Cited by 299Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 208 of the 208 references it cites were found in a registry or an index.

New translational assays for preclinical modelling of cognition in schizophrenia: The touchscreen testing method for mice and rats

Open access

Bussey, T.J., Holmes, A., Lyon, L., Mar, A.C., McAllister, K.A.L., Nithianantharajah, J., Oomen, C.A., Saksida, L.M.·2012·Neuropharmacology

DOI 10.1016/j.neuropharm.2011.04.011PMC PMC3168710

Open this paper in CoChat — free account

Abstract

We describe a touchscreen method that satisfies a proposed 'wish-list' of desirables for a cognitive testing method for assessing rodent models of schizophrenia. A number of tests relevant to schizophrenia research are described which are currently being developed and validated using this method. These tests can be used to study reward learning, memory, perceptual discrimination, object-place associative learning, attention, impulsivity, compulsivity, extinction, simple Pavlovian conditioning, and other constructs. The tests can be deployed using a 'flexible battery' approach to establish a cognitive profile for a particular mouse or rat model. We have found these tests to be capable of detecting not just impairments in function, but enhancements as well, which is essential for testing putative cognitive therapies. New tests are being continuously developed, many of which may prove particularly valuable for schizophrenia research.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuropharm.2011.04.011

Cites

208 of 208 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Source monitoring.
Johnson, M. K., Hashtroudi, S., & Lindsay, D. S. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.114.1.3 · Cited by 3,392
The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity
Nuechterlein, K. H., Green, M. F., Kern, R. S., Baade, L. E., Barch, D. M., Cohen, J. D., Essock, S., Fenton, W. S., Frese, F. J., Gold, J. M., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07010042 · Cited by 2,342
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023
A cortical–hippocampal system for declarative memory
Eichenbaum, H. (2000) · Nature reviews. Neuroscience · doi:10.1038/35036213 · Cited by 1,817
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. M., Nord, A. S., Kusenda, M., Malhotra, D., Bhandari, A., et al. (2008) · Science · doi:10.1126/science.1155174 · Cited by 1,800
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642
Self-citation
Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus
Leutgeb, J. K., Leutgeb, S., Moser, M.-B., & Moser, E. I. (2007) · Science · doi:10.1126/science.1135801 · Cited by 1,601 · cited 2×
“, 2001; Hunsaker and Kesner, 2008), electrophysiological data (Leutgeb et al., 2007) and reports that”
The neuro-symphony of stress
Joëls, M., & Baram, T. Z. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2632 · Cited by 1,521
Rare chromosomal deletions and duplications increase risk of schizophrenia
The International Schizophrenia Consortium (2008) · Nature · doi:10.1038/nature07239 · Cited by 1,475
Neuronal Coding of Prediction Errors
Schultz, W., & Dickinson, A. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.473 · Cited by 1,427
D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Sawaguchi, T., & Goldman-Rakic, P. S. (1991) · Science · doi:10.1126/science.1825731 · Cited by 1,364
The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry
Robbins, T. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1154-7 · Cited by 1,282
Cambridge Neuropsychological Test Automated Battery (CANTAB): A Factor Analytic Study of a Large Sample of Normal Elderly Volunteers
Robbins, T. W., James, M., Owen, A. M., Sahakian, B. J., McInnes, L., & Rabbitt, P. (1994) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106735 · Cited by 1,078
Pattern Separation in the Human Hippocampal CA3 and Dentate Gyrus
Bakker, A., Kirwan, C. B., Miller, M. I., & Stark, C. E. L. (2008) · Science · doi:10.1126/science.1152882 · Cited by 1,050
Diagnosing schizophrenia in the initial prodromal phase
Klosterkötter, J., Hellmich, M., Steinmeyer, E. M., & Schultze-Lutter, F. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.2.158 · Cited by 1,049
Prefrontal and medial temporal lobe interactions in long-term memory
Simons, J. S., & Spiers, H. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1178 · Cited by 961
Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
McHugh, T. J., Jones, M. W., Quinn, J. J., Balthasar, N., Coppari, R., Elmquist, J. K., Lowell, B. B., Fanselow, M. S., Wilson, M. A., & Tonegawa, S. (2007) · Science · doi:10.1126/science.1140263 · Cited by 958
Schizophrenics Show Spatial Working Memory Deficits
Park, S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120063009 · Cited by 953
Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis
Coyle, J. T. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9062-8 · Cited by 917
Hippocampal conjunctive encoding, storage, and recall: Avoiding a trade‐off
O'Reilly, R. C., & McClelland, J. L. (1994) · Hippocampus · doi:10.1002/hipo.450040605 · Cited by 914
Brain abnormality in schizophrenia
Lawrie, S. M., & Abukmeil, S. S. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.172.2.110 · Cited by 845
Hippocampal Volume Reduction in Schizophrenia as Assessed by Magnetic Resonance Imaging
Nelson, M. D., Saykin, A. J., Flashman, L. A., & Riordan, H. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.5.433 · Cited by 756
Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia
Sigurdsson, T., Stark, K. L., Karayiorgou, M., Gogos, J. A., & Gordon, J. A. (2010) · Nature · doi:10.1038/nature08855 · Cited by 702
The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications
Harrison, P. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1761-y · Cited by 693
Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1
Gilbert, P. E., Kesner, R. P., & Lee, I. (2001) · Hippocampus · doi:10.1002/hipo.1077 · Cited by 641
Neural stem cell proliferation is decreased in schizophrenia, but not in depression
Reif, A., Fritzen, S., Finger, M., Strobel, A., Lauer, M., Schmitt, A., & Lesch, K.-P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001791 · Cited by 630
Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat
McAlonan, K., & Brown, V. J. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.019 · Cited by 618
Disrupted-In-Schizophrenia 1 Regulates Integration of Newly Generated Neurons in the Adult Brain
Duan, X., Chang, J. H., Ge, S., Faulkner, R. L., Kim, J. Y., Kitabatake, Y., Liu, X.-B., Yang, C.-H., Jordan, J. D., Ma, D. K., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.010 · Cited by 611
A computational theory of hippocampal function, and empirical tests of the theory
Rolls, E. T., & Kesner, R. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.04.005 · Cited by 608
The Hippocampal Formation in Schizophrenia
Tamminga, C. A., Stan, A. D., & Wagner, A. D. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09081187 · Cited by 597
Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia
Meyer-Lindenberg, A. S., Olsen, R. K., Kohn, P. D., Brown, T., Egan, M. F., Weinberger, D. R., & Berman, K. F. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.379 · Cited by 574
Impaired recruitment of the hippocampus during conscious recollection in schizophrenia
Heckers, S., Rauch, S., Goff, D., Savage, C., Schacter, D., Fischman, A., & Alpert, N. (1998) · Nature Neuroscience · doi:10.1038/1137 · Cited by 570
Dissociation in Effects of Lesions of the Nucleus Accumbens Core and Shell on Appetitive Pavlovian Approach Behavior and the Potentiation of Conditioned Reinforcement and Locomotor Activity byd-Amphetamine
Parkinson, J. A., Olmstead, M. C., Burns, L. H., Robbins, T. W., & Everitt, B. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02401.1999 · Cited by 555
Running enhances spatial pattern separation in mice
Creer, D. J., Romberg, C., Saksida, L. M., van Praag, H., & Bussey, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911725107 · Cited by 553
Self-citation
Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex
Granon, S., Passetti, F., Thomas, K. L., Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01208.2000 · Cited by 546
Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia
Bogerts, B., Ashtari, M., Degreef, G., Alvir, J. M. J., Bilder, R. M., & Lieberman, J. A. (1990) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(90)90004-p · Cited by 543
Dissociable Contributions of the Orbitofrontal and Infralimbic Cortex to Pavlovian Autoshaping and Discrimination Reversal Learning: Further Evidence for the Functional Heterogeneity of the Rodent Frontal Cortex
Chudasama, Y., & Robbins, T. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08771.2003 · Cited by 543
Animal models of cognitive dysfunction and negative symptoms of schizophrenia: Focus on NMDA receptor antagonism
Neill, J. C., Barnes, S. A., Cook, S., Grayson, B., Idris, N. F., McLean, S. L., Snigdha, S., Rajagopal, L., & Harte, M. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.07.004 · Cited by 541
Substantia nigra/ventral tegmental reward prediction error disruption in psychosis
Murray, G. K., Corlett, P. R., Clark, L., Pessiglione, M., Blackwell, A. D., Honey, G., Jones, P. B., Bullmore, E. T., Robbins, T. W., & Fletcher, P. C. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002058 · Cited by 532
Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man
Owen, A. M., Sahakian, B. J., Semple, J. M., Polkey, C. E., & Robbins, T. W. (1995) · Neuropsychologia · doi:10.1016/0028-3932(94)00098-a · Cited by 524
Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity
Chudasama, Y., Passetti, F., Rhodes, S. E. V., Lopian, D., Desai, A., & Robbins, T. W. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.020 · Cited by 518
Cognition and control in schizophrenia: a computational model of dopamine and prefrontal function
Braver, T. S., Barch, D. M., & Cohen, J. D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00116-x · Cited by 507
The Cerebral Cortex of the Rat and Visual Attentional Function: Dissociable Effects of Mediofrontal, Cingulate, Anterior Dorsolateral, and Parietal Cortex Lesions on a Five-Choice Serial Reaction Time Task
Muir, J. L., Everitt, B. J., & Robbins, T. W. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.3.470 · Cited by 503
Different data from different labs: Lessons from studies of gene–environment interaction
Wahłsten, D., Metten, P., Phillips, T. J., Boehm, S. L., Burkhart‐Kasch, S., Dorow, J. D., Doerksen, S., Downing, C., Fogarty, J., Rodd‐Henricks, K., et al. (2002) · Journal of Neurobiology · doi:10.1002/neu.10173 · Cited by 500
Impaired recruitment of the hippocampus during conscious recollection in schizophrenia
Heckers, S., Rauch, S. L., GOFF, D. C., Savage, C. R., Schacter, D. L., Fischman, A. J., & Alpert, N. M. (1998) · NeuroImage · doi:10.1016/s1053-8119(18)30930-3 · Cited by 492
Functions of frontostriatal systems in cognition: comparative neuropsychopharmacological studies in rats, monkeys and humans
Chudasama, Y., & Robbins, T. W. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.005 · Cited by 484
The Contribution of the Medial Prefrontal Cortex, Orbitofrontal Cortex, and Dorsomedial Striatum to Behavioral Flexibility
RAGOZZINO, M. E. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.013 · Cited by 482
A Possible Role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia
Simpson, E. H., Kellendonk, C., & Kandel, E. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.014 · Cited by 478
A Meta-Analysis of Cognitive Deficits in Adults with a Diagnosis of Schizophrenia
Fioravanti, M., Carlone, O., Vitale, B., Cinti, M. E., & Clare, L. (2005) · Neuropsychology Review · doi:10.1007/s11065-005-6254-9 · Cited by 472
Stress-induced prefrontal reorganization and executive dysfunction in rodents
Holmes, A., & Wellman, C. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.11.005 · Cited by 469
Self-citation
Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms
Harrison, A. A., Everitt, B. J., & Robbins, T. W. (1997) · Psychopharmacology · doi:10.1007/s002130050410 · Cited by 452
A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis
Kesner, R. P., Lee, I., & Gilbert, P. E. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.5.333 · Cited by 447
Functional hypofrontality and working memory dysfunction in schizophrenia
Carter, C. S., Perlstein, W., Ganguli, R., Brar, J., Mintun, M., & Cohen, J. D. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.9.1285 · Cited by 403
Neural Mechanisms of a Genome-Wide Supported Psychosis Variant
Esslinger, C., Walter, H., Kirsch, P., Erk, S., Schnell, K., Arnold, C., Haddad, L., Mier, D., Opitz von Boberfeld, C., Raab, K., et al. (2009) · Science · doi:10.1126/science.1167768 · Cited by 400
Reversal of Antipsychotic-Induced Working Memory Deficits by Short-Term Dopamine D1 Receptor Stimulation
Castner, S. A., Williams, G. V., & Goldman, P. S. (2000) · Science · doi:10.1126/science.287.5460.2020 · Cited by 398
Disrupted latent inhibition in the rat with chronic amphetamine or haloperidol-induced supersensitivity: relationship to schizophrenic attention disorder.
Solomon, P. R., Crider, A. B., Winkelman, J. W., Turi, A. R., Kamer, R. M., & Kaplan, L. J. (1981) · PubMed · Cited by 385
Ionotropic Glutamate Receptors and Expression of N-Methyl- d -Aspartate Receptor Subunits in Subregions of Human Hippocampus: Effects of Schizophrenia
Gao, X.-M., Sakai, K., Roberts, R. C., Conley, R. R., Dean, B., & Tamminga, C. A. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1141 · Cited by 381
Spatial Working Memory Deficits in the Relatives of Schizophrenic Patients
Park, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950220031007 · Cited by 378
Review: Glutamate and dopamine dysregulation in schizophrenia — a synthesis and selective review
Stone, J. M., Morrison, P. D., & Pilowsky, L. S. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106073126 · Cited by 362
Differential involvement of NMDA, AMPA/kainate and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior
Di Ciano, P., Cardinal, R. N., Cowell, R. A., Little, S. J., & Everitt, B. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09471.2001 · Cited by 354
Hippocampal Volume in First-Episode Psychoses and Chronic Schizophrenia
Velakoulis, D., Pantelis, C., McGorry, P. D., Dudgeon, P., Brewer, W. J., Cook, M. J., Desmond, P. M., Bridle, N., Tierney, P., Murrie, V., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.2.133 · Cited by 354
The hippocampus and mechanisms of declarative memory
Eichenbaum, H. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00044-3 · Cited by 353
Double dissociation of the effects of medial and orbital prefrontal cortical lesions on attentional and affective shifts in mice
Bissonette, G. B., Martins, G. J., Franz, T. M., Harper, E. S., Schoenbaum, G., & Powell, E. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2820-08.2008 · Cited by 353
Comparison of set-shifting ability in patients with chronic schizophrenia and frontal lobe damage
Pantelis, C., Barber, F. Z., Barnes, T. R. E., Nelson, H. E., Owen, A. M., & Robbins, T. W. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00156-x · Cited by 347
Probabilistic reversal learning impairments in schizophrenia: Further evidence of orbitofrontal dysfunction
Waltz, J. A., & Gold, J. M. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.03.010 · Cited by 331
The Construct of Attention in Schizophrenia
Luck, S. J., & Gold, J. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.014 · Cited by 326
Association of Dorsolateral Prefrontal Cortex Dysfunction With Disrupted Coordinated Brain Activity in Schizophrenia: Relationship With Impaired Cognition, Behavioral Disorganization, and Global Function
Yoon, J. H., Minzenberg, M., Ursu, S., Walters, R., Wendelken, C., Ragland, J. D., & Carter, C. S. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07060945 · Cited by 326
Memory for spatial locations, motor responses, and objects: triple dissociation among the hippocampus, caudate nucleus, and extrastriate visual cortex
Kesner, R., Bolland, B. L., & Dakis, M. (1993) · Experimental Brain Research · doi:10.1007/bf00229361 · Cited by 324
Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia
Young, J. W., Powell, S. B., Risbrough, V. B., Marston, H. M., & Geyer, M. A. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.004 · Cited by 312
Triple dissociation of anterior cingulate, posterior cingulate, and medial frontal cortices on visual discrimination tasks using a touchscreen testing procedure for the rat.
Bussey, T. J., Muir, J. L., Everitt, B. J., & Robbins, T. W. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.5.920 · Cited by 311
Self-citation
The Case for Frontostriatal Dysfunction in Schizophrenia
Robbins, T. W. (1990) · Schizophrenia Bulletin · doi:10.1093/schbul/16.3.391 · Cited by 309
Adult neurogenesis: integrating theories and separating functions
Aimone, J. B., Deng, W., & Gage, F. H. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.04.003 · Cited by 303
Towards a muscarinic hypothesis of schizophrenia
Raedler, T. J., Bymaster, F. P., Tandon, R., Copolov, D., & Dean, B. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001924 · Cited by 298
The role of prefrontal cortex in working memory: examining the contents of consciousness
The American Association for Research into Nervous and Mental Diseases, Courtney, S. M., Petit, L., Haxby, J. V., & Ungerleider, L. G. (1998) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1998.0334 · Cited by 297
Early-stage visual processing deficits in schizophrenia
Butler, P. D., & Javitt, D. C. (2005) · Current Opinion in Psychiatry · doi:10.1097/00001504-200503000-00008 · Cited by 294
Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function
Parkinson, J. A., Dalley, J. W., Cardinal, R. N., Bamford, A., Fehnert, B., Lachenal, G., Rudarakanchana, N., Halkerston, K. M., Robbins, T. W., & Everitt, B. J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00291-7 · Cited by 288
Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice
Gerber, D., Sotnikova, T. D., Gainetdinov, R., Huang, S., Caron, M., & Tonegawa, S. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.261583798 · Cited by 282
Deficits in Impulse Control Associated with Tonically-elevated Serotonergic Function in Rat Prefrontal Cortex
Dalley, J. W. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00412-2 · Cited by 275
Dissociable roles of the central and basolateral amygdala in appetitive emotional learning
Parkinson, J. A., Robbins, T. W., & Everitt, B. J. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00960.x · Cited by 272
Impairments of Reversal Learning and Response Perseveration after Repeated, Intermittent Cocaine Administrations to Monkeys
Jentsch, D. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00355-4 · Cited by 272
Working memory, response selection, and effortful processing in rats with medial prefrontal lesions.
Granon, S., Vidal, C., Thinus‐Blanc, C., Changeux, J., & al, E. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.5.883 · Cited by 265
Abolition of the expression but not the acquisition of latent inhibition by chronic amphetamine in rats
Weiner, I., Lubow, R. E., & Feldon, J. (1984) · Psychopharmacology · doi:10.1007/bf00429734 · Cited by 263
The Shaping of a Behaviorist
D., C. P., & Skinner, B. F. (1980) · The American Journal of Psychology · doi:10.2307/1422239 · Cited by 262
Hippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluation
DeCarolis, N. A., & Eisch, A. J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.12.013 · Cited by 259
Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?: Figure 1.
Eisch, A. J., Cameron, H. A., Encinas, J. M., Meltzer, L. A., Ming, G., & Overstreet‐Wadiche, L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3798-08.2008 · Cited by 258
Impaired Fear Extinction Learning and Cortico-Amygdala Circuit Abnormalities in a Common Genetic Mouse Strain
Hefner, K. R., Whittle, N., Juhasz, J., Norcross, M. A., Karlsson, R., Saksida, L. M., Bussey, T. J., Singewald, N., & Holmes, A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4904-07.2008 · Cited by 256
Self-citation
Distinct patterns of behavioural impairments resulting from fornix transection or neurotoxic lesions of the perirhinal and postrhinal cortices in the rat
Bussey, T. J., Duck, J., Muir, J. L., & Aggleton, J. P. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00155-8 · Cited by 256
Self-citation
The touchscreen cognitive testing method for rodents: How to get the best out of your rat
Bussey, T. J., Padain, T. L., Skillings, E. A., Winters, B. D., Morton, A. J., & Saksida, L. M. (2008) · Learning & Memory · doi:10.1101/lm.987808 · Cited by 255
Self-citation
Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat
Grayson, B., Idris, N. F., & Neill, J. C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.06.012 · Cited by 243
Delay-dependent modulation of memory retrieval by infusion of a dopamine D-sub-1 agonist into the rat medial prefrontal cortex.
Floresco, S., & Phillips, A. G. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.934 · Cited by 231
Magnitude of Dopamine Release in Medial Prefrontal Cortex Predicts Accuracy of Memory on a Delayed Response Task
Phillips, A. G., Ahn, S., & Floresco, S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4653-03.2004 · Cited by 230
Weak suppression of visual context in chronic schizophrenia
Dakin, S., Carlin, P., & Hemsley, D. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.015 · Cited by 227
Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses
Law, A. J., & Deakin, J. F. W. (2001) · Neuroreport · doi:10.1097/00001756-200109170-00043 · Cited by 227
Neurobehavioral assessment in the information age
Tecott, L. H., & Nestler, E. J. (2004) · Nature Neuroscience · doi:10.1038/nn1225 · Cited by 222
Discrimination learning, reversal, and set-shifting in first-episode schizophrenia: stability over six years and specific associations with medication type and disorganization syndrome
Leeson, V. C., Robbins, T. W., Matheson, E., Hutton, S. B., Ron, M. A., Barnes, T. R. E., & Joyce, E. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.016 · Cited by 219
Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens
Dalley, J. W., Lääne, K., Theobald, D. E. H., Armstrong, H. C., Corlett, P. R., Chudasama, Y., & Robbins, T. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502080102 · Cited by 214
Dissociable effects of cingulate and medial frontal cortex lesions on stimulus-reward learning using a novel Pavlovian autoshaping procedure for the rat: Implications for the neurobiology of emotion.
Bussey, T. J., Everitt, B. J., & Robbins, T. W. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.5.908 · Cited by 210
Self-citation
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice
Li, W., Zhou, Y., Jentsch, J. D., Brown, R. A. M., Tian, X., Ehninger, D., Hennah, W., Peltonen, L., Lönnqvist, J. K., HUTTUNEN, M. O., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706900104 · Cited by 205
Working memory, response selection, and effortful processing in rats with medial prefrontal lesions.
Granon, S., Vidal, C., Thinus‐Blanc, C., et al. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.5.883 · Cited by 197
Facilitation of latent inhibition by haloperidol in rats
Weiner, I., & Feldon, J. (1987) · Psychopharmacology · doi:10.1007/bf00217073 · Cited by 194
Source monitoring deficits in patients with schizophrenia; a multinomial modelling analysis
Keefe, R. S. E., ARNOLD, M. C., Bayen, U. J., & Harvey, P. D. (1999) · Psychological Medicine · doi:10.1017/s0033291799008673 · Cited by 191
Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and ‘schizophrenia-related’ behaviors
Wiedholz, L. M., Owens, W. A., Horton, R. E., Feyder, M. J., Karlsson, R.-M., Hefner, K. R., Sprengel, R., Celikel, T., Daws, L. C., & Holmes, A. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002056 · Cited by 180
Self-citation
Findings from animals concerning when interactions between perirhinal cortex, hippocampus and medial prefrontal cortex are necessary for recognition memory
Warburton, E. C., & Brown, M. W. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.12.022 · Cited by 174
Extinction memory is impaired in schizophrenia
Holt, D. J., Lebron-Milad, K., Milad, M. R., Rauch, S. L., Pitman, R. K., Orr, S. P., Cassidy, B. S., Walsh, J. P., & Goff, D. C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.017 · Cited by 170
Contrast sensitivity for stationary and drifting spatial frequency gratings in positive- and negative-symptom schizophrenia.
Slaghuis, W. A. (1998) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.107.1.49 · Cited by 168
Contrast sensitivity for stationary and drifting spatial frequency gratings in positive- and negative-symptom schizophrenia
Slaghuis, W. A. (1998) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.107.1.49 · Cited by 168
Assessment of Glutamate Transporter GLAST (EAAT1)-Deficient Mice for Phenotypes Relevant to the Negative and Executive/Cognitive Symptoms of Schizophrenia
Karlsson, R.-M., Tanaka, K., Saksida, L. M., Bussey, T. J., Heilig, M., & Holmes, A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.215 · Cited by 165
Self-citation
Removal of the hippocampus and transection of the fornix produce comparable deficits on delayed non-matching to position by rats
Aggleton, J. P., Keith, A. B., Rawlins, J. N. P., Hunt, P. R., & Sahgal, A. (1992) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80325-0 · Cited by 161
Impaired Attention in the 3xTgAD Mouse Model of Alzheimer's Disease: Rescue by Donepezil (Aricept)
Romberg, C., Mattson, M. P., Mughal, M. R., Bussey, T. J., & Saksida, L. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5242-10.2011 · Cited by 160
Self-citation
Executive dysfunction in first-episode schizophrenia and relationship to duration of untreated psychosis: The West London Study
Joyce, E. M., Hutton, S. B., Mutsatsa, S., Gibbins, H., Webb, E., Paul, S., Robbins, T. W., & Barnes, T. R. E. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.181.43.s38 · Cited by 158
Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunitPreprint
Brigman, J. L., Feyder, M. J., Saksida, L. M., Bussey, T. J., Mishina, M., & Holmes, A. (2008) · Learning & Memory · doi:10.1101/lm.777308 · Cited by 158
Self-citation
Reinforcement and Reversal Learning in First-Episode Psychosis
Murray, G. K., Cheng, F., Clark, L., Barnett, J. H., Blackwell, A. D., Fletcher, P. C., Robbins, T. W., Bullmore, E. T., & Jones, P. B. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn078 · Cited by 155
Abnormalities of Wnt signalling in schizophrenia – evidence for neurodevelopmental abnormality
Cotter, D., Kerwin, R. W., Al-Sarraji, S., Brion, J., Chadwich, A., Lovestone, S., Anderton, B. H., & Everall, I. (1998) · Neuroreport · doi:10.1097/00001756-199805110-00024 · Cited by 152
The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice
Pieper, A. A., Wu, X., Han, T. W., Estill, S. J., Dang, Q. T., Wu, L. C., Reece-Fincanon, S., Dudley, C. A., Richardson, J. A., Brat, D. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506713102 · Cited by 150
Ultrastructural alterations in hippocampal mossy fiber synapses in schizophrenia: A postmortem morphometric study
Kolomeets, N. S., Orlovskaya, D. D., Rachmanova, V. I., & Uranova, N. A. (2005) · Synapse · doi:10.1002/syn.20153 · Cited by 149
Cognitive predictors of psychosocial functioning outcome in schizophrenia: a follow-up study of subjects participating in a rehabilitation program
Prouteau, A., Verdoux, H., Briand, C., Lesage, A., Lalonde, P., Nicole, L., Reinharz, D., & Stip, E. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.03.001 · Cited by 149
In search of a better mouse test.
Wahlsten, D., Rustay, N., Metten, P., & Crabbe, J. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00033-x · Cited by 149
Magnocellular contributions to impaired motion processing in schizophrenia
Kim, D., Wylie, G., Pasternak, R., Butler, P. D., & Javitt, D. C. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.10.008 · Cited by 146
Glutamatergic dysfunction in schizophrenia: From basic neuroscience to clinical psychopharmacology
Paz, R. D., Tardito, S., Atzori, M., & Tseng, K. Y. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.06.005 · Cited by 145
Local glutamate receptor antagonism in the rat prefrontal cortex disrupts response inhibition in a visuospatial attentional task
Murphy, E. R., Dalley, J. W., & Robbins, T. W. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2068-3 · Cited by 145
Clinical and Neurocognitive Aspects of Source Monitoring Errors in Schizophrenia
Vinogradov, S., Willis-Shore, J., Poole, J. H., Marten, E., Ober, B. A., & Shenaut, G. K. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.11.1530 · Cited by 141
Lesions of the medial and lateral striatum in the rat produce differential deficits in attentional performance
Rogers, R. D., Baunez, C., Everitt, B. J., & Robbins, T. W. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.799 · Cited by 140
Context memory and binding in schizophrenia
Waters, F. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00221-4 · Cited by 139
Disruption of Performance in the Five-Choice Serial Reaction Time Task Induced By Administration of N-Methyl-D-Aspartate Receptor Antagonists: Relevance to Cognitive Dysfunction in Schizophrenia
Amitai, N., & Markou, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.004 · Cited by 136
Relations between neuropsychological performance and brain morphological and physiological measures in monozygotic twins discordant for schizophrenia
Goldberg, T. E., Torrey, E. F., Berman, K. F., & Weinberger, D. R. (1994) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(94)90011-6 · Cited by 135
A behavioural analysis of the delayed non-matching to position task: the effects of scopolamine, lesions of the fornix and of the prelimbic region on mediating behaviours by rats
Chudasama, Y., & Muir, J. L. (1997) · Psychopharmacology · doi:10.1007/s002130050427 · Cited by 135
Evaluating the differential roles of the dorsal dentate gyrus, dorsal CA3, and dorsal CA1 during a temporal ordering for spatial locations task
Hunsaker, M. R., & Kesner, R. P. (2008) · Hippocampus · doi:10.1002/hipo.20455 · Cited by 133
Pathways between early visual processing and functional outcome in schizophrenia
Rassovsky, Y., Horan, W. P., Lee, J., Sergi, M. J., & Green, M. F. (2010) · Psychological Medicine · doi:10.1017/s0033291710001054 · Cited by 132
Trial-unique, delayed nonmatching-to-location (TUNL): A novel, highly hippocampus-dependent automated touchscreen test of location memory and pattern separation
Talpos, J. C., McTighe, S. M., Dias, R. S., Saksida, L. M., & Bussey, T. J. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.07.006 · Cited by 131
Self-citation
Neurogenesis and schizophrenia: dividing neurons in a divided mind?
Reif, A., Schmitt, A. G., Fritzen, S., & Lesch, K. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0733-3 · Cited by 128
Psychopharmacological approaches to modulating attention in the five-choice serial reaction time task: implications for schizophrenia
Chudasama, Y., & Robbins, T. W. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1805-y · Cited by 125
CNTRICS Final Task Selection: Working Memory
Barch, D. M., Berman, M. G., Engle, R. F., Jones, J. H., Jonides, J., MacDonald, A. W., Nee, D. E., Redick, T. S., & Sponheim, S. R. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn153 · Cited by 124
A novel touchscreen-automated paired-associate learning (PAL) task sensitive to pharmacological manipulation of the hippocampus: a translational rodent model of cognitive impairments in neurodegenerative disease
Talpos, J. C., Winters, B. D., Dias, R. S., Saksida, L. M., & Bussey, T. J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1526-3 · Cited by 122
Self-citation
Genetic and dopaminergic modulation of reversal learning in a touchscreen-based operant procedure for mice
Izquierdo, A., Wiedholz, L. M., Millstein, R. A., YANG, R., Bussey, T. J., Saksida, L. M., & HOLMES, A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.029 · Cited by 119
Self-citation
Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats
Amitai, N., Semenova, S., & Markou, A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0808-x · Cited by 118
Glycogen synthase kinase-3β immunoreactivity is reduced in the prefrontal cortex in schizophrenia
Beasley, C. L., Cotter, D., Khan, N., Pollard, C., Sheppard, P. W., Varndell, I. M., Lovestone, S., Anderton, B. H., & Everall, I. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01688-3 · Cited by 115
Glutamatergic aspects of schizophrenia
Tamminga, C. A. (1999) · The British Journal of Psychiatry · doi:10.1192/s0007125000293598 · Cited by 115
Perception Measurement in Clinical Trials of Schizophrenia: Promising Paradigms From CNTRICS
Green, M. F., Butler, P. D., Chen, Y., Geyer, M. A., Silverstein, S., Wynn, J. K., Yoon, J. H., & Zemon, V. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn156 · Cited by 113
Recalling Safety: Cooperative Functions of the Ventromedial Prefrontal Cortex and the Hippocampus in Extinction
Corcoran, K. A., & Quirk, G. J. (2007) · CNS Spectrums · doi:10.1017/s1092852900020915 · Cited by 111
Hippocampal and amygdaloid involvement in nonspatial and spatial working memory in rats: Effects of delay and interference.
Wan, R., Pang, K. C. H., & Olton, D. S. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.5.866 · Cited by 110
Right medial temporal–lobe contribution to object–location memory
Milner, B. A., Johnsrude, I. S., & Crane, J. (1997) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1997.0133 · Cited by 108
Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders - the case of yohimbine
Holmes, A., & Quirk, G. J. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.10.003 · Cited by 107
Self-citation
A new touchscreen test of pattern separation: effect of hippocampal lesions
McTighe, S. M., Mar, A. C., Romberg, C., Bussey, T. J., & Saksida, L. M. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32832c5eb2 · Cited by 106
Self-citation
Self-assessed cognitive dysfunction and objective performance in outpatients with schizophrenia participating in a rehabilitation program
Prouteau, A. (2003) · Schizophrenia Research · doi:10.1016/j.schres.2003.08.011 · Cited by 105
Decreased numerical density of CA3 hippocampal mossy fiber synapses in schizophrenia
Kolomeets, N. S., Orlovskaya, D. D., & Uranova, N. A. (2007) · Synapse · doi:10.1002/syn.20405 · Cited by 105
Sensitivity of the Five-Choice Serial Reaction Time Task to the Effects of Various Psychotropic Drugs in Sprague-Dawley Rats
Paine, T. A., Tomasiewicz, H. C., Zhang, K., & Carlezon, W. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.017 · Cited by 104
Increased neurogenesis in a rat ketamine model of schizophrenia
Keilhoff, G., Bernstein, H., Becker, A., Grecksch, G., & Wolf, G. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.010 · Cited by 104
Adult neurogenesis and schizophrenia: A window on abnormal early brain development?
Toro, C. T., & Deakin, J. F. W. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.09.030 · Cited by 104
Functional disconnection of a prefrontal cortical-dorsal striatal system disrupts choice reaction time performance: Implications for attentional function.
Christakou, A., Robbins, T. W., & Everitt, B. J. (2001) · Behavioral Neuroscience · doi:10.1037//0735-7044.115.4.812 · Cited by 103
Assessment of cognitive function in the heterozygous reeler mouse
Krueger‐Burg, D., Howell, J. L., Hebert, B. F., Olausson, P., Taylor, J. R., & Nairn, A. C. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0530-0 · Cited by 100
Loss of Glial Glutamate and Aspartate Transporter (Excitatory Amino Acid Transporter 1) Causes Locomotor Hyperactivity and Exaggerated Responses to Psychotomimetics: Rescue by Haloperidol and Metabotropic Glutamate 2/3 Agonist
Karlsson, R., Tanaka, K., Heilig, M. A., & Holmes, A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.001 · Cited by 100
Self-citation
Role of the anterior cingulate cortex in the control over behavior by Pavlovian conditioned stimuli in rats.
Cardinal, R. N., Parkinson, J. A., Marbini, H. D., Toner, A. J., Bussey, T. J., Robbins, T. W., & Everitt, B. J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.3.566 · Cited by 99
Self-citation
Cholinergic blockade in prefrontal cortex and hippocampus disrupts short-term memory in rats
Dunnett, S. B., Wareham, A. T., & Torres, E. M. (1990) · Neuroreport · doi:10.1097/00001756-199009000-00017 · Cited by 97
Cognition in transmembrane domain neuregulin 1 mutant mice
Duffy, L., Cappas, E., Lai, D., Boucher, A. A., & Karl, T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.07.042 · Cited by 95
Prenatal cocaine exposure impairs selective attention: Evidence from serial reversal and extradimensional shift tasks.
Garavan, H., Morgan, R. E., Mactutus, C. F., Levitsky, D. A., Booze, R. M., & Strupp, B. J. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.4.725 · Cited by 89
Visuospatial memory and learning in first-episode schizophreniform psychosis and established schizophrenia: a functional correlate of hippocampal pathology?
Wood, S. J., Proffitt, T., Mahony, K. E., SMITH, D. J., Buchanan, J., Brewer, W. J., Stuart, G. W., Velakoulis, D., McGorry, P. D., & Pantelis, C. (2002) · Psychological Medicine · doi:10.1017/s0033291702005275 · Cited by 89
Functional disconnection of a prefrontal cortical–dorsal striatal system disrupts choice reaction time performance: Implications for attentional function.
Christakou, A., Robbins, T. W., & Everitt, B. J. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.812 · Cited by 88
The hippocampus and appetitive Pavlovian conditioning: Effects of excitotoxic hippocampal lesions on conditioned locomotor activity and autoshaping
Ito, R., Everitt, B. J., & Robbins, T. W. (2005) · Hippocampus · doi:10.1002/hipo.20094 · Cited by 87
Daily activities, cognition and community functioning in persons with schizophrenia
Aubin, G., Stip, É., Gélinas, I., Rainville, C. M., & Chapparo, C. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.08.002 · Cited by 86
Hippocampal and amygdaloid involvement in nonspatial and spatial working memory in rats: Effects of delay and interference.
Wan, R., Pang, K. C. H., & Olton, D. S. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.5.866 · Cited by 85
Discrimination of Multidimensional Visual Stimuli by Mice: Intra- and Extradimensional Shifts.
Brigman, J. L., Bussey, T. J., Saksida, L. M., & Rothblat, L. A. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.3.839 · Cited by 85
Self-citation
Effects of subchronic phencyclidine (PCP) treatment on social behaviors and operant discrimination and reversal learning in C57BL/6J mice
Brigman, J. L. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.002.2009 · Cited by 85
A Sensitizing Regimen of Amphetamine Impairs Visual Attention in the 5-Choice Serial Reaction Time Test: Reversal by a D1 Receptor Agonist Injected into the Medial Prefrontal Cortex
Fletcher, P. J., Tenn, C. C., Sinyard, J., Rizos, Z., & Kapur, S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301221 · Cited by 84
Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder?
Barkus, C., Feyder, M. J., Graybeal, C., Wright, T., Wiedholz, L. M., Izquierdo, A., Kiselycznyk, C., Schmitt, W. B., Sanderson, D. J., Rawlins, J. N. P., et al. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.06.005 · Cited by 82
Self-citation
Phencyclidine exacerbates attentional deficits in a neurodevelopmental rat model of schizophrenia
Le Pen, G., Grottick, A. J., Higgins, G. A., & Moreau, J.-L. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300208 · Cited by 82
Spatial Working Memory as a Cognitive Endophenotype of Schizophrenia: Assessing Risk for Pathophysiological Dysfunction
Saperstein, A. M., Fuller, R. L. M., Avila, M. T., Adami, H. M., McMahon, R. P., Thaker, G. K., & Gold, J. M. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj072 · Cited by 81
Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?
Fitzgerald, P. J., Barkus, C., Feyder, M. J., Wiedholz, L. M., Chen, Y.-C., Karlsson, R., Machado‐Vieira, R., Graybeal, C., Sharp, T., Zarate, C. A., et al. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.08.005 · Cited by 79
Self-citation
Visuospatial learning and executive function are independently impaired in first-episode psychosis
Barnett, J. H., Sahakian, B. J., Field‐Werners, U., HILL, K. E., Brazil, R., Gallagher, O., Bullmore, E. T., & Jones, P. B. (2005) · Psychological Medicine · doi:10.1017/s0033291704004301 · Cited by 79
Clozapine Prevents a Decrease in Neurogenesis in Mice Repeatedly Treated With Phencyclidine
Maeda, K., Sugino, H., Hirose, T., Kitagawa, H., Nagai, T., Mizoguchi, H., Takuma, K., & Yamada, K. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0061424 · Cited by 76
Remediation of attentional dysfunction in rats with lesions of the medial prefrontal cortex by intra-accumbens administration of the dopamine D2/3 receptor antagonist sulpiride
Pezze, M. A., Dalley, J. W., & Robbins, T. W. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1384-4 · Cited by 74
Dorsal hippocampal N-methyl-d-aspartate receptors underlie spatial working memory performance during non-matching to place testing on the T-maze
McHugh, S. B., Niewoehner, B., Rawlins, J. N. P., & Bannerman, D. M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.07.021 · Cited by 72
Sulpiride alleviates the attentional impairments of rats with medial prefrontal cortex lesions
Passetti, F., Levita, L., & Robbins, T. W. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00229-2 · Cited by 70
Festina lente: Late-night thoughts on high-throughput screening of mouse behavior
Crabbe, J. C., & Morris, R. (2004) · Nature Neuroscience · doi:10.1038/nn1343 · Cited by 69
A computer-automated touchscreen paired-associates learning (PAL) task for mice: impairments following administration of scopolamine or dicyclomine and improvements following donepezil
Bartko, S. J., Vendrell, I., Saksida, L. M., & Bussey, T. J. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2050-1 · Cited by 69
Self-citation
The effects of 5-HT3 receptor antagonists on cognitive performance in aged monkeys
Arnsten, A. F. T., Lin, C. H., van Dyck, C. H., & Stanhope, K. J. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00162-5 · Cited by 67
Cognitive functions in prepsychotic patients
Bartók, E., Berecz, R., Glaub, T., & Degrell, I. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.01.008 · Cited by 67
Reduced top-down influences in contour detection in schizophrenia
Silverstein, S., Hatashita-Wong, M., Schenkel, L., Wilkniss, S., Kovács, I., Fehér, A., Smith, T., Goicochea, C., Uhlhaas, P., Carpiniello, K., et al. (2006) · Cognitive Neuropsychiatry · doi:10.1080/13546800444000209 · Cited by 67
Elevated 3T proton MRS glutamate levels associated with poor Continuous Performance Test (CPT-0X) scores and genetic risk for schizophrenia
Purdon, S. E., Valiakalayil, A., Hanstock, C. C., Seres, P., & Tibbo, P. G. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.11.028 · Cited by 67
Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome
Relkovic, D., Doe, C. M., Humby, T., Johnstone, K. A., Resnick, J. L., Holland, A. J., Hagan, J. J., Wilkinson, L. S., & Isles, A. R. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07048.x · Cited by 66
Effects of aripiprazole, olanzapine, and haloperidol in a model of cognitive deficit of schizophrenia in rats: relationship with glutamate release in the medial prefrontal cortex
Carli, M., Calcagno, E., Mainolfi, P., Mainini, E., & Invernizzi, R. W. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2065-7 · Cited by 65
Cognitive discernible factors between schizophrenia and schizoaffective disorder
Stip, É., Sepehry, A. A., Prouteau, A., Briand, C., Nicole, L., Lalonde, P., & LESAGE, A. D. (2005) · Brain and Cognition · doi:10.1016/j.bandc.2005.07.003 · Cited by 60
Nucleus accumbens dopamine and discriminated approach learning: interactive effects of 6-hydroxydopamine lesions and systemic apomorphine administration
Dalley, J. W., Chudasama, Y., Theobald, D. E. H., Pettifer, C., Fletcher, C., & Robbins, T. W. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1078-2 · Cited by 60
Medial Frontal Hyperactivity in Reality Distortion
Taylor, S. F., Welsh, R. C., Chen, A. C., Velander, A. J., & Liberzon, I. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.029 · Cited by 58
Discrimination Accuracy and Decision Biases in Different Types of Reality Monitoring in Schizophrenia
Brébion, G., SMITH, M. J., Gorman, J. M., et al. (1997) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199704000-00005 · Cited by 58
Measurement and treatment research to improve cognition in schizophrenia: neuropharmacological aspects
Geyer, M., & Tamminga, C. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1846-2 · Cited by 56
Effects of antipsychotic drugs on MK-801-induced attentional and motivational deficits in rats
Paine, T. A., & Carlezon, W. A. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.01.004 · Cited by 55
Muscimol, AP5, or scopolamine infused into perirhinal cortex impairs two-choice visual discrimination learning in rats
Winters, B. D., Bartko, S. J., Saksida, L. M., & Bussey, T. J. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.10.002 · Cited by 53
Self-citation
The Neuropathology of Schizophrenia
Kleinman, J. E., Casanova, M. F., & Jaskiw, G. E. (1988) · Schizophrenia Bulletin · doi:10.1093/schbul/14.2.209 · Cited by 53
Effects of repeated phencyclidine administration on adult hippocampal neurogenesis in the rat
Liu, J., Suzuki, T., Seki, T., Namba, T., Tanimura, A., & Arai, H. (2006) · Synapse · doi:10.1002/syn.20275 · Cited by 52
Predicting domain-specific insight of schizophrenia patients from symptomatology, multiple neurocognitive functions, and personality related traits
Ritsner, M. S., & Blumenkrantz, H. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2006.01.002 · Cited by 51
Rivastigmine treatment as an add‑on to antipsychotics in patients with schizophrenia and cognitive deficits
Chouinard, S., Stip, É., Poulin, J., Melun, J.-P., Godbout, R., Guillem, F., & Cohen, H. (2007) · Current Medical Research and Opinion · doi:10.1185/030079906x167372 · Cited by 51
Reward-Related Behavioral Paradigms for Addiction Research in the Mouse: Performance of Common Inbred Strains
Lederle, L. I., Weber, S. C., Wright, T., Feyder, M. J., Brigman, J. L., Crombag, H. S., Saksida, L. M., Bussey, T. J., & Holmes, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015536 · Cited by 50
Self-citation
Muscarinic Agonists for the Treatment of Cognition in Schizophrenia
Sellin, A. K., Shad, M. U., & Tamminga, C. A. (2008) · CNS Spectrums · doi:10.1017/s1092852900014048 · Cited by 49
Perceptual organization by proximity and similarity in schizophrenia
Kurylo, D. D., Pasternak, R., Silipo, G., Javitt, D. C., & Butler, P. D. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.07.001 · Cited by 46
Haloperidol and clozapine have dissociable effects in a model of attentional performance deficits induced by blockade of NMDA receptors in the mPFC
Baviera, M., Invernizzi, R. W., & Carli, M. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0959-9 · Cited by 43
Low GSK-3β in schizophrenia as a consequence of neurodevelopmental insult
Kozlovsky, N., Nadri, C., & Agam, G. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.02.003 · Cited by 42
Are relational style and neuropsychological performance predictors of social attributions in chronic schizophrenia?
Donohoe, G. J., Spoletini, I., McGlade, N., Behan, C. L., Hayden, J., O'Donoghue, T., Peel, R., Haq, F., Walker, C. P. R., O’Callaghan, E., et al. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2007.10.001 · Cited by 40
Hippocampal lesions in rats impair learning and memory for locations on a touch-sensitive computer screen: The “ASAT” task
Talpos, J. C., Dias, R. S., Bussey, T. J., & Saksida, L. M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.04.008 · Cited by 40
Self-citation
Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine
Thomson, D. M., McVie, A., MORRIS, B. J., & Pratt, J. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2020-7 · Cited by 37

Research works printed but not linked: 2

Leeson, 2009, Discrimination learning, reversal, and set-shifting in first-episode schizophrenia: stability over six years and specific associations with medication type and disorganization syndrome, Biol. Psychiatry, 66, 586, 10.1016/j.biopsych.2009.05.016 · DOI · Paper page
Nuechterlein, 2008, The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity, Am. J. Psychiatry, 165, 203, 10.1176/appi.ajp.2007.07010042 · DOI · Paper page

Sorted by citations

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
Webster, S. J., Bachstetter, A. D., Nelson, P. T., Schmitt, F. A., & Van Eldik, L. J. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00088 · Cited by 755
“Touchscreen versions of this task are also available in which the nose poke holes and stimulus lights are replaced with an LCD screen (Romberg et al., 2011; Bussey et al., 2012).”
Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome
Berry-Kravis, E. M., Lindemann, L., Jønch, A. E., Apostol, G., Bear, M. F., Carpenter, R. L., Crawley, J. N., Curie, A., Des Portes, V., Hossain, F., et al. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.221 · Cited by 336
Synaptic scaffold evolution generated components of vertebrate cognitive complexity
Nithianantharajah, J., Komiyama, N. H., McKechanie, A., Johnstone, M., Blackwood, D. H., Clair, D. S., Emes, R. D., van de Lagemaat, L. N., Saksida, L. M., Bussey, T. J., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3276 · Cited by 251
Self-citation
The touchscreen operant platform for testing working memory and pattern separation in rats and mice.
Oomen, C. A., Hvoslef-Eide, M., Heath, C. J., Mar, A. C., Horner, A. E., Bussey, T. J., & Saksida, L. M. (2013) · Nature Protocols · doi:10.1038/nprot.2013.124 · Cited by 193
Self-citation
Toward more predictive genetic mouse models of Alzheimer’s disease
Onos, K. D., Sukoff Rizzo, S. J., Howell, G. R., & Sasner, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.12.003 · Cited by 156

See all 299

Authors: Bussey, T. J., Holmes, A., Lyon, L., Mar, A. C., McAllister, K. A. L., Nithianantharajah, J., Oomen, C. A., & Saksida, L. M.
Affiliations: University of Cambridge (GB)
National Institutes of Health (US)
Corresponding author: Bussey, T.J.
ORCID: Bussey, T.J.
Holmes, A.
Mar, A.C.
Nithianantharajah, J.
Saksida, L.M.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2012-03
Volume: 62
Issue: 3
Pages: 1191-1203
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2011.04.011
PMC: PMC3168710
OpenAlex: W2099186316
Cited by: 299
References: 208
Citations by year: 2026: 6 · 2025: 13 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 55 · 2020: 27 · 2019: 19 · 2018: 22 · 2017: 29 · 2016: 18 · 2015: 28 · 2014: 13 · 2013: 16 · 2012: 17
FWCI: 11.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Commonwealth Trust, Janssen Pharmaceutica
National Institute on Alcohol Abuse and Alcoholism Intramural Research Program
Innovative Medicines Initiative Joint Undertaking (IMI) (115008)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: schizophrenia, cognitive assessment, rodent models, cognitive enhancement, reward learning, memory, perceptual discrimination, attention, impulsivity, compulsivity, extinction, classical conditioning, flexible batteries, cognitive profile, cognitive therapy
MeSH terms: Animals, Cognition Disorders, Computers, Discrimination, Psychological, Disease Models, Animal, Neuropsychological Tests, Photic Stimulation, Psychomotor Performance, Schizophrenia, Schizophrenic Psychology, Touch, Mice, Rats, Translational Research, Biomedical

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

New translational assays for preclinical modelling of cognition in schizophrenia: The touchscreen testing method for mice and rats

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks