Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216

Initial sequencing and comparative analysis of the mouse genome

Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187

High-Resolution Profiling of Histone Methylations in the Human Genome

Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361

Human DNA methylomes at base resolution show widespread epigenomic differences

Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., & Honjo, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00078-7 · Cited by 3,474

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Nan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., & Bird, A. (1998) · Nature · doi:10.1038/30764 · Cited by 3,440

Epigenetic Reprogramming in Mammalian Development

Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078

DNA methylation landscapes: Provocative insights from epigenomics

Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039

Perceptions of epigenetics

Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

He, Y.-F., Li, B.-Z., Li, Z., Liu, P., Wang, Y., Tang, Q., Ding, J., Jia, Y., Chen, Z., Li, L., et al. (2011) · Science · doi:10.1126/science.1210944 · Cited by 2,770

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,730

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700

Highly Integrated Single-Base Resolution Maps of the Epigenome in Arabidopsis

Lister, R., O'Malley, R. C., Tonti-Filippini, J., Gregory, B. D., Berry, C. C., Millar, A. H., & Ecker, J. R. (2008) · Cell · doi:10.1016/j.cell.2008.03.029 · Cited by 2,418

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Ito, S., D’Alessio, A. C., Taranova, O. V., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,373

Linking DNA methylation and histone modification: patterns and paradigms

Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267 · cited 1×

Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning

Cokus, S. J., Feng, S., Zhang, X., Chen, Z., Merriman, B., Haudenschild, C. D., Pradhan, S., Nelson, S. F., Pellegrini, M., & Jacobsen, S. E. (2008) · Nature · doi:10.1038/nature06745 · Cited by 2,256

Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

Weber, M., Hellmann, I., Stadler, M. B., Ramos, L., Pääbo, S., Rebhan, M., & Schübeler, D. (2007) · Nature Genetics · doi:10.1038/ng1990 · Cited by 2,221

The Polycomb group protein EZH2 directly controls DNA methylation

Viré, E., Brenner, C., Deplus, R., Blanchon, L., Fraga, M., Didelot, C., Morey, L., Van Eynde, A., Bernard, D., Vanderwinden, J.-M., et al. (2006) · Nature · doi:10.1038/nature04431 · Cited by 2,204

The Mammalian Epigenome

Bernstein, B. E., Meissner, A., & Lander, E. S. (2007) · Cell · doi:10.1016/j.cell.2007.01.033 · Cited by 2,086

A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells

Guenther, M. G., Levine, S. S., Boyer, L. A., Jaenisch, R., & Young, R. A. (2007) · Cell · doi:10.1016/j.cell.2007.05.042 · Cited by 1,944

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

Weber, M., Davies, J. J., Wittig, D., Oakeley, E. J., Haase, M., Lam, W. L., & Schübeler, D. (2005) · Nature Genetics · doi:10.1038/ng1598 · Cited by 1,754

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

Okano, M., Xie, S., & Li, E. (1998) · Nature Genetics · doi:10.1038/890 · Cited by 1,651

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

Revy, P., Muto, T., Levy, Y., Geissmann, F., Plebani, A., Sanal, O., Catalan, N., Forveille, M., Dufourcq-Lagelouse, R., Gennery, A., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00079-9 · Cited by 1,647

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

Ooi, S. K. T., Qiu, C., Bernstein, E., Li, K., Jia, D., Yang, Z., Erdjument-Bromage, H., Tempst, P., Lin, S.-P., Allis, C. D., et al. (2007) · Nature · doi:10.1038/nature05987 · Cited by 1,567

UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells

Bostick, M., Kim, J. K., Estève, P.-O., Clark, A., Pradhan, S., & Jacobsen, S. E. (2007) · Science · doi:10.1126/science.1147939 · Cited by 1,455

Dnmt3L and the Establishment of Maternal Genomic Imprints

Bourc'his, D., Xu, G.-L., Lin, C.-S., Bollman, B., & Bestor, T. H. (2001) · Science · doi:10.1126/science.1065848 · Cited by 1,439

A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters

Saxonov, S., Berg, P., & Brutlag, D. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510310103 · Cited by 1,401

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting

Kaneda, M., Okano, M., Hata, K., Sado, T., Tsujimoto, N., Li, E., & Sasaki, H. (2004) · Nature · doi:10.1038/nature02633 · Cited by 1,387

Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells

Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S., & Saitou, M. (2011) · Cell · doi:10.1016/j.cell.2011.06.052 · Cited by 1,379

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

Guo, J. U., Su, Y., Zhong, C., Ming, G.-L., & Song, H. (2011) · Cell · doi:10.1016/j.cell.2011.03.022 · Cited by 1,360

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.001 · Cited by 1,339

Demethylation of the zygotic paternal genome

Mayer, W., Niveleau, A., Walter, J., Fundele, R., & Haaf, T. (2000) · Nature · doi:10.1038/35000656 · Cited by 1,327

Bmp4 is required for the generation of primordial germ cells in the mouse embryo

Lawson, K. A., Dunn, N. R., Roelen, B. A. J., Zeinstra, L. M., Davis, A. M., Wright, C. V. E., Korving, J. P. W. F. M., & Hogan, B. L. M. (1999) · Genes & Development · doi:10.1101/gad.13.4.424 · Cited by 1,310

The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

Sharif, J., Muto, M., Takebayashi, S.-I., Suetake, I., Iwamatsu, A., Endo, T. A., Shinga, J., Mizutani-Koseki, Y., Toyoda, T., Okamura, K., et al. (2007) · Nature · doi:10.1038/nature06397 · Cited by 1,304

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

Tachibana, M., Sugimoto, K., Nozaki, M., Ueda, J., Ohta, T., Ohki, M., Fukuda, M., Takeda, N., Niida, H., Kato, H., et al. (2002) · Genes & Development · doi:10.1101/gad.989402 · Cited by 1,253

Suv39h-Mediated Histone H3 Lysine 9 Methylation Directs DNA Methylation to Major Satellite Repeats at Pericentric Heterochromatin

Lehnertz, B., Ueda, Y., Derijck, A. A. H. A., Braunschweig, U., Perez-Burgos, L., Kubicek, S., Chen, T., Li, E., Jenuwein, T., & Peters, A. H. F. M. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00432-9 · Cited by 1,245

Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis

Meissner, A. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki901 · Cited by 1,217

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Ko, M., Huang, Y., Jankowska, A. M., Pape, U. J., Tahiliani, M., Bandukwala, H. S., An, J., Lamperti, E. D., Koh, K. P., Ganetzky, R., et al. (2010) · Nature · doi:10.1038/nature09586 · Cited by 1,213

Dynamic Reprogramming of DNA Methylation in the Early Mouse Embryo

Santos, F., Hendrich, B., Reik, W., & Dean, W. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0501 · Cited by 1,212

Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L

Bourc'his, D., & Bestor, T. H. (2004) · Nature · doi:10.1038/nature02886 · Cited by 1,207

Epigenetic reprogramming in mouse primordial germ cells

Hajkova, P., Erhardt, S., Lane, N., Haaf, T., El-Maarri, O., Reik, W., Walter, J., & Surani, M. A. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00181-8 · Cited by 1,191

Methylation of tRNA Asp by the DNA Methyltransferase Homolog Dnmt2

Goll, M. G., Kirpekar, F., Maggert, K. A., Yoder, J. A., Hsieh, C.-L., Zhang, X., Golic, K. G., Jacobsen, S. E., & Bestor, T. H. (2006) · Science · doi:10.1126/science.1120976 · Cited by 1,190

Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells

Muramatsu, M., Sankaranand, V. S., Anant, S., Sugai, M., Kinoshita, K., Davidson, N. O., & Honjo, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18470 · Cited by 1,176

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

Gu, T.-P., Guo, F., Yang, H., Wu, H.-P., Xu, G.-F., Liu, W., Xie, Z.-G., Shi, L., He, X., Jin, S.-G., et al. (2011) · Nature · doi:10.1038/nature10443 · Cited by 1,139

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

Ficz, G., Branco, M. R., Seisenberger, S., Santos, F., Krueger, F., Hore, T. A., Marques, C. J., Andrews, S., & Reik, W. (2011) · Nature · doi:10.1038/nature10008 · Cited by 1,133

Molecular Mechanisms of Antibody Somatic Hypermutation

Di Noia, J. M., & Neuberger, M. S. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.061705.090740 · Cited by 1,106

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

Monk, M., Boubelik, M., & Lehnert, S. (1987) · Development · doi:10.1242/dev.99.3.371 · Cited by 1,094

Role of transposable elements in heterochromatin and epigenetic control

Lippman, Z., Gendrel, A.-V., Black, M., Vaughn, M. W., Dedhia, N., Richard McCombie, W., Lavine, K., Mittal, V., May, B., Kasschau, K. D., et al. (2004) · Nature · doi:10.1038/nature02651 · Cited by 1,065

Blimp1 is a critical determinant of the germ cell lineage in mice

Ohinata, Y., Payer, B., O'Carroll, D., Ancelin, K., Ono, Y., Sano, M., Barton, S. C., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., et al. (2005) · Nature · doi:10.1038/nature03813 · Cited by 1,046

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

Hata, K., Okano, M., Lei, H., & Li, E. (2002) · Development · doi:10.1242/dev.129.8.1983 · Cited by 1,039

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J., & Helin, K. (2011) · Nature · doi:10.1038/nature10066 · Cited by 1,021

Primordial germ cells in the mouse embryo during gastrulation

Ginsburg, M., Snow, M. H. L., & McLaren, A. (1990) · Development · doi:10.1242/dev.110.2.521 · Cited by 1,004

Active demethylation of the paternal genome in the mouse zygote

Oswald, J., Engemann, S., Lane, N., Mayer, W., Olek, A., Fundele, R., Dean, W., Reik, W., & Walter, J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00448-6 · Cited by 981

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a

Ramsahoye, B. H., Biniszkiewicz, D., Lyko, F., Clark, V., Bird, A. P., & Jaenisch, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5237 · Cited by 970

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

Quivoron, C., Couronné, L., Della Valle, V., Lopez, C. K., Plo, I., Wagner-Ballon, O., Do Cruzeiro, M., Delhommeau, F., Arnulf, B., Stern, M.-H., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.003 · Cited by 924

Neuronal Activity–Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

Ma, D. K., Jang, M.-H., Guo, J. U., Kitabatake, Y., Chang, M.-L., Pow-anpongkul, N., Flavell, R. A., Lu, B., Ming, G.-L., & Song, H. (2009) · Science · doi:10.1126/science.1166859 · Cited by 924

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

Mohn, F., Weber, M., Rebhan, M., Roloff, T. C., Richter, J., Stadler, M. B., Bibel, M., & Schübeler, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.007 · Cited by 917

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

Bestor, T., Laudano, A., Mattaliano, R., & Ingram, V. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90122-2 · Cited by 913

Molecular Signals of Epigenetic States

Bonasio, R., Tu, S., & Reinberg, D. (2010) · Science · doi:10.1126/science.1191078 · Cited by 912

A molecular programme for the specification of germ cell fate in mice

Saitou, M., Barton, S. C., & Surani, M. A. (2002) · Nature · doi:10.1038/nature00927 · Cited by 893

Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency

Popp, C., Dean, W., Feng, S., Cokus, S. J., Andrews, S., Pellegrini, M., Jacobsen, S. E., & Reik, W. (2010) · Nature · doi:10.1038/nature08829 · Cited by 860

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

Tachibana, M., Ueda, J., Fukuda, M., Takeda, N., Ohta, T., Iwanari, H., Sakihama, T., Kodama, T., Hamakubo, T., & Shinkai, Y. (2005) · Genes & Development · doi:10.1101/gad.1284005 · Cited by 845

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

Lei, H., Oh, S. P., Okano, M., Jüttermann, R., Goss, K. A., Jaenisch, R., & Li, E. (1996) · Development · doi:10.1242/dev.122.10.3195 · Cited by 816

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

Cortellino, S., Xu, J., Sannai, M., Moore, R., Caretti, E., Cigliano, A., Le Coz, M., Devarajan, K., Wessels, A., Soprano, D., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.020 · Cited by 809

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

Pastor, W. A., Pape, U. J., Huang, Y., Henderson, H. R., Lister, R., Ko, M., McLoughlin, E. M., Brudno, Y., Mahapatra, S., Kapranov, P., et al. (2011) · Nature · doi:10.1038/nature10102 · Cited by 804

Mutagenic deamination of cytosine residues in DNA

Duncan, B. K., & Miller, J. H. (1980) · Nature · doi:10.1038/287560a0 · Cited by 792

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

Wossidlo, M., Nakamura, T., Lepikhov, K., Marques, C. J., Zakhartchenko, V., Boiani, M., Arand, J., Nakano, T., Reik, W., & Walter, J. (2011) · Nature Communications · doi:10.1038/ncomms1240 · Cited by 792

Nuclear reprogramming to a pluripotent state by three approaches

Yamanaka, S., & Blau, H. M. (2010) · Nature · doi:10.1038/nature09229 · Cited by 776

Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

Koh, K. P., Yabuuchi, A., Rao, S., Huang, Y., Cunniff, K., Nardone, J., Laiho, A., Tahiliani, M., Sommer, C. A., Mostoslavsky, G., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.01.008 · Cited by 776

The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase

Fuks, F. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg332 · Cited by 760

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation

Barreto, G., Schäfer, A., Marhold, J., Stach, D., Swaminathan, S. K., Handa, V., Döderlein, G., Maltry, N., Wu, W., Lyko, F., et al. (2007) · Nature · doi:10.1038/nature05515 · Cited by 758

Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)

Valinluck, V. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh739 · Cited by 756

Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b

Chen, T., Ueda, Y., Dodge, J. E., Wang, Z., & Li, E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5594-5605.2003 · Cited by 751

Active DNA Demethylation Mediated by DNA Glycosylases

Zhu, J.-K. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134205 · Cited by 745

Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.

Kafri, T., Ariel, M., Brandeis, M., Shemer, R., Urven, L., McCarrey, J., Cedar, H., & Razin, A. (1992) · Genes & Development · doi:10.1101/gad.6.5.705 · Cited by 736

Whole-Genome Analysis of Histone H3 Lysine 4 and Lysine 27 Methylation in Human Embryonic Stem Cells

Pan, G., Tian, S., Nie, J., Yang, C., Ruotti, V., Wei, H., Jonsdottir, G. A., Stewart, R., & Thomson, J. A. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.003 · Cited by 711

Dynamic CpG island methylation landscape in oocytes and preimplantation embryos

Smallwood, S. A., Tomizawa, S.-I., Krueger, F., Ruf, N., Carli, N., Segonds-Pichon, A., Sato, S., Hata, K., Andrews, S. R., & Kelsey, G. (2011) · Nature Genetics · doi:10.1038/ng.864 · Cited by 699

Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

Hanna, J. H., Saha, K., & Jaenisch, R. (2010) · Cell · doi:10.1016/j.cell.2010.10.008 · Cited by 698

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

Iqbal, K., Jin, S.-G., Pfeifer, G. P., & Szabó, P. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014033108 · Cited by 692

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

Bransteitter, R., Pham, P., Scharff, M. D., & Goodman, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730835100 · Cited by 680

Acquired mutations in TET2 are common in myelodysplastic syndromes

Langemeijer, S. M. C., Kuiper, R. P., Berends, M., Knops, R., Aslanyan, M. G., Massop, M., Stevens-Linders, E., van Hoogen, P., van Kessel, A. G., Raymakers, R. A. P., et al. (2009) · Nature Genetics · doi:10.1038/ng.391 · Cited by 680

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

Bhutani, N., Brady, J. J., Damian, M., Sacco, A., Corbel, S. Y., & Blau, H. M. (2010) · Nature · doi:10.1038/nature08752 · Cited by 676

Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse

Lane, N., Dean, W., Erhardt, S., Hajkova, P., Surani, A., Walter, J., & Reik, W. (2003) · genesis · doi:10.1002/gene.10168 · Cited by 667

Chromatin dynamics during epigenetic reprogramming in the mouse germ line

Hajkova, P., Ancelin, K., Waldmann, T., Lacoste, N., Lange, U. C., Cesari, F., Lee, C., Almouzni, G., Schneider, R., & Surani, M. A. (2008) · Nature · doi:10.1038/nature06714 · Cited by 664

Genetic and Epigenetic Regulators of Pluripotency

Surani, M. A., Hayashi, K., & Hajkova, P. (2007) · Cell · doi:10.1016/j.cell.2007.02.010 · Cited by 658

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

Rai, K., Huggins, I. J., James, S. R., Karpf, A. R., Jones, D. A., & Cairns, B. R. (2008) · Cell · doi:10.1016/j.cell.2008.11.042 · Cited by 657

Genome-Wide Demethylation of Arabidopsis Endosperm

Hsieh, T.-F., Ibarra, C. A., Silva, P., Zemach, A., Eshed-Williams, L., Fischer, R. L., & Zilberman, D. (2009) · Science · doi:10.1126/science.1172417 · Cited by 650

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

Down, T. A., Rakyan, V. K., Turner, D. J., Flicek, P., Li, H., Kulesha, E., Gräf, S., Johnson, N., Herrero, J., Tomazou, E. M., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1414 · Cited by 648

Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells

Wu, H., D’Alessio, A. C., Ito, S., Xia, K., Wang, Z., Cui, K., Zhao, K., Eve Sun, Y., & Zhang, Y. (2011) · Nature · doi:10.1038/nature09934 · Cited by 646

Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells

Xu, Y., Wu, F., Tan, L., Kong, L., Xiong, L., Deng, J., Barbera, A. J., Zheng, L., Zhang, H., Huang, S., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.005 · Cited by 632

Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse

Rossant, J., & Tam, P. P. L. (2009) · Development · doi:10.1242/dev.017178 · Cited by 631

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

Thomson, J. P., Skene, P. J., Selfridge, J., Clouaire, T., Guy, J., Webb, S., Kerr, A. R. W., Deaton, A., Andrews, R., James, K. D., et al. (2010) · Nature · doi:10.1038/nature08924 · Cited by 625

Whole-Genome Mapping of Histone H3 Lys4 and 27 Trimethylations Reveals Distinct Genomic Compartments in Human Embryonic Stem Cells

Zhao, X. D., Han, X., Chew, J. L., Liu, J., Chiu, K. P., Choo, A., Orlov, Y. L., Sung, W.-K., Shahab, A., Kuznetsov, V. A., et al. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.004 · Cited by 615

The bases of the nucleic acids of some bacterial and animal viruses: the occurrence of 5-hydroxymethylcytosine

Wyatt, G. R., & Cohen, S. S. (1953) · Biochemical Journal · doi:10.1042/bj0550774 · Cited by 608

Targets and dynamics of promoter DNA methylation during early mouse development

Borgel, J., Guibert, S., Li, Y., Chiba, H., Schübeler, D., Sasaki, H., Forné, T., & Weber, M. (2010) · Nature Genetics · doi:10.1038/ng.708 · Cited by 601

Critical function of Prdm14 for the establishment of the germ cell lineage in mice

Yamaji, M., Seki, Y., Kurimoto, K., Yabuta, Y., Yuasa, M., Shigeta, M., Yamanaka, K., Ohinata, Y., & Saitou, M. (2008) · Nature Genetics · doi:10.1038/ng.186 · Cited by 581

PGC7/Stella protects against DNA demethylation in early embryogenesis

Nakamura, T., Arai, Y., Umehara, H., Masuhara, M., Kimura, T., Taniguchi, H., Sekimoto, T., Ikawa, M., Yoneda, Y., Okabe, M., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1519 · Cited by 580

Extensive Demethylation of Repetitive Elements During Seed Development Underlies Gene Imprinting

Gehring, M., Bubb, K. L., & Henikoff, S. (2009) · Science · doi:10.1126/science.1171609 · Cited by 571

Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements

Liang, G., Chan, M. F., Tomigahara, Y., Tsai, Y. C., Gonzales, F. A., Li, E., Laird, P. W., & Jones, P. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.2.480-491.2002 · Cited by 569

A Signaling Principle for the Specification of the Germ Cell Lineage in Mice

Ohinata, Y., Ohta, H., Shigeta, M., Yamanaka, K., Wakayama, T., & Saitou, M. (2009) · Cell · doi:10.1016/j.cell.2009.03.014 · Cited by 555

Proliferation and migration of primordial germ cells during compensatory growth in mouse embryos

Tam, P. P. L., & Snow, M. H. L. (1981) · Development · doi:10.1242/dev.64.1.133 · Cited by 550

The AID/APOBEC family of nucleic acid mutators

Conticello, S. G. (2008) · Genome Biology · doi:10.1186/gb-2008-9-6-229 · Cited by 546

Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice

Seki, Y., Hayashi, K., Itoh, K., Mizugaki, M., Saitou, M., & Matsui, Y. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.11.025 · Cited by 544

Maintenance of self‐renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b

Tsumura, A., Hayakawa, T., Kumaki, Y., Takebayashi, S., Sakaue, M., Matsuoka, C., Shimotohno, K., Ishikawa, F., Li, E., Ueda, H. R., et al. (2006) · Genes to Cells · doi:10.1111/j.1365-2443.2006.00984.x · Cited by 542

Molecular Cloning of an Apolipoprotein B Messenger RNA Editing Protein

Teng, B., Burant, C. F., & Davidson, N. O. (1993) · Science · doi:10.1126/science.8511591 · Cited by 536

Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication

Estève, P.-O., Chin, H. G., Smallwood, A., Feehery, G. R., Gangisetty, O., Karpf, A. R., Carey, M. F., & Pradhan, S. (2006) · Genes & Development · doi:10.1101/gad.1463706 · Cited by 536

X Chromosome Dosage Compensation: How Mammals Keep the Balance

Payer, B., & Lee, J. T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091711 · Cited by 521

Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development

Dawlaty, M. M., Ganz, K., Powell, B. E., Hu, Y.-C., Markoulaki, S., Cheng, A. W., Gao, Q., Kim, J., Choi, S.-W., Page, D. C., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.07.010 · Cited by 508

Endogenous Cytosine Damage Products Alter the Site Selectivity of Human DNA Maintenance Methyltransferase DNMT1

Valinluck, V., & Sowers, L. C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3123 · Cited by 501

Activation-induced Cytidine Deaminase Deaminates 5-Methylcytosine in DNA and Is Expressed in Pluripotent Tissues

Morgan, H. D., Dean, W., Coker, H. A., Reik, W., & Petersen-Mahrt, S. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407695200 · Cited by 493

Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development

Hirasawa, R., Chiba, H., Kaneda, M., Tajima, S., Li, E., Jaenisch, R., & Sasaki, H. (2008) · Genes & Development · doi:10.1101/gad.1667008 · Cited by 489

The Discovery of 5‐Formylcytosine in Embryonic Stem Cell DNA

Pfaffeneder, T., Hackner, B., Truß, M., Münzel, M., Müller, M., Deiml, C. A., Hagemeier, C., & Carell, T. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201103899 · Cited by 483

Maternal control of early mouse development

Li, L., Zheng, P., & Dean, J. (2010) · Development · doi:10.1242/dev.039487 · Cited by 481

Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal

Hemberger, M., Dean, W., & Reik, W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2727 · Cited by 476

Genome-Wide Reprogramming in the Mouse Germ Line Entails the Base Excision Repair Pathway

Hajkova, P., Jeffries, S. J., Lee, C., Miller, N., Jackson, S. P., & Surani, M. A. (2010) · Science · doi:10.1126/science.1187945 · Cited by 473

Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.

Bestor, T. H. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05326.x · Cited by 461

Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice

Seki, Y., Yamaji, M., Yabuta, Y., Sano, M., Shigeta, M., Matsui, Y., Saga, Y., Tachibana, M., Shinkai, Y., & Saitou, M. (2007) · Development · doi:10.1242/dev.005611 · Cited by 460

Comprehensive high-throughput arrays for relative methylation (CHARM)

Irizarry, R. A., Ladd-Acosta, C., Carvalho, B., Wu, H., Brandenburg, S. A., Jeddeloh, J. A., Wen, B., & Feinberg, A. P. (2008) · Genome Research · doi:10.1101/gr.7301508 · Cited by 433

Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA

Szwagierczak, A., Bultmann, S., Schmidt, C. S., Spada, F., & Leonhardt, H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq684 · Cited by 432

G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

Tachibana, M., Matsumura, Y., Fukuda, M., Kimura, H., & Shinkai, Y. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.192 · Cited by 429

Chromosome methylation patterns during mammalian preimplantation development

Rougier, N., Bourc’his, D., Gomes, D. M., Niveleau, A., Plachot, M., Pàldi, A., & Viegas-Péquignot, E. (1998) · Genes & Development · doi:10.1101/gad.12.14.2108 · Cited by 428

Differential H4 acetylation of paternal and maternal chromatin precedes DNA replication and differential transcriptional activity in pronuclei of 1-cell mouse embryos

Adenot, P. G., Mercier, Y., Renard, J.-P., & Thompson, E. M. (1997) · Development · doi:10.1242/dev.124.22.4615 · Cited by 427

Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells

Okano, M. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.11.2536 · Cited by 423

Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells

Lee, J., Inoue, K., Ono, R., Ogonuki, N., Kohda, T., Kaneko-Ishino, T., Ogura, A., & Ishino, F. (2002) · Development · doi:10.1242/dev.129.8.1807 · Cited by 420

Epigenetic reprogramming during early development in mammals

Santos, F., & Dean, W. (2004) · Reproduction · doi:10.1530/rep.1.00221 · Cited by 411

Large-scale structure of genomic methylation patterns

Rollins, R. A., Haghighi, F., Edwards, J. R., Das, R., Zhang, M. Q., Ju, J., & Bestor, T. H. (2006) · Genome Research · doi:10.1101/gr.4362006 · Cited by 389

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

Cortázar, D., Kunz, C., Selfridge, J., Lettieri, T., Saito, Y., MacDougall, E., Wirz, A., Schuermann, D., Jacobs, A. L., Siegrist, F., et al. (2011) · Nature · doi:10.1038/nature09672 · Cited by 387

stella Is a Maternal Effect Gene Required for Normal Early Development in Mice

Payer, B., Saitou, M., Barton, S. C., Thresher, R., Dixon, J. P. C., Zahn, D., Colledge, W. H., Carlton, M. B. L., Nakano, T., & Surani, M. A. (2003) · Current Biology · doi:10.1016/j.cub.2003.11.026 · Cited by 372

The role of DNA methylation in setting up chromatin structure during development

Hashimshony, T., Zhang, J., Keshet, I., Bustin, M., & Cedar, H. (2003) · Nature Genetics · doi:10.1038/ng1158 · Cited by 359

Global Mapping of DNA Methylation in Mouse Promoters Reveals Epigenetic Reprogramming of Pluripotency Genes

Farthing, C. R., Ficz, G., Ng, R. K., Chan, C.-F., Andrews, S., Dean, W., Hemberger, M., & Reik, W. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000116 · Cited by 353

The Histone Methyltransferase SETDB1 and the DNA Methyltransferase DNMT3A Interact Directly and Localize to Promoters Silenced in Cancer Cells

Li, H., Rauch, T., Chen, Z.-X., Szabó, P. E., Riggs, A. D., & Pfeifer, G. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513249200 · Cited by 341

Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice

Kurimoto, K., Yabuta, Y., Ohinata, Y., Shigeta, M., Yamanaka, K., & Saitou, M. (2008) · Genes & Development · doi:10.1101/gad.1649908 · Cited by 341

Functional cooperation between HP1 and DNMT1 mediates gene silencing

Smallwood, A., Estève, P.-O., Pradhan, S., & Carey, M. (2007) · Genes & Development · doi:10.1101/gad.1536807 · Cited by 339

The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse

Vincent, S. D., Dunn, N. R., Sciammas, R., Shapiro-Shalef, M., Davis, M. M., Calame, K., Bikoff, E. K., & Robertson, E. J. (2005) · Development · doi:10.1242/dev.01711 · Cited by 337

Direct estimates of human per nucleotide mutation rates at 20 loci causing mendelian diseases

Kondrashov, A. S. (2003) · Human Mutation · doi:10.1002/humu.10147 · Cited by 336

Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice

Millar, C. B., Guy, J., Sansom, O. J., Selfridge, J., MacDougall, E., Hendrich, B., Keightley, P. D., Bishop, S. M., Clarke, A. R., & Bird, A. (2002) · Science · doi:10.1126/science.1073354 · Cited by 328

Isolation and Initial Characterization of a Novel Zinc Finger Gene, DNMT3L, on 21q22.3, Related to the Cytosine-5- Methyltransferase 3 Gene Family

Aapola, U., Shibuya, K., Scott, H. S., Ollila, J., Vihinen, M., Heino, M., Shintani, A., Kawasaki, K., Minoshima, S., Krohn, K., et al. (2000) · Genomics · doi:10.1006/geno.2000.6168 · Cited by 317

Methylation levels of maternal and paternal genomes during preimplantation development

HOWLETT, S. K., & REIK, W. (1991) · Development · doi:10.1242/dev.113.1.119 · Cited by 313

The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase.

Navaratnam, N., Morrison, J. R., Bhattacharya, S., Patel, D., Funahashi, T., Giannoni, F., Teng, B. B., Davidson, N. O., & Scott, J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36836-x · Cited by 293

Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis

Webster, K. E., O'Bryan, M. K., Fletcher, S., Crewther, P. E., Aapola, U., Craig, J., Harrison, D. K., Aung, H., Phutikanit, N., Lyle, R., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500702102 · Cited by 290

A role for the elongator complex in zygotic paternal genome demethylation

Okada, Y., Yamagata, K., Hong, K., Wakayama, T., & Zhang, Y. (2010) · Nature · doi:10.1038/nature08732 · Cited by 266

Global hypomethylation of the genome in XX embryonic stem cells

Zvetkova, I., Apedaile, A., Ramsahoye, B., Mermoud, J. E., Crompton, L. A., John, R., Feil, R., & Brockdorff, N. (2005) · Nature Genetics · doi:10.1038/ng1663 · Cited by 247

Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes

Wossidlo, M., Arand, J., Sebastiano, V., Lepikhov, K., Boiani, M., Reinhardt, R., Schöler, H., & Walter, J. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.80 · Cited by 244

DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity

Dong, K. B., Maksakova, I. A., Mohn, F., Leung, D., Appanah, R., Lee, S., Yang, H. W., Lam, L. L., Mager, D. L., Schübeler, D., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.193 · Cited by 242

Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes

Tomizawa, S.-I., Kobayashi, H., Watanabe, T., Andrews, S., Hata, K., Kelsey, G., & Sasaki, H. (2011) · Development · doi:10.1242/dev.061416 · Cited by 241

TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation

Cimmino, L., Abdel-Wahab, O., Levine, R. L., & Aifantis, I. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.08.007 · Cited by 234

Evolution of imprinting mechanisms: the battle of the sexes begins in the zygote

Reik, W., & Walter, J. (2001) · Nature Genetics · doi:10.1038/85804 · Cited by 232

McrBC: a multisubunit GTP-dependent restriction endonuclease

Sutherland, E., Coe, L., & Raleigh, E. A. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90925-a · Cited by 223

X Chromosome Reactivation Initiates in Nascent Primordial Germ Cells in Mice

Sugimoto, M., & Abe, K. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030116 · Cited by 214

UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells

Kim, J. K., Estève, P.-O., Jacobsen, S. E., & Pradhan, S. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn961 · Cited by 209

Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells

Meilinger, D., Fellinger, K., Bultmann, S., Rothbauer, U., Bonapace, I. M., Klinkert, W. E. F., Spada, F., & Leonhardt, H. (2009) · EMBO reports · doi:10.1038/embor.2009.201 · Cited by 194

Primordial germ cells

Wylie, C. C. (1980) · Nature · doi:10.1038/283509a0 · Cited by 191

Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain

Frauer, C., Hoffmann, T., Bultmann, S., Casa, V., Cardoso, M. C., Antes, I., & Leonhardt, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021306 · Cited by 180

Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome

Ueda, Y., Okano, M., Williams, C., Chen, T., Georgopoulos, K., & Li, E. (2006) · Development · doi:10.1242/dev.02293 · Cited by 171

The multi-domain protein Np95 connects DNA methylation and histone modification

Rottach, A., Frauer, C., Pichler, G., Bonapace, I. M., Spada, F., & Leonhardt, H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1152 · Cited by 164

Transgenerational epigenetic inheritance in health and disease

Whitelaw, N. C., & Whitelaw, E. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.07.001 · Cited by 164

Genome-Wide Profiling of DNA Methylation Reveals Transposon Targets of CHROMOMETHYLASE3

Tompa, R., McCallum, C. M., Delrow, J., Henikoff, J. G., van Steensel, B., & Henikoff, S. (2002) · Current Biology · doi:10.1016/s0960-9822(01)00622-4 · Cited by 161

GADD45A Does Not Promote DNA Demethylation

Jin, S.-G., Guo, C., & Pfeifer, G. P. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000013 · Cited by 161

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers

Oda, M., Glass, J. L., Thompson, R. F., Mo, Y., Olivier, E. N., Figueroa, M. E., Selzer, R. R., Richmond, T., Zhang, X., Dannenberg, L. O., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp260 · Cited by 157

Targeted Disruption of the Mouse apobec-1 Gene Abolishes Apolipoprotein B mRNA Editing and Eliminates Apolipoprotein B48

Hirano, K., Young, S. G., Farese, R. V., Ng, J. K., Sande, E., Warburton, C., Powell-Braxton, L., & Davidson, N. O. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9887 · Cited by 155

Heterochromatin establishment in the context of genome-wide epigenetic reprogramming

Probst, A. V., & Almouzni, G. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.02.002 · Cited by 153

X-chromosome activity of the mouse primordial germ cells revealed by the expression of an X-linked lacZ transgene

Tam, P., Zhou, S. X., & Tan, S. (1994) · Development · doi:10.1242/dev.120.10.2925 · Cited by 126

Dnmt1 Expression in Pre- and Postimplantation Embryogenesis and the Maintenance of IAP Silencing

Gaudet, F., Rideout, W. M., Meissner, A., Dausman, J. A., Leonhardt, H., & Jaenisch, R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.4.1640-1648.2004 · Cited by 121

DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific mannerPreprint

Oda, M., Yamagiwa, A., Yamamoto, S., Nakayama, T., Tsumura, A., Sasaki, H., Nakao, K., Li, E., & Okano, M. (2006) · Genes & Development · doi:10.1101/gad.1470906 · Cited by 105

AID to overcome the limitations of genomic information

Honjo, T., Nagaoka, H., Shinkura, R., & Muramatsu, M. (2005) · Nature Immunology · doi:10.1038/ni1218 · Cited by 102

Cloning and mapping of Np95 gene which encodes a novel nuclear protein associated with cell proliferation

Fujimori, A., Matsuda, Y., Takemoto, Y., Hashimoto, Y., Kubo, E., Araki, R., Fukumura, R., Mita, K., Tatsumi, K., & Muto, M. (1998) · Mammalian Genome · doi:10.1007/s003359900920 · Cited by 96

Bisulfite sequencing and dinucleotide content analysis of 15 imprinted mouse differentially methylated regions (DMRs): paternally methylated DMRs contain less CpGs than maternally methylated DMRs

Kobayashi, H., Suda, C., Abe, T., Kohara, Y., Ikemura, T., & Sasaki, H. (2006) · Cytogenetic and Genome Research · doi:10.1159/000090824 · Cited by 89

Resetting the Epigenome beyond Pluripotency in the Germline

Hayashi, K., & Surani, M. A. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.05.007 · Cited by 88

Oxidative damage to 5-methylcytosine in DNA

Zuo, S., Boorstein, R. J., & Teebor, G. W. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.16.3239 · Cited by 87

Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism.

Morrison, J. R., Pászty, C., Stevens, M. E., Hughes, S., Forte, T., Scott, J., & Rubin, E. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7154 · Cited by 86

Reaction of bisulfite with the 5-hydroxymethyl group in pyrimidines and in phage DNAs

Hayatsu, H., & Shiragami, M. (1979) · Biochemistry · doi:10.1021/bi00571a013 · Cited by 86

Conserved DNA methylation inGadd45a-/-mice

Engel, N., Tront, J. S., Erinle, T., Nguyen, N. H., Latham, K. E., Sapienza, C., Hoffman‐Liebermann, B., & Liebermann, D. A. (2009) · Epigenetics · doi:10.4161/epi.4.2.7858 · Cited by 86

Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage

Ziegler-Birling, C., Helmrich, A., Tora, L., & Torres‐Padilla, M. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082707cz · Cited by 85

Methylation protects cytidines from AID-mediated deamination

Larijani, M., Frieder, D., Sonbuchner, T. M., Bransteitter, R., Goodman, M. G., Bouhassira, E. E., Scharff, M. D., & Martín, A. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.09.007 · Cited by 76

Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen

Hu, X. V., Rodrigues, T. M. A., Tao, H., Baker, R. K., Miraglia, L. J., Orth, A. P., Lyons, G. E., Schultz, P. G., & Wu, X. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009025107 · Cited by 75

Chromosome silencing mechanisms in X-chromosome inactivation: unknown unknowns

Brockdorff, N. (2011) · Development · doi:10.1242/dev.065276 · Cited by 73

Safeguarding parental identity: Dnmt1 maintains imprints during epigenetic reprogramming in early embryogenesis: Figure 1.Preprint

Branco, M. R., Oda, M., & Reik, W. (2008) · Genes & Development · doi:10.1101/gad.1690508 · Cited by 72

Confounded cytosine! Tinkering and the evolution of DNA

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