Cited by 326Gut microbiota and healthGastrointestinal motility and disordersRegulation of Appetite and Obesity

The DOI matches its Crossref record; 402 of the 407 references it cites were found in a registry or an index.

The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective

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Cussotto, Sofia, Sandhu, Kiran V., Dinan, Timothy G., Cryan, John F.·2018·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2018.04.002

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Abstract

The human gut harbours trillions of symbiotic bacteria that play a key role in programming different aspects of host physiology in health and disease. These intestinal microbes are also key components of the gut-brain axis, the bidirectional communication pathway between the gut and the central nervous system (CNS). In addition, the CNS is closely interconnected with the endocrine system to regulate many physiological processes. An expanding body of evidence is supporting the notion that gut microbiota modifications and/or manipulations may also play a crucial role in the manifestation of specific behavioural responses regulated by neuroendocrine pathways. In this review, we will focus on how the intestinal microorganisms interact with elements of the host neuroendocrine system to modify behaviours relevant to stress, eating behaviour, sexual behaviour, social behaviour, cognition and addiction.

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Items 201–400 of 402

Corticotropin-Releasing Factor, But Not Corticosterone, Is Involved in Stress-Induced Relapse to Heroin-Seeking in Rats
Shaham, Y., Funk, D., Erb, S., Brown, T. J., Walker, C.-D., & Stewart, J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02605.1997 · Cited by 308 · cited 1×
“In contrast, shock-induced reinstatement of heroin or alcohol seeking depends on CRF, but not on corticosterone (Le et al., 2000; O'Callaghan et al., 2005; Shaham et al., 1997).”
Background
The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects
Tarini, J., & Wolever, T. M. S. (2010) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-119 · Cited by 304
The Intestinal Microbiota in Acute Anorexia Nervosa and During Renourishment: Relationship to Depression, Anxiety, and Eating Disorder Psychopathology
Kleiman, S. C., Watson, H. J., Bulik-Sullivan, E. C., Huh, E. Y., Tarantino, L. M., Bulik, C. M., & Carroll, I. M. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000247 · Cited by 303 · cited 1×
“Moreover, the microbial composition in the anorexic cohort was correlated with mood (Kleiman et al., 2015).”
Background
The prebiotic effects of biscuits containing partially hydrolysed guar gum and fructo-oligosaccharides – a human volunteer study
Tuohy, K. M., Kolida, S., Lustenberger, A. M., & Gibson, G. R. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2001394 · Cited by 302 · cited 1×
“carbohydrates that have been shown to modulate the intestinal microbiota by increasing the proportions of bifidobacteria and lactobacilli in humans (Tuohy et al., 2001).”
Background
The role of CRF and CRF-related peptides in the dark side of addiction
Koob, G. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.008 · Cited by 301 · cited 1×
“Interestingly, CRF is involved in the onset/development of addiction (Koob, 2010; Sarnyai et al., 2001) but the data are not always consistent.”
Background
Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders
Nankova, B. B., Agarwal, R., MacFabe, D. F., & La Gamma, E. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103740 · Cited by 294
Structural & functional consequences of chronic psychosocial stress on the microbiome & host
Bharwani, A., Mian, M. F., Foster, J. A., Surette, M. G., Bienenstock, J., & Forsythe, P. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.10.001 · Cited by 293 · cited 1×
“…stressors including maternal separation, chronic social defeat, physical restraint and overcrowding can alter the gut microbiota composition (Bailey, 2014; Bailey et al., 2011; Bharwani et al., 2016; De Palma et al., 2015; De Palma et al., 2014; Hsiao et al., 2013; Moloney et al., 2014).”
Background
Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: behavioral and electrophysiological proofs for microbiome–gut–brain axis
Davari, S., Talaei, S. A., Alaei, H., & salami, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.055 · Cited by 290 · cited 2×
“In a further preclinical study, a positive effect of probiotic supplementation on diabetes-induced cognitive impairments in rats was observed (Davari et al., 2013).”
Background
Glucocorticoid Receptor Agonist and Antagonist Administration into the Basolateral but Not Central Amygdala Modulates Memory Storage
Roozendaal, B., & McGaugh, J. L. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.3765 · Cited by 289
60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-pituitary–gonadal axis
Plant, T. M. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0113 · Cited by 289 · cited 2×
“Moreover, the activation of the HPG axis in both males and females during puberty induces individuals to acquire secondary sex features (Plant, 2015).”
Background
Brain oxytocin inhibits the (re)activity of the hypothalamo–pituitary–adrenal axis in male rats: involvement of hypothalamic and limbic brain regions
Neumann, I. D., Krömer, S. A., Toschi, N., & Ebner, K. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00197-x · Cited by 285
The prebiotics 3’Sialyllactose and 6’Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: evidence for effects on the gut-brain axis
Tarr, A. J., Galley, J. D., Fisher, S. E., Chichlowski, M., Berg, B. M., & Bailey, M. T. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.06.025 · Cited by 284 · cited 1×
“reduced stress-induced intestinal microbial disruption and anxiety-like behaviour thus confirming the hypothesis that the gut microbiota may play a crucial role in response to stress exposure (Tarr et al., 2015).”
Result
Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
Striepens, N., Kendrick, K. M., Maier, W., & Hurlemann, R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.001 · Cited by 283
Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood
Golubeva, A. V., Crampton, S., Desbonnet, L., Edge, D., O'Sullivan, O., Lomasney, K. W., Zhdanov, A. V., Crispie, F., Moloney, R. D., Borre, Y. E., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.002 · Cited by 283 · cited 3×
“genera significantly correlated with the responsiveness of the HPA axis to stress (Golubeva et al., 2015).”
BackgroundInfluentialSelf-citation
Regulation of microglial inflammatory response by sodium butyrate and short‐chain fatty acids
Huuskonen, J., Suuronen, T., Nuutinen, T., Kyrylenko, S., & Salminen, A. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705682 · Cited by 281 · cited 12×
“GABA transporters are localized on the blood-brain barrier (BBB) and allow gut- derived GABA to reach the CNS (Takanaga et al., 2001).”
Influential
Neonatal endotoxin exposure alters the development of the hypothalamic-pituitary-adrenal axis: early illness and later responsivity to stress
Shanks, N., Larocque, S., & Meaney, M. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00376.1995 · Cited by 278 · cited 1×
“Concordantly, neonatal LPS exposure decreases cerebral glucocorticoid-receptor density, whereas CRF expression is increased (Shanks et al., 1995).”
Background
Hormonal and neural mechanisms of food reward, eating behaviour and obesity
Murray, S. M., Tulloch, A. J., Gold, M. S., & Avena, N. M. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.91 · Cited by 275
The animal and human neuroendocrinology of social cognition, motivation and behavior
McCall, C., & Singer, T. (2012) · Nature Neuroscience · doi:10.1038/nn.3084 · Cited by 273
Breaking the loop: Oxytocin as a potential treatment for drug addiction
McGregor, I. S., & Bowen, M. T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.001 · Cited by 268
Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine
Kiraly, D. D., Walker, D. M., Calipari, E. S., Labonté, B., Issler, O., Peña, C. J., Ribeiro, E., Russo, S. J., & Nestler, E. J. (2016) · Scientific Reports · doi:10.1038/srep35455 · Cited by 267 · cited 1×
“sensitizing effects of repeated cocaine administration (Kiraly et al., 2016).”
Commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods
Nishino, R., Mikami, K., Takahashi, H., Tomonaga, S., Furuse, M., Hiramoto, T., Aiba, Y., Koga, Y., & Sudo, N. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12110 · Cited by 266
Behavioral effects of corticotropin-releasing factor: localization and characterization of central effects
Krahn, D. D., Gosnell, B. A., Levine, A. S., & Morley, J. E. (1988) · Brain Research · doi:10.1016/0006-8993(88)91598-3 · Cited by 265
Early androgen exposure and human gender development
Hines, M., Constantinescu, M., & Spencer, D. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0022-1 · Cited by 263 · cited 1×
“might be that males are exposed to higher intrauterine testosterone levels than females (Hines, 2006; Hines et al., 2015), with fetal testosterone associated to autistic traits and inversely correlated with social behaviour (Baron-Cohen et al.”
Background
Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner
Jašarević, E., Howard, C. D., Misic, A. M., Beiting, D. P., & Bale, T. L. (2017) · Scientific Reports · doi:10.1038/srep44182 · Cited by 262 · cited 2×
“Finally, it was recently shown that PNS alters the offspring microbiome in a sex-specific manner (Jašarević et al., 2017).”
Background
The mechanism of acetylcholine release from parasympathetic nerves
Paton, W. D. M., Vizi, E. S., & ZAR, M. A. (1971) · The Journal of Physiology · doi:10.1113/jphysiol.1971.sp009500 · Cited by 256 · cited 1×
“Neuronal efferent activation includes also the efferent branch of the vagus nerve that, when activated induces a release of acetylcholine which, in turn, affect the levels of cytokines (Paton et al., 1971).”
Background
Are plasma oxytocin in women and plasma vasopressin in men biomarkers of distressed pair-bond relationships?
Taylor, S. E., Saphire-Bernstein, S., & Seeman, T. E. (2010) · Psychological Science · doi:10.1177/0956797609356507 · Cited by 256
Symbiotic bacteria appear to mediate hyena social odors
Theis, K. R., Venkataraman, A., Dycus, J. A., Koonter, K. D., Schmitt-Matzen, E. N., Wagner, A. P., Holekamp, K. E., & Schmidt, T. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306477110 · Cited by 255 · cited 1×
“, 2014), bumblebees (Koch and Schmid-Hempel, 2011), hyenas (Theis et al., 2013), non-human primates in the wild (Tung et al.”
Background
Gut chemosensing: Interactions between gut endocrine cells and visceral afferents
Raybould, H. E. (2010) · Autonomic Neuroscience · doi:10.1016/j.autneu.2009.07.007 · Cited by 254 · cited 6×
“From NTS, afferents fibres project to the arcuate nucleus (ARC), where satiety signals are integrated with adiposity signals, leptin and insulin, and with several hypothalamic inputs.”
BackgroundInfluential
60 YEARS OF NEUROENDOCRINOLOGY: Redefining neuroendocrinology: stress, sex and cognitive and emotional regulation
McEwen, B. S., Gray, J. D., & Nasca, C. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0121 · Cited by 253
Sex differences in prenatal epigenetic programing of stress pathways
Bale, T. L. (2011) · Stress · doi:10.3109/10253890.2011.586447 · Cited by 249 · cited 1×
“Intriguingly, some researchers have pointed out that the host gender represents a key variable in stress-related behaviours (Bale, 2011; Mueller and Bale, 2008; Shansky, 2009; Shansky et al., 2010) and, given the hormonal discrepancies present among males and females, a deeper investigation of this…”
Background
Antimicrobial activity of psychotropic drugs
Munoz-Bellido, J. L., Munoz-Criado, S., & Garcı̀a-Rodrı̀guez, J. A. (2000) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(99)00154-5 · Cited by 249
Memory and learning behavior in mice is temporally associated with diet-induced alterations in gut bacteria
Li, W., Dowd, S. E., Scurlock, B., Acosta-Martinez, V., & Lyte, M. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.12.004 · Cited by 246 · cited 1×
“In another study, it has been shown that dietary-induced shifts in bacterial diversity were correlated with changes in memory and learning in mice (Li et al., 2009).”
Background
Fecal Microbiota Composition of Breast‐Fed Infants Is Correlated With Human Milk Oligosaccharides Consumed
Wang, M., Li, M., Wu, S., Lebrilla, C. B., Chapkin, R. S., Ivanov, I. V., & Donovan, S. M. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000752 · Cited by 245
The Responses of Plasma Adrenocorticotropin and Cortisol to Corticotropin-Releasing Hormone (CRH) and Cerebrospinal Fluid Immunoreactive CRH in Anorexia Nervosa Patients*
Hotta, M., Shibasaki, T., Masuda, A., Imaki, T., Demura, H., LING, N. C., & SHIZUME, K. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-2-319 · Cited by 239 · cited 14×
“In response to stress, the sympathetic nervous system (SNS) increases the release of catecholamines into systemic circulation, while CRF is released from paraventricular neurons of the hypothalamus, which then stimulate the activation of the HPA axis ultimately resulting in a release of glucocorticoids from the adrena…”
BackgroundInfluential
Gut Dysbiosis in Patients with Anorexia Nervosa
Morita, C., Tsuji, H., Hata, T., Gondo, M., Takakura, S., Kawai, K., Yoshihara, K., Ogata, K., Nomoto, K., Miyazaki, K., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0145274 · Cited by 238
NOW vs LATER brain circuits: implications for obesity and addiction
Volkow, N. D., & Baler, R. D. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.04.002 · Cited by 237 · cited 1×
“Finally, it is now well established that most drugs of abuse affect the brain via central dopamine-reward pathways (Volkow and Baler, 2015) and that the gut microbiota is a source of dopamine.”
Background
Microglia function during brain development: New insights from animal models
Bilimoria, P. M., & Stevens, B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.11.032 · Cited by 237 · cited 1×
“19 microglia are crucial for the shaping of neural circuits in the developing brain (Bilimoria and Stevens, 2015), gut-derived SCFAs might have some relevance in circuits regulating the CNS”
Background
Oxytocin and Social Bondinga
CARTER, C. S., WILLIAMS, J. R., WITT, D. M., & INSEL, T. R. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34356.x · Cited by 237 · cited 1×
“Oxytocin is a key mediator of social bonding (Carter et al., 1992).”
Background
Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat
Davey, K. J., Cotter, P. D., O'Sullivan, O., Crispie, F., Dinan, T. G., Cryan, J. F., & O'Mahony, S. M. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.83 · Cited by 236 · cited 1×
“by olanzapine alone (specifically: body weight gain, uterine fat deposition, macrophage infiltration of adipose tissue and plasma free fatty acid levels) (Davey et al., 2013).”
Background
Opposite effects of oxytocin and vasopressin on avoidance behaviour and hippocampal theta rhythm in the rat
BOHUS, B., URBAN, I., VANWIMERSMAGREIDANUS, T., & DEWIED, D. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90107-7 · Cited by 231
Exploitation of gut bacteria in the locust
Dillon, R. J., Vennard, C. T., & Charnley, A. K. (2000) · Nature · doi:10.1038/35002669 · Cited by 229
Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study
Matsumoto, M., Kibe, R., Ooga, T., Aiba, Y., Sawaki, E., Koga, Y., & Benno, Y. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00009 · Cited by 227 · cited 1×
“gut microbiota is able to modulate the central levels of catecholamines (Matsumoto et al., 2013).”
Background
Dose Effects of Recombinant Human lnterleukin-6 on Pituitary Hormone Secretion and Energy Expenditure
Tsigos, C., Papanicolaou, D. A., Defensor, R., Mitsiadis, C. S., Kyrou, I., & Chrousos, G. P. (2008) · Neuroendocrinology · doi:10.1159/000127219 · Cited by 223
The HPA axis and cocaine reinforcement
Goeders, N. E. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00034-8 · Cited by 219 · cited 1×
“For example, cocaine has been shown to stimulate the HPA axis through a CRF-mediated mechanism in male rats (Goeders, 1997, 2002), and both CRF mRNA levels and circulating corticosterone are increased on cocaine withdrawal (Mantsch et al., 2007b).”
Background
Microbial endocrinology: Host-microbiota neuroendocrine interactions influencing brain and behavior
Lyte, M. (2014) · Gut Microbes · doi:10.4161/gmic.28682 · Cited by 217 · cited 12×
“GABA transporters are localized on the blood-brain barrier (BBB) and allow gut- derived GABA to reach the CNS (Takanaga et al., 2001).”
BackgroundInfluential
Oxytocin Levels in Social Anxiety Disorder
Hoge, E. A., Pollack, M. H., Kaufman, R. E., Zak, P. J., & Simon, N. M. (2008) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2008.00051.x · Cited by 213
Circadian rhythms in the development of obesity: potential role for the circadian clock within the adipocyte
Bray, M. S., & Young, M. E. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00277.x · Cited by 213
Prenatal stress affects placental cytokines and neurotrophins, commensal microbes, and anxiety-like behavior in adult female offspring
Gur, T. L., Shay, L., Palkar, A. V., Fisher, S., Varaljay, V. A., Dowd, S., & Bailey, M. T. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.021 · Cited by 213 · cited 1×
“were found in adult female offspring of PNS-exposed dams (Gur et al., 2017).”
Background
Oxytocin increases autonomic cardiac control: Moderation by loneliness
Norman, G. J., Cacioppo, J. T., Morris, J. S., Malarkey, W. B., Berntson, G. G., & DeVries, A. C. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2010.11.006 · Cited by 211 · cited 2×
“supports the concept that the gastrointestinal microbiota composition and richness may be responsible, together with other factors, for the host eating behaviour and appetite (Alcock et al., 2014; Fetissov, 2017; Goyal et al., 2015; Norris et al., 2013).”
Background
Etiology of autistic features: the persisting neurotoxic effects of propionic acid
El-Ansary, A. K., Bacha, A. B., & Kotb, M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-74 · Cited by 209 · cited 1×
“, 2014) and lower levels of GABA, serotonin and dopamine in vivo (El-Ansary et al., 2012).”
Background
Oxytocin reduces caloric intake in men
Lawson, E. A., Marengi, D. A., DeSanti, R. L., Holmes, T. M., Schoenfeld, D. A., & Tolley, C. J. (2015) · Obesity · doi:10.1002/oby.21069 · Cited by 208
Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data.
Delzenne, N., Cani, P. D., & Neyrinck, A. (2007) · Journal of NutriLife · doi:10.1093/jn/137.11.2547s · Cited by 208 · cited 22×
“#3 promoted the release of the hormone GLP-1, resulting in reduced food intake and improved glucose tolerance (Yadav et al., 2013).”
BackgroundInfluential
A Note: Gut bacteria produce components of a locust cohesion pheromone
Dillon, R. J., Vennard, C. T., & Charnley, A. K. (2002) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2002.01581.x · Cited by 205
Maternal Prenatal Anxiety and Stress Predict Infant Illnesses and Health Complaints
Beijers, R., Jansen, J., Riksen-Walraven, M., & de Weerth, C. (2010) · PEDIATRICS · doi:10.1542/peds.2009-3226 · Cited by 203 · cited 1×
“In addition to neonatal stress, prenatal stress (PNS) also has powerful and enduring effects on behaviour (Beijers et al., 2010; Frye and Wawrzycki, 2003; Maccari et al., 2003; MorleyFletcher et al., 2003).”
Background
Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.004 · Cited by 202 · cited 1×
“behaviour characteristic in late life (Scott et al., 2017).”
Self-citation
Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods
Byrne, C. S., Chambers, E. S., Alhabeeb, H., Chhina, N., Morrison, D. J., Preston, T., Tedford, C., Fitzpatrick, J., Irani, C., Busza, A., et al. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.126706 · Cited by 201 · cited 23×
“#3 promoted the release of the hormone GLP-1, resulting in reduced food intake and improved glucose tolerance (Yadav et al., 2013).”
BackgroundInfluential
Helicobacter pylori eradication and l-dopa absorption in patients with PD and motor fluctuations
Pierantozzi, M., Pietroiusti, A., Brusa, L., Galati, S., Stefani, A., Lunardi, G., Fedele, E., Sancesario, G., Bernardi, G., Bergamaschi, A., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000221672.01272.ba · Cited by 199
Administration of Antibiotics to Children Before Age 2 Years Increases Risk for Childhood Obesity
Scott, F. I., Horton, D. B., Mamtani, R., Haynes, K., Goldberg, D. S., Lee, D. Y., & Lewis, J. D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.006 · Cited by 198 · cited 1×
“antibiotics during childhood increases the risk of obesity, thus demonstrating that the gut microbiota composition/stability may play a key role in the onset of obesity (Azad et al., 2014; Scott et al., 2016; Trasande et al., 2013).”
Background
Resistant starch, large bowel fermentation and a broader perspective of prebiotics and probiotics
Bird, A. R., Conlon, M. A., Christophersen, C. T., & Topping, D. L. (2010) · Beneficial Microbes · doi:10.3920/bm2010.0041 · Cited by 197
The microbiome regulates amygdala-dependent fear recall
Hoban, A. E., Stilling, R. M., Moloney, G., Shanahan, F., Dinan, T. G., Clarke, G., & Cryan, J. F. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.100 · Cited by 197 · cited 2×
“Interestingly, it has recently been shown that germ-free mice are not impaired in the acquisition of a fear learning response but have marked deficits in fear recall (Hoban et al., 2017).”
Background
Corticosteroids and the Control of Function in the Hypothalamo‐Pituitary‐Adrenal (HPA) Axisa
Dallman, M. F., Akana, S. F., LEVIN, N., Walker, C. D., BRADBURY, M. J., Suemaru, S., & SCRIBNER, K. S. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39206.x · Cited by 195 · cited 2×
“Interestingly, under physiological conditions the HPA axis has a continuous oscillatory activity synchronized with circadian and ultradian rhythms (Dallman et al., 1994; Dickmeis et al., 2013; Tsigos and Chrousos, 2002a).”
Background
Alzheimer?s disease: the impact of age-related changes in reproductive hormones
Meethal, S. V., & Atwood, C. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4381-3 · Cited by 194
Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking
Ambroggi, F., Turiault, M., Milet, A., Deroche‐Gamonet, V., Parnaudeau, S., Balado, É., Barik, J., van der Veen, R., Maroteaux, G., Lemberger, T., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2282 · Cited by 194
Estrogen Promotes Stress Sensitivity in a Prefrontal Cortex-Amygdala Pathway
Shansky, R. M., Hamo, C., Hof, P. R., Lou, W., McEwen, B. S., & Morrison, J. H. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq003 · Cited by 191 · cited 1×
“the host gender represents a key variable in stress-related behaviours (Bale, 2011; Mueller and Bale, 2008; Shansky, 2009; Shansky et al., 2010) and, given the hormonal discrepancies present among males and females, a deeper investigation of this aspect is required.”
Background
HPA axis function and drug addictive behaviors: insights from studies with Lewis and Fischer 344 inbred rats
Kosten, T. A., & Ambrosio, E. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00035-x · Cited by 190
Gastrointestinal inflammation by gut microbiota disturbance induces memory impairment in mice
Jang, S.-E., Lim, S.-M., Jeong, J.-J., Jang, H.-M., Lee, H.-J., Han, M. J., & Kim, D.-H. (2018) · Mucosal Immunology · doi:10.1038/mi.2017.49 · Cited by 190
Access to mutualistic endosymbiotic microbes: an underappreciated benefit of group living
Lombardo, M. P. (2007) · Behavioral Ecology and Sociobiology · doi:10.1007/s00265-007-0428-9 · Cited by 189 · cited 2×
“have suggested that the endosymbiotic microbes shared in group living have influenced the evolution of social behaviour (Lombardo, 2008; Montiel-Castro et al., 2013; Troyer, 1984).”
Background
Immunomodulation by commensal and probiotic bacteria
Forsythe, P., & Bienenstock, J. (2010) · Immunological Investigations · doi:10.3109/08820131003667978 · Cited by 189 · cited 1×
“probiotics have a direct effect on the immune system (Duerkop et al., 2009b; Forsythe and Bienenstock, 2010).”
Background
Prenatal stress in rats predicts immobility behavior in the forced swim test
Morley‐Fletcher, S., Darnaudéry, M., Koehl, M., Casolini, P., Reeth, O. V., & Maccari, S. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03293-1 · Cited by 184
Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin.
Uehara, Y., Shimizu, H., Ohtani, K., Sato, N., & Mori, M. (1998) · Diabetes · doi:10.2337/diabetes.47.6.890 · Cited by 183
Constitutional thinness and lean anorexia nervosa display opposite concentrations of peptide YY, glucagon-like peptide 1, ghrelin, and leptin
Germain, N., Galusca, B., le Roux, C. W., Bossu, C., Ghatei, M. A., Lang, F., Bloom, S. R., & Estour, B. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.967 · Cited by 182 · cited 20×
“PYY levels ↑, ghrelin levels ↓ Alajeeli, 2016 Sexual behaviour Rat GF GF rats do not have discriminative urinary odours needed for mating Singh et al., 1990 Locust GF Gut bacteria are responsible for the production of guaiacol, a key component of pheromones.”
BackgroundInfluential
Increased oral detection, but decreased intestinal signaling for fats in mice lacking gut microbiota
Duca, F. A., Swartz, T. D., Sakar, Y., & Covasa, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039748 · Cited by 181 · cited 23×
“#3 promoted the release of the hormone GLP-1, resulting in reduced food intake and improved glucose tolerance (Yadav et al., 2013).”
BackgroundInfluential
GAT2/BGT-1 as a System Responsible for the Transport of γ-Aminobutyric Acid at the Mouse Blood–Brain Barrier
Takanaga, H., Ohtsuki, S., Hosoya, K., & Terasaki, T. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00012 · Cited by 179 · cited 12×
“GABA transporters are localized on the blood-brain barrier (BBB) and allow gut- derived GABA to reach the CNS (Takanaga et al., 2001).”
BackgroundInfluential
Probiotic Microbes Sustain Youthful Serum Testosterone Levels and Testicular Size in Aging Mice
Poutahidis, T., Springer, A., Levkovich, T., Qi, P., Varian, B. J., Lakritz, J. R., Ibrahim, Y. M., Chatzigiagkos, A., Alm, E. J., & Erdman, S. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084877 · Cited by 177 · cited 2×
“Interestingly, administration of the probiotic L. reuteri has been shown to increase testosterone levels in aging mice (Poutahidis et al., 2014).”
Background
Probiotics: interaction with gut microbiome and antiobesity potential.
Arora, T., Singh, S., & Sharma, R. K. (2013) · Nutrition · doi:10.1016/j.nut.2012.07.017 · Cited by 176 · cited 2×
“eating behaviour, as well as playing a role in obesity (Arora et al., 2013; Belguesmia et al., 2016; Delzenne et al., 2011; Forssten et al., 2013).”
Background
Gut microbiota and metabolic disorders: how prebiotic can work?
Delzenne, N. M., Neyrinck, A. M., & Cani, P. D. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114512004047 · Cited by 175
Autoantibodies against appetite-regulating peptide hormones and neuropeptides: Putative modulation by gut microflora
Fetissov, S. O., Hamze Sinno, M., Coëffier, M., Bole-Feysot, C., Ducrotté, P., Hökfelt, T., & Déchelotte, P. (2008) · Nutrition · doi:10.1016/j.nut.2007.12.006 · Cited by 175 · cited 1×
“implications in hunger and satiety pathways (Fetissov et al., 2008).”
Prenatal testosterone and gender-related behaviour
Hines, M. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02236 · Cited by 173 · cited 2×
“might be that males are exposed to higher intrauterine testosterone levels than females (Hines, 2006; Hines et al., 2015), with fetal testosterone associated to autistic traits and inversely correlated with social behaviour (Baron-Cohen et al.”
Background
A natural solution for obesity: Bioactives for the prevention and treatment of weight gain. A review
Torres‐Fuentes, C., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2014) · Nutritional Neuroscience · doi:10.1179/1476830513y.0000000099 · Cited by 172
The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats
Dluzen, D. E., Muraoka, S., Engelmann, M., & Landgraf, R. (1998) · Peptides · doi:10.1016/s0196-9781(98)00047-3 · Cited by 169 · cited 1×
“Indeed, central administration of OXT in the olfactory bulb facilitates and prolongs social recognition in male rats (Dluzen et al., 2000; Dluzen et al., 1998).”
Background
Memory enhancement of classical fear conditioning by post-training injections of corticosterone in rats
Hui, G. K. (2003) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2003.09.002 · Cited by 168
A neuroendocrine role in cocaine reinforcement
Goeders, N. E. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00027-9 · Cited by 168 · cited 1×
“For example, cocaine has been shown to stimulate the HPA axis through a CRF-mediated mechanism in male rats (Goeders, 1997, 2002), and both CRF mRNA levels and circulating corticosterone are increased on cocaine withdrawal (Mantsch et al., 2007b).”
Background
Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei
Marvel, F. A., Chen, C.-C., Badr, N. A., Gaykema, R. P. A., & Goehler, L. E. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.09.004 · Cited by 163
Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high‐functioning level
Wermter, A., Kamp‐Becker, I., Hesse, P., Schulte‐Körne, G., Strauch, K., & Remschmidt, H. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31032 · Cited by 163
Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male
Corradi, P. F., Corradi, R. B., & Greene, L. W. (2016) · Urologic Clinics of North America · doi:10.1016/j.ucl.2016.01.001 · Cited by 162 · cited 1×
“neuroendocrine axis plays a critical part in the development and regulation of different body processes, mainly the reproductive and immune systems (Corradi et al., 2016).”
Background
Lactobacillus johnsonii inhibits indoleamine 2,3‐dioxygenase and alters tryptophan metabolite levels in BioBreeding rats
Valladares, R. B., Bojilova, L., Potts, A. H., Cameron, E., Gardner, C. L., Lorca, G. L., & González, C. F. (2013) · The FASEB Journal · doi:10.1096/fj.12-223339 · Cited by 160 · cited 1×
“Moreover, the administration of Lactobacillus johnsonii in rats has been shown to lower circulating kynurenine levels with concomitant increase in serotonin levels (Valladares et al., 2013).”
Background
Gut Vagal Afferents Differentially Modulate Innate Anxiety and Learned Fear
Klarer, M., Arnold, M., Günther, L., Winter, C., Langhans, W., & Meyer, U. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0252-14.2014 · Cited by 159 · cited 1×
“was associated with region-dependent changes in noradrenaline and ɣ-aminobutyric acid (GABA) levels in key areas of the limbic system, but not with functional alterations in the HPA axis (Klarer et al., 2014).”
Background
Administration of Non-Absorbable Antibiotics to Pregnant Mice to Perturb the Maternal Gut Microbiota Is Associated with Alterations in Offspring Behavior
Tochitani, S., Ikeno, T., Ito, T., Sakurai, A., Yamauchi, T., & Matsuzaki, H. (2016) · PLOS ONE · doi:10.1371/journal.pone.0138293 · Cited by 157 · cited 2×
“31 anxiety-like behaviour thus suggesting that disruption of maternal gut microbiota during pregnancy may lead to alterations in the behaviour of their offspring (Tochitani et al., 2016).”
Background
Endogenous oxytocin is involved in short-term olfactory memory in female rats
Engelmann, M., Ebner, K., Wotjak, C. T., & Landgraf, R. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00084-3 · Cited by 156 · cited 1×
“rats, intracerebroventricular administration of an OXT antagonist interfered with the animals’ ability to establish normal social memory (Engelmann et al., 1998).”
Background
Microbial lysate upregulates host oxytocin
Varian, B. J., Poutahidis, T., DiBenedictis, B. T., Levkovich, T., Ibrahim, Y., Didyk, E., Shikhman, L., Cheung, H. K., Hardas, A., Ricciardi, C. E., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.002 · Cited by 153 · cited 1×
“40 suggests that the gut microbiota is able to directly modulate the levels of host oxytocin (Poutahidis et al., 2013; Varian et al., 2017) and so it is interesting to speculate as to whether”
Background
Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway
DeCastro, M., Nankova, B. B., Shah, P., Patel, P., Mally, P. V., Mishra, R., & La Gamma, E. F. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.09.002 · Cited by 149
Sertraline enhances the activity of antimicrobial agents against pathogens of clinical relevance
Ayaz, M., Subhan, F., Ahmed, J., Khan, A.-U., Ullah, F., Ullah, I., Ali, G., Syed, N.-I.-H., & Hussain, S. (2015) · Journal of Biological Research-Thessaloniki · doi:10.1186/s40709-015-0028-1 · Cited by 147
Individual differences underlying susceptibility to addiction: Role for the endogenous oxytocin system
Buisman‐Pijlman, F. T. A., Sumracki, N. M., Gordon, J. J., Hull, P. R., Carter, C. S., & Tops, M. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.09.005 · Cited by 147
Stress and VTA synapses: implications for addiction and depression
Polter, A. M., & Kauer, J. A. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12490 · Cited by 147 · cited 1×
“risk factor that can also be comorbid with addiction is depression (Polter and Kauer, 2014).”
Background
The circadian clock and glucocorticoids – interactions across many time scales
Dickmeis, T., Weger, B. D., & Weger, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.05.012 · Cited by 144 · cited 1×
“activity synchronized with circadian and ultradian rhythms (Dallman et al., 1994; Dickmeis et al., 2013; Tsigos and Chrousos, 2002a).”
Background
Impact of Resistant Starch on Body Fat Patterning and Central Appetite Regulation
So, P., Yu, W.-S., Kuo, Y., Wasserfall, C. H., Goldstone, A. P., Bell, J. D., & Frost, G. S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001309 · Cited by 143 · cited 1×
“Increasing evidence suggests that metabolites produced by the colonic microbiota, such as SCFAs, modulate feeding behaviour via central mechanisms (Frost et al., 2014; Shen et al., 2009; So et al., 2007).”
Background
New trends and perspectives in the evolution of neurotransmitters in microbial, plant, and animal cells
Roshchina, V. V. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-20215-0_2 · Cited by 143 · cited 14×
“GABA transporters are localized on the blood-brain barrier (BBB) and allow gut- derived GABA to reach the CNS (Takanaga et al., 2001).”
BackgroundInfluential
Leptin Signaling Targets the Thyrotropin-Releasing Hormone Gene Promoterin Vivo
Guo, F., Bakal, K., Minokoshi, Y., & Hollenberg, A. N. (2004) · Endocrinology · doi:10.1210/en.2003-1312 · Cited by 142
Feeding the brain and nurturing the mind: linking nutrition and the gut microbiota to brain development
Goyal, M. S., Venkatesh, S., Milbrandt, J., Gordon, J. I., & Raichle, M. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511465112 · Cited by 141 · cited 1×
“supports the concept that the gastrointestinal microbiota composition and richness may be responsible, together with other factors, for the host eating behaviour and appetite (Alcock et al., 2014; Fetissov, 2017; Goyal et al., 2015; Norris et al., 2013).”
Background
Sex differences in cocaine-induced behavioral responses, pharmacokinetics, and monoamine levels
Festa, E. D., Russo, S. J., Gazi, F. M., Niyomchai, T., Kemen, L. M., Lin, S., Foltz, R. L., Jenab, S., & Quiñones-Jenab, V. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.11.017 · Cited by 137 · cited 2×
“46 studies have suggested that females are more susceptible than males (Devaud et al., 2003; Festa et al., 2004) and that this might be due to gonadal hormones (Festa et al.”
Background
Up-regulation of intestinal type 1 taste receptor 3 and sodium glucose luminal transporter-1 expression and increased sucrose intake in mice lacking gut microbiota
Swartz, T. D., Duca, F. A., de Wouters, T., Sakar, Y., & Covașă, M. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511003412 · Cited by 137
A centenary of gastrointestinal endocrinology
Rehfeld, J. F. (2004) · Hormone and Metabolic Research · doi:10.1055/s-2004-826154 · Cited by 136 · cited 2×
“EEC secretory products are released in response to diverse stimuli and influence a variety of physiological functions in the host such as control of intestinal secretion and motility, regulation of food intake and metabolism (Rehfeld, 2004).”
Background
Pituicytes, Glia and Control of Terminal Secretion
Hatton, G. I. (1988) · Journal of Experimental Biology · doi:10.1242/jeb.139.1.67 · Cited by 134
Effect of prenatal stress and gonadal hormone condition on depressive behaviors of female and male rats
Frye, C. A., & Wawrzycki, J. M. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(03)00159-4 · Cited by 132 · cited 1×
“In addition to neonatal stress, prenatal stress (PNS) also has powerful and enduring effects on behaviour (Beijers et al., 2010; Frye and Wawrzycki, 2003; Maccari et al., 2003; MorleyFletcher et al., 2003).”
Background
Recent advances in the neurobiology of depression.
Nemeroff, C. B. (2002) · PubMed · Cited by 131
High fat diet drives obesity regardless the composition of gut microbiota in mice
Rabot, S., Membrez, M., Blancher, F., Berger, B. W., Moine, D., Krause, L., Bibiloni, R., Bruneau, A., Gérard, P., Siddharth, J., et al. (2016) · Scientific Reports · doi:10.1038/srep32484 · Cited by 131 · cited 1×
“Nevertheless, it has been shown that, when obesity is driven by the diet, the intestinal microbiome does not play a role in the onset of the obese phenotype (Rabot et al., 2016).”
Background
Effects of a Brown Beans Evening Meal on Metabolic Risk Markers and Appetite Regulating Hormones at a Subsequent Standardized Breakfast: A Randomized Cross-Over Study
Nilsson, A. C., Johansson, E., Ekström, L. M. N. K., & Björck, I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059985 · Cited by 130
Neural Pathways Controlling Central and Peripheral Oxytocin Release During Stress
Onaka, T. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01186.x · Cited by 130 · cited 1×
“In rodents, peripheral and central oxytocin levels have been found to increase in response to a wide variety of stressful stimuli, such as conditioned fear stimuli and restraint stress (Neumann et al., 2000; Onaka, 2004).”
Background
The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin inhibits male copulatory behaviour in rats
Argiolas, A., Collu, M., Gessa, G. L., Melis, M. R., & Serra, G. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90675-9 · Cited by 125
Consumption of barley β-glucan ameliorates fatty liver and insulin resistance in mice fed a high-fat diet
Choi, J. S., Kim, H., Jung, M. H., Hong, S., & Song, J. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900127 · Cited by 125 · cited 1×
“In a recent study the administration of both β-glucan and inulin attenuated weight gain in high fat fed mice (Arora et al., 2012), confirming findings of others (Cani et al., 2004; Cani et al., 2005; Choi et al., 2010).”
Result
A relationship between oxytocin and anxiety of romantic attachment
Marazziti (2006) · Clinical Practice and Epidemiology in Mental Health · doi:10.1186/1745-0179-2-28 · Cited by 124
Decreased Nocturnal Oxytocin Levels in Anorexia Nervosa Are Associated With Low Bone Mineral Density and Fat Mass
Lawson, E. A., Donoho, D. A., Blum, J. I., Meenaghan, E. M., Misra, M., Herzog, D. B., Sluss, P. M., Miller, K. K., & Klibanski, A. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06617 · Cited by 124 · cited 1×
“, 1986) and oxytocin (Demitrack, 1990; Lawson et al., 2011; Lawson et al., 2012) have been found to be altered in patients suffering from anorexia nervosa.”
Background
Comparison of the gut microbiota profile in breast-fed and formula-fed Korean infants using pyrosequencing
Lee, S. A., Lim, J. Y., Kim, B. S., Cho, S. J., Kim, N. Y., Kim, O. B., & Kim, Y. (2015) · Nutrition Research and Practice · doi:10.4162/nrp.2015.9.3.242 · Cited by 123
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon‐gamma, severity of symptoms and psychiatric co‐morbidity
Fitzgerald, P., Eugene, M. C., Clarke, G. A., Scully, P., Barry, S., Eamonn, M. M. Q., Shanahan, F., Cryan, J. F., & Dinan, T. G. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01195.x · Cited by 122 · cited 1×
“metabolised to kynurenine and the disruption of this metabolic pathway has been linked to both gastrointestinal and brain disorders (Fitzgerald et al., 2008).”
Background
Thyroid hormones, the brain, and affective disorders.
Joffe, R. T., & Sokolov, S. T. H. (1994) · PubMed · Cited by 121
Oxytocin Secretion Is Associated with Severity of Disordered Eating Psychopathology and Insular Cortex Hypoactivation in Anorexia Nervosa
Lawson, E. A., Holsen, L. M., Santin, M., Meenaghan, E. M., Eddy, K. T., Becker, A. E., Herzog, D. B., Goldstein, J. M., & Klibanski, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1702 · Cited by 121 · cited 1×
“, 1986) and oxytocin (Demitrack, 1990; Lawson et al., 2011; Lawson et al., 2012) have been found to be altered in patients suffering from anorexia nervosa.”
Background
Social attraction mediated by fruit flies' microbiome
Venu, I., Durisko, Z., Xu, J., & Dukas, R. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.099648 · Cited by 120 · cited 1×
“Drosophila (Lize et al., 2014; Venu et al., 2014), bumblebees (Koch and Schmid-Hempel, 2011), hyenas (Theis et al.”
Background
Continuous blockade of brain glucocorticoid receptors facilitates spatial learning and memory in rats
Oitzl, M. S., Fluttert, M., Sutanto, W., & de Kloet, E. R. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00381.x · Cited by 119
Associations of Cocaine Use and HIV Infection With the Intestinal Microbiota, Microbial Translocation, and Inflammation
Volpe, G. E., Ward, H., Mwamburi, M., Dinh, D. M., Bhalchandra, S., WANKE, C. A., & Kane, A. V. (2014) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2014.75.347 · Cited by 117
CSF oxytocin in anorexia nervosa and bulimia nervosa: clinical and pathophysiologic considerations
Demitrack, M. A., Lesem, M. D., LISTWAK, S. J., Brandt, H., Jimerson, D. C., & Gold, P. W. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.7.882 · Cited by 116 · cited 1×
“Interestingly, also CRF (Glowa et al., 1992; Hotta et al., 1986) and oxytocin (Demitrack, 1990; Lawson et al., 2011; Lawson et al., 2012) have been found to be altered in patients suffering from anorexia nervosa.”
Background
Efflux inhibition by selective serotonin reuptake inhibitors in Escherichia coli
Bohnert, J. A., Szymaniak-Vits, M., Schuster, S., & Kern, W. V. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr258 · Cited by 114 · cited 1×
“confirmed by the synergistic effect of some SSRIs in combination with antibiotics; as well as their effects against some antibiotic-resistant bacteria (Bohnert et al., 2011; Munoz-Bellido et al., 1996, 2000).”
Background
Contrasting effects of Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 on the composition of murine brain fatty acids and gut microbiota
Wall, R., Marques, T. M., O’Sullivan, Ó., Ross, R. P., Shanahan, F., Quigley, E. M. M., Dinan, T. G., Kiely, B., Fitzgerald, G. F., Cotter, P. D., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.026435 · Cited by 112 · cited 3×
“acids play important roles in cognitive processes such as memory and learning (Wall et al., 2012).”
BackgroundInfluential
Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice
Delmée, E., Cani, P. D., Gual, G., Knauf, C., Burcelin, R., Maton, N., & Delzenne, N. M. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.05.013 · Cited by 111 · cited 1×
“GLP-1 production with beneficial physiological consequences (Delmee et al., 2006).”
Effect of a single maternal separation at different pup ages on the corticosterone stress response in adult and aged rats
Lehmann, J., Russig, H. D., Feldon, J., & Pryce, C. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00788-8 · Cited by 111
Causes and consequences of obesity: the contribution of recent twin studies
Naukkarinen, J., Rissanen, A., Kaprio, J. A., & Pietiläinen, K. H. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.192 · Cited by 110
Kin recognition inDrosophila: the importance of ecology and gut microbiota
Lizé, A., McKay, R., & Lewis, Z. (2013) · The ISME Journal · doi:10.1038/ismej.2013.157 · Cited by 106 · cited 1×
“Drosophila (Lize et al., 2014; Venu et al., 2014), bumblebees (Koch and Schmid-Hempel, 2011), hyenas (Theis et al.”
Background
Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students
Linnen, A.-M., Ellenbogen, M. A., Cardoso, C., & Joober, R. (2012) · Stress · doi:10.3109/10253890.2011.631154 · Cited by 104 · cited 1×
“Moreover, oxytocin administration in humans was able to decrease the subjective stress ratings (Heinrichs et al., 2003) as well as increase the parasympathetic cardiac control (Norman et al., 2011) and decrease the salivary cortisol levels (Ditzen et al., 2009; Linnen et al., 2012).”
Background
Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa
Nakahara, T., Kojima, S., Tanaka, M., Yasuhara, D., Harada, T., Sagiyama, K., Muranaga, T., Nagai, N., Nakazato, M., Nozoe, S.-I., et al. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.07.021 · Cited by 104
Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples
Behnia, B., Heinrichs, M., Bergmann, W., Jung, S., Germann, J., Schedlowski, M., Hartmann, U., & Kruger, T. H. C. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.01.009 · Cited by 103 · cited 1×
“Oxytocin is released by the posterior pituitary gland, acts also as mediator of sexual behaviour (Argiolas et al., 1988; Behnia et al., 2014; Witt and Insel, 1994).”
Background
Increased Fos Expression in Oxytocin Neurons Following Masculine Sexual Behavior
Witt, D. M., & Insel, T. R. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00549.x · Cited by 102 · cited 1×
“Oxytocin is released by the posterior pituitary gland, acts also as mediator of sexual behaviour (Argiolas et al., 1988; Behnia et al., 2014; Witt and Insel, 1994).”
Background
Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date
Lee, M. R., Rohn, M. C. H., Tanda, G., & Leggio, L. (2016) · CNS Drugs · doi:10.1007/s40263-016-0313-z · Cited by 102 · cited 1×
“At the same time, mounting preclinical evidence is suggesting that oxytocin might represent a novel treatment for addictive disorders (Lee et al., 2016; McGregor and Bowen, 2012).”
Background
Dietary-resistant starch and glucose metabolism
Robertson, M. D. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283536931 · Cited by 102 · cited 1×
“…reported that the modulation of microbiota activity using different non-digestible carbohydrates affects appetite (Bird et al., 2010; Daud et al., 2014; Delzenne et al., 2013; Frost et al., 1999; Klosterbuer et al., 2012; Nilsson et al., 2013; Robertson, 2012; Tarini and Wolever, 2010).”
Background
Oxytocin induces preservation of social recognition in male rats by activating α‐adrenoceptors of the olfactory bulb
Dluzen, D. E., Muraoka, S., Engelmann, M., Ebner, K., & Landgraf, R. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00952.x · Cited by 100 · cited 1×
“Indeed, central administration of OXT in the olfactory bulb facilitates and prolongs social recognition in male rats (Dluzen et al., 2000; Dluzen et al., 1998).”
Background
The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity
Daud, N. M., Ismail, N. A., Thomas, E. L., Fitzpatrick, J. A., Bell, J. D., Swann, J. R., Costabile, A., Childs, C. E., Pedersen, C., Goldstone, A. P., et al. (2014) · Obesity · doi:10.1002/oby.20754 · Cited by 99
Effect of Maternal Probiotic Intervention on HPA Axis, Immunity and Gut Microbiota in a Rat Model of Irritable Bowel Syndrome
Barouei, J., Moussavi, M., & Hodgson, D. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046051 · Cited by 99 · cited 1×
“dysfunction and to some extent against disturbance of the gut microbiota provoked by MS and/or adult restraint stress (Barouei et al., 2012).”
Background
Obestatin, Acyl Ghrelin, and Des-acyl Ghrelin Responses to an Oral Glucose Tolerance Test in the Restricting Type of Anorexia Nervosa
Harada, T., Nakahara, T., Yasuhara, D., Kojima, S., Sagiyama, K., Amitani, H., Laviano, A., Naruo, T., & Inui, A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.005 · Cited by 92
Effects of corticotropin releasing hormone on appetitive behaviors
Glowa, J. R., Barrett, J. E., Russell, J., & Gold, P. W. (1992) · Peptides · doi:10.1016/0196-9781(92)90097-m · Cited by 90 · cited 2×
“Interestingly, also CRF (Glowa et al., 1992; Hotta et al., 1986) and oxytocin (Demitrack, 1990; Lawson et al.”
Background
Resistant Starch and Pullulan Reduce Postprandial Glucose, Insulin, and GLP-1, but Have No Effect on Satiety in Healthy Humans
Klosterbuer, A. S., Thomas, W. T. B., & Slavin, J. L. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf303083r · Cited by 90
Antidepressants Cause Lethal Disruption of Membrane Function in the Human Protozoan Parasite Leishmania
Zilberstein, D., & Dwyer, D. M. (1984) · Science · doi:10.1126/science.6505677 · Cited by 90 · cited 1×
“TCAs also present in vitro activity against the parasites Plasmodium falciparum (Basco and Le Bras, 1990; Salama and Facer, 1990) and Leishmania spp. (Zilberstein and Dwyer, 1984).”
Background
Dietary Resistant Starch Increases Hypothalamic POMC Expression in Rats
Shen, L., Keenan, M. J., Martin, R. J., Tulley, R. T., Raggio, A. M., McCutcheon, K. L., & Zhou, J. (2008) · Obesity · doi:10.1038/oby.2008.483 · Cited by 90 · cited 1×
“Increasing evidence suggests that metabolites produced by the colonic microbiota, such as SCFAs, modulate feeding behaviour via central mechanisms (Frost et al., 2014; Shen et al., 2009; So et al., 2007).”
Background
Influence of Stressor-Induced Nervous System Activation on the Intestinal Microbiota and the Importance for Immunomodulation
Bailey, M. T. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_12 · Cited by 89 · cited 1×
“…stressors including maternal separation, chronic social defeat, physical restraint and overcrowding can alter the gut microbiota composition (Bailey, 2014; Bailey et al., 2011; Bharwani et al., 2016; De Palma et al., 2015; De Palma et al., 2014; Hsiao et al., 2013; Moloney et al., 2014).”
Background
Testosterone Administration Reduces Lying in Men
Wibral, M., Dohmen, T., Klingmüller, D., Weber, B., & Falk, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046774 · Cited by 88 · cited 1×
“Testosterone levels, for example, have been shown to relate to prosocial behaviour (Wibral et al., 2012).”
Background
Immune Dysregulation in Autism Spectrum Disorder
Hsiao, E. Y. (2013) · International Review of Neurobiology · doi:10.1016/b978-0-12-418700-9.00009-5 · Cited by 87 · cited 9×
“Studies of the gut microbiota in children with ASD are limited in quantity and quality; however, some have pointed out differences in the microbiota composition between ASD and healthy children (Finegold et al., 2010; Kang et al., 2013; Parracho et al., 2005).”
BackgroundMethodInfluential
Early Life Activation of Toll-Like Receptor 4 Reprograms Neural Anti-Inflammatory Pathways
Mouihate, A., Galic, M. A., Ellis, S. L., Spencer, S. J., Tsutsui, S., & Pittman, Q. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6078-09.2010 · Cited by 87
Hypothesis: Bacteria Control Host Appetites
Norris, V., Molina, F., & Gewirtz, A. T. (2012) · Journal of Bacteriology · doi:10.1128/jb.01384-12 · Cited by 87
Rearing rats in a germ-free environment eliminates their odors of individuality
Singh, P. B., Herbert, J., Roser, B. J., Arnott, L., Tucker, D. K., & Brown, R. E. (1990) · Journal of Chemical Ecology · doi:10.1007/bf01014099 · Cited by 85 · cited 1×
“sexual behaviour, with the discriminative urinary odours present in conventional housed rats being abolished in germ-free rats, indicating a key role of bacteria in determining the unique odours responsible for the host behaviour (Singh et al., 1990).”
Background
Male predominance in autism: neuroendocrine influences on arousal and social anxiety
Pfaff, D. W., Rapin, I., & Goldman, S. (2011) · Autism Research · doi:10.1002/aur.191 · Cited by 85 · cited 1×
“prone to develop ASD than females (Baron-Cohen et al., 2011; Pfaff et al., 2011).”
Vagal Interoceptive Modulation of Motivated Behavior
Maniscalco, J. W., & Rinaman, L. (2018) · Physiology · doi:10.1152/physiol.00036.2017 · Cited by 83 · cited 1×
“secreted by EECs activate vagal afferent pathways (Bonaz et al., 2018; Maniscalco and Rinaman, 2018; Raybould, 2010b) however, it is unclear how the brain might “decipher” the information coming from the gut.”
Background
“Stress” is 80 Years Old: From Hans Selye Original Paper in 1936 to Recent Advances in GI Ulceration
Szabó, S., Yoshida, M., Filakovszky, J., & Juhasz, G. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170622110046 · Cited by 81 · cited 1×
“Selye described stress as a nonspecific and predictable response of the body to demands placed upon it (Szabo et al., 2017).”
Background
Stress Enables Synaptic Depression in CA1 Synapses by Acute and Chronic Morphine: Possible Mechanisms for Corticosterone on Opiate Addiction
Yang, Y., Zheng, X., Wang, Y., Cao, J., Dong, Z., Cai, J., Sui, N., & Xu, L. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5544-03.2004 · Cited by 77
Inhibitory influence of corticotropin releasing factor on components of sexual behaviour in the male rat
SIRINATHSINGHJI, D. J. S. (1987) · Brain Research · doi:10.1016/0006-8993(87)91236-4 · Cited by 76 · cited 1×
“…selected for this review because they have been shown to be modulated by neuroendocrine routes (Bos et al., 2012; Carter, 1992; Kosten and Ambrosio, 2002; McCall and Singer, 2012; McEwen and Sapolsky, 1995; Murray et al., 2014; Sirinathsinghji, 1987; Smith et al., 2002; Tsigos and Chrousos, 2002b).”
Background
Drunk bugs: Chronic vapour alcohol exposure induces marked changes in the gut microbiome in mice
Peterson, V. L., Jury, N. J., Cabrera‐Rubio, R., Draper, L. A., Crispie, F., Cotter, P. D., Dinan, T. G., Holmes, A., & Cryan, J. F. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.049 · Cited by 75
Microbes, herbivory and the evolution of social behavior
Troyer, K. (1984) · Journal of Theoretical Biology · doi:10.1016/0022-5193(84)90016-x · Cited by 74 · cited 1×
“…numerous studies have been focusing on how social interactions take place across different species and some studies have suggested that the endosymbiotic microbes shared in group living have influenced the evolution of social behaviour (Lombardo, 2008; Montiel-Castro et al., 2013; Troyer, 1984).”
Background
Differential Effects of Two Fermentable Carbohydrates on Central Appetite Regulation and Body Composition
Arora, T., Loo, R. L., Anastasovska, J., Gibson, G. R., Tuohy, K. M., Sharma, R. K., Swann, J. R., Deaville, E. R., Sleeth, M. L., Thomas, E. L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043263 · Cited by 73
Sex Differences in the Central Nervous System Actions of Ethanol
Devaud, L. L., Alele, P. E., & Chadda, R. (2003) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v15.i1.20 · Cited by 70 · cited 1×
“46 studies have suggested that females are more susceptible than males (Devaud et al., 2003; Festa et al., 2004) and that this might be due to gonadal hormones (Festa et al.”
Background
Microbes and Oxytocin
Erdman, S. E., & Poutahidis, T. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.07.004 · Cited by 69 · cited 1×
“…axis and play a critical role in social bonding (Meyer-Lindenberg et al., 2011) and, as mentioned above, the gut microbiota is able to modulate levels of the hormone oxytocin (Erdman and Poutahidis, 2016; Varian et al., 2017) thus potentially impacting on social behaviour.”
Background
Monocarboxylate 4 mediated butyrate transport in a rat intestinal epithelial cell line
Kekuda, R., Manoharan, P., Baseler, W., & Sundaram, U. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2407-x · Cited by 68 · cited 7×
“However, it is unlikely that these microbial-derived catecholamines have any effect at a central level, as they are not able to cross the BBB (blood-brain barrier).”
BackgroundInfluential
Effects of cocaine on the contents of neurohypophyseal hormones in the plasma and in different brain structures in rats
Sarnyai, Z., Vecsernyés, M., Laczi, F., Bíró, É., Szabó, G., & Kovács, G. L. (1992) · Neuropeptides · doi:10.1016/0143-4179(92)90006-i · Cited by 66
Acute cocaine alters oxytocin levels in the medial preoptic area and amygdala in lactating rat dams: implications for cocaine-induced changes in maternal behavior and maternal aggression
Elliott, J., Lubin, D. A., Walker, C. H., & Johns, J. M. (2001) · Neuropeptides · doi:10.1054/npep.2001.0854 · Cited by 66
Cytokines and the brain corticosteroid receptor balance: Relevance to pathophysiology of neuroendocrine-immune communication
de Kloet, E. R., Oitzl, M. S., & Schöbitz, B. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90002-7 · Cited by 64
Altered Pituitary Sensitivity to Corticotropin‐Releasing Factor and Arginine Vasopressin Participates in the Stress Hyporesponsiveness of Lactation in the Rat
Toufexis, Tesolin, Huang, & Walker (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00381.x · Cited by 63 · cited 2×
“response to stress, particularly during pregnancy and lactation in mammals (Goland et al., 1991; Ma et al., 2005; Toufexis et al., 1999).”
Background
Reduced Hypothalamic Vasopressin Secretion Underlies Attenuated Adrenocorticotropin Stress Responses in Pregnant Rats
Ma, S., Shipston, M. J., Morilak, D. A., & Russell, J. A. (2005) · Endocrinology · doi:10.1210/en.2004-1368 · Cited by 60 · cited 1×
“response to stress, particularly during pregnancy and lactation in mammals (Goland et al., 1991; Ma et al., 2005; Toufexis et al., 1999).”
Background
Factors influencing the development of a personal tailored microbiota in the neonate, with particular emphasis on antibiotic therapy
Faa, G., Gerosa, C., Fanni, D., Nemolato, S., Eyken, P. V., & Fanos, V. (2013) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2013.829700 · Cited by 59
Faecal transplant eases symptoms of Parkinson's disease
Ananthaswamy, A. (2011) · The New Scientist · doi:10.1016/s0262-4079(11)60124-3 · Cited by 56 · cited 1×
“Moreover, Helicobacter pylori has been shown to affect L-DOPA levels (Pierantozzi et al., 2006) and neurologic improvement has also been reported in one patient with Parkinson's disease after faecal transplantation for chronic constipation (Ananthaswamy, 2011).”
Background
Daily cocaine self-administration under long-access conditions augments restraint-induced increases in plasma corticosterone and impairs glucocorticoid receptor-mediated negative feedback in rats
Mantsch, J. R., Cullinan, W. E., Tang, L. C., Baker, D. L., Katz, E. S., Hoks, M. A., & Ziegler, D. R. (2007) · Brain Research · doi:10.1016/j.brainres.2007.05.080 · Cited by 54
Chronic gestational cocaine treatment decreases oxytocin levels in the medial preoptic area, ventral tegmental area and hippocampus in Sprague-Dawley rats
Johns, J. M., Lubin, D. A., Walker, C. H., Meter, K. E., & Mason, G. (1997) · Neuropeptides · doi:10.1016/s0143-4179(97)90037-8 · Cited by 53
Plasma Leptin Response to Acute Fasting and Refeeding in Untreated Women with Bulimia Nervosa
Monteleone, P., Bortolotti, F., Fabrazzo, M., Rocca, A. L., Fuschino, A., & Maj, M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6673 · Cited by 52
The Hypothalamus-Pituitary-Adrenal Axis
(2007) · Neuroimmune biology · doi:10.1016/s1567-7443(07)x0003-6 · Cited by 50
Psychological stress enhances the colonization of the stomach by Helicobacter pylori in the BALB/c mouse
Guo, G., Jia, K.-R., Shi, Y., Liu, X.-F., Liu, K.-Y., Qi, W., Guo, Y., Zhang, W.-J., Wang, T., Xiao, B., et al. (2009) · Stress · doi:10.3109/10253890802642188 · Cited by 44 · cited 1×
“pylori (Guo et al., 2009), corroborating the crucial role”
Reversal of chloroquine resistance with desipramine in isolates of Plasmodium falciparum from Central and West Africa
Basco, L. K., & Bras, J. L. (1990) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(90)90006-z · Cited by 43
In-vitro activity of psychiatric drugs against Corynebacterium urealyticum (Corynebacterium group D2)
Muñioz-Bellido, J. L., Muñioz-Bellido, S., & García-Rodrfguez, J. A. (1996) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/37.5.1005 · Cited by 42 · cited 1×
“The antimicrobial activity of some antidepressants is further confirmed by the synergistic effect of some SSRIs in combination with antibiotics; as well as their effects against some antibiotic-resistant bacteria (Bohnert et al., 2011; Munoz-Bellido et al., 1996, 2000).”
Background
Novel probiotic evidence of lactobacilli on immunomodulation and regulation of satiety hormones release in intestinal cells
Belguesmia, Y., Domenger, D., Caron, J., Dhulster, P., Ravallec, R., Drider, D., & Cudennec, B. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.04.014 · Cited by 42 · cited 1×
“eating behaviour, as well as playing a role in obesity (Arora et al., 2013; Belguesmia et al., 2016; Delzenne et al., 2011; Forssten et al., 2013).”
Background
Deranged Secretion of Ghrelin and Obestatin in the Cephalic Phase of Vagal Stimulation in Women with Anorexia Nervosa
Monteleone, P., Serritella, C., Martiadis, V., & Maj, M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.006 · Cited by 41
Symbiotic commensal bacteria direct maturation of the host immune system
Edelman, S., & Kasper, D. L. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32830c4355 · Cited by 37
Changes in satiety hormone concentrations and feed intake in rats in response to lactic acid bacteria
Forssten, S. D., Korczyńska, M. Z., Zwijsen, R. M. L., Noordman, W. H., Madetoja, M., & Ouwehand, A. C. (2013) · Appetite · doi:10.1016/j.appet.2013.06.093 · Cited by 37 · cited 2×
“eating behaviour, as well as playing a role in obesity (Arora et al., 2013; Belguesmia et al., 2016; Delzenne et al., 2011; Forssten et al., 2013).”
Background
The hypothalamopituitary–adrenal axis and alcohol preference
O’Callaghan, M. J., Croft, A. P., Jacquot, C., & Little, H. J. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.08.006 · Cited by 37
Mechanism of action of tricyclic drugs on Escherichia coli and Yersinia enterocolitica plasmid maintenance and replication.
(1992) · PubMed · Cited by 36
Estrogen, stress and the brain: progress toward unraveling gender discrepancies in major depressive disorder
Shansky, R. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.46 · Cited by 36 · cited 2×
“…some researchers have pointed out that the host gender represents a key variable in stress-related behaviours (Bale, 2011; Mueller and Bale, 2008; Shansky, 2009; Shansky et al., 2010) and, given the hormonal discrepancies present among males and females, a deeper investigation of this aspect is…”
Background
Effects of iron supplementation on growth, gut microbiota, metabolomics and cognitive development of rat pups
Alexeev, E. E., He, X., Slupsky, C. M., & Lönnerdal, B. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179713 · Cited by 36
Physiology of the Hypothalamic-Pituitary-Thyroid Axis
Mariotti, S., & Beck‐Peccoz, P. (2016) · Cited by 35
Desipramine reversal of chloroquine resistance in wild isolates of Plasmodium falciparum
Salama, A. D., & Facer, C. (1990) · The Lancet · doi:10.1016/0140-6736(90)90034-3 · Cited by 34 · cited 1×
“TCAs also present in vitro activity against the parasites Plasmodium falciparum (Basco and Le Bras, 1990; Salama and Facer, 1990) and Leishmania spp.”
Background
Peripheral Administration of Human Corticotropin-Releasing Hormone: A Novel Method to Increase Energy Expenditure and Fat Oxidation in Man1
Smith, S. R., de Jonge, L., Pelleymounter, M. A., Nguyen, T. N., Harris, R. B. S., York, D. A., Redmann, S. M., Rood, J. C., & Bray, G. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7491 · Cited by 34 · cited 1×
“Another brain area involved in appetite regulation is the PVN, responsible of producing anorexigenic peptides such as thyrotropin releasing hormone (TRH) (Guo et al., 2004), CRF (Krahn et al., 1988; Smith et al., 2001; Uehara et al., 1998) and oxytocin (Lawson et al., 2015).”
Background
Reduction of Alzheimer's disease beta-amyloid pathology in the absence of gut microbiotaPreprint
Harach, T., Marungruang, N., Dutilleul, N., Cheatham, V., Coy, K. D. M., Neher, J. J., Jucker, M., Fåk, F., T., Lasser, et al. (2015) · arXiv (Cornell University) · doi:10.48550/arxiv.1509.02273 · Cited by 34 · cited 1×
“Moreover, neither germ- free nor antibiotic-treated transgenic Alzheimer’s mice develop the characteristic plaques (Harach et al., 2015; Minter et al., 2016).”
Background
Restraint-induced corticosterone secretion and hypothalamic CRH mRNA expression are augmented during acute withdrawal from chronic cocaine administration
Mantsch, J. R., Taves, S., Khan, T., Katz, E. S., Sajan, T., Tang, L. C., Cullinan, W. E., & Ziegler, D. R. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.01.036 · Cited by 33
Endocrine and Reproductive Physiology
(2013) · Elsevier eBooks · doi:10.1016/c2010-0-69035-3 · Cited by 32
Sentence memory affected by vasopressin analog (DDAVP) in cross-over experiment
Till, R. E., & Beckwith, B. E. (1985) · Peptides · doi:10.1016/0196-9781(85)90103-2 · Cited by 32
Regulation of renal urea transport by vasopressin.
Sands, J. M., Blount, M. A., & Klein, J. D. (2011) · PubMed · Cited by 30
Adrenocorticotropin and Cortisol Responses to Vasopressin during Pregnancy*
Goland, R., Wardlaw, S. L., MacCarter, G. D., Warren, W. B., & Stark, R. I. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-2-257 · Cited by 30 · cited 1×
“response to stress, particularly during pregnancy and lactation in mammals (Goland et al., 1991; Ma et al., 2005; Toufexis et al., 1999).”
Background
Effects of orally applied butyrate bolus on histone acetylation and cytochrome P450 enzyme activity in the liver of chicken – a randomized controlled trial
Mátis, G., Neogrády, Z., Csikó, G., Kulcsár, A., Kenéz, Á., & Huber, K. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-12 · Cited by 30 · cited 1×
“directly influence neurotransmitters’ synthesis and to inhibit the histone deacetylases may be responsible for their behavioural effects (Donohoe et al., 2012; Matis et al., 2013).”
Background
Recent advances in the neurobiology of depression
Normann, C., & Berger, T. (2003) · CRC Press eBooks · doi:10.3109/9780203002889-5 · Cited by 30
Influence of neurohypophyseal peptides on the formation of active avoidance conditioned reflex behavior
Ибрагимов, Р. Ш. (1990) · Neuroscience and Behavioral Physiology · doi:10.1007/bf01195453 · Cited by 28 · cited 1×
“The hormones oxytocin and vasopressin play a fundamental role in this inter- neuronal communication and several studies have demonstrated the involvement of these hormones in cognitive processes (Bohus et al., 1978; Dantzer et al., 1987; Ibragimov, 1990; Till and Beckwith, 1985).”
Background
Untitled work
(2009) · PubMed · Cited by 27
Peripheral Administration of Human Corticotropin-Releasing Hormone: A Novel Method to Increase Energy Expenditure and Fat Oxidation in Man
Smith, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.5.1991 · Cited by 25
Untitled work
(1988) · PubMed · Cited by 24
Testosterone Effects on Luteinizing Hormone and Follicle‐Stimulating Hormone Responses to Gonadotropin‐Releasing Hormone in the Mouse
Huang, B., Leu, S.-F., Yang, H., & NORMAN, R. L. (2001) · Journal of Andrology · doi:10.1002/j.1939-4640.2001.tb02208.x · Cited by 23 · cited 1×
“In males, FSH and LH stimulate the production of testosterone, a hormone required for normal spermatogenesis (Huang et al., 2001; Walker and Cheng, 2005).”
Background
Cronobacter sakazakii infection alters serotonin transporter and improved fear memory retention in the rat
Sivamaruthi, B. S., Madhumita, R., Balamurugan, K., & Rajan, K. E. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00188 · Cited by 22 · cited 1×
“microbes are able to interact with the CNS through the vagus nerve and control the production and/or release of neurotransmitters (Sivamaruthi et al., 2015).”
Background
Fetal testosterone and autistic traits: A response to three fascinating commentaries
Baron‐Cohen, S., Bonnie Auyeung, B., Ashwin, E., & Knickmeyer, R. C. (2009) · British Journal of Psychology · doi:10.1348/000712608x394271 · Cited by 22
Effect of large bowel fermentation on insulin, glucose, free fatty acids, and glucagon-like peptide 1 (7-36) amide in patients with coronary heart disease
Frost, G. S., Brynes, A. E., & Leeds, A. (1999) · Nutrition · doi:10.1016/s0899-9007(98)00177-4 · Cited by 19
Binding of tricyclic antidepressant drugs to trophozoites of giardia lamblia
Weinbach, E. C., Levenbook, L., & Alling, D. W. (1992) · Comparative Biochemistry and Physiology Part C: Comparative Pharmacology · doi:10.1016/0742-8413(92)90131-p · Cited by 18 · cited 1×
“coli, Yersinia enterocolitica (Csiszar and Molnar, 1992; Molnar, 1988) and the parasite Giardia lamblia (Weinbach et al., 1992).”
Background
Effect of probiotic consumption in the level of peptide YY, ghrelin hormone and body weight in Iraqi obese female
Alajeeli, F. (2017) · Journal of Obesity & Weight loss Therapy · Cited by 3

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5 of the 407 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Chrousos, 1995, The hypothalamic–pituitary–adrenal axis and immune-mediated inflammation, N. Engl. J. Med., 332, 1351, 10.1056/NEJM199505183322008 · DOI · Paper page
Tsigos, 2002, Hypothalamic–pituitary–adrenal axis, neuroendocrine factors and stress, J. Psychosom. Res., 53, 865, 10.1016/S0022-3999(02)00429-4 · DOI · Paper page

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The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review
Clemente‐Suárez, V. J., Beltrán-Velasco, A. I., Redondo-Flórez, L., Martín-Rodríguez, A., & Tornero-Aguilera, J. F. (2023) · Nutrients · doi:10.3390/nu15122749 · Cited by 933
Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis
Ma, Q., Xing, C., Long, W., Wang, H. Y., Liu, Q., & Wang, R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1434-3 · Cited by 767
“A notable role of human digestive system in brain development has been proposed [15, 50].”
Background
Gut Microbiota and Energy Homeostasis in Fish
Butt, R. L., & Volkoff, H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00009 · Cited by 637
A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia
McGuinness, A. J., Davis, J. A., Dawson, S. L., Loughman, A., Collier, F., O’Hely, M., Simpson, C. A., Green, J., Marx, W., Hair, C., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01456-3 · Cited by 502
“They influence many aspects of physiology via neural, hormonal and immunological pathways [1, 2], so much so that some describe the gut microbiome as a ‘virtual organ’ [3, 4].”
Background

See all 326

Authors: Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F.
Affiliations: University College Cork (IE)
Corresponding author: Cryan, John F.
ORCID: Cussotto, Sofia
Dinan, Timothy G.
Cryan, John F.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2018-10
Volume: 51
Pages: 80-101
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2018.04.002
OpenAlex: W2804326576
Cited by: 326
References: 407
Citations by year: 2026: 17 · 2025: 43 · 2024: 53 · 2023: 43 · 2022: 54 · 2021: 36 · 2020: 43 · 2019: 32 · 2018: 5
FWCI: 2.84
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: gut microbiota, gut-brain axis, neuroendocrine system, behavioral responses, stress, eating behaviour, sexual behavior, social behavior, cognition, addiction, host-microbe interactions
MeSH terms: Gastrointestinal Microbiome, Animals, Brain, Feeding Behavior, Humans, Learning, Neurosecretory Systems, Sexual Behavior, Social Behavior, Stress, Psychological, Behavior, Addictive

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The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective

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