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Depression and immunity: A meta-analytic review.
Abstract
A meta-analysis indicated that clinical depression was associated with several large alterations in cellular immunity. Analyzing only methodologically sound studies, reliable immune alterations included lowered proliferative response of lymphocytes to mitogens (effect size rs = .24-.45), lowered natural killer cell activity (r = .28), and alterations in numbers of several white blood cell populations (rs = .11-.77). Immune alterations were greater in both older and hospitalized samples. There was also evidence of a linear relation between intensity of depressive affect and indicators of cellular immunity. Estimates of sample sizes needed to detect reliable effects for each immune outcome are provided. How neuroendocrine mechanisms or health practices might link depression to immunity is discussed, and design features needed to better understand these pathways are specified.
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Citations
Cites
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Primary, Secondary, and Meta-Analysis of Research
GLASS, G. V. (1976) · Educational Researcher · doi:10.3102/0013189x005010003 · Cited by 4,890
The Hopkins Symptom Checklist (HSCL): A self-report symptom inventory
Derogatis, L. R., Lipman, R. S., Rickels, K., Uhlenhuth, E. H., & Covi, L. (1974) · Behavioral Science · doi:10.1002/bs.3830190102 · Cited by 4,604
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689
Cited by
Health promotion from the perspective of Social Cognitive Theory
Bandura, A. (1998) · Psychology & Health · doi:10.1080/08870449808407422 · Cited by 3,087
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
Effect size guidelines for individual differences researchers
Gignac, G. E., & Szodorai, E. T. (2016) · Personality and Individual Differences · doi:10.1016/j.paid.2016.06.069 · Cited by 2,860
Risky families: Family social environments and the mental and physical health of offspring
Repetti, R. L., Taylor, S. E., & Seeman, T. E. (2002) · Psychological Bulletin · doi:10.1037/0033-2909.128.2.330 · Cited by 2,884
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766
Uchino, B. N., Cacioppo, J. T., & Kiecolt-Glaser, J. K. (1996) · Psychological Bulletin · doi:10.1037/0033-2909.119.3.488 · Cited by 2,727
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206
Does positive affect influence health?
Pressman, S. D., & Cohen, S. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.6.925 · Cited by 2,087
Self-citationMiller, G. E., Chen, E., & Parker, K. J. (2011) · Psychological Bulletin · doi:10.1037/a0024768 · Cited by 1,785
Is caregiving hazardous to one’s physical health? A meta-analysis
Vitaliano, P. P., Zhang, J., & Scanlan, J. M. (2003) · Psychological Bulletin · doi:10.1037/0033-2909.129.6.946 · Cited by 1,734
Gallo, L. C., & Matthews, K. A. (2003) · Psychological Bulletin · doi:10.1037/0033-2909.129.1.10 · Cited by 1,366
Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology.
Kiecolt-Glaser, J. K., McGuire, L., Robles, T. F., & Glaser, R. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135217 · Cited by 1,176
Maier, S. F., & Watkins, L. R. (1998) · Psychological Review · doi:10.1037/0033-295x.105.1.83 · Cited by 1,130
Stetler, C., & Miller, G. E. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820ad12b · Cited by 1,123
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
Mood disorders in the medically ill: scientific review and recommendations
Evans, D. L., Charney, D. S., Lewis, L., Golden, R. N., Gorman, J. M., Krishnan, K. R. R., Nemeroff, C. B., Bremner, J. D., Carney, R. M., Coyne, J. C., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.001 · Cited by 1,071
The Relationship of Depression and Stressors to Immunological Assays: A Meta-Analytic Review
Zorrilla, E. P., Luborsky, L., McKay, J. R., Rosenthal, R., Houldin, A., Tax, A., McCorkle, R., Seligman, D. A., & Schmidt, K. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0597 · Cited by 995
Health psychology: what is an unhealthy environment and how does it get under the skin?
Taylor, S. E., Repetti, R. L., & Seeman, T. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.411 · Cited by 936
The Relationship Context of Human Behavior and Development
Reis, H. T., Collins, W. A., & Berscheid, E. (2000) · Psychological Bulletin · doi:10.1037/0033-2909.126.6.844 · Cited by 853
Hunter, J. E., & Schmidt, F. L. (2000) · International Journal of Selection and Assessment · doi:10.1111/1468-2389.00156 · Cited by 833
Chronic stress alters the immune response to influenza virus vaccine in older adults.
Kiecolt-Glaser, J. K., Glaser, R., Gravenstein, S., Malarkey, W. B., & Sheridan, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.3043 · Cited by 789
Depression as a risk factor for cardiac mortality and morbidity
Carney, R. M., Freedland, K. E., Miller, G. E., & Jaffe, A. S. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00311-2 · Cited by 746
Depressive disorders and immunity: 20 years of progress and discovery
Irwin, M. R., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.01.010 · Cited by 676
The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression
Müller, N., & Schwarz, M. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002006 · Cited by 670
Role of depression, stress, and trauma in HIV disease progression
Leserman, J. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181777a5f · Cited by 662
Major Depression and Activation of The Inflammatory Response System
Maes, M. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_2 · Cited by 617
Endotoxin produces a depressive-like episode in rats
Yirmiya, R. (1996) · Brain Research · doi:10.1016/0006-8993(95)01415-2 · Cited by 604
Black, S. A., Markides, K. S., & Ray, L. A. (2003) · Diabetes Care · doi:10.2337/diacare.26.10.2822 · Cited by 587
Mittermaier, C., Dejaco, C., Waldhoer, T., Oefferlbauer-Ernst, A., Miehsler, W., Beier, M., Tillinger, W., Gangl, A., & Moser, G. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000106907.24881.f2 · Cited by 532
Optimism is associated with mood, coping, and immune change in response to stress.
Segerstrom, S. C., Taylor, S. E., Kemeny, M. E., & Fahey, J. L. (1998) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.74.6.1646 · Cited by 527
Stress hormone-mediated invasion of ovarian cancer cells
Sood, A. K., Bhatty, R., Kamat, A. A., Landen, C. N., Han, L., Thaker, P. H., Li, Y., Gershenson, D. M., Lutgendorf, S., & Cole, S. W. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1698 · Cited by 491
Early Environment, Emotions, Responses to Stress, and Health
Taylor, S. E., Lerner, J. S., Sage, R. M., Lehman, B. J., & Seeman, T. E. (2004) · Journal of Personality · doi:10.1111/j.1467-6494.2004.00300.x · Cited by 390
Inflammation, Depression and Dementia: Are they Connected?
Leonard, B. E. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9385-y · Cited by 342
Stress, age, and immune function: toward a lifespan approach
Graham, J. E., Christian, L. M., & Kiecolt-Glaser, J. K. (2006) · Journal of Behavioral Medicine · doi:10.1007/s10865-006-9057-4 · Cited by 329
Denson, T. F., Spanovic, M., & Miller, N. (2009) · Psychological Bulletin · doi:10.1037/a0016909 · Cited by 328
LESERMAN, J., PETITTO, J. M., GU, H., GAYNES, B. N., BARROSO, J., GOLDEN, R. N., PERKINS, D. O., FOLDS, J. D., & EVANS, D. L. (2002) · Psychological Medicine · doi:10.1017/s0033291702005949 · Cited by 311
The Effects of Mind-Body Therapies on the Immune System: Meta-Analysis
Morgan, N., Irwin, M. R., Chung, M., & Wang, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100903 · Cited by 294
“It has been well-established that psychological stress and depression impair anti-viral immune responses and activate innate immunity or markers of inflammation via effector pathways, such as the sympathetic nervous system and the hypothalamus-pituitaryadrenal (HPA) axis [23–28].”
BackgroundAnxiety and depression in patients with rheumatoid arthritis
Isik, A., Koca, S. S., Ozturk, A., & Mermi, O. (2007) · Clinical Rheumatology · doi:10.1007/s10067-006-0407-y · Cited by 276
Coping with Prostate Cancer: A Meta-Analytic Review
Roesch, S. C., Adams, L., Hines, A., Palmores, A., Vyas, P., Tran, C., Pekin, S., & Vaughn, A. A. (2005) · Journal of Behavioral Medicine · doi:10.1007/s10865-005-4664-z · Cited by 261
The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
Raison, C. L., & Miller, A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.2 · Cited by 253
A psychoneuroimmunological review on cytokines involved in antidepressant treatment response
Janssen, D. G. A., Caniato, R. N., Verster, J. C., & Baune, B. T. (2010) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1103 · Cited by 240
Hestad, K. A., Tønseth, S., Støen, C. D., Ueland, T., & Aukrust, P. (2003) · The Journal of ECT · doi:10.1097/00124509-200312000-00002 · Cited by 235
Cytokines, stress, and depressive illness
Anisman, H., & Merali, Z. (2002) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00009-0 · Cited by 225
Gene expression in major depressive disorder
Jansen, R., Penninx, B. W. J. H., Madar, V, Xia, K., Milaneschi, Y., Hottenga, J. J., Hammerschlag, A. R., Beekman, A., van der Wee, N., Smit, J. H., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.57 · Cited by 224
Depression, inflammation, and pain in patients with rheumatoid arthritis.
Kojima, M., Kojima, T., Suzuki, S., Oguchi, T., Oba, M., Tsuchiya, H., Sugiura, F., Kanayama, Y., Furukawa, T. A., Tokudome, S., et al. (2009) · Arthritis Care & Research · doi:10.1002/art.24647 · Cited by 217
Cytokines, “depression due to a general medical condition”, and antidepressant drugs
Yirmiya, R., Weidenfeld, J., Pollak, Y., Morag, M., Morag, A., Avitsur, R., Barak, O., Reichenberg, A., Cohen, E., Shavit, Y., et al. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_16 · Cited by 208
Stress-induced neuroinflammation: role of the toll-like receptor-4 pathway
Gárate, I., Garcia-Bueno, B., Madrigal, J. L. M., Caso, J. R., Alou, L., Gomez-Lus, M. L., Micó, J. A., & Leza, J. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.005 · Cited by 202
Suarez, E. C., Krishnan, R. R., & Lewis, J. G. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000035719.79068.2b · Cited by 199
Cytokines and depression: fortuitous or causative association?
Dantzer, R., Wollman, E., Vitkovic, L., & Yirmiya, R. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000572 · Cited by 174
Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer
Sephton, S. E., Dhabhar, F. S., Keuroghlian, A. S., Giese-Davis, J., McEwen, B. S., Ionan, A. C., & Spiegel, D. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.07.007 · Cited by 170
Assessment and treatment of depression in the cancer patient
Newport, D. J., & Nemeroff, C. B. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(98)00011-7 · Cited by 167
Kéri, S., Szabó, C., & Kelemen, O. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.03.020 · Cited by 165
Vascular endothelial growth factor and social support in patients with ovarian carcinoma
Lutgendorf, S. K., Johnsen, E. L., Cooper, B., Anderson, B., Sorosky, J. I., Buller, R. E., & Sood, A. K. (2002) · Cancer · doi:10.1002/cncr.10739 · Cited by 160
Psychoneuroimmunology of depression: clinical implications
Irwin, M. (2002) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2001.0654 · Cited by 160
Depression and C-Reactive Protein: Population-Based Health 2000 Study
Elovainio, M., Aalto, A.-M., Kivimäki, M., Pirkola, S., Sundvall, J., Lönnqvist, J., & Reunanen, A. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31819e333a · Cited by 157
Haapakoski, R., Ebmeier, K. P., Alenius, H., & Kivimäki, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.11.012 · Cited by 157
Mindfulness as a moderator of neuroticism–outcome relations: A self-regulation perspective
Feltman, R., Robinson, M. D., & Ode, S. (2009) · Journal of Research in Personality · doi:10.1016/j.jrp.2009.08.009 · Cited by 146
Patient personality and mortality: A 4-year prospective examination of chronic renal insufficiency.
Christensen, A. J., Ehlers, S. L., Wiebe, J. S., Moran, P. J., Raichle, K., Ferneyhough, K., & Lawton, W. J. (2002) · Health Psychology · doi:10.1037/0278-6133.21.4.315 · Cited by 141
Psychological testing and psychological assessment: A review of evidence and issues.
Meyer, G. J., Finn, S. E., Eyde, L. D., Kay, G. G., Moreland, K. L., Dies, R. R., Eisman, E. J., Kubiszyn, T. W., & Reed, G. M. (2001) · American Psychologist · doi:10.1037//0003-066x.56.2.128 · Cited by 1,469
Steel, J. L., Geller, D. A., Kim, K. H., Butterfield, L. H., Spring, M., Grady, J., Sun, W., Marsh, W., Antoni, M., Dew, M. A., et al. (2016) · Cancer · doi:10.1002/cncr.29906 · Cited by 116
Neurohormonal and inflammatory hyper-responsiveness to acute mental stress in depression.
Weinstein, A. A., Deuster, P. A., Francis, J. L., Bonsall, R. W., Tracy, R. P., & Kop, W. J. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.01.016 · Cited by 113
Dissociation of inflammatory markers and natural killer cell activity in major depressive disorder
Pike, J. L., & Irwin, M. R. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.05.004 · Cited by 101
Optimism, Goal Conflict, and Stressor-Related Immune Change
Segerstrom, S. C. (2001) · Journal of Behavioral Medicine · doi:10.1023/a:1012271410485 · Cited by 100
Relationship between respiratory mortality and self-perceptions of aging
Levy, B. R., & Myers, L. M. (2005) · Psychology & Health · doi:10.1080/14768320500066381 · Cited by 101
Immunity and depression: Insomnia, Retardation, and reduction of natural killer cell activity
Cover, H., & Irwin, M. (1994) · Journal of Behavioral Medicine · doi:10.1007/bf01858106 · Cited by 97
Untreated depression and tuberculosis treatment outcomes, quality of life and disability, Ethiopia
Ambaw, F., Mayston, R., Hanlon, C., Medhin, G., & Alem, A. (2018) · Bulletin of the World Health Organization · doi:10.2471/blt.17.192658 · Cited by 98
Childhood adversity and cell-mediated immunity in young adulthood: does type and timing matter?
Slopen, N., McLaughlin, K. A., Dunn, E. C., & Koenen, K. C. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.10.018 · Cited by 77
Savard, J., Miller, S. M., Mills, M., O'Leary, A., Harding, H., Douglas, S. D., Mangan, C. E., Belch, R., & Winokur, A. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199907000-00014 · Cited by 62
Interleukin-6 and use of social support in gynecologic cancer patients
Lutgendorf, S. K., Anderson, B., Sorosky, J. I., Buller, R. E., & Lubaroff, D. M. (2000) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0702_3 · Cited by 56
Social relationships and immune processes in HIV seropositive gay and bisexual men
Miller, G. E., Kemeny, M. E., Taylor, S. E., Cole, S. W., & Visscher, B. R. (1997) · Annals of Behavioral Medicine · doi:10.1007/bf02883331 · Cited by 48
Substance use disorders: Psychoneuroimmunological mechanisms and new targets for therapy
Loftis, J. M., & Huckans, M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.04.011 · Cited by 47
Rao, U., McGinty, D. J., Shinde, A., McCracken, J. T., & Poland, R. E. (1999) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(99)00036-6 · Cited by 39
Chen, X., Pu, J., Liu, Y., Tian, L., Chen, Y., Gui, S., Xu, S., Song, X., & Xie, P. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113320 · Cited by 34
Psychosocial Stress as a Risk Factor for Sepsis: A Population-Based Cohort Study
Ojard, C., Donnelly, J. P., Safford, M. M., Griffin, R., & Wang, H. E. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000120 · Cited by 24
Weaver, T. L., Nishith, P., & Resick, P. A. (1998) · Cognitive and Behavioral Practice · doi:10.1016/s1077-7229(98)80023-0 · Cited by 18
Kinsman, L. M., Norrie, H. J., Rachor, G. S., & Asmundson, G. J. G. (2024) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2024_500 · Cited by 2
Metadata
- Authors
- Herbert, T. B., & Cohen, S.
- Venue
- Psychological Bulletin
- Published
- 1993
- Volume
- 113
- Issue
- 3
- Pages
- 472-486
- ISSN
- 0033-2909 (ISSN-L)
- 1939-1455
- OpenAlex
- W2085241964
- Cited by
- 803
- References
- 5
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- closed
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