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Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019
Open accessPreprint — published as 10.1371/journal.pbio.3000411 · Paper page
Abstract
Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting are vital to this process; it allows readers to assess the reliability of the findings, and repeat or build upon the work of other researchers. The NC3Rs developed the ARRIVE guidelines in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments. Despite widespread endorsement by the scientific community, the impact of the ARRIVE guidelines on the transparency of reporting in animal research publications has been limited. We have revised the ARRIVE guidelines to update them and facilitate their use in practice. The revised guidelines are published alongside this paper. This Explanation and Elaboration document was developed as part of the revision. It provides further information about each of the 21 items in ARRIVE 2019, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples of good reporting from the published literature.
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Cites
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007) · Behavior Research Methods · doi:10.3758/bf03193146 · Cited by 65,971
The FAIR Guiding Principles for scientific data management and stewardship
Wilkinson, M. D., Dumontier, M., Aalbersberg, I. J., Appleton, G., Axton, M., Baak, A., Blomberg, N., Boiten, J.-W., da Silva Santos, L. B., Bourne, P. E., et al. (2016) · Scientific Data · doi:10.1038/sdata.2016.18 · Cited by 18,423
Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gotzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2010) · BMJ · doi:10.1136/bmj.c869 · Cited by 8,883
Pseudoreplication and the Design of Ecological Field Experiments
Hurlbert, S. H. (1984) · Ecological Monographs · doi:10.2307/1942661 · Cited by 8,377
Power failure: why small sample size undermines the reliability of neuroscience
Button, K. S., Ioannidis, J. P. A., Mokrysz, C., Nosek, B. A., Flint, J., Robinson, E. S. J., & Munafò, M. R. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3475 · Cited by 7,641 · cited 1×
“Low power has three effects: first, within the experiment, real effects are more likely to be missed; second, where an effect is detected, this will often be an over-estimation of the true effect size [25]; and finally, when low power is combined with publication bias, there is an increase in the false positive rate i…”
BackgroundImproving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000412 · Cited by 7,300
Self-citationImproving bioscience research reporting: The ARRIVE guidelines for reporting animal research
Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.72351 · Cited by 6,277
Self-citationSchulz (1995) · doi:10.1001/jama.1995.03520290060030 · Cited by 5,634
Effect size, confidence interval and statistical significance: a practical guide for biologists
Nakagawa, S., & Cuthill, I. C. (2007) · Biological Reviews · doi:10.1111/j.1469-185x.2007.00027.x · Cited by 3,835 · cited 1×
“In studies where statistical power is low, and/or hypothesis-testing is inappropriate, providing the effect size and confidence interval indicates how small or large an effect might really be, so a reader can judge the biological significance of the data [142, 143].”
BackgroundSelf-citationA manifesto for reproducible science
Munafò, M. R., Nosek, B. A., Bishop, D. V. M., Button, K. S., Chambers, C. D., Percie du Sert, N., Simonsohn, U., Wagenmakers, E.-J., Ware, J. J., & Ioannidis, J. P. A. (2017) · Nature Human Behaviour · doi:10.1038/s41562-016-0021 · Cited by 3,397
Encyclopedia of Research Design
Salkind, N. (2010) · doi:10.4135/9781412961288 · Cited by 2,347
Measuring the Prevalence of Questionable Research Practices With Incentives for Truth Telling
John, L. K., Loewenstein, G., & Prelec, D. (2012) · Psychological Science · doi:10.1177/0956797611430953 · Cited by 2,239
Pharmaceutical industry sponsorship and research outcome and quality: systematic review
Lexchin, J., Bero, L. A., Djulbegovic, B., & Clark, O. (2003) · BMJ · doi:10.1136/bmj.326.7400.1167 · Cited by 2,147 · cited 1×
“For example, bias, as indicated by a prevalence of more favourable outcomes, has been demonstrated for clinical research funded by industry compared to studies funded by other sources [239-241].”
ResultThe preregistration revolution
Nosek, B. A., Ebersole, C. R., DeHaven, A. C., & Mellor, D. T. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708274114 · Cited by 1,998
Policy: NIH to balance sex in cell and animal studies
Clayton, J. A., & Collins, F. S. (2014) · Nature · doi:10.1038/509282a · Cited by 1,816
Industry sponsorship and research outcome
Lundh, A., Lexchin, J., Mintzes, B., Schroll, J. B., & Bero, L. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.mr000033.pub3 · Cited by 1,697
Guidelines for the welfare and use of animals in cancer research
An ad hoc committee of the National Cancer Research Institute, Workman, P., Aboagye, E. O., Balkwill, F., Balmain, A., Bruder, G., Chaplin, D. J., Double, J. A., Everitt, J., Farningham, D. A. H., et al. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605642 · Cited by 1,442
How to increase value and reduce waste when research priorities are set
Chalmers, I., Bracken, M. B., Djulbegovic, B., Garattini, S., Grant, J., Gülmezoglu, A. M., Howells, D. W., Ioannidis, J. P. A., & Oliver, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62229-1 · Cited by 1,436
Self-citationThe Extent and Consequences of P-Hacking in Science
Head, M. L., Holman, L., Lanfear, R., Kahn, A. T., & Jennions, M. D. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002106 · Cited by 1,388 · cited 1×
“Studies that claim to test a hypothesis but do not specify a pre-defined primary outcome measure, or those that change the primary outcome measure after data were collected (also known as primary outcome switching) are liable to selectively report only statistically significant results, favouring more positive finding…”
ResultCan Animal Models of Disease Reliably Inform Human Studies?
van der Worp, H. B., Howells, D. W., Sena, E. S., Porritt, M. J., Rewell, S., O'Collins, V., & Macleod, M. R. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000245 · Cited by 1,354
Self-citationAVMA Guidelines for the Euthanasia of Animals: 2013 Edition
Leary, S., Underwood, W. J., Anthony, R., Cartner, S. C., Corey, D. G., Grandin, T., Greenacre, C. B., Gwaltney-Bran, S., McCrackin, M. A., Meyer, R. E., et al. (2013) · Cited by 1,351
McGrath, J. C., & Lilley, E. (2015) · British Journal of Pharmacology · doi:10.1111/bph.12955 · Cited by 1,321
Reducing waste from incomplete or unusable reports of biomedical research
Glasziou, P., Altman, D. G., Bossuyt, P., Boutron, I., Clarke, M., Julious, S., Michie, S., Moher, D., & Wager, E. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62228-x · Cited by 1,319
A call for transparent reporting to optimize the predictive value of preclinical research
Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., Crystal, R. G., Darnell, R. B., Ferrante, R. J., Fillit, H., et al. (2012) · Nature · doi:10.1038/nature11556 · Cited by 1,196
Self-citationGuidelines for the Design and Statistical Analysis of Experiments Using Laboratory Animals
Festing, M. F. W., & Altman, D. G. (2002) · ILAR Journal · doi:10.1093/ilar.43.4.244 · Cited by 1,110
Gray, L. E. (2000) · Toxicological Sciences · doi:10.1093/toxsci/58.2.350 · Cited by 1,084
The ARRIVE guidelines 2019: updated guidelines for reporting animal research
Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/703181 · Cited by 1,036
Self-citationTurner, P. V., Brabb, T., Pekow, C. A., & Vasbinder, M. A. (2011) · PubMed · Cited by 1,032
Allocation concealment in randomised trials: defending against deciphering
Schulz, K. F., & Grimes, D. A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07750-4 · Cited by 923
Olfactory exposure to males, including men, causes stress and related analgesia in rodents
Sorge, R. E., Martin, L. J., Isbester, K. A., Sotocinal, S. G., Rosen, S., Tuttle, A. H., Wieskopf, J. S., Acland, E. L., Dokova, A., Kadoura, B., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2935 · Cited by 905
Minimization: A new method of assigning patients to treatment and control groups
Taves, D. R. (1974) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1974155443 · Cited by 891
Sharing Detailed Research Data Is Associated with Increased Citation Rate
Piwowar, H. A., Day, R. S., & Fridsma, D. B. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000308 · Cited by 881
Bias in treatment assignment in controlled clinical trials
Chalmers, T. C., Celano, P., Sacks, H. S., & Smith, H. (1983) · New England Journal of Medicine · doi:10.1056/nejm198312013092204 · Cited by 864
Kilkenny, C., Parsons, N., Kadyszewski, E., Festing, M. F. W., Cuthill, I. C., Fry, D., Hutton, J., & Altman, D. G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007824 · Cited by 860
Self-citationRegistered Reports: A Method to Increase the Credibility of Published Results
Nosek, B. A., & Lakens, D. (2014) · Social Psychology · doi:10.1027/1864-9335/a000192 · Cited by 716 · cited 1×
“Explanation Akin to the approach taken for clinical trials, protocol registration has emerged as a mechanism that is likely to improve the transparency of animal research [215, 220, 221].”
MethodRobust research needs many lines of evidence
Munafò, M. R., & Davey Smith, G. (2018) · Nature · doi:10.1038/d41586-018-01023-3 · Cited by 666
FELASA working group on revision of guidelines for health monitoring of rodents and rabbits, Mähler (Convenor), M., Berard, M., Feinstein, R., Gallagher, A., Illgen-Wilcke, B., Pritchett-Corning, K., & Raspa, M. (2014) · Laboratory Animals · doi:10.1177/0023677213516312 · Cited by 646 · cited 1×
“The immune or microbiological status of the animals can also influence welfare, experimental variability and scientific outcomes [106-108].”
BackgroundLang, T. A., & Altman, D. G. (2015) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2014.09.006 · Cited by 642
Open science challenges, benefits and tips in early career and beyond
Allen, C., & Mehler, D. M. A. (2019) · PLOS Biology · doi:10.1371/journal.pbio.3000246 · Cited by 608
Industry sponsorship and research outcome
Lundh, A., Sismondo, S., Lexchin, J., Busuioc, O. A., & Bero, L. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.mr000033.pub2 · Cited by 605
Taming anxiety in laboratory mice
Hurst, J. L., & West, R. S. (2010) · Nature Methods · doi:10.1038/nmeth.1500 · Cited by 599
Light activates the adrenal gland: Timing of gene expression and glucocorticoid release
Ishida, A., Mutoh, T., Ueyama, T., Bando, H., Masubuchi, S., Nakahara, D., Tsujimoto, G., & Okamura, H. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.009 · Cited by 589
Issues in Outcomes Research: An Overview of Randomization Techniques for Clinical Trials
Kang, M., Ragan, B. G., & Park, J.-H. (2008) · Journal of Athletic Training · doi:10.4085/1062-6050-43.2.215 · Cited by 555 · cited 1×
“This splits up the experiment into smaller sub-experiments (blocks), and treatments are randomised to experimental units within each block [24, 68, 69].”
MethodTreatment allocation by minimisation
Altman, D. G., & Bland, J. M. (2005) · BMJ · doi:10.1136/bmj.330.7495.843 · Cited by 550
More informative abstracts revisited.
Haynes, R. B., Mulrow, C. D., Huth, E. J., Altman, D. G., & Gardner, M. J. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-1-69 · Cited by 526
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
Simon, M. M., Greenaway, S., White, J. K., Fuchs, H., Gailus-Durner, V., Wells, S., Sorg, T., Wong, K., Bedu, E., Cartwright, E. J., et al. (2013) · Genome Biology · doi:10.1186/gb-2013-14-7-r82 · Cited by 507
Design, power, and interpretation of studies in the standard murine model of ALS
Scott, S., Kranz, J. E., Cole, J., Lincecum, J. M., Thompson, K., Kelly, N., Bostrom, A., Theodoss, J., Al‐Nakhala, B. M., Vieira, F. G., et al. (2008) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960701856300 · Cited by 504 · cited 1×
“When reasons are not disclosed the reliability of the conclusions is in question, as inappropriate data cleaning has the potential to bias study outcomes [50].”
BackgroundHrobjartsson, A., Thomsen, A. S. S., Emanuelsson, F., Tendal, B., Hilden, J., Boutron, I., Ravaud, P., & Brorson, S. (2012) · BMJ · doi:10.1136/bmj.e1119 · Cited by 483
Ideal homes? Housing effects on rodent brain and behaviour
Würbel, H. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01718-5 · Cited by 471
Self-citationImpact of animal handling on the results of 18F-FDG PET studies in mice.
Fueger, B. J., Czernin, J. G., Hildebrandt, I. J., Tran, C., Halpern, B. S., Stout, D., Phelps, M. E., & Weber, W. (2006) · PubMed · Cited by 455
Bayol, S. A., Farrington, S. J., & Stickland, N. C. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507812037 · Cited by 417
Natural pathogens of laboratory mice, rats, and rabbits and their effects on research
Baker, D. G. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.2.231 · Cited by 394
The effect of experimenter bias on the performance of the albino rat
Rosenthal, R., & Fode, K. L. (2007) · Behavioral Science · doi:10.1002/bs.3830080302 · Cited by 384
The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis?
Lazic, S. E. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-5 · Cited by 381 · cited 2×
“This may invalidate the analysis and resulting conclusions [21, 22] (see also item 7 – Statistical methods).”
BackgroundMethodJensen, T., Kiersgaard, M., Sørensen, D., & Mikkelsen, L. (2013) · Laboratory Animals · doi:10.1177/0023677213501659 · Cited by 373
Does age matter? The impact of rodent age on study outcomes
Jackson, S. J., Andrews, N., Ball, D., Bellantuono, I., Gray, J., Hachoumi, L., Holmes, A., Latcham, J., Petrie, A., Potter, P., et al. (2017) · Laboratory Animals · doi:10.1177/0023677216653984 · Cited by 369
Boutron, I., Altman, D. G., Hopewell, S., Vera-Badillo, F., Tannock, I., & Ravaud, P. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.7503 · Cited by 368
Statistics notes. Treatment allocation in controlled trials: why randomise?
Altman, D. G., & Bland, J. M. (1999) · BMJ · doi:10.1136/bmj.318.7192.1209 · Cited by 362
Risk of bias in reports of in vivo research: a focus for improvement
Macleod, M. R., Lawson McLean, A., Kyriakopoulou, A., Serghiou, S., de Wilde, A., Sherratt, N., Hirst, T., Hemblade, R., Bahor, Z., Nunes-Fonseca, C., et al. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002273 · Cited by 358
Self-citationLikelihood of Null Effects of Large NHLBI Clinical Trials Has Increased over Time
Kaplan, R. M., & Irvin, V. L. (2015) · PLOS ONE · doi:10.1371/journal.pone.0132382 · Cited by 356
Willner, P. (1986) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(86)90051-5 · Cited by 346
Kokolus, K. M., Capitano, M. L., Lee, C.-T., Eng, J. W.-L., Waight, J. D., Hylander, B. L., Sexton, S., Hong, C.-C., Gordon, C. J., Abrams, S. I., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304291110 · Cited by 335
Garner, J. P. (2005) · ILAR Journal · doi:10.1093/ilar.46.2.106 · Cited by 329 · cited 1×
“Environmental enrichment Reduces anxiety [180, 181], stress [180, 181] and abnormal repetitive behaviour [182-184].”
BackgroundMacleod, M. R., van der Worp, H. B., Sena, E. S., Howells, D. W., Dirnagl, U., & Donnan, G. A. (2008) · Stroke · doi:10.1161/strokeaha.108.515957 · Cited by 319
Self-citationBaker, D., Lidster, K., Sottomayor, A., & Amor, S. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001756 · Cited by 305
Self-citationAccuracy of data in abstracts of published research articles
Pitkin, R. M. (1999) · JAMA · doi:10.1001/jama.281.12.1110 · Cited by 302
GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior
Hunt, R. F., Girskis, K. M., Rubenstein, J. L., Alvarez-Buylla, A., & Baraban, S. C. (2013) · Nature Neuroscience · doi:10.1038/nn.3392 · Cited by 301
Eyre-Walker, A., & Stoletzki, N. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001675 · Cited by 297
How scientists fool themselves – and how they can stop
Nuzzo, R. (2015) · Nature · doi:10.1038/526182a · Cited by 296
Pitman, D. L., Ottenweller, J. E., & Natelson, B. H. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90097-2 · Cited by 295
The need for randomization in animal trials: an overview of systematic reviews
Hirst, J. A., Howick, J., Aronson, J. K., Roberts, N., Perera, R., Koshiaris, C., & Heneghan, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098856 · Cited by 294
What exactly is ‘N’ in cell culture and animal experiments?
Lazic, S. E., Clarke-Williams, C. J., & Munafò, M. R. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2005282 · Cited by 291
A survey of the statistical power of research in behavioral ecology and animal behavior
Jennions, M. D. (2003) · Behavioral Ecology · doi:10.1093/beheco/14.3.438 · Cited by 278 · cited 2×
“Second, although several systemic inflammatory conditions have disturbances in the innate immune system as important features, and some of these again specifically encompassing distorted TLR9 signalling [34], sustained TLR9 stimulation does not necessarily represent a clinically relevant inflammatory condition.”
BackgroundReproducibility of preclinical animal research improves with heterogeneity of study samples
Voelkl, B., Vogt, L., Sena, E. S., & Würbel, H. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2003693 · Cited by 262
Self-citationPrevalence of sexual dimorphism in mammalian phenotypic traits
Karp, N. A., Mason, J., Beaudet, A. L., Benjamini, Y., Bower, L., Braun, R. E., Brown, S. D. M., Chesler, E. J., Dickinson, M. E., Flenniken, A. M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15475 · Cited by 257
Self-citationStodden, V., Guo, P., & Ma, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067111 · Cited by 257
Modulation of aggression in male mice: influence of group size and cage size
Van Loo, P. L. P., Mol, J. A., Koolhaas, J. M., Van Zutphen, B. F. M., & Baumans, V. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00425-5 · Cited by 249
A Hierarchy of H3K4me3 and H3K27me3 Acquisition in Spatial Gene Regulation in Xenopus Embryos
Akkers, R. C., van Heeringen, S. J., Jacobi, U. G., Janssen-Megens, E. M., Françoijs, K.-J., Stunnenberg, H. G., & Veenstra, G. J. C. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.08.005 · Cited by 245
Techniques and probes for the study of Xenopus tropicalis development
Khokha, M. K., Chung, C., Bustamante, E. L., Gaw, L. W. K., Trott, K. A., Yeh, J., Lim, N., Lin, J. C. Y., Taverner, N., Amaya, E., et al. (2002) · Developmental Dynamics · doi:10.1002/dvdy.10184 · Cited by 241
Hannan, A. J. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12102 · Cited by 240
Distinguishing between exploratory and confirmatory preclinical research will improve translation
Kimmelman, J., Mogil, J. S., & Dirnagl, U. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001863 · Cited by 236
Self-citationEstablishing an appropriate period of acclimatization following transportation of laboratory animals
Obernier, J. A., & Baldwin, R. L. (2006) · ILAR Journal · doi:10.1093/ilar.47.4.364 · Cited by 228
Genetic origins of social networks in rhesus macaques
Brent, L. J. N., Heilbronner, S. R., Horvath, J. E., Gonzalez-Martinez, J., Ruiz-Lambides, A., Robinson, A. G., Skene, J. H. P., & Platt, M. L. (2013) · Scientific Reports · doi:10.1038/srep01042 · Cited by 220
Reproducibility and replicability of rodent phenotyping in preclinical studies
Kafkafi, N., Agassi, J., Chesler, E. J., Crabbe, J. C., Crusio, W. E., Eilam, D., Gerlai, R., Golani, I., Gomez-Marin, A., Heller, R., et al. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.01.003 · Cited by 215
Self-citationD. Chambers, C., 1 Cardiff University Brain Research Imaging Centre, S. O. P., Feredoes, E., D. Muthukumaraswamy, S., & J. Etchells, P. (2014) · AIMS Neuroscience · doi:10.3934/neuroscience.2014.1.4 · Cited by 213
On determining sample size in experiments involving laboratory animals
Festing, M. F. (2018) · Laboratory Animals · doi:10.1177/0023677217738268 · Cited by 213
Behavioral and physiological mouse assays for anxiety: a survey in nine mouse strains
Bouwknecht, J. A., & Paylor, R. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00200-0 · Cited by 209
Hawkins, P., Morton, D. B., Burman, O., Dennison, N., Honess, P., Jennings, M., Lane, S., Middleton, V, Roughan, J. V., Wells, S., et al. (2011) · Laboratory Animals · doi:10.1258/la.2010.010031 · Cited by 204
Rearing environmental enrichment in two inbred strains of mice: 1. Effects on emotional reactivity
Chapillon, P., Manneché, C., Belzung, C., & Caston, J. (1999) · Behavior Genetics · doi:10.1023/a:1021437905913 · Cited by 202
Endogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection
Velazquez, E. M., Nguyen, H., Heasley, K. T., Saechao, C. H., Gil, L. M., Rogers, A. W. L., Miller, B. M., Rolston, M. R., Lopez, C. A., Litvak, Y., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0407-8 · Cited by 201
Progress in using systematic reviews of animal studies to improve translational research
Hooijmans, C. R., & Ritskes-Hoitinga, M. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001482 · Cited by 195
A systematic approach for establishing humane endpoints
Morton, D. B. (2000) · ILAR Journal · doi:10.1093/ilar.41.2.80 · Cited by 193
Gouveia, K., & Hurst, J. L. (2017) · Scientific Reports · doi:10.1038/srep44999 · Cited by 193
Carbone, L., & Austin, J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0155001 · Cited by 191
To group or not to group? Good practice for housing male laboratory mice
Kappel, S., Hawkins, P., & Mendl, M. (2017) · Animals · doi:10.3390/ani7120088 · Cited by 190
The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)
Percie du Sert, N., Alfieri, A., Allan, S. M., Carswell, H. V., Deuchar, G. A., Farr, T. D., Flecknell, P., Gallagher, L., Gibson, C. L., Haley, M. J., et al. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17709185 · Cited by 190
Self-citationImproving the translational hit of experimental treatments in multiple sclerosis
Vesterinen, H. M., Sena, E. S., ffrench-Constant, C., Williams, A., Chandran, S., & Macleod, M. R. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510379612 · Cited by 182
Self-citationLimitations are not properly acknowledged in the scientific literature
Ioannidis, J. P. A. (2007) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2006.09.011 · Cited by 180
on behalf of the IICARus Collaboration, Hair, K., Macleod, M. R., & Sena, E. S. (2019) · Research Integrity and Peer Review · doi:10.1186/s41073-019-0069-3 · Cited by 174
Self-citationLeung, V., Rousseau-Blass, F., Beauchamp, G., & Pang, D. S. J. (2018) · PLOS ONE · doi:10.1371/journal.pone.0197882 · Cited by 172
Neurodegeneration in an animal model of Parkinson’s disease is exacerbated by a high-fat diet
Morris, J. K., Bomhoff, G. L., Stanford, J. A., & Geiger, P. C. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00449.2010 · Cited by 163
Standards for cell line authentication and beyond
Almeida, J. L., Cole, K. D., & Plant, A. L. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002476 · Cited by 154
More than 3Rs: The importance of scientific validity for harm-benefit analysis of animal research
Würbel, H. (2017) · Lab Animal · doi:10.1038/laban.1220 · Cited by 152
Self-citationThe Design and Statistical Analysis of Animal Experiments
Bate, S. T., & Clark, R. A. (2014) · doi:10.1017/cbo9781139344319 · Cited by 150 · cited 4×
“This splits up the experiment into smaller sub-experiments (blocks), and treatments are randomised to experimental units within each block [24, 68, 69].”
BackgroundMethodInfluentialRanson, A., Cheetham, C. E. J., Fox, K. D., & Sengpiel, F. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112204109 · Cited by 139
Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration
Huang, W., Feng, Y., Liang, J., Yu, H., Wang, C., Wang, B., Wang, M., Jiang, L., Meng, W., Cai, W., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03019-z · Cited by 139
Pradillo, J. M., Dénes, Á., Greenhalgh, A. D., Boutin, H., Drake, C., McColl, B. W., Barton, E. C., Proctor, S. D., Russell, J. C., Rothwell, N. J., et al. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.101 · Cited by 138
Gaspani, L., Bianchi, M., Limiroli, E., Panerai, A. E., & Sacerdote, P. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00165-0 · Cited by 136
The quality of reporting of trial abstracts is suboptimal: survey of major general medical journals
Berwanger, O., Ribeiro, R. A., Finkelsztejn, A., Watanabe, M., Suzumura, E. A., Duncan, B. B., Devereaux, P. J., & Cook, D. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2008.05.013 · Cited by 133
The devil is in the details: incomplete reporting in preclinical animal research
Avey, M. T., Moher, D., Sullivan, K. J., Fergusson, D., Griffin, G., Grimshaw, J. M., Hutton, B., Lalu, M. M., Macleod, M., Marshall, J., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0166733 · Cited by 130
Self-citationBias in the reporting of sex and age in biomedical research on mouse models
Flórez-Vargas, O., Brass, A., Karystianis, G., Bramhall, M., Stevens, R., Cruickshank, S., & Nenadic, G. (2016) · eLife · doi:10.7554/elife.13615 · Cited by 124
Side effects of pain and analgesia in animal experimentation
Jirkof, P. (2017) · Lab Animal · doi:10.1038/laban.1216 · Cited by 124
Banwell, V., Sena, E. S., & Macleod, M. R. (2009) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2008.11.009 · Cited by 123
Self-citationThe anorectic effects of CRH and restraint stress decrease with repeated exposures
Krahn, D. D., Gosnell, B. A., & Majchrzak, M. J. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90046-5 · Cited by 122
Biomedical Data Sharing and Reuse: Attitudes and Practices of Clinical and Scientific Research Staff
Federer, L., Lu, Y., Joubert, D., Welsh, J. A., & Brandys, B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129506 · Cited by 120
The Experimental Design Assistant
Percie du Sert, N., Bamsey, I., Bate, S. T., Berdoy, M., Clark, R. A., Cuthill, I., Fry, D., Karp, N. A., Macleod, M., Moon, L., et al. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2003779 · Cited by 118
Self-citationHolman, C., Piper, S. K., Grittner, U., Diamantaras, A. A., Kimmelman, J., Siegerink, B., & Dirnagl, U. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002331 · Cited by 114
Self-citationGarner, J. P., Dufour, B. D., Gregg, L. E., Weisker, S. M., & Mench, J. A. (2004) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2004.07.004 · Cited by 109
Flavonone treatment reverses airway inflammation and remodelling in an asthma murine model
de Toledo, A. C., Sakoda, C. P. P., Perini, A., Pinheiro, N., Magalhães, R., Grecco, S. S., Tibério, I., Câmara, N. O. S., Martins, M., Lago, J. H. G., et al. (2012) · British Journal of Pharmacology · doi:10.1111/bph.12062 · Cited by 107
Experimental Design for the Life Sciences
(2016) · Oxford University Press eBooks · doi:10.1093/hesc/9780198717355.001.0001 · Cited by 106
Whole animal experiments should be more like human randomized controlled trials
Muhlhausler, B. S., Bloomfield, F. H., & Gillman, M. W. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001481 · Cited by 105
High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice
Sanger Mouse Genetics Project, Podrini, C., Cambridge, E. L., Lelliott, C. J., Carragher, D. M., Estabel, J., Gerdin, A.-K., Karp, N. A., Scudamore, C. L., Ramírez‐Solis, R., et al. (2013) · Mammalian Genome · doi:10.1007/s00335-013-9456-0 · Cited by 101
Self-citationAging has a complex effect on a rat model of ischemic stroke
Shapira, S., Sapir, M., Wengier, A., Grauer, E., & Kadar, T. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03270-x · Cited by 99
Auvergne, R., Leré, C., El Bahh, B., Arthaud, S., Lespinet, V., Rougier, A., & Le Gal La Salle, G. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03355-3 · Cited by 98
Preparation of animals for research—issues to consider for rodents and rabbits
Conour, L. A., Murray, K. A., & Brown, M. J. (2006) · ILAR Journal · doi:10.1093/ilar.47.4.283 · Cited by 98
A longitudinal study of the effects of experimenter bias on the operant learning of laboratory rats
Rosenthal, R., & Lawson, R. (1964) · Journal of Psychiatric Research · doi:10.1016/0022-3956(64)90003-2 · Cited by 97
(2001) · PubMed · Cited by 96
Handling method alters the hedonic value of reward in laboratory mice
Clarkson, J. M., Dwyer, D. M., Flecknell, P. A., Leach, M. C., & Rowe, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-20716-3 · Cited by 91
Burdge, G. C., Lillycrop, K. A., Jackson, A. A., Gluckman, P. D., & Hanson, M. A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507815819 · Cited by 91
Can, Ö. S., Yılmaz, A. A., Hasdoğan, M., Alkaya, F., Turhan, S. Ç., Can, M. F., & Alanoğlu, Z. (2010) · European Journal of Anaesthesiology · doi:10.1097/eja.0b013e32833fb96f · Cited by 90
Redfern, W. S., Tse, K. K.-Y., Grant, C., Keerie, A. F. A., Simpson, D. J. W., Pedersen, J. C., Rimmer, V., Leslie, L., Klein, S., Karp, N. A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181068 · Cited by 89
Self-citationWhy we need confidence intervals
Altman, D. G. (2005) · World Journal of Surgery · doi:10.1007/s00268-005-7911-0 · Cited by 88
Use of Factorial Designs to Optimize Animal Experiments and Reduce Animal Use
Shaw, R., Festing, M. F. W., Peers, I. S., & Furlong, L. (2002) · ILAR Journal · doi:10.1093/ilar.43.4.223 · Cited by 87
Relationship between sponsorship and failure rate of dental implants: a systematic approach
Popelut, A., Valet, F., Fromentin, O., Thomas, A., & Bouchard, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010274 · Cited by 86
Falk, H., Forde, P. F., Bay, M. L., Mangalanathan, U. M., Højman, P., Soden, D. M., & Gehl, J. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1301332 · Cited by 85
Effects of cage-change frequency and bedding volume on mice and their microenvironment.
(2009) · Europe PMC (PubMed Central) · Cited by 83
Hendershott, T. R., Cronin, M. E., Langella, S., McGuinness, P. S., & Basu, A. C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.004 · Cited by 83
Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats
Ash, J. A., Lu, H., Taxier, L. R., Long, J. M., Yang, Y., Stein, E. A., & Rapp, P. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525309113 · Cited by 83
Time to include the gut microbiota in the hygienic standardisation of laboratory rodents
Bleich, A., & Hansen, A. K. (2012) · Comparative Immunology, Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2011.12.006 · Cited by 82
The need for littermate controls
Holmdahl, R., & MALISSEN, B. (2011) · European Journal of Immunology · doi:10.1002/eji.201142048 · Cited by 80
El-Agroudy, N. N., El‐Naga, R. N., El‐Razeq, R. A., & El‐Demerdash, E. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13611 · Cited by 80
The Importance of Reporting Housing and Husbandry in Rat Research
Prager, E. M., Bergstrom, H. C., Grunberg, N. E., & Johnson, L. R. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00038 · Cited by 79
In vivo biosafety model to assess the risk of adverse events from retroviral and lentiviral vectors.
Bauer, G., Dao, M., Case, S. S., Meyerrose, T., Wirthlin, L., Zhou, P., Wang, X.-L., Herrbrich, P. E., Arevalo, J., Csik, S., et al. (2008) · Molecular Therapy · doi:10.1038/mt.2008.93 · Cited by 77
Why we need to report more than 'Data were Analyzed by t-tests or ANOVA'
Weissgerber, T. L., Garcia-Valencia, O., Garovic, V. D., Milic, N. M., & Winham, S. J. (2018) · eLife · doi:10.7554/elife.36163 · Cited by 76
High-efficiency non-mosaic CRISPR-mediated knock-in and indel mutation in F0 Xenopus
Aslan, Y., Tadjuidje, E., Zorn, A. M., & Cha, S. (2017) · Development · doi:10.1242/dev.152967 · Cited by 76
Bandrowski, A. E., & Martone, M. E. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.030 · Cited by 75
The researchers’ view of scientific rigor—survey on the conduct and reporting of in vivo research
Reichlin, T. S., Vogt, L., & Würbel, H. (2016) · PLOS ONE · doi:10.1371/journal.pone.0165999 · Cited by 72 · cited 2×
“Studies measuring the impact of ARRIVE on the quality of reporting have produced mixed results [6-11] and there is evidence that in vivo scientists are not sufficiently aware of the importance of reporting the information covered in the guidelines, and fail to appreciate the relevance to their work or their research f…”
BackgroundSelf-citationCamp, D. M., Loeffler, D. A., Farrah, D. M., Borneman, J. N., & LeWitt, P. A. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-17 · Cited by 72
Preclinical efficacy studies in investigator brochures: do they enable risk–benefit assessment?
Wieschowski, S., Chin, W. W. L., Federico, C., Sievers, S., Kimmelman, J., & Strech, D. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2004879 · Cited by 70
Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks
Hsieh, L. S., Wen, J. H., Miyares, L. C., Lombroso, P. J., & Bordey, A. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.11.035 · Cited by 69
Gulin, J. E. N., Rocco, D. M., & García-Bournissen, F. (2015) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0004194 · Cited by 66
Alterations of the murine gut microbiome with age and allergic airway disease
Vital, M., Harkema, J. R., Rizzo, M., Tiedje, J., & Brandenberger, C. (2015) · Journal of Immunology Research · doi:10.1155/2015/892568 · Cited by 65
Haseman, J. K., Ney, E., Nyska, A., & Rao, G. N. (2003) · Toxicologic Pathology · doi:10.1080/01926230390241927 · Cited by 63
Development Temperature Has Persistent Effects on Muscle Growth Responses in Gilthead Sea Bream
de la serrana, D. G., Vieira, V. L. A., Andree, K. B., Darias, M. J., Estévez, A., Gisbert, E., & Johnston, I. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051884 · Cited by 63
DeBoer, S. P., Garner, J. P., McCain, R., Lay, D., Eicher, S., & Marchant, J. N. (2015) · Animal Welfare · doi:10.7120/09627286.24.1.015 · Cited by 62
Impact of IVC housing on emotionality and fear learning in male C3HeB/FeJ and C57BL/6J mice
Kallnik, M., Elvert, R., Ehrhardt, N., Kissling, D., Mahabir, E., Welzl, G., Faus-Kessler, T., de Angelis, M. H., Wurst, W., Schmidt, J., et al. (2007) · Mammalian Genome · doi:10.1007/s00335-007-9002-z · Cited by 58
Dalbøge, L. S., Pedersen, P. J., Hansen, G., Fabricius, K., Hansen, H. B., Jelsing, J., & Vrang, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135634 · Cited by 57
Mantis, C., Kandela, I. K., Aird, F., & Reproducibility Project: Cancer Biology (2017) · eLife · doi:10.7554/elife.17584 · Cited by 56
Randomization Does Not Help Much, Comparability Does
Saint‐Mont, U. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132102 · Cited by 55
Environmental enrichment: Evidence for an unexpected therapeutic influence
Kotloski, R. J., & Sutula, T. P. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.11.012 · Cited by 55
Accelerating Biomedical Discoveries through Rigor and Transparency
Hewitt, J., Brown, L. L., Murphy, S. J., Grieder, F. B., & Silberberg, S. D. (2017) · ILAR Journal · doi:10.1093/ilar/ilx011 · Cited by 55
Self-citationDíaz, A., Perez, A. M., Sreevatsan, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129213 · Cited by 54
Embryonic zebrafish xenograft assay of human cancer metastasis
Hill, D. S., Chen, L., Snaar-Jagalska, E. B., & Chaudhry, B. (2018) · F1000Research · doi:10.12688/f1000research.16659.2 · Cited by 53
Animal Welfare Standards and International Collaborations
Bayne, K. A. L., & Turner, P. V. (2018) · ILAR Journal · doi:10.1093/ilar/ily024 · Cited by 53
Berghof, T. V. L., van der Klein, S. A. S., Arts, J. A. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131088 · Cited by 52
Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis
Grasselli, G., Rossi, S., Musella, A., Gentile, A., Loizzo, S., Muzio, L., Sanza, C. D., Errico, F., Musumeci, G., Haji, N., et al. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02178.x · Cited by 50
Increasing efficiency of preclinical research by group sequential designs
Neumann, K., Grittner, U., Piper, S. K., Rex, A., Flórez-Vargas, O., Karystianis, G., Schneider, A., Wellwood, I., Siegerink, B., Ioannidis, J. P. A., et al. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2001307 · Cited by 50
Self-citationBartlang, M. S., Neumann, I. D., Slattery, D. A., Uschold-Schmidt, N., Kraus, D., Helfrich-Förster, C., & Reber, S. O. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0267 · Cited by 49
Optimized design and analysis of preclinical intervention studies in vivo
Laajala, T. D., Jumppanen, M., Huhtaniemi, R., Fey, V., Kaur, A., Knuuttila, M., Aho, E., Oksala, R., Westermarck, J., Mäkelä, S., et al. (2016) · Scientific Reports · doi:10.1038/srep30723 · Cited by 48
De novo transcriptome assembly for the spiny mouse (Acomys cahirinus)
Mamrot, J., Legaie, R., Ellery, S. J., Wilson, T., Seemann, T., Powell, D., Gardner, D. K., Walker, D. W., Temple-Smith, P. D., Papenfuss, A. T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09334-7 · Cited by 46
Rice, A. S. C., Morland, R., Huang, W., Currie, G. L., Sena, E. S., & Macleod, M. R. (2013) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2013.02.002 · Cited by 42
Self-citationThe Resource Identification Initiative: a cultural shift in publishing
Bandrowski, A., Brush, M., Grethe, J. S., Haendel, M. A., Kennedy, D. N., Hill, S., Hof, P. R., Martone, M. E., Pols, M., Tan, S. C., et al. (2016) · Journal of Comparative Neurology · doi:10.1002/cne.23913 · Cited by 41
Bero, L., Anglemyer, A., Vesterinen, H., & Krauth, D. (2016) · Environment International · doi:10.1016/j.envint.2015.10.011 · Cited by 41
Gaskill, B. N., & Garner, J. P. (2017) · Lab Animal · doi:10.1038/laban.1218 · Cited by 41
Brock, A. J., Goody, S. M. G., Mead, A. N., Sudwarts, A., Parker, M. O., & Brennan, C. H. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.242628 · Cited by 41
Genchi, M., Prati, P., Vicari, N., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133593 · Cited by 40
Repeated Witnessing of Conspecifics in Pain: Effects on Emotional Contagion
Carrillo, M., Migliorati, F., Bruls, R., Han, Y., Heinemans, M., Pruis, I. J., Gazzola, V., & Keysers, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136979 · Cited by 40
WALKER, M. D., Fureix, C., Palme, R., Newman, J. A., Dallaire, J. A., & Mason, G. J. (2016) · BMC Medical Research Methodology · doi:10.1186/s12874-016-0113-7 · Cited by 39
Reporting standards for preclinical studies of stroke therapy
Vahidy, F., Schäbitz, W.-R., Fisher, M., & Aronowski, J. (2016) · Stroke · doi:10.1161/strokeaha.116.013643 · Cited by 39
Ameen‐Ali, K. E., Eacott, M. J., & Easton, A. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.08.006 · Cited by 37
Evaluation of the effects of space allowance on measures of animal welfare in laboratory mice
Bailoo, J. D., Murphy, E., Varholick, J. A., Novak, J., Palme, R., & Würbel, H. (2018) · Scientific Reports · doi:10.1038/s41598-017-18493-6 · Cited by 37
Self-citationKrauth, D., Anglemyer, A., Philipps, R., & Bero, L. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001770 · Cited by 36
Simply a nest? Effects of different enrichments on stereotypic and anxiety-related behaviour in mice
Gross, A. N.-M., Engel, A. K. J., & Würbel, H. (2011) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2011.06.020 · Cited by 35
Self-citationCommentary: Mouse Genetic Nomenclature: Standardization of Strain, Gene, and Protein Symbols
Sundberg, J. P., & Schofield, P. N. (2010) · Veterinary Pathology · doi:10.1177/0300985810374837 · Cited by 32
Comparison of two cannulation methods for assessment of intracavernosal pressure in a rat model
Zhao, S., Kang, R., Deng, T., Luo, L., Wang, J., Li, E., Luo, J., Liu, L., Wan, S., & Zhao, Z. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193543 · Cited by 32
Benedeti, P. D. B., Paulino, P. V. R., Marcondes, M. I., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148224 · Cited by 30
Effects of Habitat Complexity on Pair-Housed Zebrafish.
Keck, V. A., Edgerton, D. S., Hajizadeh, S., et al. (2015) · PubMed · Cited by 30
Impact of tank background on the welfare of the African clawed frog, Xenopus laevis (Daudin)
Holmes, A. M., Emmans, C. J., Jones, N., Coleman, R., Smith, T. E., & Hosie, C. A. (2016) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2016.09.005 · Cited by 30
Kwan, S. T., King, J. H., Grenier, J. K., Yan, J., Jiang, X., Roberson, M. S., & Caudill, M. A. (2018) · Nutrients · doi:10.3390/nu10040417 · Cited by 30
Kolahian, S., Sadri, H., Shahbazfar, A. A., Amani, M., Mazadeh, A., & Mirani, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133374 · Cited by 26
Hamilton, N., Sabroe, I., & Renshaw, S. A. (2018) · F1000Research · doi:10.12688/f1000research.14507.1 · Cited by 26
Reynolds, P. S., Fisher, B. J., McCarter, J., Sweeney, C., Martin, E. J., Middleton, P., Ellenberg, M., Fowler, E., Brophy, D. F., Fowler, A. A., et al. (2018) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000001844 · Cited by 25
Self-citationLorkeers, S. J. J. O., Gho, J. M. I. H., Koudstaal, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143953 · Cited by 23
Robinson, I., Dowdall, T., & Meert, T. F. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.078 · Cited by 22
Sacilotto, N., Castillo, J., Riffo‐Campos, Á. L., Flores, J. M., Hibbitt, O., Wade‐Martins, R., López, C., Rodrigo, M. I., Franco, L., & López‐Rodas, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132477 · Cited by 22
Donner, D. G., Elliott, G. E., Beck, B. R., Bulmer, A. C., & Toit, E. F. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138019 · Cited by 22
Paul, A. K., Gueven, N., & Dietis, N. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.04.034 · Cited by 21
(2015) · PubMed Central · Cited by 20
Nemeth, M., Millesi, E., Wagner, K., & Wallner, B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140485 · Cited by 20
Nguyen, T. T., Bazzoli, C., & Mentré, F. (2011) · Statistics in Medicine · doi:10.1002/sim.4390 · Cited by 19
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Lilley, E., Stanford, S. C., Kendall, D. E., Alexander, S. P. H., Cirino, G., Docherty, J. R., George, C. H., Insel, P. A., Izzo, A. A., Ji, Y., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15178 · Cited by 1,214
Self-citationThe ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15193 · Cited by 1,081
Self-citationThe ARRIVE guidelines 2.0: updated guidelines for reporting animal research
Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., et al. (2020) · The Journal of Physiology · doi:10.1113/jp280389 · Cited by 593
Self-citationSynaptic degeneration in Alzheimer disease
Tzioras, M., McGeachan, R. I., Durrant, C. S., & Spires-Jones, T. L. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-022-00749-z · Cited by 504
Islam, A., Saito, T., Saido, T., & Ali, A. B. (2023) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2022.03.001 · Cited by 17
Metadata
- Authors
- Percie du Sert, N., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., Garner, P., Holgate, S. T., Howells, D. W., Hurst, V., Karp, N. A., Lidster, K., MacCallum, C. J., Macleod, M., Pearl, E. J., Petersen, O., Rawle, F., Reynolds, P., Rooney, K., Sena, E. S., Silberberg, S. D., Steckler, T., & Würbel, H.
- Venue
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Published
- 2019-07-15
- OpenAlex
- W2956261120
- Cited by
- 559
- References
- 237
- Type
- posted content
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.