Cited by 229Gut microbiota and healthNutritional Studies and DietTryptophan and brain disorders

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The Role of the Gut Microbiota in Dietary Interventions for Depression and Anxiety

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Bear, Tracey L K, Dalziel, Julie E, Coad, Jane, Roy, Nicole C, Butts, Christine A, Gopal, Pramod K·2020·Advances in Nutrition

DOI 10.1093/advances/nmaa016PMC PMC7360462

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Abstract

There is emerging evidence that an unhealthy dietary pattern may increase the risk of developing depression or anxiety, whereas a healthy dietary pattern may decrease it. This nascent research suggests that dietary interventions could help prevent, or be an alternative or adjunct therapy for, depression and anxiety. The relation, however, is complex, affected by many confounding variables, and is also likely to be bidirectional, with dietary choices being affected by stress and depression. This complexity is reflected in the data, with sometimes conflicting results among studies. As the research evolves, all characteristics of the relation need to be considered to ensure that we obtain a full understanding, which can potentially be translated into clinical practice. A parallel and fast-growing body of research shows that the gut microbiota is linked with the brain in a bidirectional relation, commonly termed the microbiome-gut-brain axis. Preclinical evidence suggests that this axis plays a key role in the regulation of brain function and behavior. In this review we discuss possible reasons for the conflicting results in diet-mood research, and present examples of areas of the diet-mood relation in which the gut microbiota is likely to be involved, potentially explaining some of the conflicting results from diet and depression studies. We argue that because diet is one of the most significant factors that affects human gut microbiota structure and function, nutritional intervention studies need to consider the gut microbiota as an essential piece of the puzzle.

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“Some studies have shown no evidence of inflammation alongside behavioral changes (88, 108) or only a partial effect (98, 109, 110); however, even subclinical gut infection without overt inflammation caused behavioral changes in mice (87).”
Background
Are Anxiety and Depression Related to Gastrointestinal Symptoms in the General Population?
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N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota
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Lydiard, 2001, Irritable bowel syndrome, anxiety, and depression: what are the links?, J Clin Psychiatry, 62, 38

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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451
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Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options
Kumar, A., Pramanik, J., Goyal, N., Chauhan, D., Sivamaruthi, B. S., Prajapati, B. G., & Chaiyasut, C. (2023) · Pharmaceuticals · doi:10.3390/ph16040565 · Cited by 171
Gut-Brain-Microbiota Axis: Antibiotics and Functional Gastrointestinal Disorders
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The Relationship Between the Gut Microbiome-Immune System-Brain Axis and Major Depressive Disorder
Foster, J. A., Baker, G. B., & Dursun, S. M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.721126 · Cited by 161

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Authors: Bear, T. L. K., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K.
Affiliations: Riddet Institute (NZ)
AgResearch (NZ)
Massey University (NZ)
Corresponding author: Bear, Tracey L K
ORCID: Bear, Tracey L K
Dalziel, Julie E
Coad, Jane
Roy, Nicole C
Butts, Christine A
Gopal, Pramod K
Venue: Advances in Nutrition
Publisher: Elsevier BV
Published: 2020-07
Volume: 11
Issue: 4
Pages: 890-907
ISSN: 2156-5376 (ISSN-L)
2161-8313
DOI: 10.1093/advances/nmaa016
PMC: PMC7360462
OpenAlex: W3011103980
Cited by: 229
References: 254
Citations by year: 2026: 17 · 2025: 43 · 2024: 39 · 2023: 53 · 2022: 43 · 2021: 27 · 2020: 7
FWCI: 3.11
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc/4.0/ (vor)
Locations: Advances in Nutrition (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Figshare (submittedVersion, cc-by-nc)
Funders: Tertiary Education Commission
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: gut microbiota, depression, anxiety, microbiome-gut-brain axis, dietary intervention, bidirectional relationship, conflicting study results
MeSH terms: Gastrointestinal Microbiome, Anxiety, Brain, Depression, Humans, Microbiota

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The Role of the Gut Microbiota in Dietary Interventions for Depression and Anxiety

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