Cited by 129Muscle Physiology and DisordersNutrition and Health in AgingAdipose Tissue and Metabolism

The DOI matches its Crossref record; 480 of the 482 references it cites were found in a registry or an index.

Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention

Open access

Brioche, Thomas, Pagano, Allan F., Py, Guillaume, Chopard, Angèle·2016·Molecular Aspects of Medicine

DOI 10.1016/j.mam.2016.04.006

Open this paper in CoChat — free account

Abstract

Identification of cost-effective interventions to maintain muscle mass, muscle strength, and physical performance during muscle wasting and aging is an important public health challenge. It requires understanding of the cellular and molecular mechanisms involved. Muscle-deconditioning processes have been deciphered by means of several experimental models, bringing together the opportunities to devise comprehensive analysis of muscle wasting. Studies have increasingly recognized the importance of fatty infiltrations or intermuscular adipose tissue for the age-mediated loss of skeletal-muscle function and emphasized that this new important factor is closely linked to inactivity. The present review aims to address three main points. We first mainly focus on available experimental models involving cell, animal, or human experiments on muscle wasting. We next point out the role of intermuscular adipose tissue in muscle wasting and aging and try to highlight new findings concerning aging and muscle-resident mesenchymal stem cells called fibro/adipogenic progenitors by linking some cellular players implicated in both FAP fate modulation and advancing age. In the last part, we review the main data on the efficiency and molecular and cellular mechanisms by which exercise, replacement hormone therapies, and β-hydroxy-β-methylbutyrate prevent muscle wasting and sarcopenia. Finally, we will discuss a potential therapeutic target of sarcopenia: glucose 6-phosphate dehydrogenase.

Integrity signals

Registry

Crossref · 10.1016/j.mam.2016.04.006

Cites

480 of 480 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

1 retracted

RETRACTED ARTICLE: Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis
Fico, A., Paglialunga, F., Cigliano, L., Abrescia, P., Verde, P., Martini, G., Iaccarino, I., & Filosa, S. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401420 · Cited by 147
Retracted
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission
Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521
Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia
Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256 · cited 4×
“Muscle deconditioning occurring with aging is characterized by a decrease in muscle mass, in muscle strength, and in physical performance and is considered a geriatric syndrome called sarcopenia (Cruz-Jentoft et al., 2010; Fielding et al., 2011; Morley et al., 2011; Muscaritoli et al., 2010).”
BackgroundMethodInfluential
The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083 · cited 1×
“…deterioration of the physical condition resulting in an increased risk of falls and fractures, a progressive inability to perform basic activities of daily living, loss of independence for the elderly, and ultimately, death (Cruz-Jentoft, 2012; Delmonico et al., 2007; Goodpaster et al., 2006).”
Background
The Transforming Growth Factor-Beta Family
Massagué, J. (1990) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.06.110190.003121 · Cited by 3,041
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery
Guralnik, J. M., Ferrucci, L., Pieper, C. F., Leveille, S. G., Markides, K. S., Ostir, G. V., Studenski, S., Berkman, L. F., & Wallace, R. B. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.4.m221 · Cited by 2,898
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
What is the cause of the ageing atrophy?
Lexell, J. E., Taylor, C. C., & Sjöstróm, M. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90132-3 · Cited by 2,142
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.
Stitt, T. N., Drujan, D., Clarke, B. A., Panaro, F., Timofeyva, Y., Kline, W. O., Gonzalez, M., Yancopoulos, G. D., & Glass, D. J. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00211-4 · Cited by 1,964
Inhibition of Adipogenesis by Wnt Signaling
Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., & MacDougald, O. A. (2000) · Science · doi:10.1126/science.289.5481.950 · Cited by 1,876
Invited Review: Aging and sarcopenia
Doherty, T. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00347.2003 · Cited by 1,764
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763
Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”
Muscaritoli, M., Anker, S. D., Argilés, J., Aversa, Z., Bauer, J. M., Biolo, G., Boirie, Y., Bosaeus, I., Cederholm, T., Costelli, P., et al. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.12.004 · Cited by 1,732 · cited 2×
“Muscle deconditioning occurring with aging is characterized by a decrease in muscle mass, in muscle strength, and in physical performance and is considered a geriatric syndrome called sarcopenia (Cruz-Jentoft et al., 2010; Fielding et al., 2011; Morley et al., 2011; Muscaritoli et al., 2010).”
Background
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Joe, A. W. B., Yi, L., Natarajan, A., Le Grand, F., So, L., Wang, J., Rudnicki, M. A., & Rossi, F. M. V. (2010) · Nature Cell Biology · doi:10.1038/ncb2015 · Cited by 1,690
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0610com · Cited by 1,539
Balance in elderly patients: the "get-up and go" test.
Mathias, S., Nayak, U. S., & Isaacs, B. (1986) · PubMed · Cited by 1,539
Mechanisms regulating skeletal muscle growth and atrophy
Schiaffino, S., Dyar, K. A., Ciciliot, S., Blaauw, B., & Sandri, M. (2013) · The FEBS Journal · doi:10.1111/febs.12253 · Cited by 1,492
Longitudinal study of muscle strength, quality, and adipose tissue infiltration
Delmonico, M. J., Harris, T. B., Visser, M., Park, S. W., Conroy, M. B., Velasquez-Mieyer, P., Boudreau, R., Manini, T. M., Nevitt, M., Newman, A. B., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28047 · Cited by 1,446
Aging of skeletal muscle: a 12-yr longitudinal study
Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1321 · Cited by 1,443
Muscle Mass, Muscle Strength, and Muscle Fat Infiltration as Predictors of Incident Mobility Limitations in Well-Functioning Older Persons
Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403
Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review
Mitchell, W. K., Williams, J., Atherton, P., Larvin, M., Lund, J., & Narici, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00260 · Cited by 1,377
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367
Decline in skeletal muscle mitochondrial function with aging in humans
Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501559102 · Cited by 1,333
Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle
Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S., & Tsuchida, K. (2010) · Nature Cell Biology · doi:10.1038/ncb2014 · Cited by 1,315
Cellular and molecular mechanisms of muscle atrophy
Bonaldo, P., & Sandri, M. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.010389 · Cited by 1,284
Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study
Goodpaster, B. H., Carlson, C. L., Visser, M., Kelley, D. E., Scherzinger, A., Harris, T. B., Stamm, E., & Newman, A. B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2157 · Cited by 1,226
Resistance Exercise in Individuals With and Without Cardiovascular Disease: 2007 Update: A Scientific Statement From the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism
Williams, M. A., Haskell, W. L., Ades, P. A., Amsterdam, E. A., Bittner, V., Franklin, B. A., Gulanick, M., Laing, S. T., & Stewart, K. J. (2007) · Circulation · doi:10.1161/circulationaha.107.185214 · Cited by 1,211
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211
Skeletal Muscle Cutpoints Associated with Elevated Physical Disability Risk in Older Men and Women
Janssen, I. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh058 · Cited by 1,190
Growth Hormone and the Insulin-Like Growth Factor System in Myogenesis*
Florini, J. R., Ewton, D. Z., & Coolican, S. A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-5-481 · Cited by 1,148
Muscle strength and speed of movement in relation to age and muscle morphology
Larsson, L., Grimby, G., & Karlsson, J. (1979) · Journal of Applied Physiology · doi:10.1152/jappl.1979.46.3.451 · Cited by 1,135
Sarcopenia with limited mobility: an international consensus
Morley, J. E., Abbatecola, A. M., Argiles, J. M., Baracos, V., Bauer, J., Bhasin, S., Cederholm, T., Stewart Coats, A. J., Cummings, S. R., Evans, W. J., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.04.014 · Cited by 1,125
Notch-Mediated Restoration of Regenerative Potential to Aged Muscle
Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science · doi:10.1126/science.1087573 · Cited by 1,121
Skeletal muscle hypertrophy and atrophy signaling pathways
Glass, D. J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.04.018 · Cited by 1,106 · cited 1×
“Conversely, a decrease in mechanical constraints will lead to muscle deconditioning and atrophy (Bonaldo and Sandri, 2013; Glass, 2005; Jackman and Kandarian, 2004; Kandarian and Stevenson, 2002; Pagano et al., 2015; Ventadour and Attaix, 2006).”
Background
Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
Goodpaster, B. H., Leland Thaete, F., Simoneau, J.-A., & Kelley, D. E. (1997) · Diabetes · doi:10.2337/diacare.46.10.1579 · Cited by 1,012
Geriatric muscle stem cells switch reversible quiescence into senescence
Sousa-Victor, P., Gutarra, S., García-Prat, L., Rodriguez-Ubreva, J., Ortet, L., Ruiz-Bonilla, V., Jardí, M., Ballestar, E., González, S., Serrano, A. L., et al. (2014) · Nature · doi:10.1038/nature13013 · Cited by 1,010
The Molecular Basis of Skeletal Muscle Atrophy
Jackman, R. W., & Kandarian, S. C. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00579.2003 · Cited by 1,008 · cited 1×
“Conversely, a decrease in mechanical constraints will lead to muscle deconditioning and atrophy (Bonaldo and Sandri, 2013; Glass, 2005; Jackman and Kandarian, 2004; Kandarian and Stevenson, 2002; Pagano et al., 2015; Ventadour and Attaix, 2006).”
Background
Hindlimb unloading rodent model: technical aspects
Morey, E. R., & Globus, R. K. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00969.2001 · Cited by 998
Longitudinal Muscle Strength Changes in Older Adults: Influence of Muscle Mass, Physical Activity, and Health
HUGHES, V. A., Frontera, W. R., Wood, M., Evans, W. J., Dallal, G. E., Roubenoff, R., & Singh, M. A. F. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.5.b209 · Cited by 935
Skeletal Muscle Power: A Critical Determinant of Physical Functioning in Older Adults
Reid, K. F., & Fielding, R. A. (2012) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31823b5f13 · Cited by 913 · cited 2×
“Skeletal muscle plays a central role in locomotion enabling a person to perform activities of daily living, posture maintenance, and balance (Reid and Fielding, 2012).”
Background
The aged niche disrupts muscle stem cell quiescence
Chakkalakal, J. V., Jones, K. M., Basson, M. A., & Brack, A. S. (2012) · Nature · doi:10.1038/nature11438 · Cited by 851
Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study
Visser, M., Kritchevsky, S. B., Goodpaster, B. H., Newman, A. B., Nevitt, M., Stamm, E., & Harris, T. B. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50217.x · Cited by 845
Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women
Delmonico, M. J., Harris, T. B., Lee, J., Visser, M., Nevitt, M., Kritchevsky, S. B., Tylavsky, F. A., Newman, A. B., & for the Health, A. A. B. C. S. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01140.x · Cited by 819
Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration
Heredia, J. E., Mukundan, L., Chen, F. M., Mueller, A. A., Deo, R. C., Locksley, R. M., Rando, T. A., & Chawla, A. (2013) · Cell · doi:10.1016/j.cell.2013.02.053 · Cited by 818
Contractile properties of skeletal muscles from young, adult and aged mice.
Brooks, S. V., & Faulkner, J. A. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017279 · Cited by 777 · cited 8×
“Indeed, in response to 8 weeks of treadmill training (5 days per week, 40 min per session at 16.4 m/min), there was an increase in muscle content of Beclin-1, LC3, and Lamp-2 proteins in old mice along with an increase in EDL and gastrocnemius weight (Kim et al., 2013).”
BackgroundInfluential
Regulation of Wnt Signaling during Adipogenesis
Bennett, C. N., Ross, S. E., Longo, K. A., Bajnok, L., Hemati, N., Johnson, K. W., Harrison, S. D., & MacDougald, O. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204527200 · Cited by 743
Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors
Lemos, D. R., Babaeijandaghi, F., Low, M., Chang, C.-K., Lee, S. T., Fiore, D., Zhang, R.-H., Natarajan, A., Nedospasov, S. A., & Rossi, F. M. V. (2015) · Nature Medicine · doi:10.1038/nm.3869 · Cited by 740
The Effect of Testosterone Replacement on Endogenous Inflammatory Cytokines and Lipid Profiles in Hypogonadal Men
Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031069 · Cited by 731
Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis
Fernández-Balsells, M. M., Murad, M. H., Lane, M., Lampropulos, J. F., Albuquerque, F., Mullan, R. J., Agrwal, N., Elamin, M. B., Gallegos-Orozco, J. F., Wang, A. T., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2575 · Cited by 713
The global prevalence of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis
Nkhoma, E. T., Poole, C., Vannappagari, V. X., Hall, S. A., & Beutler, E. (2009) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2008.12.005 · Cited by 709
Glucose‐6‐phosphate dehydrogenase, NADPH, and cell survival
Stanton, R. C. (2012) · IUBMB Life · doi:10.1002/iub.1017 · Cited by 706
Glucocorticoid-Induced Skeletal Muscle Atrophy
Schakman, O., Kalista, S., Barbé, C., Loumaye, A., & Thissen, J. P. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.036 · Cited by 705
Added value of physical performance measures in predicting adverse health-related events: results from the health, aging and body composition study
Cesari, M., Kritchevsky, S. B., Newman, A. B., Simonsick, E. M., Harris, T. B., Penninx, B. W., Brach, J. S., Tylavsky, F. A., Satterfield, S., Bauer, D. C., et al. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02126.x · Cited by 702
Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle
Uezumi, A., Ito, T., Morikawa, D., Shimizu, N., Yoneda, T., Segawa, M., Yamaguchi, M., Ogawa, R., Matev, M. M., Miyagoe-Suzuki, Y., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.086629 · Cited by 680
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
Cosgrove, B. D., Gilbert, P. M., Porpiglia, E., Mourkioti, F., Lee, S. P., Corbel, S. Y., Llewellyn, M. E., Delp, S. L., & Blau, H. M. (2014) · Nature Medicine · doi:10.1038/nm.3464 · Cited by 677
Increased cytokine production in mononuclear cells of healthy elderly people
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665
From space to Earth: Advances in human physiology from 20 years of bed rest studies (1986–2006)
Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J., & Vernikos, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0474-z · Cited by 658
Intermuscular fat: a review of the consequences and causes
Addison, O., Marcus, R. L., LaStayo, P. C., & Ryan, A. S. (2014) · International Journal of Endocrinology · doi:10.1155/2014/309570 · Cited by 656
Role of muscle loss in the age-associated reduction in VO2 max
Fleg, J. L., & Lakatta, E. G. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.65.3.1147 · Cited by 640
Impact of Aerobic Exercise Training on Age-Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity
Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., Rizza, R. A., Coenen-Schimke, J. M., & Nair, K. S. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1888 · Cited by 631
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials
Marzetti, E., Calvani, R., Cesari, M., Buford, T. W., Lorenzi, M., Behnke, B. J., & Leeuwenburgh, C. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.024 · Cited by 627
Effects of weight loss on regional fat distribution and insulin sensitivity in obesity.
Goodpaster, B. H., Kelley, D. E., Wing, R. R., Meier, A., & Thaete, F. L. (1999) · Diabetes · doi:10.2337/diabetes.48.4.839 · Cited by 608
[42] Glucose-6-phosphate dehydrogenase 6-phosphogluconic dehydrogenase
Kornberg, A., Horecker, B. L., Horecker, B. L., & Smyrniotis, P. Z. (1955) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(55)01046-x · Cited by 601
Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells
Bjornson, C. R. R., Cheung, T. H., Liu, L., Tripathi, P. V., Steeper, K. M., & Rando, T. A. (2012) · Stem Cells · doi:10.1002/stem.773 · Cited by 598
Endurance Exercise as a Countermeasure for Aging
Lanza, I. R., Short, D. K., Short, K. R., Raghavakaimal, S., Basu, R., Joyner, M. J., McConnell, J. P., & Nair, K. S. (2008) · Diabetes · doi:10.2337/db08-0349 · Cited by 582
p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice
Bernet, J. D., Doles, J. D., Hall, J. K., Kelly Tanaka, K., Carter, T. A., & Olwin, B. B. (2014) · Nature Medicine · doi:10.1038/nm.3465 · Cited by 573
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
Robey, R. B., & Hay, N. (2006) · Oncogene · doi:10.1038/sj.onc.1209595 · Cited by 550
Glucose‐6‐phosphate dehydrogenase: a “housekeeping” enzyme subject to tissue‐specific regulation by hormones, nutrients, and oxidant stress
Kletzien, R. F., Harris, P. K. W., & Foellmi, L. A. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.2.8119488 · Cited by 548
Physiology of a Microgravity Environment Invited Review: Microgravity and skeletal muscle
Fitts, R. H., Riley, D. R., & Widrick, J. J. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.2.823 · Cited by 548
Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans
Balagopal, P., Rooyackers, O., Adey, D., Ades, P. A., & Nair, K. S. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.4.e790 · Cited by 541
Insulin-like Growth Factor-1 (IGF-1) Inversely Regulates Atrophy-induced Genes via the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Pathway
Latres, E., Amini, A. R., Amini, A. A., Griffiths, J., Martin, F. J., Wei, Y., Lin, H. C., Yancopoulos, G. D., & Glass, D. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407517200 · Cited by 538
Growth hormone and the insulin-like growth factor system in myogenesis
Florini, J. R. (1996) · Endocrine Reviews · doi:10.1210/er.17.5.481 · Cited by 536
Importance of Glucose-6-phosphate Dehydrogenase Activity for Cell Growth
Tian, W.-N., Braunstein, L. D., Pang, J., Stuhlmeier, K. M., Xi, Q. J., Tian, X., & Stanton, R. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10609 · Cited by 534
A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State
Mourikis, P., Sambasivan, R., Castel, D., Rocheteau, P., Bizzarro, V., & Tajbakhsh, S. (2012) · Stem Cells · doi:10.1002/stem.775 · Cited by 526
Loss of skeletal muscle mass in aging: Examining the relationship of starvation, sarcopenia and cachexia
Thomas, D. R. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.03.008 · Cited by 521
Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.
Ho, K. Y., Veldhuis, J. D., Johnson, M. L., Furlanetto, R., Evans, W. S., Alberti, K. G., & Thorner, M. O. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113450 · Cited by 503
Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-κB activation in response to tumor necrosis factor α
Li, Y., Schwartz, R. J., Waddell, I. D., Holloway, B. R., & Reid, M. B. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.10.871 · Cited by 502
Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22–65 years
Larsson, L., Sjödin, B., & Karlsson, J. (1978) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1978.tb06187.x · Cited by 500
Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells
Carlson, M. E., Hsu, M., & Conboy, I. M. (2008) · Nature · doi:10.1038/nature07034 · Cited by 498
A review of the clinical evidence for exercise in osteoarthritis of the hip and knee
Bennell, K. L., & Hinman, R. S. (2011) · Journal of Science and Medicine in Sport · doi:10.1016/j.jsams.2010.08.002 · Cited by 492
Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly
Verdijk, L. B., Koopman, R., Schaart, G., Meijer, K., Savelberg, H. H. C. M., & van Loon, L. J. C. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00278.2006 · Cited by 489
Age and aerobic exercise training effects on whole body and muscle protein metabolism
Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., & Nair, K. S. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00366.2003 · Cited by 470 · cited 5×
“…can significantly increase O2max and endurance capacity in older adults and rodents (Hammeren et al., 1992; Huang et al., 2005; Koltai et al., 2012; Lambertucci et al., 2007; Lanza et al., 2008; Malbut et al., 2002; Radak et al., 2002; Safdar et al., 2010; Short et al., 2004; Short et al., 2003).”
BackgroundInfluential
Weight stability masks sarcopenia in elderly men and women
Gallagher, D., Ruts, E., Visser, M., Heshka, S., Baumgartner, R. N., Wang, J., Pierson, R. N., Pi-Sunyer, F. X., & Heymsfield, S. B. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.2.e366 · Cited by 466
Age Changes in Body Composition Revealed by Computed Tomography
Borkan, G. A., Hults, D. E., Gerzof, S. G., Robbins, A. H., & Silbert, C. K. (1983) · Journal of Gerontology · doi:10.1093/geronj/38.6.673 · Cited by 460
Silencing of Epidermal Growth Factor Receptor Suppresses Hypoxia-Inducible Factor-2–Driven VHL −/− Renal Cancer
Smith, K., Gunaratnam, L., Morley, M., Franovic, A., Mekhail, K., & Lee, S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0169 · Cited by 457
Histochemical and enzymatic comparison of the gastrocnemius muscle of young and elderly men and women
Coggan, A. R., Spina, R. J., King, D. S., Rogers, M. A., Rogers, M. A., Brown, M., Nemeth, P. M., & Holloszy, J. O. (1992) · Journal of Gerontology · doi:10.1093/geronj/47.3.b71 · Cited by 456
Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men: A Randomized Controlled Trial
Blackman, M. R. (2002) · JAMA · doi:10.1001/jama.288.18.2282 · Cited by 455
The developmental origins of sarcopenia
Sayer, A. A., Syddall, H., Martin, H., Patel, H., Baylis, D., & Cooper, C. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982703 · Cited by 450
Skeletal muscle fat infiltration: impact of age, inactivity, and exercise
Marcus, R. L., Addison, O., Kidde, J. P., Dibble, L. E., & Lastayo, P. C. (2010) · The Journal of nutrition, health and aging · doi:10.1007/s12603-010-0081-2 · Cited by 449
Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells
Pellegrinet, L., Rodilla, V., Liu, Z., Chen, S., Koch, U., Espinosa, L., Kaestner, K. H., Kopan, R., Lewis, J. H., & Radtke, F. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.005 · Cited by 448
Animal Models of Steatosis
Koteish, A. A., & Diehl, A. M. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-12932 · Cited by 447
Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial
Goodpaster, B. H., Chomentowski, P., Ward, B. K., Rossi, A., Glynn, N. W., Delmonico, M. J., Kritchevsky, S. B., Pahor, M., & Newman, A. B. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90425.2008 · Cited by 446
Mitochondrial function and apoptotic susceptibility in aging skeletal muscle
Chabi, B., Ljubicic, V., Menzies, K. J., Huang, J. H., Saleem, A., & Hood, D. A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00347.x · Cited by 437
The central role of muscle stem cells in regenerative failure with aging
Blau, H. M., Cosgrove, B. D., & Ho, A. T. V. (2015) · Nature Medicine · doi:10.1038/nm.3918 · Cited by 437
Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
Butcher, S. K., Chahal, H., Nayak, L., Sinclair, A., Henriquez, N. V., Sapey, E., O'Mahony, D., & Lord, J. M. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.6.881 · Cited by 436
The size and strength of the quadriceps muscles of old
Men, Y., Young, A., Stokes, M. J., & Crowe, M. J. (1985) · Clinical Physiology · doi:10.1111/j.1475-097x.1985.tb00590.x · Cited by 433
Inhibition of JAK-STAT signaling stimulates adult satellite cell function
Price, F. D., von Maltzahn, J., Bentzinger, C. F., Dumont, N. A., Yin, H., Chang, N. C., Wilson, D. H., Frenette, J., & Rudnicki, M. A. (2014) · Nature Medicine · doi:10.1038/nm.3655 · Cited by 433
Skeletal muscle fiber quality in older men and women
Frontera, W. R., Suh, D., Krivickas, L. S., HUGHES, V. A., Goldstein, R., & Roubenoff, R. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c611 · Cited by 424
Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness
Ryall, J. G., Schertzer, J. D., & Lynch, G. S. (2008) · Biogerontology · doi:10.1007/s10522-008-9131-0 · Cited by 423
Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging
Carnio, S., LoVerso, F., Baraibar, M. A., Longa, E., Khan, M. M., Maffei, M., Reischl, M., Canepari, M., Loefler, S., Kern, H., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.061 · Cited by 423
Muscle transplantation between young and old rats: age of host determines recovery
Carlson, B. M., & Faulkner, J. A. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.256.6.c1262 · Cited by 417
Skeletal muscle atrophy and increased intramuscular fat after incomplete spinal cord injury
Gorgey, A. S., & Dudley, G. A. (2007) · Spinal Cord · doi:10.1038/sj.sc.3101968 · Cited by 415
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
Baker, D. J., Perez-Terzic, C., Jin, F., Pitel, K. S., Niederländer, N. J., Jeganathan, K., Yamada, S., Reyes, S., Rowe, L., Hiddinga, H. J., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1744 · Cited by 408 · cited 1×
“More recently, Nozaki et al. (2015) developed the C2C12 cell line from the BubR1 hypomorphic mouse model of accelerated-aging (Baker et al., 2008); these cells are characterized by a subpopulation of muscle stem cells expressing p16Ink4a (Nozaki et al., 2015).”
Background
Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women
Yarasheski, K. E., Zachwieja, J. J., & Bier, D. M. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.2.e210 · Cited by 406
Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity
Guo, T., Jou, W., Chanturiya, T., Portas, J., Gavrilova, O., & McPherron, A. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004937 · Cited by 402
World Population Ageing 2015
Nations, U. (2017) · Statistical Papers - United Nations (Ser. A), Population and Vital Statistics Report · doi:10.18356/88fa44e7-en · Cited by 400
Satellite cells in human skeletal muscle; from birth to old age
Verdijk, L. B., Snijders, T., Drost, M., Delhaas, T., Kadi, F., & van Loon, L. J. C. (2014) · AGE · doi:10.1007/s11357-013-9583-2 · Cited by 399
Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise
Wohlgemuth, S. E., Seo, A. Y., Marzetti, E., Lees, H. A., & Leeuwenburgh, C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2009.11.002 · Cited by 397
Effect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise training
Nissen, S., Sharp, R., Ray, M., Rathmacher, J. A., Rice, D., Fuller, J. C., Connelly, A. S., & Abumrad, N. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.5.2095 · Cited by 393
Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay
Veldhuis, J. D., Liem, A. Y., South, S. A., WELTMAN, A. L., Weltman, J. Y., Clemmons, D., Abbott, R. D., Mulligan, T., Johnson, M. L., & Pincus, S. M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.11.7593428 · Cited by 391
Atrogin-1, MuRF-1, and sarcopenia
Gumucio, J. P., & Mendias, C. L. (2012) · Endocrine · doi:10.1007/s12020-012-9751-7 · Cited by 378
Prolonged space flight-induced alterations in the structure and function of human skeletal muscle fibres
Fitts, R. H., Trappe, S. W., COSTILL, D. L., Gallagher, P. M., Creer, A. C., Colloton, P. A., Peters, J., Romatowski, J. G., Bain, J. L. W., & Riley, D. A. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.188508 · Cited by 377
Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly men
Verdijk, L. B., Gleeson, B. G., Jonkers, R. A. M., Meijer, K., Savelberg, H. H. C. M., Dendale, P., & van Loon, L. J. C. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gln050 · Cited by 372
Effects of exercise on depressive symptoms in older adults with poorly responsive depressive disorder
Mather, A. S., Rodriguez, C., Guthrie, M., McHarg, A. M., Reid, I., & McMurdo, M. E. T. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.180.5.411 · Cited by 370
Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women.
Simoneau, J., Colberg, S. R., Thaete, F. L., & Kelley, D. E. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.2.7781930 · Cited by 362 · cited 1×
“…sensitivity observed during aging and obesity (Goodpaster et al., 1999; Goodpaster et al., 2000; Goodpaster et al., 1997; Ryan and Nicklas, 1999; Simoneau et al., 1995), and on the other hand, the fact that FAPs can be the main stem cell population implicated in sarcopenia-related IMAT…”
Background
Regional changes in muscle mass following 17 weeks of bed rest
LeBlanc, A. D., Schneider, V. S., Evans, H. J., Pientok, C., Rowe, R., & Spector, E. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.5.2172 · Cited by 359 · cited 1×
“These studies have collectively shown that the antigravity extensors of the knee and ankle are the most affected (Alkner and Tesch, 2004b; LeBlanc et al., 1992; Rittweger et al., 2005).”
Background
Efficacy of myonuclear addition may explain differential myofiber growth among resistance-trained young and older men and women
Petrella, J. K., Kim, J.-S., Cross, J. M., Kosek, D. J., & Bamman, M. M. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2006 · Cited by 356
Lower limb skeletal muscle function after 6 wk of bed rest
Berg, H. E., Larsson, L., & Tesch, P. A. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.1.182 · Cited by 352
Muscle atrophy and bone loss after 90 days' bed rest and the effects of flywheel resistive exercise and pamidronate: Results from the LTBR study
Rittweger, J., Frost, H. M., Schießl, H., Ohshima, H., Alkner, B. A., Tesch, P. A., & Felsenberg, D. (2005) · Bone · doi:10.1016/j.bone.2004.11.014 · Cited by 351
Low Testosterone in Men with Type 2 Diabetes: Significance and Treatment
Grossmann, M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0118 · Cited by 350
Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors
Minetti, G., Colussi, C., Adami, R., Serra, C., Mozzetta, C., Parente, V., Fortuni, S., Straino, S., Sampaolesi, M., Padova, M. D., et al. (2006) · Nature Medicine · doi:10.1038/nm1479 · Cited by 343
Adipogenesis and aging: does aging make fat go MAD
Kirkland, J. L., Tchkonia, T., Pirtskhalava, T., Han, J., & Karagiannides, I. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00014-1 · Cited by 339
Skeletal muscle satellite cells: Changes in proliferation potential as a function of age
Schultz, E., & Lipton, B. H. (1982) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(82)90105-1 · Cited by 335
Defective myoblasts identified in Duchenne muscular dystrophy
Blau, H. M., Webster, C., & Pavlath, G. K. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.15.4856 · Cited by 335
Regenerative potential of human skeletal muscle during aging
Renault, V. M., Thorne, L., Eriksson, P., Butler-Browne, G. S., & Mouly, V. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00017.x · Cited by 332
Reduced physical activity increases intermuscular adipose tissue in healthy young adults
Manini, T. M., Clark, B. C., Nalls, M. A., Goodpaster, B. H., Ploutz-Snyder, L. L., & Harris, T. B. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.377 · Cited by 332
Enhanced Glutathione Levels and Oxidoresistance Mediated by Increased Glucose-6-phosphate Dehydrogenase Expression
Salvemini, F., Franzè, A., Iervolino, A., Filosa, S., Salzano, S., & Ursini, M. V. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.2750 · Cited by 331
Muscle hypertrophy and fast fiber type conversions in heavy resistance-trained women.
Staron, R. S., Malicky, E. S., Leonardi, M. J., Falkel, J. E., Hagerman, F. C., & Dudley, G. A. (1990) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/bf00572189 · Cited by 328
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy
Calvani, R., Joseph, A.-M., Adhihetty, P. J., Miccheli, A., Bossola, M., Leeuwenburgh, C., Bernabei, R., & Marzetti, E. (2013) · bchm · doi:10.1515/hsz-2012-0247 · Cited by 328
Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women
Song, M.-Y., Ruts, E., Kim, J., Janumala, I., Heymsfield, S., & Gallagher, D. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.874 · Cited by 324
Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults
Coen, P. M., Jubrias, S. A., Distefano, G., Amati, F., Mackey, D. C., Glynn, N. W., Manini, T. M., Wohlgemuth, S. E., Leeuwenburgh, C., Cummings, S. R., et al. (2013) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gls196 · Cited by 323 · cited 1×
“…perturbations in mitochondrial energetics of skeletal muscle have been shown to correlate with reduced O2max (Short et al., 2005), walking capacity (Coen et al., 2013), and maximal isometric strength (Safdar et al., 2010) in older adults and are associated with an increase in muscle fatigability…”
Background
Immune Modulation of Stem Cells and Regeneration
Aurora, A. B., & Olson, E. N. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.06.009 · Cited by 322
Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance
Lee, H.-Y., Choi, C. S., Birkenfeld, A. L., Alves, T. C., Jornayvaz, F. R., Jurczak, M. J., Zhang, D., Woo, D. K., Shadel, G. S., Ladiges, W., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.004 · Cited by 319
Normal values for handgrip strength in 920 men and women aged over 65 years, and longitudinal changes over 4 years in 620 survivors
Bassey, E. J., & Harries, U. (1993) · Clinical Science · doi:10.1042/cs0840331 · Cited by 318
Reversal of cancer-related wasting using oral supplementation with a combination of β-hydroxy-β-methylbutyrate, arginine, and glutamine
May, P. E., Barber, A. E., D'Olimpio, J. T., Hourihane, A., & Abumrad, N. N. (2002) · The American Journal of Surgery · doi:10.1016/s0002-9610(02)00823-1 · Cited by 318
The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis
Perrini, S., Laviola, L., Carreira, M. C., Cignarelli, A., Natalicchio, A., & Giorgino, F. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0431 · Cited by 317
Spaceflight and Bone Turnover: Correlation with a New Rat Model of Weightlessness
Morey, E. R. (1979) · BioScience · doi:10.2307/1307797 · Cited by 315
Muscle morphology, enzymatic activity, and muscle strength in elderly men: A follow‐up study
ANIANSSON, A., Hedberg, M., Henning, G., & Grimby, G. (1986) · Muscle & Nerve · doi:10.1002/mus.880090702 · Cited by 314
Peroxisome-proliferator-activated receptor γ suppresses Wnt/β-catenin signalling during adipogenesis
Moldes, M., Zuo, Y., Morrison, R. F., Silva, D., Park, B.-H., Liu, J., & Farmer, S. R. (2003) · Biochemical Journal · doi:10.1042/bj20030426 · Cited by 312
Senescence-accelerated mouse (SAM): a biogerontological resource in aging research
Takeda, T. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00008-1 · Cited by 311
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review
Wilson, G. J., Wilson, J. M., & Manninen, A. H. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-1 · Cited by 306
Knee extensor and plantar flexor muscle size and function following 90 days of bed rest with or without resistance exercise
Alkner, B. A., & Tesch, P. A. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1172-8 · Cited by 306
Role of exercise on sarcopenia in the elderly.
Montero-Fernández, N., & Rexach, J. A. S. (2013) · PubMed · Cited by 306
Identification and characterization of PDGFRα+ mesenchymal progenitors in human skeletal muscle
Uezumi, A., Fukada, S., Yamamoto, N., Ikemoto‐Uezumi, M., Nakatani, M., Morita, M., Yamaguchi, A., Yamada, H., Nishino, I., Hamada, Y., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.161 · Cited by 304
Satellite cells and myonuclei in young and elderly women and men
Kadi, F., Charifi, N., Denis, C., & Lexell, J. E. (2003) · Muscle & Nerve · doi:10.1002/mus.10510 · Cited by 298
Evidence for a myogenic stem cell that is exhausted in dystrophic muscle
Heslop, L., Morgan, J. E., & Partridge, T. A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.12.2299 · Cited by 297
Intramuscular adipose tissue, sarcopenia, and mobility function in older individuals
Marcus, R. L., Addison, O., Dibble, L. E., Foreman, K. B., Morrell, G., & LaStayo, P. (2012) · Journal of Aging Research · doi:10.1155/2012/629637 · Cited by 296
Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy.
Furuno, K., Goodman, M. N., & Goldberg, A. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38923-9 · Cited by 295
Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78–84 and 23–32 yr olds
Hasten, D. L., Pak-Loduca, J., Obert, K. A., & Yarasheski, K. E. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.4.e620 · Cited by 294
Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults
Deutz, N. E. P., Pereira, S. L., Hays, N. P., Oliver, J. S., Edens, N. K., Evans, C. M., & Wolfe, R. R. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.02.011 · Cited by 287 · cited 6×
“Deutz et al. (2013) did not report any effect of HMB on muscle strength after 10 days of bed rest in the elderly (men and women) but showed a clear tendency to limit the decrease observed; the latter result did not reach statistical significance probably due to the small sample size.”
BackgroundInfluential
Lifelong physical exercise delays age-associated skeletal muscle decline
Zampieri, S., Pietrangelo, L., Loefler, S., Fruhmann, H., Vogelauer, M., Burggraf, S., Pond, A., Grim-Stieger, M., Cvecka, J., Sedliak, M., et al. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu006 · Cited by 282
Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle
Stevenson, E. J., Giresi, P. G., Koncarevic, A., & Kandarian, S. C. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00033.x · Cited by 278
Is stair climb power a clinically relevant measure of leg power impairments in at-risk older adults?
Bean, J. F., Kiely, D. K., LaRose, S., Alian, J., & Frontera, W. R. (2007) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2007.02.004 · Cited by 278
The origin of intermuscular adipose tissue and its pathophysiological implications
Vettor, R., Milan, G., Franzin, C., Sanna, M., Coppi, P. D., Rizzuto, R., & Federspil, G. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00229.2009 · Cited by 274
Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells
Wen, Y., Bi, P., Liu, W., Asakura, A., Keller, C., & Kuang, S. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06753-11 · Cited by 271
Nutritional role of the leucine metabolite β-hydroxy β-methylbutyrate (HMB)
Nissen, S., & Abumrad, N. N. (1997) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(97)00048-x · Cited by 269
Alterations in muscle attenuation following detraining and retraining in resistance-trained older adults
Taaffe, D. R., Henwood, T. R., Nalls, M. A., Walker, D. G., Lang, T. F., & Harris, T. B. (2009) · Gerontology · doi:10.1159/000182084 · Cited by 269
Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle
Radák, Z., Naito, H., Kaneko, T., Tahara, S., Nakamoto, H., Takahashi, R., Cardozo-Pelaez, F., & Goto, S. (2002) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-002-0918-6 · Cited by 269
G6PD protects from oxidative damage and improves healthspan in mice
Pereira, S. N., Fernández-Marcos, P. J., Brioche, T., Gómez‐Cabrera, M. C., Salvador‐Pascual, A., Flores, J. M., Viña, J., & Serrano, M. (2016) · Nature Communications · doi:10.1038/ncomms10894 · Cited by 269
Self-citation
Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia
Ibebunjo, C., Chick, J. M., Kendall, T., Eash, J. K., Li, C., Zhang, Y., Vickers, C., Wu, Z., Clarke, B. A., Shi, J., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01036-12 · Cited by 267
Muscle hypertrophy in men and women
Cureton, K. J., Collins, M. A., Hill, D. W., & McELHANNON, F. M. (1988) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198808000-00003 · Cited by 266
Identification of a molecular signature of sarcopenia
Giresi, P. G., Stevenson, E. J., Theilhaber, J., Koncarevic, A., Parkington, J. D., Fielding, R. A., & Kandarian, S. C. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00249.2004 · Cited by 265
Strength of Isometric and Isokinetic Contractions
Murray, M., Gardner, G. M., MOLLINGER, L. A., & SEPIC, S. B. (1980) · Physical Therapy · doi:10.1093/ptj/60.4.412 · Cited by 265
Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.
Tiao, G. M., Hobler, S. C., Wang, J. J., Meyer, T. A., Luchette, F. A., Fischer, J. E., & Hasselgren, P.-O. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119143 · Cited by 264
Effect of β-hydroxy-β-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
Flakoll, P. J., Sharp, R. L., Baier, S. M., Levenhagen, D. K., Carr, C., & Nissen, S. (2004) · Nutrition · doi:10.1016/j.nut.2004.01.009 · Cited by 263
Mitochondrial biogenesis in exercise and in ageing☆
Viña, J., Gómez‐Cabrera, M. C., Borrás, C., Froio, T., Sanchis‐Gomar, F., Martinez-Bello, V. E., & Pallardó, F. V. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.06.006 · Cited by 261
Activity-Dependent Signaling Pathways Controlling Muscle Diversity and Plasticity
Schiaffino, S., Sandri, M., & Murgia, M. (2007) · Physiology · doi:10.1152/physiol.00009.2007 · Cited by 261
Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice
Mozzetta, C., Consalvi, S., Saccone, V., Tierney, M. T., Diamantini, A., Mitchell, K. J., Marazzi, G., Borsellino, G., Battistini, L., Sassoon, D. A., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202096 · Cited by 261
Associations between body composition and gait-speed decline: results from the health, aging, and body composition study
Beavers, K. M., Beavers, D. P., Houston, D. K., Harris, T. B., Hue, T. F., Koster, A., Newman, A. B., Simonsick, E. M., Studenski, S. A., Nicklas, B. J., et al. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.047860 · Cited by 259
Age effect on transcript levels and synthesis rate of muscle MHC and response to resistance exercise
Balagopal, P., Coenen-Schimke, J. M., Ades, P. A., Adey, D., & Nair, K. S. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e203 · Cited by 258
Importance of glucose-6-phosphate dehydrogenase activity in cell death
Tian, W.-N., Braunstein, L. D., Apse, K. A., Pang, J., Rose, M., Tian, X., & Stanton, R. C. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.5.c1121 · Cited by 258
Composition of Skeletal Muscle Evaluated with Computed Tomography
Goodpaster, B. H., Thaete, F. L., & Kelley, D. E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06416.x · Cited by 257
Satellite cell numbers in young and older men 24 hours after eccentric exercise
Dreyer, H. C., Blanco, C. E., Sattler, F. R., Schroeder, E. T., & Wiswell, R. A. (2006) · Muscle & Nerve · doi:10.1002/mus.20461 · Cited by 256
The impact of sarcopenia and exercise training on skeletal muscle satellite cells
Snijders, T., Verdijk, L. B., & van Loon, L. J. C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.003 · Cited by 254
Metabolic functions of glucocorticoid receptor in skeletal muscle
Kuo, T., Harris, C. A., & Wang, J.-C. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.03.003 · Cited by 254
Metabolic Regulation of Oocyte Cell Death through the CaMKII-Mediated Phosphorylation of Caspase-2
Nutt, L. K., Margolis, S. S., Jensen, M. V., Herman, C. E., Dunphy, W. G., Rathmell, J. C., & Kornbluth, S. A. (2005) · Cell · doi:10.1016/j.cell.2005.07.032 · Cited by 251
Molecular aging and rejuvenation of human muscle stem cells
Carlson, M. E., Suetta, C., Conboy, M. J., Aagaard, P., Mackey, A., Kjaer, M., & Conboy, I. (2009) · EMBO Molecular Medicine · doi:10.1002/emmm.200900045 · Cited by 245
Physiopathological Mechanism of Sarcopenia
Walrand, S., Guillet, C., Salles, J., Cano, N., & Boirie, Y. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2011.03.005 · Cited by 235 · cited 1×
“…and Malmstrom, 2013), increased production of proinflammatory cytokines (e.g., interleukin 6 and TNF-α) (Lee et al., 2007), insulin resistance (Walrand et al., 2011), neuromuscular aberrations (Edstrom et al., 2007; Piasecki et al., 2015), dysregulation of microRNAs (McGregor et al., 2014;…”
Background
Nutritional Treatment for Acquired Immunodeficiency Virus‐Associated Wasting Using β‐Hydroxy β‐Methylbutyrate, Glutamine, and Arginine: A Randomized, Double‐Blind, Placebo‐Controlled Study
Clark, R. E., Feleke, G., Din, M., Yasmin, T., Singh, G., Khan, F. A., & Rathmacher, J. A. (2000) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607100024003133 · Cited by 230
Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men ≥76 yr old
Yarasheski, K. E., Pak-Loduca, J., Hasten, D. L., Obert, K. A., Brown, M. B., & Sinacore, D. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e118 · Cited by 226
Elderly men and women benefit equally from prolonged resistance-type exercise training
Leenders, M., Verdijk, L. B., van der Hoeven, L., van Kranenburg, J., Nilwik, R., & van Loon, L. J. C. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gls241 · Cited by 226
Age-related muscle dysfunction
Thompson, L. V. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2008.05.003 · Cited by 226
Body Composition in 70-Year-Old Adults Responds to Dietary β-Hydroxy-β-Methylbutyrate Similarly to That of Young Adults
Vukovich, M. D., Stubbs, N. B., & Bohlken, R. M. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.7.2049 · Cited by 222
Decline in isokinetic force with age: muscle cross-sectional area and specific force
Jubrias, S. A., Odderson, I. R., Esselman, P. C., & Conley, K. E. (1997) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s004240050392 · Cited by 222
Reduced Satellite Cell Numbers and Myogenic Capacity in Aging Can Be Alleviated by Endurance Exercise
Shefer, G., Rauner, G., Yablonka‐Reuveni, Z., & Benayahu, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013307 · Cited by 220
Glucose-6-Phosphate Dehydrogenase Overexpression Decreases Endothelial Cell Oxidant Stress and Increases Bioavailable Nitric Oxide
Leopold, J. A., Zhang, Y., Scribner, A. W., Stanton, R. C., & Loscalzo, J. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000056744.26901.ba · Cited by 219
Age-Related Differences in Knee Muscle Strength in Normal Women
MURRAY, M. P., Duthie, E. H., Gambert, S. R., Sepic, S. B., & MOLLINGER, L. A. (1985) · Journal of Gerontology · doi:10.1093/geronj/40.3.275 · Cited by 218
Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults
Safdar, A., Hamadeh, M. J., Kaczor, J. J., Raha, S., deBeer, J., & Tarnopolsky, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010778 · Cited by 217
Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humans
Mayhew, D. L., Kim, J.-S., Cross, J. M., Ferrando, A. A., & Bamman, M. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91234.2008 · Cited by 215
Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise
Brook, M. S., Wilkinson, D. J., Phillips, B. E., Pérez‐Schindler, J., Philp, A., Smith, K., & Atherton, P. J. (2015) · Acta Physiologica · doi:10.1111/apha.12532 · Cited by 214
Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle
Stevenson, E. J., Giresi, P. G., Koncarevic, A., et al. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.044701 · Cited by 212
Exercise and Sarcopenia
Phu, S., Boersma, D., & Duque, G. (2015) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2015.04.011 · Cited by 212
Overexpression of Glucose-6-Phosphate Dehydrogenase Is Associated with Lipid Dysregulation and Insulin Resistance in Obesity
Park, J., Rho, H. K., Kim, K. H., Choe, S. S., Lee, Y. S., & Kim, J. B. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.5146-5157.2005 · Cited by 212
Effects of aerobic exercise training on antioxidant enzyme activities and mRNA levels in soleus muscle from young and aged rats
Lambertucci, R. H., Levada‐Pires, A. C., Rossoni, L. V., Curi, R., & Pithon‐Curi, T. C. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.12.006 · Cited by 211

Research works printed but not linked: 2

Kimura, 2014, β-Hydroxy-β-methylbutyrate facilitates PI3K/Akt-dependent mammalian target of rapamycin and FoxO1/3a phosphorylations and alleviates tumor necrosis factor α/interferon γ-induced MuRF-1 expression in C2C12 cells, Nutr. Res, 34, 368, 10.1016/j.nutres.2014.02.003 · DOI
Lecker, 2004, Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression, FASEB J., 18, 39, 10.1096/fj.03-0610com · DOI · Paper page

Sorted by citations

Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review
Li, C., Yu, K., Shyh‐Chang, N., Jiang, Z., Liu, T., Ma, S., Luo, L., Guang, L., Liang, K., Ma, W., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12901 · Cited by 626
Imaging of sarcopenia: old evidence and new insights
Albano, D., Messina, C., Vitale, J. A., & Sconfienza, L. M. (2019) · European Radiology · doi:10.1007/s00330-019-06573-2 · Cited by 400
Epidemiology of sarcopenia and insight into possible therapeutic targets
Dennison, E. M., Sayer, A. A., & Cooper, C. C. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.60 · Cited by 302
Mouse models of sarcopenia: classification and evaluation
Xie, W., He, M., Yu, D., Wu, Y., Wang, X., Lv, S., Xiao, W., & Li, Y. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12709 · Cited by 240
Sarcopenia: imaging assessment and clinical application
Chianca, V., Albano, D., Messina, C., Gitto, S., Ruffo, G., Guarino, S., Grande, F. D., & Sconfienza, L. M. (2021) · Abdominal Radiology · doi:10.1007/s00261-021-03294-3 · Cited by 218

See all 129

Authors: Brioche, T., Pagano, A. F., Py, G., & Chopard, A.
Affiliations: Université de Montpellier (FR)
Corresponding author: Brioche, Thomas
ORCID: Brioche, Thomas
Pagano, Allan F.
Py, Guillaume
Chopard, Angèle
Venue: Molecular Aspects of Medicine
Publisher: Elsevier BV
Published: 2016-08
Volume: 50
Issue: 50
Pages: 56-87
ISSN: 0098-2997 (ISSN-L)
DOI: 10.1016/j.mam.2016.04.006
OpenAlex: W2344822791
Cited by: 129
References: 482
Citations by year: 2026: 10 · 2025: 9 · 2024: 17 · 2023: 8 · 2022: 19 · 2021: 17 · 2020: 18 · 2019: 8 · 2018: 14 · 2017: 8 · 2016: 1
FWCI: 0.93
Type: journal article
Language: en
Open access: green
hal.science
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Aspects of Medicine (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, cc-by-sa)
Funders: Centre National d'Etudes Spatiales
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: muscle atrophy, sarcopenia, aging, intermuscular adipose tissue, fatty infiltration, muscle deconditioning, fibro-adipogenic progenitors, mesenchymal stem cells, physical activity, hormone replacement therapy, beta-hydroxy-beta-methylbutyrate, glucose-6-phosphate dehydrogenase, muscle mass and strength, physical performance
MeSH terms: Adipose Tissue, Aging, Animals, Glucosephosphate Dehydrogenase, Humans, Mitochondria, Models, Theoretical, Valerates, Weightlessness, Signal Transduction, Exercise, Apoptosis, Muscle, Skeletal, Dietary Supplements, Hormone Replacement Therapy, Models, Animal, Sarcopenia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks