In vivo NIR-II fluorescence imaging for biology and medicine

A clearer vision for in vivo imaging

Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839

Near-infrared fluorophores for biomedical imaging

Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,048

Second window for in vivo imaging

Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848

Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization

Chen, R. J., Zhang, Y., Wang, D., & Dai, H. (2001) · Journal of the American Chemical Society · doi:10.1021/ja010172b · Cited by 2,534

Optical Sectioning Deep Inside Live Embryos by Selective Plane Illumination Microscopy

Huisken, J., Swoger, J., Bene, F. D., Wittbrodt, J., & Stelzer, E. H. K. (2004) · Science · doi:10.1126/science.1100035 · Cited by 2,370

Nonlinear structured-illumination microscopy: Wide-field fluorescence imaging with theoretically unlimited resolution

Gustafsson, M. G. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406877102 · Cited by 2,270

A small-molecule dye for NIR-II imaging

Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778

Carbon nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery

Liu, Z., Tabakman, S. M., Welsher, K., & Dai, H. (2009) · Nano Research · doi:10.1007/s12274-009-9009-8 · Cited by 1,729

In vivo three-photon microscopy of subcortical structures within an intact mouse brain

Horton, N. G., Wang, K., Kobat, D., Clark, C. G., Wise, F. W., Schaffer, C. B., & Xu, C. (2013) · Nature Photonics · doi:10.1038/nphoton.2012.336 · Cited by 1,505

A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice

Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287

First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows

Hu, Z., Fang, C., Li, B., Zhang, Z., Cao, C., Cai, M., Su, S., Sun, X., Shi, X., Li, C., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0494-0 · Cited by 1,126

Through-skull fluorescence imaging of the brain in a new near-infrared window

Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., et al. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.166 · Cited by 1,052

Multifunctional in vivo vascular imaging using near-infrared II fluorescence

Hong, G., Lee, J. C., Robinson, J. T., Raaz, U., Xie, L., Huang, N. F., Cooke, J. P., & Dai, H. (2012) · Nature Medicine · doi:10.1038/nm.2995 · Cited by 995

Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Zhu, S., Tian, R., Antaris, A. L., Chen, X. S., & Dai, H. (2019) · Advanced Materials · doi:10.1002/adma.201900321 · Cited by 976

Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window

Welsher, K., Sherlock, S. P., & Dai, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014501108 · Cited by 958

Ag 2 S Quantum Dot: A Bright and Biocompatible Fluorescent Nanoprobe in the Second Near-Infrared Window

Zhang, Y., Hong, G., Zhang, Y., Chen, G., Li, F., Dai, H., & Wang, Q. (2012) · ACS Nano · doi:10.1021/nn301218z · Cited by 765

In Vivo Fluorescence Imaging with Ag 2 S Quantum Dots in the Second Near‐Infrared Region

Hong, G., Robinson, J. T., Zhang, Y., Diao, S., Antaris, A. L., Wang, Q., & Dai, H. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201206059 · Cited by 742

X-ray-activated persistent luminescence nanomaterials for NIR-II imaging

Pei, P., Chen, Y., Sun, C., Fan, Y., Yang, Y., Liu, X., Lu, L., Zhao, M., Zhang, H., Zhao, D., et al. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00922-3 · Cited by 718

HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes

Girard, J.-P., Moussion, C., & Förster, R. (2012) · Nature Reviews Immunology · doi:10.1038/nri3298 · Cited by 713

Next-generation in vivo optical imaging with short-wave infrared quantum dots

Bruns, O. T., Bischof, T. S., Harris, D. K., Franke, D., Shi, Y., Riedemann, L., Bartelt, A., Jaworski, F. B., Carr, J. A., Rowlands, C. J., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0056 · Cited by 686

A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

Antaris, A. L., Chen, H., Diao, S., Ma, Z., Zhang, Z., Zhu, S., Wang, J., Lozano, A. X., Fan, Q., Chew, L., et al. (2017) · Nature Communications · doi:10.1038/ncomms15269 · Cited by 623

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

Herisson, F., Frodermann, V., Courties, G., Rohde, D., Sun, Y., Vandoorne, K., Wojtkiewicz, G. R., Masson, G. S., Vinegoni, C., Kim, J., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0213-2 · Cited by 610

J -Aggregates of Cyanine Dye for NIR-II in Vivo Dynamic Vascular Imaging beyond 1500 nm

Sun, C., Li, B., Zhao, M., Wang, S., Lei, Z., Lu, L., Zhang, H., Feng, L., Dou, C., Yin, D., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10043 · Cited by 582

Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms

Liu, T., Upadhyayula, S., Milkie, D. E., Singh, V. P., Wang, K., Swinburne, I. A., Mosaliganti, K. R., Collins, Z. M., Hiscock, T. W., Shea, J., et al. (2018) · Science · doi:10.1126/science.aaq1392 · Cited by 577

In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles

Zhong, Y., Ma, Z., Wang, F., Wang, X., Yang, Y., Liu, Y., Zhao, X., Li, J., Du, H., Zhang, M., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0262-4 · Cited by 575

Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm

Zhong, Y., Ma, Z., Zhu, S., Yue, J., Zhang, M., Antaris, A. L., Yuan, J., Cui, R., Wan, H., Zhou, Y., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00917-6 · Cited by 563

Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance

Yang, Q., Hu, Z., Zhu, S., Ma, R., Ma, H., Ma, Z., Wan, H., Zhu, T., Jiang, Z., Liu, W., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b10334 · Cited by 554

Near-infrared fluorescent proteins for multicolor in vivo imaging

Shcherbakova, D. M., & Verkhusha, V. V. (2013) · Nature Methods · doi:10.1038/nmeth.2521 · Cited by 541

Indocyanine Green

Reinhart, M. B., Huntington, C. R., Blair, L. J., Heniford, B. T., & Augenstein, V. A. (2015) · Surgical Innovation · doi:10.1177/1553350615604053 · Cited by 518

Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing

Wang, S., Fan, Y., Li, D., Sun, C., Lei, Z., Lu, L., Wang, T., & Zhang, F. (2019) · Nature Communications · doi:10.1038/s41467-019-09043-x · Cited by 510

Overcoming the energy gap law in near-infrared OLEDs by exciton–vibration decoupling

Wei, Y., Wang, S. F., Hu, Y., Liao, L., Chen, D., Chang, K., Wang, C.-W., Liu, S., Chan, W., Liao, J., et al. (2020) · Nature Photonics · doi:10.1038/s41566-020-0653-6 · Cited by 501

Rational Design of Molecular Fluorophores for Biological Imaging in the NIR‐II Window

Yang, Q., Ma, Z., Wang, H., Zhou, B., Zhu, S., Zhong, Y., Wang, J., Wan, H., Antaris, A., Ma, R., et al. (2017) · Advanced Materials · doi:10.1002/adma.201605497 · Cited by 467

NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer

Wang, P., Fan, Y., Lu, L., Liu, L., Fan, L., Zhao, M., Xie, Y., Xu, C., & Zhang, F. (2018) · Nature Communications · doi:10.1038/s41467-018-05113-8 · Cited by 457

Atomic‐Precision Gold Clusters for NIR‐II Imaging

Liu, H., Hong, G., Luo, Z., Chen, J., Chang, J., Gong, M., He, H., Jiang, Y., Yuan, X. F., Li, L., et al. (2019) · Advanced Materials · doi:10.1002/adma.201901015 · Cited by 451

A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues

Wan, H., Yue, J., Zhu, S., Uno, T., Zhang, X., Yang, Q., Yu, K., Hong, G., Wang, J., Li, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03505-4 · Cited by 450

Corrigendum: Optical properties of biological tissues: a review

Jacques, S. L. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/14/5007 · Cited by 434

Review of fluorescence guided surgery systems: identification of key performance capabilities beyond indocyanine green imaging

DSouza, A. V., Lin, H., Henderson, E. R., Samkoe, K. S., & Pogue, B. W. (2016) · Journal of Biomedical Optics · doi:10.1117/1.jbo.21.8.080901 · Cited by 432

Bright quantum dots emitting at ∼1,600 nm in the NIR-IIb window for deep tissue fluorescence imaging

Zhang, M., Yue, J., Cui, R., Ma, Z., Wan, H., Wang, F., Zhu, S., Zhou, Y., Kuang, Y., Zhong, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806153115 · Cited by 432

In vivo two-photon microscopy to 1.6-mm depth in mouse cortex

Kobat, D., Horton, N. G., & Xu, C. (2011) · Journal of Biomedical Optics · doi:10.1117/1.3646209 · Cited by 431

Real‐Time and High‐Resolution Bioimaging with Bright Aggregation‐Induced Emission Dots in Short‐Wave Infrared Region

Qi, J., Sun, C., Zebibula, A., Zhang, H., Kwok, R. T. K., Zhao, X., Xi, W., Lam, J. W. Y., Qian, J., & Tang, B. Z. (2018) · Advanced Materials · doi:10.1002/adma.201706856 · Cited by 418

Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm

Diao, S., Blackburn, J. L., Hong, G., Antaris, A. L., Chang, J., Wu, J. Z., Zhang, B., Cheng, K., Kuo, C. J., & Dai, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201507473 · Cited by 417

Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore

Zhang, X., Wang, H., Antaris, A. L., Li, L., Diao, S., Ma, R., Nguyen, A., Hong, G., Ma, Z., Wang, J., et al. (2016) · Advanced Materials · doi:10.1002/adma.201600706 · Cited by 386

Tunable Narrow Band Emissions from Dye-Sensitized Core/Shell/Shell Nanocrystals in the Second Near-Infrared Biological Window

Shao, W., Chen, G., Kuzmin, A., Kutscher, H. L., Pliss, A., Ohulchanskyy, T. Y., & Prasad, P. N. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b08973 · Cited by 386

Stable, Wavelength‐Tunable Fluorescent Dyes in the NIR‐II Region for In Vivo High‐Contrast Bioimaging and Multiplexed Biosensing

Lei, Z., Sun, C., Pei, P., Wang, S., Li, D., Zhang, X., & Zhang, F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201904182 · Cited by 362

Shortwave infrared polymethine fluorophores matched to excitation lasers enable non-invasive, multicolour in vivo imaging in real time

Cosco, E. D., Spearman, A. L., Ramakrishnan, S., Lingg, J. G. P., Saccomano, M., Pengshung, M., Arús, B. A., Wong, K. C. Y., Glasl, S., Ntziachristos, V., et al. (2020) · Nature Chemistry · doi:10.1038/s41557-020-00554-5 · Cited by 347

Biological imaging without autofluorescence in the second near-infrared region

Diao, S., Hong, G., Antaris, A. L., Blackburn, J. L., Cheng, K., Cheng, Z., & Dai, H. (2015) · Nano Research · doi:10.1007/s12274-015-0808-9 · Cited by 346

A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging

Wang, T., Wang, S., Liu, Z., He, Z., Yu, P., Zhao, M., Zhang, H., Lu, L., Wang, Z., Wang, Z., et al. (2021) · Nature Materials · doi:10.1038/s41563-021-01063-7 · Cited by 308 · cited 1×

In vivo non-invasive confocal fluorescence imaging beyond 1,700 nm using superconducting nanowire single-photon detectors

Wang, F., Ren, F., Ma, Z., Qu, L., Gourgues, R., Xu, C., Baghdasaryan, A., Li, J., Zadeh, I. E., Los, J. W. N., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01130-3 · Cited by 296

Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging

Shen, H., Sun, F., Zhu, X., Zhang, J., Ou, X., Zhang, J., Xu, C., Sung, H. H. Y., Williams, I. D., Chen, S., et al. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c07443 · Cited by 292

Fluorescence-amplified nanocrystals in the second near-infrared window for in vivo real-time dynamic multiplexed imaging

Yang, Y., Chen, Y., Pei, P., Fan, Y., Wang, S., Zhang, H., Zhao, D., Qian, B., & Zhang, F. (2023) · Nature Nanotechnology · doi:10.1038/s41565-023-01422-2 · Cited by 290

NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing

Lu, L., Li, B., Ding, S., Fan, Y., Wang, S., Sun, C., Zhao, M., Zhao, C.-X., & Zhang, F. (2020) · Nature Communications · doi:10.1038/s41467-020-18051-1 · Cited by 274

A General Strategy for Development of Activatable NIR‐II Fluorescent Probes for In Vivo High‐Contrast Bioimaging

Ren, T., Wang, Z., Xiang, Z., Lu, P., Lai, H., Yuan, L., Zhang, X., & Tan, W. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202009986 · Cited by 273

Multiplexed NIR‐II Probes for Lymph Node‐Invaded Cancer Detection and Imaging‐Guided Surgery

Tian, R., Ma, H., Zhu, S., Lau, J., Ma, R., Liu, Y., Lin, L., Chandra, S., Wang, S., Zhu, X., et al. (2020) · Advanced Materials · doi:10.1002/adma.201907365 · Cited by 269

Renal‐clearable Molecular Semiconductor for Second Near‐Infrared Fluorescence Imaging of Kidney Dysfunction

Huang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201909560 · Cited by 258 · cited 2×

High-sensitivity imaging of time-domain near-infrared light transducer

Gu, Y., Guo, Z., Yuan, W., Kong, M., Liu, Y., Liu, Y., Gao, Y., Feng, W., Wang, F., Zhou, J., et al. (2019) · Nature Photonics · doi:10.1038/s41566-019-0437-z · Cited by 249

Light-sheet microscopy in the near-infrared II window

Wang, F., Wan, H., Ma, Z., Zhong, Y., Sun, Q., Tian, Y., Qu, L., Du, H., Zhang, M., Li, L., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0398-7 · Cited by 237

Indocyanine green fluorescence in second near-infrared (NIR-II) window

Starosolski, Z. A., Bhavane, R. C., Ghaghada, K. B., Vasudevan, S. A., Kaay, A., & Annapragada, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187563 · Cited by 221

Scanning superlens microscopy for non-invasive large field-of-view visible light nanoscale imaging

Wang, F., Liu, L., Yu, H., Wen, Y., Yu, P., Liu, Z., Wang, Y., & Li, W. J. (2016) · Nature Communications · doi:10.1038/ncomms13748 · Cited by 202

Shortwave Infrared in Vivo Imaging with Gold Nanoclusters

Chen, Y., Montana, D. M., Wei, H., Cordero, J. M., Schneider, M., Guével, X. L., Chen, O., Bruns†, O. T., & Bawendi, M. G. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03070 · Cited by 184

Influence of oxygen saturation on the optical scattering properties of human red blood cells in the spectral range 250 to 2000 nm

Friebel, M. F., Helfmann, J., Netz, U. J., & Meinke, M. C. (2009) · Journal of Biomedical Optics · doi:10.1117/1.3127200 · Cited by 182

A mini-review on rare-earth down-conversion nanoparticles for NIR-II imaging of biological systems

Zhong, Y., & Dai, H. (2020) · Nano Research · doi:10.1007/s12274-020-2721-0 · Cited by 164

Absorption by water increases fluorescence image contrast of biological tissue in the shortwave infrared

Carr, J. A., Aellen, M., Franke, D., So, P. T. C., Bruns†, O. T., & Bawendi, M. G. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803210115 · Cited by 153

Rational design of a super-contrast NIR-II fluorophore affords high-performance NIR-II molecular imaging guided microsurgery

Tian, R., Ma, H., Yang, Q., Wan, H., Zhu, S., Chandra, S., Sun, H., Kiesewetter, D. O., Niu, G., Liang, Y., et al. (2018) · Chemical Science · doi:10.1039/c8sc03751e · Cited by 151

Bioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition

Ma, H., Zhang, X., Liu, L., Huang, Y., Sun, S., Chen, K., Qi, X., Liu, P., Yan, Y., Wang, Y., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh7828 · Cited by 151

NIRII‐HDs: A Versatile Platform for Developing Activatable NIR‐II Fluorogenic Probes for Reliable In Vivo Analyte Sensing

Qin, Z., Ren, T., Zhou, H., Zhang, X., He, L., Li, Z., Zhang, X., & Yuan, L. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202201541 · Cited by 140

X-ray-Induced Shortwave Infrared Biomedical Imaging Using Rare-Earth Nanoprobes

Naczynski, D. J., Sun, C., Türkcan, S. C., Jenkins, C. H., Koh, A. L., Ikeda, D. M., Pratx, G., & Xing, L. (2014) · Nano Letters · doi:10.1021/nl504123r · Cited by 139

Engineering of Reversible NIR‐II Redox‐Responsive Fluorescent Probes for Imaging of Inflammation In Vivo

He, L., He, L., Xu, S., Ren, T., Zhang, X., Qin, Z., Zhang, X., & Yuan, L. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202211409 · Cited by 136

Deep learning for in vivo near-infrared imaging

Ma, Z., Wang, F., Wang, W., Zhong, Y., & Dai, H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021446118 · Cited by 135

Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging

Chang, Y., Chen, H., Xie, X., Wan, Y., Li, Q., Wu, F., Yang, R., Wang, W., & Kong, X. (2023) · Nature Communications · doi:10.1038/s41467-023-36813-5 · Cited by 131

Incorporation of Planar Blocks into Twisted Skeletons: Boosting Brightness of Fluorophores for Bioimaging beyond 1500 Nanometer

Liu, S., Chen, R., Zhang, J., Li, Y., He, M., Fan, X., Zhang, H., Lu, X., Kwok, R. T. K., Lin, H., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c07527 · Cited by 129

Polymethine Molecular Platform for Ratiometric Fluorescent Probes in the Second near-Infrared Window

Lan, Q., Yu, P., Yan, K., Li, X., Zhang, F., & Lei, Z. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c10041 · Cited by 124

Phosphorylcholine-conjugated gold-molecular clusters improve signal for Lymph Node NIR-II fluorescence imaging in preclinical cancer models

Baghdasaryan, A., Wang, F., Ren, F., Ma, Z., Li, J., Zhou, X., Grigoryan, L., Xu, C., & Dai, H. (2022) · Nature Communications · doi:10.1038/s41467-022-33341-6 · Cited by 123

Developing a Bright NIR‐II Fluorophore with Fast Renal Excretion and Its Application in Molecular Imaging of Immune Checkpoint PD‐L1

Wan, H., Ma, H., Zhu, S., Wang, F., Tian, Y., Ma, R., Yang, Q., Hu, Z., Zhu, T., Wang, W., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201804956 · Cited by 120

An Activatable NIR‐II Fluorescent Reporter for In Vivo Imaging of Amyloid‐β Plaques

Miao, J., Miao, M., Jiang, Y., Zhao, M., Li, Q., Zhang, Y., An, Y., Pu, K., & Miao, Q. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202216351 · Cited by 119

A Bright, Renal‐Clearable NIR‐II Brush Macromolecular Probe with Long Blood Circulation Time for Kidney Disease Bioimaging

Yao, C., Chen, Y., Zhao, M., Wang, S., Wu, B., Yang, Y., Yin, D., Yu, P., Zhang, H., & Zhang, F. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202114273 · Cited by 117

Comparing the effective attenuation lengths for long wavelength in vivo imaging of the mouse brain

Wang, M., Wu, C., Sinefeld, D., Li, B., Xia, F., & Xu, C. (2018) · Biomedical Optics Express · doi:10.1364/boe.9.003534 · Cited by 114

Propylenedioxy Thiophene Donor to Achieve NIR-II Molecular Fluorophores with Enhanced Brightness

Ma, H., Liu, C., Hu, Z., Yu, P., Zhu, X., Ma, R., Sun, Z., Zhang, C.-H., Sun, H., Zhu, S., et al. (2020) · Chemistry of Materials · doi:10.1021/acs.chemmater.9b05159 · Cited by 110

NIR‐II Fluorescence Endoscopy for Targeted Imaging of Colorectal Cancer

Suo, Y., Wu, F., Xu, P., Shi, H., Wang, T., Liu, H., & Cheng, Z. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900974 · Cited by 106

Image formation by linear and nonlinear digital scanned light-sheet fluorescence microscopy with Gaussian and Bessel beam profiles

Olarte, O. E., Licea‐Rodriguez, J., Palero, J. A., Gualda, E. J., Artigas, D., Mayer, J., Swoger, J., Sharpe, J. A., Rocha‐Mendoza, I., Rangel-Rojo, R., et al. (2012) · Biomedical Optics Express · doi:10.1364/boe.3.001492 · Cited by 105

High-precision tumor resection down to few-cell level guided by NIR-IIb molecular fluorescence imaging

Wang, F., Qu, L., Ren, F., Baghdasaryan, A., Jiang, Y., Hsu, R., Liang, P., Li, J., Zhu, G., Ma, Z., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2123111119 · Cited by 105

Regulatory Aspects of Optical Methods and Exogenous Targets for Cancer Detection

Tummers, W. S. F. J., Warram, J. M., Tipirneni, K. E., Fengler, J., Jacobs, P. M., Shankar, L. K., Henderson, L. A., Ballard, B., Pfefer, T. J., Pogue, B. W., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3217 · Cited by 104

Light-sheet microscopy with attenuation-compensated propagation-invariant beams

Nylk, J., McCluskey, K., Preciado, M. A., Mazilu, M., Yang, Z., Gunn‐Moore, F. J., Aggarwal, S., Tello, J. A., Ferrier, D. E. K., & Dholakia, K. (2018) · Science Advances · doi:10.1126/sciadv.aar4817 · Cited by 103

Aggregation‐Induced Emission (AIE) Nanoparticles‐Assisted NIR‐II Fluorescence Imaging‐Guided Diagnosis and Surgery for Inflammatory Bowel Disease (IBD)

Fan, X., Xia, Q., Zhang, Y., Li, Y., Feng, Z., Zhou, J., Qi, J., Tang, B. Z., Qian, J., & Lin, H. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101043 · Cited by 94

Near-Infrared II Fluorescence for Imaging Hindlimb Vessel Regeneration With Dynamic Tissue Perfusion Measurement

Hong, G., Lee, J. C., Jha, A., Diao, S., Nakayama, K. H., Hou, L., Doyle, T. C., Robinson, J. T., Antaris, A. L., Dai, H., et al. (2014) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.000305 · Cited by 93

A theranostic agent for cancer therapy and imaging in the second near-infrared window

Ma, Z., Wan, H., Wang, W., Zhang, X., Uno, T., Yang, Q., Yue, J., Gao, H., Zhong, Y., Tian, Y., et al. (2018) · Nano Research · doi:10.1007/s12274-018-2210-x · Cited by 92

Design and synthesis of a small molecular NIR-II chemiluminescence probe for in vivo - activated H 2 S imaging

Chen, Z., Su, L., Wu, Y., Liu, J., Wu, R., Li, Q., Wang, C., Liu, L., & Song, J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2205186120 · Cited by 90

In vivo NIR-II structured-illumination light-sheet microscopy

Wang, F., Ma, Z., Zhong, Y., Salazar, F., Xu, C., Ren, F., Qu, L., Wu, A. M., & Dai, H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023888118 · Cited by 85

Shortwave-infrared-light-emitting probes for the in vivo tracking of cancer vaccines and the elicited immune responses

Ren, F., Wang, F., Baghdasaryan, A., Li, Y., Liu, H., Hsu, R., Wang, C., Li, J., Zhong, Y., Salazar, F. B., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01083-5 · Cited by 85

NIR-II fluorescence in vivo confocal microscopy with aggregation-induced emission dots

Yu, W., Guo, B., Zhang, H., Zhou, J., Yu, X., Zhu, L. J., Xue, D., Liu, W., Sun, X., & Qian, J. (2019) · 中国科学通报：英文版 · doi:10.1016/j.scib.2019.02.019 · Cited by 84

Oxyhaemoglobin saturation NIR-IIb imaging for assessing cancer metabolism and predicting the response to immunotherapy

Fang, Z., Wang, C., Yang, J., Song, Z., Xie, C., Ji, Y., Wang, Z., Du, X., Zheng, Q., Chen, C., et al. (2023) · Nature Nanotechnology · doi:10.1038/s41565-023-01501-4 · Cited by 84

Imaging through a scattering wall using absorption

Yoo, K. M., Liu, F., & Alfano, R. R. (1991) · Optics Letters · doi:10.1364/ol.16.001068 · Cited by 83

Short-Wave Infrared Confocal Fluorescence Imaging of Deep Mouse Brain with a Superconducting Nanowire Single-Photon Detector

Xia, F., Gevers, M., Fognini, A., Mok, A. T. Y., Li, B., Akbari, N., Zadeh, I. E., Qin-Dregely, J., & Xu, C. (2021) · ACS Photonics · doi:10.1021/acsphotonics.1c01018 · Cited by 68

Bacterial Phytochromes, Cyanobacteriochromes and Allophycocyanins as a Source of Near-Infrared Fluorescent Probes

Oliinyk, O. S., Chernov, K. G., & Verkhusha, V. V. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081691 · Cited by 64

Drug-Based Optical Agents: Infiltrating Clinics at Lower Risk

Scheuer, W., van Dam, G. M., Dobosz, M., Schwaiger, M., & Ntziachristos, V. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003572 · Cited by 63

NIR-II cell endocytosis-activated fluorescent probes for in vivo high-contrast bioimaging diagnostics

He, Y., Wang, S., Yu, P., Yan, K., Ming, J., Yao, C., He, Z., El‐Toni, A. M., Khan, A., Zhu, X., et al. (2021) · Chemical Science · doi:10.1039/d1sc02763h · Cited by 60

Comparison of penetration depth between two-photon excitation and single-photon excitation in imaging through turbid tissue media

Gu, M., Gan, X. S., Kisteman, A., & Xu, M. G. (2000) · Applied Physics Letters · doi:10.1063/1.1308059 · Cited by 59

Sentinel Lymph Node Biopsy in Breast Cancer

Chatterjee, A., Serniak, N., & Czerniecki, B. J. (2015) · The Cancer Journal · doi:10.1097/ppo.0000000000000090 · Cited by 58

Using the shortwave infrared to image middle ear pathologies

Carr, J. A., Valdez, T. A., Bruns†, O. T., & Bawendi, M. G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610529113 · Cited by 58

Long-term monitoring of intravital biological processes using fluorescent protein-assisted NIR-II imaging

Chen, M., Feng, Z., Fan, X., Sun, J., Geng, W., Wu, T., Sheng, J., Qian, J., & Xu, Z. (2022) · Nature Communications · doi:10.1038/s41467-022-34274-w · Cited by 57

Cross‐Link‐Functionalized Nanoparticles for Rapid Excretion in Nanotheranostic Applications

Ma, Z., Wang, F., Zhong, Y., Salazar, F. B., Li, J., Zhang, M., Ren, F., Wu, A. M., & Dai, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202008083 · Cited by 56

Deep-tissue SWIR imaging using rationally designed small red-shifted near-infrared fluorescent protein

Oliinyk, O. S., Ma, C., Pletnev, S. V., Baloban, M., Taboada, C., Sheng, H., Yao, J., & Verkhusha, V. V. (2022) · Nature Methods · doi:10.1038/s41592-022-01683-0 · Cited by 55

Zn-doping enhances the photoluminescence and stability of PbS quantum dots for in vivo high-resolution imaging in the NIR-II window

Shi, X., Chen, S., Luo, M., Huang, B., Zhang, G., Cui, R., & Zhang, M. (2020) · Nano Research · doi:10.1007/s12274-020-2843-4 · Cited by 50

First clinical applications for the NIR-II imaging with ICG in microsurgery

Wu, Y., Suo, Y., Wang, Z., Yu, Y., Duan, S., Liu, H., Qi, B., Jian, C., Hu, X., Zhang, D., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1042546 · Cited by 49

Deep Imaging in Tissue and Biomedical Materials

(2017) · doi:10.1201/9781315206554 · Cited by 41

Airy beam assisted NIR-II light-sheet microscopy

Liu, P., Shi, T., Li, H., Chen, H., Huang, Y., Ma, H., Zhu, T., Zhao, R., Li, Y., Qi, X., et al. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101628 · Cited by 41

High brightness NIR-II nanofluorophores based on fused-ring acceptor molecules

Zhu, X., Liu, C., Hu, Z., Liu, H., Wang, J., Wang, Y., Wang, X., Ma, R., Zhang, X., Sun, H., et al. (2020) · Nano Research · doi:10.1007/s12274-020-2901-y · Cited by 34

Fluorescence molecular imaging systems for intraoperative image-guided surgery

Kim, T., O'Brien, C., Choi, H. S., & Jeong, M. Y. (2017) · Applied Spectroscopy Reviews · doi:10.1080/05704928.2017.1323311 · Cited by 32

Near-infrared-II ratiometric fluorescence probes for non-invasive detection and precise navigation surgery of metastatic sentinel lymph nodes

Li, M., Zheng, X., Han, T., Ma, S., Wang, Y., Sun, B., Xu, J., Wang, X., Zhang, S., Zhu, S., et al. (2022) · Theranostics · doi:10.7150/thno.78085 · Cited by 32

Intravital confocal fluorescence lifetime imaging microscopy in the second near-infrared window

Yu, J. Y., Zhang, R., Gao, Y., Sheng, Z., Gu, M., Sun, Q., Liao, J., Wu, T. H., Lin, Z., Wu, P., et al. (2020) · Optics Letters · doi:10.1364/ol.394684 · Cited by 30

Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Methylene Blue

Xue, D., Wu, D., Lu, Z., Neuhaus, J., Zebibula, A., Feng, Z., Cheng, S., Zhou, J., Qian, J., & Li, G. (2022) · Engineering · doi:10.1016/j.eng.2021.07.032 · Cited by 22

Dynamically monitoring lymphatic and vascular systems in physiological and pathological conditions of a swine model via a portable NIR-II imaging system with ICG

Wang, Z., Yu, Y., Wu, Y., Gao, S., Hu, L., Jian, C., Qi, B., & Yu, A. (2022) · International Journal of Medical Sciences · doi:10.7150/ijms.71956 · Cited by 17

Carotenoid-to-Bacteriochlorophyll Energy Transfer in the LH1–RC Core Complex of a Bacteriochlorophyll b Containing Purple Photosynthetic Bacterium Blastochloris viridis

Magdaong, N. C. M., Niedzwiedzki, D. M., Goodson, C. M., & Blankenship, R. E. (2016) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6b04307 · Cited by 15

Cherenkov excited short-wavelength infrared fluorescence imaging in vivo with external beam radiation

Cao, X., Jiang, S., Jia, M. J., Gunn, J. R., Miao, T., Davis, S. C., Brůža, P., & Pogue, B. W. (2018) · Journal of Biomedical Optics · doi:10.1117/1.jbo.24.5.051405 · Cited by 15

Fluorescently Labeled Cetuximab-IRDye800 for Guided Surgical Excision of Ameloblastoma: A Proof of Principle Study

Morlandt, A. B., Moore, L. S., Johnson, A. O., Smith, C. M., Stevens, T. M., Warram, J. M., MacDougall, M. J., Rosenthal, E. L., & Amm, H. M. (2020) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2020.05.022 · Cited by 14

Shortwave infrared fluorescence imaging of peripheral organs in awake and freely moving mice

Arús, B. A., Cosco, E. D., Yiu, J., Balba, I., Bischof, T. S., Sletten, E. M., & Bruns†, O. T. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1135494 · Cited by 12

3,4-Ethylenedithio thiophene donor for NIR-II fluorophores with improved quantum yields

Liu, C., Wang, X., Zhu, X., Ma, R., Lin, Q., & Liang, Y. (2023) · Materials Chemistry Frontiers · doi:10.1039/d2qm01278b · Cited by 6

Near Infrared-II Fluorescent protein for In-vivo ImagingPreprint

Chang, Z., Liu, C., Zhao, S., Chen, J., Zhang, X., Tian, H., & Sun, Q. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.04.482971 · Cited by 3

Waves in Random Media

Genack, A. Z., Chabanov, A. A., Sebbah, P., & van Tiggelen, B. A. (2005) · Elsevier eBooks · doi:10.1016/b0-12-369401-9/00608-2 · Cited by 2

Combining Near-infrared Excitation with Swept Confocally-aligned Planar Excitation (SCAPE) Microscopy for Fast, Volumetric Imaging in Mouse Brain

Yu, H., Galwaduge, P. T., Voleti, V., Patel, K., Shaik, M. A., Li, W., & Hillman, E. M. C. (2018) · Optics in the Life Sciences · doi:10.1364/brain.2018.bf3c.3 · Cited by 2

NIR-II light in clinical oncology: opportunities and challenges

Zhang, Z., Du, Y., Shi, X., Wang, K., Qu, Q., Liang, Q. Y., Ma, X., He, K., Chi, C., Tang, J., et al. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00892-0 · Cited by 397

Near-infrared II fluorescence imaging

Schmidt, E. L., Ou, Z., Ximendes, E. C., Cui, H., Keck, C. H. C., Jaque, D., & Hong, G. (2024) · Nature Reviews Methods Primers · doi:10.1038/s43586-024-00301-x · Cited by 392

High-brightness transition metal-sensitized lanthanide near-infrared luminescent nanoparticles

Ming, J., Chen, Y., Miao, H., Fan, Y., Wang, S., Chen, Z., Guo, Z., Guo, Z., Qi, L., Wang, X., et al. (2024) · Nature Photonics · doi:10.1038/s41566-024-01517-9 · Cited by 149

Organic photosensitizers: from molecular design to phototheranostics

Zhang, T., Qu, X., Shao, J., & Dong, X. (2025) · Chemical Society Reviews · doi:10.1039/d5cs00599j · Cited by 149

Molecular Gold Nanoclusters for Advanced NIR-II Bioimaging and Therapy

Baghdasaryan, A., & Dai, H. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00835 · Cited by 131

Recent advances in NIR-II fluorescence imaging for biomedical applications

Xu, B., Xu, K., Li, S., Sheng, H., Li, H., Zhang, X., Wang, Y., Feng, S., & Chen, J. (2026) · Advanced Interventional Materials · doi:10.1016/j.advim.2026.100016 · Cited by 3

Advances in the near-infrared Ⅱ for in vivo fluorescence imaging applications: A review

Zou, M., Wang, Y., Jiao, J., Lv, M., & Mo, T. (2025) · Talanta · doi:10.1016/j.talanta.2025.128630 · Cited by 15

Recent Advances in Second Near-Infrared Region (NIR-II) Fluorophores and Biomedical Applications

Chen, Y., Xue, L., Zhu, Q., Feng, Y., & Wu, M. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.750404 · Cited by 97

NIR-II Fluorophores: From Synthesis to Biological Applications

Duo, Y., Zhao, L., Wang, Z.-G., & Liu, S. (2023) · Journal of Analysis and Testing · doi:10.1007/s41664-023-00254-2 · Cited by 46

Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications

Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037