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The genetics of depression: successful genome-wide association studies introduce new challenges

Ormel, J., Hartman, C. A., & Snieder, H. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0450-5 · Cited by 120

Estrogen protects against ??-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt

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microRNAs as novel antidepressant targets: converging effects of ketamine and electroconvulsive shock therapy in the rat hippocampus

O'Connor, R. M., Grenham, S., Dinan, T. G., & Cryan, J. F. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000448 · Cited by 114

Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD

Maddox, S. A., Kilaru, V., Shin, J. H., Jovanović, T., Almli, L. M., Dias, B. G., Norrholm, S. D., Fani, N., Michopoulos, V., Ding, Z., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.250 · Cited by 107

The opposite effects of stress on dendritic spines in male vs. female rats are NMDA receptor‐dependent

Shors, T. J., Falduto, J., & Leuner, B. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.03065.x · Cited by 106

Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression

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Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses

Zuloaga, D. G., Heck, A., Guzman, R. M. D., & Handa, R. J. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00319-2 · Cited by 99

Repression of Astrocytic Connexins in Cortical and Subcortical Brain Regions and Prefrontal Enrichment of H3K9me3 in Depression and Suicide

Nagy, C., Torres-Platas, S. G., Mechawar, N., & Turecki, G. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw071 · Cited by 98

Number of manic episodes is associated with elevated DNA oxidation in bipolar I disorder

Soeiro‐de‐Souza, M. G., Andreazza, A. C., Carvalho, A. F., Machado‐Vieira, R., Young, L. T., & Moreno, R. A. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000047 · Cited by 97

Estrogen Receptor (ER)β Isoforms Rather Than ERα Regulate Corticotropin-Releasing Hormone Promoter Activity through an Alternate Pathway

Miller, W. J. S., Suzuki, S., Miller, L. K., Handa, R., & Uht, R. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5540-03.2004 · Cited by 97

Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice

Shen, E., Ahern, T. H., Cheung, I. K., Straubhaar, J., Dincer, A., Houston, I. B., Vries, G. J. D., Akbarian, S., & Forger, N. G. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.08.006 · Cited by 94

Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder

He, S., Liu, X., Jiang, K., Peng, D., Hong, W., Fang, Y., Qian, Y., Yu, S., & Li, H. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.03.015 · Cited by 94

H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression

Cruceanu, C., Alda, M., Nagy, C., Freemantle, E., Rouleau, G. A., & Turecki, G. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000363 · Cited by 93

Changes in miRNA-132 and miR-124 levels in non-treated and citalopram-treated patients with depression

Fang, Y., Qiu, Q., Zhang, S., Sun, L., Li, G., Xiao, S., & Li, X. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.090 · Cited by 90

Non-Coding RNAs in Psychiatric Disorders and Suicidal Behavior

Yoshino, Y., & Dwivedi, Y. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.543893 · Cited by 85

Maternal Deprivation Enhances Behavioral Vulnerability to Stress Associated with miR-504 Expression in Nucleus Accumbens of Rats

Zhang, Y., Zhu, X., Bai, M., Zhang, L., Xue, L., & Yi, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069934 · Cited by 84

Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse

Reinius, B., Shi, C., Hengshuo, L., Sandhu, K. S., Radomska, K. J., Rosen, G. D., Lu, L., Kullander, K., Williams, R. W., & JAZIN, E. E. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-614 · Cited by 82

Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice

Li, H., Kawatake-Kuno, A., Inaba, H., Miyake, Y., Itoh, Y., Ueki, T., Oishi, N., Murai, T., Suzuki, T., & Uchida, S. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.004 · Cited by 36

Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons

Kawatake-Kuno, A., Li, H., Inaba, H., Hikosaka, M., Ishimori, E., Ueki, T., Garkun, Y., Morishita, H., Narumiya, S., Oishi, N., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.023 · Cited by 31

GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency

Inaba, H., Li, H., Kawatake-Kuno, A., Dewa, K., Nagai, J., Oishi, N., Murai, T., & Uchida, S. (2023) · Science Advances · doi:10.1126/sciadv.ade5397 · Cited by 32

A Multiscale View of the Mechanisms Underlying Ketamine’s Antidepressant Effects: An Update on Neuronal Calcium Signaling

Kawatake-Kuno, A., Murai, T., & Uchida, S. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.749180 · Cited by 26

Development and validation of a predictive model for depression in patients with advanced stage of cardiovascular-kidney-metabolic syndrome

Zha, B., Cai, A., Yu, H., & Wang, Z. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.04.139 · Cited by 17

Understanding the epigenetic basis of sex differences in depression

Hodes, G. E., Walker, D. M., Labonté, B., Nestler, E. J., & Russo, S. J. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23876 · Cited by 87

Epigenetic dysregulation in depression: molecular mechanisms, clinical biomarkers, and therapeutic opportunities

Li, J., Guan, X., Zhang, R., & Zhang, H. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08772-0

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246

Molecular programs underlying differences in the expression of mood disorders in males and females

Mena, F., & Benoit, L. (2019) · Brain Research · doi:10.1016/j.brainres.2019.05.016 · Cited by 9

Epigenetic mechanisms of major depression: Targeting neuronal plasticity

Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181