and volume of migrating cells by a novel fluorescence microscopy technique

Bottier, C., Gabella, C., Vianay, B., Buscemi, L., Sbalzarini, I. F., Meister, J.-J., & Verkhovsky, A. B. (2011) · Lab on a Chip · doi:10.1039/c1lc20807a · Cited by 54

The influence of matrix elasticity on chondrocyte behavior in 3D

Schuh, E., Hofmann, S., Stok, K. S., Notbohm, H., Müller, R., & Rotter, N. (2011) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.501 · Cited by 52

Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B

Fung, J., Lai, C., Seto, W., Wong, D. K.-H., & Yuen, M. (2010) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2010.01355.x · Cited by 52

Substrate mechanics and cell spreading*1

Keese, C. R. (1991) · Experimental Cell Research · doi:10.1016/0014-4827(91)90406-k · Cited by 52

Efficacy of Simvastatin Treatment of Valvular Interstitial Cells Varies With the Extracellular Environment

Monzack, E. L., Gu, X., & Masters, K. S. B. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179218 · Cited by 52

Embryonic Stem Cells Do Not Stiffen on Rigid Substrates

Poh, Y., Chowdhury, F., Tanaka, T. S., & Wang, N. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.04.057 · Cited by 51

Substrate stiffness-modulated registry phase correlations in cardiomyocytes map structural order to coherent beating

Dasbiswas, K., Majkut, S. J., Discher, D., & Safran, S. (2015) · Nature Communications · doi:10.1038/ncomms7085 · Cited by 51

Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption

Lampi, M. C., Faber, C. J., Huynh, J., Bordeleau, F., Zanotelli, M. R., & Reinhart‐King, C. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147033 · Cited by 48

Concise total synthesis of glucosepane

Draghici, C., Wang, T., & Spiegel, D. A. (2015) · Science · doi:10.1126/science.aac9655 · Cited by 46

Substrate Stiffness Combined with Hepatocyte Growth Factor Modulates Endothelial Cell Behavior

Chang, H., Liu, X., Hu, M., Zhang, H., Li, B., Ren, K., Boudou, T., Albigès‐Rizo, C., Picart, C., & Ji, J. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b00318 · Cited by 46

Endothelial directed collective migration depends on substrate stiffness via localized myosin contractility and cell-matrix interactions

Canver, A. C., Ngo, O., Urbano, R. L., & Clyne, A. M. (2015) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2015.12.037 · Cited by 43

Substrate stiffness‐dependent exacerbation of endothelial permeability and inflammation: mechanisms and potential implications in ALI and PH (2017 Grover Conference Series)

Karki, P., & Birukova, A. A. (2018) · Pulmonary Circulation · doi:10.1177/2045894018773044 · Cited by 40

Effects of extracellular matrix viscoelasticity on cellular behaviour

Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020) · Nature · doi:10.1038/s41586-020-2612-2 · Cited by 2,224

Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction

Noskovicova, N., Hinz, B., & Pakshir, P. (2021) · Cells · doi:10.3390/cells10071794 · Cited by 184

The extracellular matrix viscoelasticity as a regulator of cell and tissue dynamics

Elosegui-Artola, A. (2021) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2021.04.002 · Cited by 170

Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells

Mierke, C. T. (2024) · Cells · doi:10.3390/cells13010096 · Cited by 146

Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation

Luo, P., Huang, R., Wu, Y., Liu, X., Shan, Z., Gong, L., Deng, S., Liu, H., Fang, J., Wu, S., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.05.011 · Cited by 36