Impact of prosocial neuropeptides on human brain function
Abstract
Oxytocin and vasopressin are key effectors of social behaviour (Insel, T. R. and Fernald, R. D. (2004). Annu. Rev. Neurosci., 27: 697-722). Oxytocin effects in humans were recently demonstrated by a behavioural study showing selectively increased trust after hormone administration (Kosfeld, M., et al. (2005). Nature, 435: 673-676). Since this suggested involvement of the amygdala, which is linked to trust (Winston, J. S., et al. (2002). Nat. Neurosci., 5: 277-283) - presumably because of its role in danger monitoring - and highly expresses oxytocin receptors (Huber, D., et al. (2005). Science, 308: 245-248), we studied amygdala circuitry after double-blind crossover intranasal application of placebo or oxytocin (Kirsch, P., et al. (2005). J. Neurosci., 25: 11489-11493). Oxytocin potently reduced amygdala activation and decreased coupling to brainstem regions implicated in autonomic and behavioural manifestations of fear, indicating a neural mechanism for the effects of oxytocin in social cognition in humans and providing a potential therapeutic approach to social anxiety currently being tested in social phobia and autism. Furthermore, these data suggested a translational genetic approach. Preliminary findings (data not presented) from our laboratory using imaging genetics indeed implicate genetic variants for both AVPR1A, encoding the primary receptor of vasopressin in brain, and the oxytocin receptor, OXTR, in amygdala regulation and activation. Taken together, our results indicate neural mechanisms for human social behaviour mediating genetic risk for autism through an impact on amygdala signalling and provide a rationale for exploring therapeutic strategies aimed at abnormal amygdala function in this disorder and in social dysfunction in general.
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Oxytocin has received substantial interest as a potential treatment for psychiatric conditions such as autism, although clinical trials show modest effects.
“Oxytocin has received substantial interest as a potential treatment for psychiatric conditions such as autism spectrum conditions (ASC; henceforth autism),3 although clinical trials show modest effects.4, 5, 6”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [3]
Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340 · see citing works
Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., & Jenike, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00411.1998 · Cited by 2,205 · see citing works
Functional Connectivity: The Principal-Component Analysis of Large (PET) Data Sets
Friston, K. J., Frith, C., Liddle, P., & Frackowiak, R. (1993) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.1993.4 · Cited by 2,094 · see citing works
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980 · see citing works
Self-citationCognitive neuroscience of human social behaviour
Adolphs, R. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1056 · Cited by 1,657 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
Self-citationA mechanism for impaired fear recognition after amygdala damage
Adolphs, R., Gosselin, F., Buchanan, T. W., Tranel, D., Schyns, P., & Damasio, A. R. (2005) · Nature · doi:10.1038/nature03086 · Cited by 1,331 · cited 6× · see citing works
“…potently activate amygdala (Whalen et al., 1998), lesions of the amygdala impair recognition of fearful faces and lead to social disinhibition (Adolphs et al., 2005), and decreased amygdala activation has been linked to genetic hypersociability (Meyer-Lindenberg et al., 2005) and increased…”
BackgroundResultInfluentialOxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173 · see citing works
Social Bonds of Female Baboons Enhance Infant Survival
Silk, J. B., Alberts, S. C., & Altmann, J. (2003) · Science · doi:10.1126/science.1088580 · Cited by 1,157 · see citing works
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043 · see citing works
Automatic and intentional brain responses during evaluation of trustworthiness of faces
Winston, J. S., Strange, B. A., O'Doherty, J., & Dolan, R. J. (2002) · Nature Neuroscience · doi:10.1038/nn816 · Cited by 993 · see citing works
The Amygdala Response to Emotional Stimuli: A Comparison of Faces and Scenes
Hariri, A. R., Tessitore, A., Mattay, V. S., Fera, F., & Weinberger, D. R. (2002) · NeuroImage · doi:10.1006/nimg.2002.1179 · Cited by 984 · see citing works
The Human Amygdala in Social Judgment
Adolphs, R., Tranel, D., & Damásio, A. R. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0027 · Cited by 882 · see citing works
Neural mechanisms of genetic risk for impulsivity and violence in humans
Meyer-Lindenberg, A., Buckholtz, J. W., Kolachana, B., R. Hariri, A., Pezawas, L., Blasi, G., Wabnitz, A., Honea, R., Verchinski, B., Callicott, J. H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511311103 · Cited by 876 · see citing works
Self-citationNeocortical modulation of the amygdala response to fearful stimuli
Hariri, A. R., Mattay, V. S., Tessitore, A., Fera, F., & Weinberger, D. R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01786-9 · Cited by 828 · see citing works
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804 · see citing works
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · cited 3× · see citing works
“Interestingly, the same group has also recently shown that oxytocin improves performance on a ‘‘mind reading’’ task in which emotional states of others have to be inferred based on pictures of the eyes (Domes et al., 2007a).”
BackgroundResultKiehl, K. A., Smith, A., Hare, R. D., Mendrek, A., Forster, B. B., Brink, J., & Liddle, P. F. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01222-7 · Cited by 767 · see citing works
Plasma oxytocin levels in autistic children
Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728 · see citing works
Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., Vollstädt‐Klein, S., Grüsser, S. M., Flor, H., Schumann, G., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1366 · Cited by 700 · see citing works
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693 · see citing works
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689 · see citing works
HOW THE BRAIN PROCESSES SOCIAL INFORMATION: Searching for the Social Brain
Insel, T. R., & Fernald, R. D. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144148 · Cited by 556 · see citing works
A neurobiological basis of social attachment.
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.726 · Cited by 553 · see citing works
Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Mei, S., Gong, X., Zhang, Y., Yang, X., & Zhang, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.013 · Cited by 553 · see citing works
Microsatellite instability generates diversity in brain and sociobehavioral traits
Hammock, E. A. D., & Young, L. J. (2005) · Science · doi:10.1126/science.1111427 · Cited by 545 · see citing works
Bielsky, I. F., Hu, S.-B., Szegda, K. L., Westphal, H., & Young, L. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300360 · Cited by 531 · see citing works
Brain Oxytocin Correlates with Maternal Aggression: link to Anxiety
Bosch, O. J., Meddle, S. L., Beiderbeck, D. I., Douglas, A. J., & Neumann, I. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1342-05.2005 · Cited by 439 · see citing works
Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
CARTER, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.025 · Cited by 432 · see citing works
Meyer-Lindenberg, A., Mervis, C. B., & Faith Berman, K. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1906 · Cited by 411 · see citing works
Self-citationOxytocin and autistic disorder: alterations in peptide forms
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404 · see citing works
A validated network of effective amygdala connectivity
Stein, J. L., Wiedholz, L. M., Bassett, D. S., Weinberger, D. R., Zink, C. F., Mattay, V. S., & Meyer-Lindenberg, A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.022 · Cited by 392 · see citing works
Self-citationLoup, F., Tribollet, E., Dubois-Dauphin, M., & Dreifuss, J. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90345-v · Cited by 378 · see citing works
Neural correlates of genetically abnormal social cognition in Williams syndrome
Meyer-Lindenberg, A., Hariri, A. R., Munoz, K. E., Mervis, C. B., Mattay, V. S., Morris, C. A., & Berman, K. F. (2005) · Nature Neuroscience · doi:10.1038/nn1494 · Cited by 357 · see citing works
Self-citationAn Anxiolytic Action of Oxytocin is Enhanced by Estrogen in the Mouse
MCCARTHY, M. M., MCDONALD, C. H., BROOKS, P. J., & GOLDMAN, D. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00212-0 · Cited by 328 · see citing works
Knafo, A., Israel, S., Darvasi, A., Bachner‐Melman, R., Uzefovsky, F., Cohen, L., Feldman, E., Lerer, E., Laiba, E., Raz, Y., et al. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00341.x · Cited by 294 · see citing works
The amygdala, social behavior, and danger detection
AMARAL, D. G. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1280.015 · Cited by 293 · cited 4× · see citing works
“Consistent with the assumption that amygdala activation represents a danger signal in social interaction (Amaral, 2003), both conscious and implicit distrust of faces predicts amygdala activation (Winston et al.”
BackgroundResultInfluentialAnxiety, Fears, and Phobias in Persons With Williams Syndrome
Dykens, E. M. (2003) · Developmental Neuropsychology · doi:10.1080/87565641.2003.9651896 · Cited by 289 · see citing works
Oxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 289 · see citing works
Kim, S.-J., Young, L. J., Gonen, D., Veenstra-VanderWeele, J., Courchesne, R., Courchesne, E., Lord, C., Leventhal, B. L., Cook Jr, E. H., & Insel, T. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001125 · Cited by 265 · see citing works
Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions
Prather, M. D., Lavenex, P., Mauldin-Jourdain, M. L., Mason, W. A., Capitanio, J. P., Mendoza, S. P., & Amaral, D. G. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00445-6 · Cited by 248 · see citing works
Yirmiya, N., Rosenberg, C., Levi, S., Salomon, S., Shulman, C., Nemanov, L., Dina, C., & Ebstein, R. P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001812 · Cited by 232 · see citing works
Buckholtz, J., Callicott, J., Kolachana, B., Hariri, A. R., Goldberg, T., Genderson, M., Egan, M., Mattay, V., Weinberger, D., & Meyer-Lindenberg, A. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002020 · Cited by 224 · see citing works
Self-citationExamination of AVPR1a as an autism susceptibility gene
Wassink, T. H., Piven, J., Vieland, V. J., Pietila, J., Goedken, R. J., Folstein, S. E., & Sheffield, V. C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001503 · Cited by 212 · see citing works
Oxytocin, Vasopressin, and Autism: Is There a Connection?
Insel, T. R., O’Brien, D. J., & Leckman, J. F. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0049 · Cited by 211 · see citing works
Towards the neural basis for hypersociability in a genetic syndrome
Bellugi, U., Adolphs, R., Cassady, C., & Chiles, M. (1999) · NeuroReport · doi:10.1097/00001756-199906030-00006 · Cited by 207 · see citing works
Neuroendocrine basis of social recognition
Winslow, J. T., & Insel, T. R. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.009 · Cited by 180 · see citing works
Septal vasopressin modulates anxiety-related behaviour in rats
Liebsch, G., Wotjak, C. T., Landgraf, R., & Engelmann, M. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)13069-x · Cited by 173 · see citing works
Pitman, R. K., Orr, S. P., & Lasko, N. B. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90035-f · Cited by 150 · see citing works
Winslow, J., & Insel, T. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-07-02032.1991 · Cited by 145 · see citing works
Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families
Ylisaukko‐oja, T., Alarcón, M., Cantor, R. M., Auranen, M., Vanhala, R., Kempas, E., von Wendt, L., Järvelä, I. E., Geschwind, D. H., & Peltonen, L. (2005) · Annals of Neurology · doi:10.1002/ana.20722 · Cited by 136 · see citing works
Heritability of social cognitive skills in children and adolescents
Scourfield, J., Martin, N. C., Lewis, G., & McGuffin, P. (1999) · The British Journal of Psychiatry · doi:10.1192/bjp.175.6.559 · Cited by 110 · see citing works
Vasopressin administration modulates anxiety-related behavior in rats
Appenrodt, E., Schnabel, R., & Schwarzberg, H. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00119-x · Cited by 91 · see citing works
Thibonnier, M., Graves, M. K., Wagner, M., Chatelain, N., Soubrier, F., Corvol, P. L., Willard, H. F., & Jeunemaı̂tre, X. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1108 · Cited by 73 · see citing works
Does oxytocin deficiency mediate social deficits in autism?
Modahl, C., FEIN, D. A., Waterhouse, L. H., & Newton, N. R. (1992) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01048246 · Cited by 72 · see citing works
Stoehr, J. D., Cramer, C. P., & North, W. G. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90067-h · Cited by 36 · see citing works
Ибрагимов, Р. Ш. (1990) · Neuroscience and Behavioral Physiology · doi:10.1007/bf01195453 · Cited by 28 · see citing works
Commentary on the possible role of oxytocin in autism
Panksepp, J. (1993) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01046058 · Cited by 20 · see citing works
Flagged first, then by citations
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Sorted by citations
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Self-citationOxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans
Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909579106 · Cited by 812 · see citing works
The Peptide That Binds: A Systematic Review of Oxytocin and its Prosocial Effects in Humans
MacDonald, K., & MacDonald, T. M. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673220903523615 · Cited by 585 · see citing works
The Neurobiology of Anxiety Disorders: Brain Imaging, Genetics, and Psychoneuroendocrinology
Martin, E. I., Ressler, K. J., Binder, E. B., & Nemeroff, C. (2009) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.05.004 · Cited by 132 · see citing works
Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer–Lindenberg, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003296107 · Cited by 564 · see citing works
Self-citationIntranasal Administration of Oxytocin Increases Envy and Schadenfreude (Gloating)
Shamay-Tsoory, S. G., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., & Levkovitz, Y. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.009 · Cited by 542 · see citing works
Bos, P. A., Panksepp, J., Bluthé, R.-M., & Honk, J. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.01.002 · Cited by 429 · see citing works
Keltner, D., Kogan, A., Piff, P. K., & Saturn, S. R. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115054 · Cited by 298 · see citing works
Neuroscience of human social interactions and adult attachment style
Vrtička, P., & Vuilleumier, P. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00212 · Cited by 285 · see citing works
“By contrast, no relation was found between attachment insecurities and a polymorphism of the oxytocin receptor (OXTR) gene (Gillath et al., 2008), even though the latter has been associated with other individual differences in social behavior (Meyer-Lindenberg, 2008).”
BackgroundChang, S. W. C., Barter, J. W., Ebitz, R. B., Watson, K. K., & Platt, M. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114621109 · Cited by 252 · see citing works
Deconstructing sociality, social evolution and relevant nonapeptide functions
Goodson, J. L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.005 · Cited by 206 · see citing works
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Sripada, C. S., Phan, K. L., Labuschagne, I., Welsh, R., Nathan, P. J., & Wood, A. G. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000533 · Cited by 197 · see citing works
Intranasal administration of oxytocin: behavioral and clinical effects, a review
Veening, J. G., & Olivier, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.012 · Cited by 169 · see citing works
The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology.
Martin, E. I., Ressler, K., Binder, E., & Nemeroff, C. (2010) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2010.07.006 · Cited by 494 · see citing works
The social phenotype of Williams syndrome
Järvinen, A., Korenberg, J. R., & Bellugi, U. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.12.006 · Cited by 161 · see citing works
The role of oxytocin in male and female reproductive behavior
Veening, J. G., A, T. R. D. J., Waldinger, M. D., Korte, S. M., & Olivier, B. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.045 · Cited by 156 · see citing works
Quintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.011 · Cited by 149 · see citing works
Effects of intranasal oxytocin on 'compassion focused imagery'
Rockliff, H., Karl, A., McEwan, K., Gilbert, J., Matos, M., & Gilbert, P. (2011) · Emotion · doi:10.1037/a0023861 · Cited by 147 · see citing works
Grewen, K. M., Davenport, R. E., & Light, K. C. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00968.x · Cited by 146 · see citing works
A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder
Olff, M., Langeland, W., Witteveen, A., & Denys, D. (2010) · CNS Spectrums · doi:10.1017/s109285290000047x · Cited by 135 · see citing works
Oxytocin-messages via the cerebrospinal fluid: Behavioral effects; a review
Veening, J. G., A, T. R. D. J., & Barendregt, H. P. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.05.004 · Cited by 126 · see citing works
Investigating the genetic basis of altruism: the role of the COMT Val158Met polymorphism
Reuter, M., Frenzel, C., Walter, N. T., Markett, S. A., & Montag, C. (2010) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq083 · Cited by 120 · see citing works
Dai, L., Carter, C. S., Ying, J., Bellugi, U., Pournajafi-Nazarloo, H., & Korenberg, J. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038513 · Cited by 119 · see citing works
Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women
Bethlehem, R. A. I., Lombardo, M. V., Lai, M.-C., Auyeung, B., Crockford, S. K., Deakin, J., Soubramanian, S., Sule, A., Kundu, P., Voon, V, et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.72 · Cited by 96 · see citing works
Genetic Influences on Social Cognition
Skuse, D., & Gallagher, L. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212f562 · Cited by 95 · see citing works
Social memories in rodents: Methods, mechanisms and modulation by stress
van der Kooij, M. A., & Sandi, C. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.006 · Cited by 92 · see citing works
Oxytocin enhances the perception of biological motion in humans
Kéri, S., & Benedek, G. (2009) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.9.3.237 · Cited by 84 · see citing works
Pohl, T. T., Young, L. J., & Bosch, O. J. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2017.12.011 · Cited by 83 · see citing works
Oxytocin receptor dynamics in the brain across development and species
Vaidyanathan, R., & Hammock, E. A. D. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22403 · Cited by 82 · see citing works
The other side of the coin: oxytocin decreases the adherence to fairness norms
Radke, S., & de Bruijn, E. R. A. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00193 · Cited by 73 · see citing works
Neurobiology of human affiliative behaviour: implications for psychiatric disorders
Bora, E., Yücel, M., & Allen, N. B. (2009) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328329e970 · Cited by 68 · see citing works
Harony, H., & Wagner, S. (2010) · Neurosignals · doi:10.1159/000321035 · Cited by 62 · see citing works
Oxytocin and Memory of Emotional Stimuli: Some Dance to Remember, Some Dance to Forget
Maroun, M., & Wagner, S. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.016 · Cited by 61 · see citing works
Arginine Vasopressin selectively enhances recognition of sexual cues in male humans
Guastella, A. J., Kenyon, A. R., Unkelbach, C., Alvares, G. A., & Hickie, I. B. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.023 · Cited by 59 · see citing works
Bartholomeusz, C. F., Ganella, E. P., Labuschagne, I., Bousman, C., & Pantelis, C. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.06.007 · Cited by 54 · see citing works
Reconsidering GHB: orphan drug or new model antidepressant?
Bosch, O. G., Quednow, B. B., Seifritz, E., & Wetter, T. C. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111421975 · Cited by 49 · see citing works
Who is to blame? Oxytocin promotes nonpersonalistic attributions in response to a trust betrayal
Klackl, J., Pfundmair, M., Agroskin, D., & Jonas, E. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2012.11.010 · Cited by 47 · see citing works
Shou, X., Xu, X., Zeng, X., Liu, Y., Yuan, H., Xing, Y., Jia, M., Wei, Q.-Y., Han, S., Zhang, R., et al. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0109-2 · Cited by 44 · see citing works
Kiss, I., Levy‐Gigi, E., & Kéri, S. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.08.005 · Cited by 45 · see citing works
Evidence for alterations in stimulatory G proteins and oxytocin levels in children with autism
Jacobson, J. D., Ellerbeck, K. A., Kelly, K., Fleming, K., Jamison, T. R., Coffey, C. W., Smith, C. M., Reese, R. M., & Sands, S. A. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.014 · Cited by 41 · see citing works
Huffmeijer, R., Alink, L. R. A., Mattie Tops, A., Grewen, K., Light, K. C., Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.11.008 · Cited by 42 · see citing works
Zhao, X., Mohammed, R., Tran, H., Erickson, M., & Kentner, A. C. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.03.018 · Cited by 43 · see citing works
An integrated framework for the role of oxytocin in multistage social decision‐making
Piva, M., & Chang, S. W. C. (2018) · American Journal of Primatology · doi:10.1002/ajp.22735 · Cited by 38 · see citing works
“These include the prosocial hypothesis (Macdonald & Macdonald, 2010; Meyer-Lindenberg, 2008), which states that OT increases positive social behaviors such as trust and altruism, the social salience hypothesis (Shamay-Tsoory & Abu-Akel, 2016), which states that OT instead seems to enhance the…”
BackgroundNylander, I., & Roman, E. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00077 · Cited by 40 · see citing works
The Search for an Effective Therapy to Treat Fragile X Syndrome: Dream or Reality?
Castagnola, S., Bardoni, B., & Maurin, T. (2017) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2017.00015 · Cited by 40 · see citing works
Neural mechanisms of female sexual behavior in the rat; comparison with male ejaculatory control
Veening, J. G., Coolen, L. M., & Gerrits, P. O. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.025 · Cited by 38 · see citing works
Reuter, M., Montag, C., Altmann, S., Bendlow, F., Elger, C. E., Kirsch, P., Becker, A. J., Schoch, S., Simon, M., Weber, B., et al. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1214174 · Cited by 37 · see citing works
Autism - A Neurodevelopmental Journey from Genes to Behaviour
Eapen, V. (2011) · InTech eBooks · doi:10.5772/974 · Cited by 36 · see citing works
Oxytocin mechanisms of stress response and aggression in a territorial finch
Goodson, J. L., Schrock, S. E., & Kingsbury, M. A. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.01.016 · Cited by 34 · see citing works
Stress-related depression: Neuroendocrine, genetic, and therapeutical aspects
Bosch, O., Seifritz, E., & Wetter, T. C. (2012) · World Journal of Biological Psychiatry · doi:10.3109/15622975.2012.665477 · Cited by 36 · see citing works
Schmidt, M., Braun, K., Brandwein, C., Rossetti, A. C., Ciurana, S. G., Riva, M. A., Deuschle, M., Bock, J., Gass, P., & Gröger, N. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.06.027 · Cited by 33 · see citing works
Schwartz, S. S., Gallagher, R. J., & Berkson, G. (1986) · PubMed · Cited by 32 · see citing works
Love and Attachment: The Psychobiology of Social Bonding
Stein, D. J., & Vythilingum, B. (2009) · CNS Spectrums · doi:10.1017/s1092852900025384 · Cited by 28 · see citing works
Oxytocin and Vasopressin: Social Neuropeptides
Stein, D. J. (2009) · CNS Spectrums · doi:10.1017/s1092852900023841 · Cited by 24 · see citing works
Zhang, X., Li, P., Otieno, S., Li, H., & Leppänen, P. H. T. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105411 · Cited by 23 · see citing works
Kasahara, M., Groenink, L., Kas, M. J., Bijlsma, E. Y., Olivier, B., & Sarnyai, Z. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.12.029 · Cited by 23 · see citing works
Haugstad, G. K., Kirste, U. M., Leganger, S., Håkonsen, E., & Haugstad, T. S. (2011) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2011.02.005 · Cited by 22 · see citing works
Using transgenic mouse models to study oxytocin's role in the facilitation of species propagation
Lee, H., Pagani, J. H., & Young, W. S. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.042 · Cited by 19 · see citing works
Oxytocin instantiates empathy and produces prosocial behaviors
Barraza, J. A., & Zak, P. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.022 · Cited by 18 · see citing works
Polk, R. J., Horta, M., Lin, T., Porges, E. C., Ojeda, M., Nazarloo, H. P., Carter, C. S., & Ebner, N. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0048 · Cited by 11 · see citing works
Broad characterization of endogenous peptides in the tree shrew visual system
Ranc, V., Petruzziello, F., Kretz, R., Argandoña, E., Zhang, X., & Rainer, G. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.01.028 · Cited by 13 · see citing works
Psychopharmakologie autistischer Störungen
Poustka, L., Banaschewski, T., & Poustka, F. (2011) · Der Nervenarzt · doi:10.1007/s00115-010-3238-7 · Cited by 13 · see citing works
Lin, T., Pehlivanoglu, D., Ziaei, M., Liu, P., Woods, A. J., Feifel, D., Fischer, H., & Ebner, N. C. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.838642 · Cited by 8 · see citing works
Munk, A. J. L., Hermann, A., El‐Shazly, J., Grant, P. S., & Hennig, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151991 · Cited by 10 · see citing works
Thompson, R. R. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104742 · Cited by 10 · see citing works
Envy and Schadenfreude: The Neural Correlates of Competitive Emotions
Dvash, J., & Shamay‐Tsoory, S. (2011) · doi:10.1002/9781118101803.ch9 · Cited by 10 · see citing works
The Use of Oxytocin in Personality Disorders: Rationale and Current Status
Pérez-Rodríguez, M. M., Derish, N. E., & New, A. S. (2014) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-014-0026-1 · Cited by 7 · see citing works
Domschke, K., Kapfhammer, H., & Deckert, J. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_69 · Cited by 8 · see citing works
Fear of Home Birth in Doctors and Obstetric Iatrogenesis
Lokugamage, A. U. (2011) · International Journal of Childbirth · doi:10.1891/2156-5287.1.4.263 · Cited by 7 · see citing works
Neurobiologically based interventions for autism spectrum disorders-rationale and new directions
Poustka, L., Brandeis, D., Hohmann, S., Holtmann, M. H., Bölte, S., & Banaschewski, T. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-139010 · Cited by 7 · see citing works
Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in womenPreprint
Bethlehem, R. A. I., Lombardo, M. V., Lai, M.-C., Auyeung, B., Crockford, S. K., Deakin, J., Soubramanian, S., Sule, A., Kundu, P., Voon, V., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/068585 · Cited by 7 · see citing works
Oxytocin and vasopressin: the social networking buttons of the body
Mitra, A. K. (2021) · AIMS molecular science · doi:10.3934/molsci.2021003 · Cited by 6 · see citing works
Skwerer, D. P. (2017) · International review of research in developmental disabilities · doi:10.1016/bs.irrdd.2017.08.004 · Cited by 7 · see citing works
Stay social, stay young: a bioanthropological outlook on the processes linking sociality and ageing
Iannuzzi, V., Narboux‐Nême, N., Lehoczki, A., Levi, G., & Giuliani, C. (2024) · GeroScience · doi:10.1007/s11357-024-01416-5 · Cited by 6 · see citing works
Schmidt, S. D., Zinn, C. G., Behling, J. A. K., Furian, A. F., Furini, C. R. G., Myskiw, J. D. C., & Izquierdo, I. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107423 · Cited by 5 · see citing works
Brain Oxytocin is a Main Regulator of Prosocial Behaviour - Link to Psychopathology
Lukas, M., & Inga, N. (2011) · InTech eBooks · doi:10.5772/18841 · Cited by 4 · see citing works
The roles of vasopressin and oxytocin in aggression
Pagani, J. H., Wersinger, S. R., & Young, W. S. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.014 · Cited by 4 · see citing works
Biological Advances in Personality Disorders
Pérez-Rodríguez, M. M., Zaluda, L. C., & New, A. S. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.2.146 · Cited by 4 · see citing works
Heinrichs, M., Chen, F. S., & Domes, G. (2012) · Wiley eBooks · doi:10.1002/9781119945901.ch8 · Cited by 4 · see citing works
Can Oxytocin Improve Core Brain and Behavioral Features of Autism Spectrum Disorders in Children?
Gordon, I. (2013) · Research and perspectives in neurosciences · doi:10.1007/978-3-319-02904-7_11 · Cited by 3 · see citing works
Verhagen, M., Engels, R. C. M. E., & van Roekel, E. (2014) · Open Journal of Depression · doi:10.4236/ojd.2014.34017 · Cited by 3 · see citing works
Social Inequalities, Family Relationships, and Child Health
Flinn, M. V. (2010) · National symposium on family issues · doi:10.1007/978-1-4419-7361-0_14 · Cited by 3 · see citing works
Bases hormonals de la conducta prosocial: una revisió de la literatura
Lerma, F. S., Manuel, M. V., & Susana, L. T. (2016) · Anuari de Psicologia de la Societat Valenciana de Psicologia · doi:10.7203/anuari.psicologia.16.1.189 · Cited by 2 · see citing works
Domschke, K., Kapfhammer, H., & Deckert, J. (2016) · Springer eBooks · doi:10.1007/978-3-642-45028-0_69-1 · Cited by 2 · see citing works
Neuroscience of Social Understanding
Thacker, R., & Reddy, K. J. (2024) · Advances in human resources management and organizational development book series · doi:10.4018/979-8-3693-1858-4.ch003 · Cited by 2 · see citing works
Abdulai-Saiku, S., & Vyas, A. (2021) · Pathogens · doi:10.3390/pathogens10111495 · Cited by 2 · see citing works
Nataraj, M., Kumble, C. N., Ganjekar, S., & Desai, G. (2022) · doi:10.1093/med/9780198861478.003.0037 · Cited by 1 · see citing works
Reproductive Hormones and Stages of Life in Women: Moderators of Mood and Cardiovascular Health
Girdler, S. S., & Light, K. C. (2010) · Springer eBooks · doi:10.1007/978-0-387-09488-5_38 · Cited by 1 · see citing works
The social, genetic and environmental aspects
Castle, D. J., & Abel, K. M. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781107045132.002 · Cited by 1 · see citing works
Choleris, E., Pfaff, D. W., & Kavaliers, M. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.021 · Cited by 1 · see citing works
Intranasal oxytocin modulates very early visual processing of emotional facesPreprint
Hugrass, L., Labuschagne, I., Mu, E., Price, A., & Crewther, D. P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.15.440078 · Cited by 1 · see citing works
Kaya, K., Önal, D., Kartal, Y., Budak, M. T., Karabulut, E., Oğuz, K. K., & Pehli̇vanoğlu, B. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.24.554569 · Cited by 1 · see citing works
Effects of central neuropeptides on social preference and social recognition in male rats
Lukas, M. (2011) · University of Regensburg Publication Server (University of Regensburg) · doi:10.5283/epub.22540
Arias, J. M. C., & Jaramillo, C. A. L. (2013) · International journal of psychological research · doi:10.21500/20112084.725
Maternal caregiving, oxytocin and mental illness
Abel, K. M., & Elmadih, A. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781107045132.005
How Neuroscience Can Help to Understand the Working of Emotions and Empathy in Leadership
Motschnig, R., & Ryback, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-45486-3_15
Gender dimorphism in parasitic behavioural manipulation hypothesis
Abdulai-Saiku, S. (2017) · doi:10.32657/10356/72521
Breathing patterns in longstanding pain disorders
Haugstad, G. K., & Haugstad, T. S. (2013) · Elsevier eBooks · doi:10.1016/b978-0-7020-4980-4.00022-8
- Authors
- MEYERLINDENBERG, A.
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2008
- Volume
- 170
- Pages
- 463-470
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1480002351
- Cited by
- 109
- References
- 61
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 7 · 2013: 13 · 2012: 11
- FWCI
- 29.85
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, vasopressin, amygdala, social behavior, trust, social anxiety, social anxiety disorder, autism spectrum disorder, AVPR1A, oxytocin receptor, imaging genetics, genetic risk
- MeSH terms
- Administration, Intranasal, Amygdala, Animals, Autistic Disorder, Brain, Brain Stem, Cognition, Humans, Neuropeptides, Oxytocin, Social Behavior, Genetic Variation, Signal Transduction, Receptors, Vasopressin, Receptors, Oxytocin, Mice, Knockout, Recognition, Psychology, Models, Animal, Mice
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