Cited by 288

The DOI matches its Crossref record; 192 of the 192 references it cites were found in a registry or an index.

Calorie restriction as an intervention in ageing

Open access

López‐Lluch, Guillermo, Navas, Plácido·2016·The Journal of Physiology

Open this paper in CoChat — free account

Abstract

Ageing causes loss of function in tissues and organs, is accompanied by a chronic inflammatory process and affects life‐ and healthspan. Calorie restriction (CR) is a non‐genetic intervention that prevents age‐associated diseases and extends longevity in most of the animal models studied so far. CR produces a pleiotropic effect and improves multiple metabolic pathways, generating benefits to the whole organism. Among the effects of CR, modulation of mitochondrial activity and a decrease in oxidative damage are two of the hallmarks. Oxidative damage is reduced by the induction of endogenous antioxidant systems and modulation of the peroxidability index in cell membranes. Mitochondrial activity changes are regulated by inhibition of IGF‐1 and Target of Rapamycin (TOR)‐dependent activities and activation of AMP‐dependent kinase (AMPK) and the sirtuin family of proteins. The activity of PGC‐1α and FoxO is regulated by these systems and is involved in mitochondria biogenesis, oxidative metabolism activity and mitochondrial turnover. The use of mimetics and the regulation of common factors have demonstrated that these molecular pathways are essential to explain the effect of CR in the organism. Finally, the anti‐inflammatory effect of CR is an interesting emerging factor to be taken into consideration. In the present revision we focus on the general effect of CR and other mimetics in longevity, focusing especially on the cardiovascular system and skeletal muscle. image

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1113/jp270543

Cites

192 of 192 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Hallmarks of Aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787
Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance
Bravo, L. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01670.x · Cited by 4,030
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Oxidative Stress, Caloric Restriction, and Aging
Sohal, R. S., & Weindruch, R. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,131
Geroscience: Linking Aging to Chronic Disease
Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764
The genetics of ageing
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491
The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size
McCay, C. M., Crowell, M. F., & Maynard, L. A. (1935) · The Journal of Nutrition · doi:10.1093/jn/10.1.63 · Cited by 2,264
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · cited 1×
“Some time ago it was demonstrated that the orthologue of mammalian SIRT-1, Sir2, was able to increase lifespan in S. cerevisiae and in invertebrates such as C. elegans and D. melanogaster (Kaeberlein et al. 1999; Tissenbaum & Guarente, 2001; Wood et al. 2004).”
Background
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,603
Gene expression profile of aging and its retardation by caloric restriction
Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473
Metformin improves healthspan and lifespan in mice
Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445
The Endocrine Regulation of Aging by Insulin-like Signals
Tatar, M., Bartke, A., & Antebi, A. (2003) · Science · doi:10.1126/science.1081447 · Cited by 1,337
Decline in skeletal muscle mitochondrial function with aging in humans
Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501559102 · Cited by 1,333
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.002 · Cited by 1,320
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
Qiu, X., Brown, K., Hirschey, M. D., Verdin, E., & Chen, D. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.015 · Cited by 1,310
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
Gerhart‐Hines, Z., Rodgers, J. T., Bare, O., Lerin, C., Kim, S., Mostoslavsky, R., Alt, F. W., Wu, Z., & Puigserver, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601633 · Cited by 1,294
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.011 · Cited by 1,209
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · cited 3×
“This same effect has been also found in mice (Harrison et al. 2009; Selman et al. 2009).”
Background
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · cited 3×
“Nitric oxide synthase is induced by CR in mice and human muscle (Nisoli et al. 2005; Civitarese et al. 2007) and plays an important role in CR-induced mitochondrial biogenesis, since in eNOS−/− mice, the effect of CR is blocked (Nisoli et al.”
Background
Peroxisome Proliferator-Activated Receptor γ Coactivator 1 Coactivators, Energy Homeostasis, and Metabolism
Handschin, C., & Spiegelman, B. M. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0037 · Cited by 1,090
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
Nemoto, S., Fergusson, M. M., & Finkel, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501485200 · Cited by 1,047
Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress
Rolo, A. P., & Palmeira, C. M. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.01.003 · Cited by 1,007
FOXO3A genotype is strongly associated with human longevity
Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., Masaki, K. H., Willcox, D. C., Rodriguez, B., & Curb, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801030105 · Cited by 983
The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice
Solon-Biet, S. M., McMahon, A. C., Ballard, J. W. O., Ruohonen, K., Wu, L. E., Cogger, V. C., Warren, A., Huang, X., Pichaud, N., Melvin, R. G., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.009 · Cited by 904
SIRT1 Promotes Endothelium-Dependent Vascular Relaxation by Activating Endothelial Nitric Oxide Synthase
Mattagajasingh, I., Kim, C.-S., Naqvi, A., Yamamori, T., Hoffman, T. A., Jung, S.-B., DeRicco, J., Kasuno, K., & Irani, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704329104 · Cited by 881
Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans
Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., Smith, S. R., & Ravussin, E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040076 · Cited by 790
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789
Caloric restriction
Speakman, J. R., & Mitchell, S. E. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.07.001 · Cited by 749
Extending life span by increasing oxidative stress
Ristow, M., & Schmeisser, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.010 · Cited by 722
Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis
Kong, X., Wang, R., Xue, Y., Liu, X., Zhang, H., Chen, Y., Fang, F., & Chang, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011707 · Cited by 718
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
Colman, R. J., Beasley, T. M., Kemnitz, J. W., Johnson, S. C., Weindruch, R., & Anderson, R. M. (2014) · Nature Communications · doi:10.1038/ncomms4557 · Cited by 711
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency
López-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M. V., Allard, J., Ingram, D. K., Navas, P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510452103 · Cited by 699
Self-citation
The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.
Cm, M., Crowell, M. F., & MAYNARD, L. A. (1989) · PubMed · Cited by 670
Oxidative capacity and ageing in human muscle
Conley, K. E., Jubrias, S. A., & Esselman, P. C. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00203.x · Cited by 651 · cited 1×
“Several studies found that mitochondrial biogenesis is impaired during ageing, especially in high-energy-demanding tissues such as muscle, brain or heart (Conley et al. 2000; Short et al. 2005).”
Background
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
Apfeld, J., O'Connor, G., McDonagh, T., DiStefano, P. S., & Curtis, R. (2004) · Genes & Development · doi:10.1101/gad.1255404 · Cited by 643
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
Kume, S., Uzu, T., Horiike, K., Chin-Kanasaki, M., Isshiki, K., Araki, S.-I., Sugimoto, T., Haneda, M., Kashiwagi, A., & Koya, D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41376 · Cited by 640
Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
Miller, R. A., Harrison, D. E., Astle, C. M., Fernandez, E., Flurkey, K., Han, M., Javors, M. A., Li, X., Nadon, N. L., Nelson, J. F., et al. (2014) · Aging Cell · doi:10.1111/acel.12194 · Cited by 621
Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research
Fabbri, E., Zoli, M., Gonzalez-Freire, M., Salive, M. E., Studenski, S. A., & Ferrucci, L. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.03.013 · Cited by 563
Toward a unified theory of caloric restriction and longevity regulation
Sinclair, D. A. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.019 · Cited by 563
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
Ristow, M., & Schmeisser, K. (2014) · Dose-Response · doi:10.2203/dose-response.13-035.ristow · Cited by 534
Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice
Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-9261com · Cited by 532
Hormesis in aging
Rattan, S. I. S. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.03.002 · Cited by 498
Mitochondrial Aging and Age-Related Dysfunction of Mitochondria
Chistiakov, D. A., Sobenin, I. A., Revin, V. V., Orekhov, A. N., & Bobryshev, Y. V. (2014) · BioMed Research International · doi:10.1155/2014/238463 · Cited by 497
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
Palacios, O. M., Carmona, J. J., Michan, S., Chen, K. Y., Manabe, Y., III, J. L. W., Goodyear, L. J., & Tong, Q. (2009) · Aging · doi:10.18632/aging.100075 · Cited by 487
Calorie restriction and sirtuins revisited
Guarente, L. (2013) · Genes & Development · doi:10.1101/gad.227439.113 · Cited by 464
Sir2-Independent Life Span Extension by Calorie Restriction in Yeast
Kaeberlein, M., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020296 · Cited by 441
Effects of Physical Activity on Life Expectancy With Cardiovascular Disease
Franco, O. H. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.20.2355 · Cited by 438
Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans
Tóth, M. L., Sigmond, T., Borsos, É., Barna, J., Erdélyi, P., Takács-Vellai, K., Orosz, L., Kovács, A. L., Csikós, G., Sass, M., et al. (2008) · Autophagy · doi:10.4161/auto.5618 · Cited by 428
Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits
Ristow, M. (2014) · Nature Medicine · doi:10.1038/nm.3624 · Cited by 417 · cited 3×
“CR induces the antioxidant response, increases pathways and molecules involved in removing cell damage and modulates mitochondrial activity (Ristow, 2014).”
Background
Inflammation, ageing and chronic disease
Pawelec, G., Goldeck, D., & Derhovanessian, E. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.03.007 · Cited by 415
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
Imai, S.-I., & Guarente, L. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.02.003 · Cited by 390
Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys
Kayo, T., Allison, D. B., Weindruch, R., & Prolla, T. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081061898 · Cited by 384
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
Kendrick, A. A., Choudhury, M., Rahman, S. M., McCurdy, C. E., Friederich, M., Van Hove, J. L. K., Watson, P. A., Birdsey, N., Bao, J., Gius, D., et al. (2011) · Biochemical Journal · doi:10.1042/bj20100791 · Cited by 382
A holidic medium for Drosophila melanogaster
Piper, M. D. W., Blanc, E., Leitão-Gonçalves, R., Yang, M., He, X., Linford, N. J., Hoddinott, M. P., Hopfen, C., Soultoukis, G. A., Niemeyer, C., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2731 · Cited by 376
The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
Kenyon, C. (2011) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0276 · Cited by 376
The role of AMP‐activated protein kinase in mitochondrial biogenesis
Reznick, R. M., & Shulman, G. I. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109512 · Cited by 373
Sensing of energy and nutrients by AMP-activated protein kinase
Hardie, D. G. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.001925 · Cited by 372
Mitochondrial biogenesis and healthy aging
López-Lluch, G., Irusta, P. M., Navas, P., & de Cabo, R. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.014 · Cited by 364
Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial
Weiss, E. P., Racette, S. B., Villareal, D. T., Fontana, L., Steger-May, K., Schechtman, K. B., Klein, S., & Holloszy, J. O. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.1033 · Cited by 353
Aging in Rhesus Monkeys: Relevance to Human Health Interventions
Roth, G. S., Mattison, J. A., Ottinger, M. A., Chachich, M. E., Lane, M. A., & Ingram, D. K. (2004) · Science · doi:10.1126/science.1102541 · Cited by 353
Metformin Alleviates Hepatosteatosis by Restoring SIRT1-Mediated Autophagy Induction via an AMP-Activated Protein Kinase-Independent Pathway
Song, Y. M., Lee, Y.-H., Kim, J.-W., Ham, D.-S., Kang, E.-S., Cha, B. S., Lee, H. C., & Lee, B.-W. (2015) · Autophagy · doi:10.4161/15548627.2014.984271 · Cited by 332
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
Li, Y., Xu, W., McBurney, M. W., & Longo, V. D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.05.004 · Cited by 331
Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise
Goncalves, R. L. S., Quinlan, C. L., Perevoshchikova, I. V., Hey-Mogensen, M., & Brand, M. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.619072 · Cited by 329 · cited 2×
“As in the case of other regulators such as sirtuins, its effect on longevity has been observed in several organisms from yeast to mammals.”
Background
Aging and Innate Immunity
Solana, R., Pawelec, G., & Tarazona, R. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.003 · Cited by 313
Molecular mechanisms linking calorie restriction and longevity
Merry, B. J. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00038-9 · Cited by 304
Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction
Chung, H. Y., Kim, H. J., Kim, K. W., Choi, J. S., & Yu, B. P. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10203 · Cited by 297
Dietary factors, hormesis and health
Mattson, M. P. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.08.004 · Cited by 291
DAMPs as mediators of sterile inflammation in aging-related pathologies
Feldman, N., Rotter-Maskowitz, A., & Okun, E. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.003 · Cited by 283
Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging
Hyun, D.-H., Emerson, S. S., Jo, D.-G., Mattson, M. P., & de Cabo, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608008103 · Cited by 267
Minireview: The Role of Oxidative Stress in Relation to Caloric Restriction and Longevity
Gredilla, R., & Barja, G. (2005) · Endocrinology · doi:10.1210/en.2005-0378 · Cited by 265
Reconsidering the Role of Mitochondria in Aging
Gonzalez-Freire, M., de Cabo, R., Bernier, M., Sollott, S. J., Fabbri, E., Navas, P., & Ferrucci, L. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv070 · Cited by 244
Self-citation
Inflamm-Aging, Cytokines and Aging: State of the Art, New Hypotheses on the Role of Mitochondria and New Perspectives from Systems Biology
Salvioli, S., Capri, M., Valensin, S., Tieri, P., Monti, D., Ottaviani, E., & Franceschi, C. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777947470 · Cited by 242
Mechanisms Underlying Caloric Restriction and Lifespan Regulation: Implications for Vascular Aging
Ungvari, Z., Parrado-Fernandez, C., Csiszar, A., & de Cabo, R. (2008) · Circulation Research · doi:10.1161/circresaha.107.168369 · Cited by 238
Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys
Kemnitz, J. W., Roecker, E. B., Weindruch, R., Elson, D. F., Baum, S. T., & Bergman, R. N. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.4.e540 · Cited by 236
Role of adiponectin in human skeletal muscle bioenergetics
Civitarese, A. E., Ukropcova, B., Carling, S., Hulver, M., DeFronzo, R. A., Mandarino, L., Ravussin, E., & Smith, S. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.002 · Cited by 234
MARK-AGE biomarkers of ageing
Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H. J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., et al. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.006 · Cited by 228
Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle
Zainal, T. A., Oberley, T. D., Allison, D. B., Szweda, L. I., & Weindruch, R. (2000) · The FASEB Journal · doi:10.1096/fj.99-0881com · Cited by 215
Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases
Chung, H. Y., Lee, E. K., Choi, Y. J., Kim, J. M., Kim, D. H., Zou, Y., Kim, C. H., Lee, J., Kim, H. S., Kim, N. D., et al. (2011) · Journal of Dental Research · doi:10.1177/0022034510387794 · Cited by 215
Alteration of antioxidant enzymes with aging in rat skeletal muscle and liver
Ji, L. L., Dillon, D., & Wu, E. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.258.4.r918 · Cited by 215
On the importance of fatty acid composition of membranes for aging
Hulbert, A. J. (2005) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2004.11.024 · Cited by 209
The Effect of Retardation of Growth Upon the Breeding Period and Duration of Life of Rats
Osborne, T. B., Mendel, L. B., & Ferry, E. L. (1917) · Science · doi:10.1126/science.45.1160.294 · Cited by 204
Sirtuins, Aging, and Metabolism
Guarente, L. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010629 · Cited by 202
Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila
Slack, C., Foley, A., & Partridge, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047699 · Cited by 199
Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
Schenk, S., McCurdy, C. E., Philp, A., Chen, M. Z., Holliday, M. J., Bandyopadhyay, G. K., Osborn, O., Baar, K., & Olefsky, J. M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58554 · Cited by 197
The Mitochondrial Free Radical Theory of Aging
Barja, G. (2014) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-394625-6.00001-5 · Cited by 193
Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans
Hwang, A. B., Ryu, E.-A., Artan, M., Chang, H.-W., Kabir, M. H., Nam, H.-J., Lee, D., Yang, J.-S., Kim, S., Mair, W. B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411199111 · Cited by 188
The role of systemic inflammation in age‐related muscle weakness and wasting
Degens, H. (2010) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2009.01018.x · Cited by 185
2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase
Wang, Q., Liang, B., Shirwany, N. A., & Zou, M.-H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017234 · Cited by 182
Autophagy in Yeast: ATOR-Mediated Response to Nutrient Starvation
Kamada, Y., Sekito, T., & Ohsumi, Y. (2004) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-18930-2_5 · Cited by 174
Controlling caloric consumption: protocols for rodents and rhesus monkeys☆
Pugh, T. D., Klopp, R. G., & Weindruch, R. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00043-3 · Cited by 174
A low-glycemic load diet facilitates greater weight loss in overweight adults with high insulin secretion but not in overweight adults with low insulin secretion in the CALERIE Trial
Pittas, A. G., Das, S. K., Hajduk, C. L., Golden, J., Saltzman, E., Stark, P. C., Greenberg, A. S., & Roberts, S. B. (2005) · Diabetes Care · doi:10.2337/diacare.28.12.2939 · Cited by 163
What are the roles of calorie restriction and diet quality in promoting healthy longevity?
Rizza, W., Veronese, N., & Fontana, L. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2013.11.002 · Cited by 162
Effects of Intermittent Feeding Upon Growth and Life Span in Rats
Goodrick, C. L., Ingram, D. K., Reynolds, M. A., Freeman, J. R., & Cider, N. L. (1982) · Gerontology · doi:10.1159/000212538 · Cited by 158
The importance of plasma membrane coenzyme Q in aging and stress responses
Navas, P., Villalba, J. M., & de Cabo, R. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.02.010 · Cited by 158
Self-citation
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
Goto, M. (2008) · PubMed · Cited by 156
Calorie Restriction and Dietary Restriction Mimetics: A Strategy for Improving Healthy Aging and Longevity
Testa, G., Biasi, F., Poli, G., & Chiarpotto, E. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660699 · Cited by 153
Aging is not a disease: implications for intervention
Rattan, S. I. S. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500196 · Cited by 148
Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver
de Cabo, R., Cabello, R., Ríos, M. D. C. M., López‐Lluch, G., Ingram, D. K., Lane, M. A., & Navas, P. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.12.003 · Cited by 147
Self-citation
A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction
Miller, B. F., Robinson, M. M., Bruss, M. D., Hellerstein, M. K., & Hamilton, K. L. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00769.x · Cited by 143
Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade
Kwon, J., Han, E., Bui, C., Shin, W., Lee, J. H., Lee, S., Choi, Y., Lee, A., Lee, K., Park, C., et al. (2012) · EMBO Reports · doi:10.1038/embor.2011.246 · Cited by 143
Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Ageing Achievement
Candore, G., Caruso, C., Jirillo, E., Magrone, T., & Vasto, S. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883868 · Cited by 140
Intermittent fasting and dietary supplementation with 2‐deoxy‐ D ‐glucose improve functional and metabolic cardiovascular risk factors in rats
Wan, R., Camandola, S., & Mattson, M. P. (2003) · The FASEB Journal · doi:10.1096/fj.02-0996fje · Cited by 138
Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in rats
Minor, R. K., Smith, D. L., Sossong, A. M., Kaushik, S., Poosala, S., Spangler, E. L., Roth, G. S., Lane, M. A., Allison, D. B., de Cabo, R., et al. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.11.025 · Cited by 136
Hormesis, cell death and aging
Martins, I., Galluzzi, L., & Kroemer, G. (2011) · Aging · doi:10.18632/aging.100380 · Cited by 131
Will calorie restriction work in humans?
Cava, E., & Fontana, L. (2013) · Aging · doi:10.18632/aging.100581 · Cited by 130
The Interplay Between Respiratory Supercomplexes and ROS in Aging
Genova, M. L., & Lenaz, G. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6214 · Cited by 130
Age-associated miRNA Alterations in Skeletal Muscle from Rhesus Monkeys reversed by caloric restriction
Mercken, E. M., Majounie, E., Ding, J., Guo, R., Kim, J., Bernier, M., Mattison, J. A., Cookson, M., Gorospe, M., de Cabo, R., et al. (2013) · Aging · doi:10.18632/aging.100598 · Cited by 125
The caloric restriction paradigm: Implications for healthy human aging
Anderson, R. M., & Weindruch, R. (2012) · American Journal of Human Biology · doi:10.1002/ajhb.22243 · Cited by 125
Caloric Restriction and Aging: Controversial Issues
Masoro, E. J. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.1.14 · Cited by 123
Caloric Restriction: IMPLICATIONS FOR HUMAN CARDIOMETABOLIC HEALTH
Bales, C. W., & Kraus, W. E. (2013) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0b013e318295019e · Cited by 121
2-Deoxy-D-Glucose Feeding in Rats Mimics Physiologic Effects of Calorie Restriction
Lane, M. A., Ingram, D. K., & Roth, G. S. (1998) · Rejuvenation Research · doi:10.1089/rej.1.1998.1.327 · Cited by 118
Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity
Gonzalez, A. A., Kumar, R., Mulligan, J. D., Davis, A. J., Weindruch, R. H., & Saupe, K. W. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00172.2004 · Cited by 118
Plasma Membrane Redox System in the Control of Stress-Induced Apoptosis
Villalba, J. M., & Navas, P. (2000) · Antioxidants and Redox Signaling · doi:10.1089/ars.2000.2.2-213 · Cited by 115
Self-citation
The Relationship between Muscle Fiber Type-Specific PGC-1α Content and Mitochondrial Content Varies between Rodent Models and Humans
Gouspillou, G., Sgarioto, N., Norris, B. A., Barbat-Artigas, S., Aubertin-Leheudre, M., Morais, J., Burelle, Y., Taivassalo, T., & Hepple, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103044 · Cited by 115
Impaired quality control of mitochondria: Aging from a new perspective
Weber, T. A., & Reichert, A. S. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.018 · Cited by 112
Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation
Sczelecki, S., Besse-Patin, A., Abboud, A., Kleiner, S., Laznik-Bogoslavski, D., Wrann, C. D., Ruas, J. L., Haibe-Kains, B., & Estall, J. L. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00578.2013 · Cited by 108
Mitochondrial Metabolic Reprogramming Induced by Calorie Restriction
Martín‐Montalvo, A., & de Cabo, R. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4866 · Cited by 106
Nuclear Factor Erythroid 2-Related Factor 2 Deletion Impairs Glucose Tolerance and Exacerbates Hyperglycemia in Type 1 Diabetic Mice
Aleksunes, L. M., Reisman, S. A., Yeager, R. L., Goedken, M. J., & Klaassen, C. D. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.162271 · Cited by 106
Glycolytic inhibition as a strategy for developing calorie restriction mimetics
Ingram, D. K., & Roth, G. S. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.12.001 · Cited by 104
Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle
Li, L., Mühlfeld, C., Niemann, B., Pan, R., Li, R., Hilfiker‐Kleiner, D., Chen, Y., & Rohrbach, S. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0213-9 · Cited by 103
Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle
McKiernan, S. H., Colman, R. J., Lopez, M. E., Beasley, T. M., Aiken, J. M., Anderson, R. M., & Weindruch, R. H. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.09.011 · Cited by 97
Physical Activity and Mortality in Frail, Community-Living Elderly Patients
Landi, F., Cesari, M., Onder, G., Lattanzio, F., Gravina, E. M., Bernabei, R., & on Behalf of the SilverNet-HC Study Group (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.8.m833 · Cited by 96
Mitochondria, oxidative stress, and antioxidant defences.
Lenaz, G., Bovina, C., Formiggini, G., & Castelli, G. P. (1999) · Acta Biochimica Polonica · doi:10.18388/abp.1999_4179 · Cited by 89
Counting the Calories: The Role of Specific Nutrients in Extension of Life Span by Food Restriction
Piper, M. D. W., Mair, W. B., & Partridge, L. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.5.549 · Cited by 88
AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD
Brandauer, J., Agerholm, M., Kellezi, H., Risis, S., Frøsig, C., Vienberg, S. G., & Treebak, J. T. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00085 · Cited by 87
Acetate metabolism and aging: An emerging connection
Shimazu, T., Hirschey, M. D., Huang, J.-Y., Ho, L., & Verdin, E. M. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.05.001 · Cited by 81
The diet restriction paradigm: a brief review of the effects of every-other-day feeding
Anson, R. M., Jones, B., & de Cabo, R. (2005) · AGE · doi:10.1007/s11357-005-3286-2 · Cited by 78
Dietary restriction: standing up for sirtuins
Baur, J. A., Chen, D., Chini, E. N., Chua, K., Cohen, H. Y., Cabo, R. D., Deng, C., Dimmeler, S., Gius, D., Guarente, L. P., et al. (2010) · Science · doi:10.1126/science.329.5995.1012 · Cited by 76
Energy requirements in nonobese men and women: results from CALERIE
Redman, L. M., Kraus, W. E., Bhapkar, M. V., Das, S. K., Racette, S. B., Martin, C. K., Fontana, L., Wong, W. W., Roberts, S. B., & Ravussin, É. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.065631 · Cited by 73
Anti-Inflammatory Effect of Resveratrol in Old Mice Liver
Tung, B. T., Rodríguez-Bies, E., Talero, E., Gamero-Estévez, E., Motilva, V., Navas, P., & López-Lluch, G. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.02.004 · Cited by 71
Self-citation
Invertebrate models of age-related muscle degeneration
Augustin, H., & Partridge, L. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.011 · Cited by 70
Formation of free acetate by isolated perfused livers from normal, starved and diabetic rats
Seufert, C. D., Graf, M., Janson, G., Kuhn, A., & Söling, H. (1974) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(74)90631-7 · Cited by 64
Life Extension by Calorie Restriction in Humans
Everitt, A. V., & Couteur, D. G. L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.005 · Cited by 63
Dietary Caloric Restriction Prevents the Age-Related Decline in Plasma Melatonin Levels of Rhesus Monkeys
Roth, G. S., Lesnikov, V. A., Lesnikov, M., Ingram, D. K., & Lane, M. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7655 · Cited by 62
Effects of caloric restriction on oxidative stress parameters
Stankovic, M. S., Mladenović, D. R., Ninković, M., Vučević, D. B., & Radosavljević, T. S. (2013) · General Physiology and Biophysics · doi:10.4149/gpb_2013027 · Cited by 59
Alterations of Ultrastructural and Fission/Fusion Markers in Hepatocyte Mitochondria From Mice Following Calorie Restriction With Different Dietary Fats
Khraiwesh, H. M., Lopez-Dominguez, J. A., López‐Lluch, G., Navas, P., de Cabo, R., Ramsey, J. J., Villalba, J. M., & González-Reyes, J. A. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt006 · Cited by 57
Self-citation
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Alcocer‐Gómez, E., Garrido‐Maraver, J., Bullón, P., Marín‐Aguilar, F., Cotán, D., Carrión, Á. M., Álvarez-Suárez, J. M., Giampieri, F., Sánchez-Alcázar, J. A., Battino, M. A., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.03.005 · Cited by 56
Organ and tissue-dependent effect of resveratrol and exercise on antioxidant defenses of old mice
Tùng, B. T., Rodríguez-Bies, E., Thanh, H. N., Le‐Thi‐Thu, H., Navas, P., Sánchez, V. M., & López‐Lluch, G. (2015) · Aging Clinical and Experimental Research · doi:10.1007/s40520-015-0366-8 · Cited by 55
Self-citation
Membrane alteration as a basis of aging and the protective effects of calorie restriction
Yu, B. P. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.020 · Cited by 51
Adult-Onset Energy Restriction of Rhesus Monkeys Attenuates Oxidative Stress–Induced Cytokine Expression by Peripheral Blood Mononuclear Cells
Kim, M.-J., Aiken, J. M., Havighurst, T. C., Hollander, J. M., Ripple, M. O., & Weindruch, R. H. (1997) · Journal of Nutrition · doi:10.1093/jn/127.12.2293 · Cited by 51
A Functional Analysis Reveals Dependence on the Anaphase-Promoting Complex for Prolonged Life Span in Yeast
Harkness, T. A. A., Shea, K. A., Legrand, C., Brahmania, M., & Davies, G. F. (2004) · Genetics · doi:10.1534/genetics.104.027771 · Cited by 50
The influence of systemic inflammation on skeletal muscle in physically active elderly women
Wåhlin‐Larsson, B., Carnac, G., & Kadi, F. (2014) · AGE · doi:10.1007/s11357-014-9718-0 · Cited by 49
Role of Hormesis in Life Extension by Caloric Restriction
Masoro, E. J. (2007) · Dose-Response · doi:10.2203/dose-response.06-005.masoro · Cited by 49
Calorie restriction can reverse, as well as prevent, aging cardiomyopathy
Yan, L., Gao, S., Ho, D. W. T., Park, M., Ge, H., Wang, C., Tian, Y., Lai, L., Lorenzo, M. S. D., Vatner, D. E., et al. (2013) · AGE · doi:10.1007/s11357-012-9508-5 · Cited by 47
Resveratrol Up-Regulates the Erythrocyte Plasma Membrane Redox System and Mitigates Oxidation-Induced Alterations in Erythrocytes During Aging in Humans
Pandey, K. B., & Rizvi, S. I. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1419 · Cited by 46
Age-associated development of inflammation in Wistar rats: Effects of caloric restriction
Horrillo, D., Sierra, J., Arribas, C., García-San Frutos, M., Carrascosa, J. M., Lauzurica, N., Fernández-Agulló, T., & Ros, M. (2011) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2011.577435 · Cited by 45
Dietary restriction, glycolysis, hormesis and ageing
Hipkiss, A. R. (2006) · Biogerontology · doi:10.1007/s10522-006-9034-x · Cited by 45
Mouse liver plasma membrane redox system activity is altered by aging and modulated by calorie restriction
López‐Lluch, G., Ríos, M. D. C. M., Lane, M. A., Navas, P., & de Cabo, R. (2005) · AGE · doi:10.1007/s11357-005-2726-3 · Cited by 45
Self-citation
Quality control systems in cardiac aging
Quarles, E. K., Dai, D., Tocchi, A., Basisty, N., Gitari, L., & Rabinovitch, P. S. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.02.003 · Cited by 44
Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver
To, K., Yamaza, H., Komatsu, T., Hayashida, T., Hayashi, H., Toyama, H., Chiba, T., Higami, Y., & Shimokawa, I. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.07.003 · Cited by 44
Predicting whether dietary restriction would increase longevity in species not tested so far
Bourg, É. L. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.01.001 · Cited by 44
Physical activity affects plasma coenzyme Q10 levels differently in young and old humans
del Pozo-Cruz, J., Rodríguez-Bies, E., Ballesteros‐Simarro, M., Navas‐Enamorado, I., Tùng, B. T., Navas, P., & López‐Lluch, G. (2014) · Biogerontology · doi:10.1007/s10522-013-9491-y · Cited by 44
Self-citation
Ox-Lp(a) transiently induces HUVEC autophagy via an ROS-dependent PAPR-1-LKB1–AMPK–mTOR pathway
Li, G.-H., Lin, X., Zhang, H., Li, S., He, X., Zhang, K., Peng, J., Tang, Y., Zeng, J., Zhao, Y., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.09.020 · Cited by 41
Mitochondrial Function in Human Neuroblastoma Cells Is Up-Regulated and Protected by NQO1, a Plasma Membrane Redox Enzyme
Kim, J., Kim, S.-K., Kim, H. K., Mattson, M. P., & Hyun, D. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069030 · Cited by 41
What Determines the Duration of Life in Metazoa?
Loeb, J., & Northrop, J. H. (1917) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.3.5.382 · Cited by 41
A critical role of SNF1A/dAMPKα (Drosophila AMP-activated protein kinase α) in muscle on longevity and stress resistance in Drosophila melanogaster
Tohyama, D., & Yamaguchi, A. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.126 · Cited by 41
Calorie restriction and NAD+/sirtuin counteract the hallmarks of aging
Michán, S. (2014) · Frontiers in bioscience · doi:10.2741/4283 · Cited by 41
Dietary supplementation with 2-deoxy- d -glucose improves cardiovascular and neuroendocrine stress adaptation in rats
Wan, R., Camandola, S., & Mattson, M. P. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00932.2003 · Cited by 41
Relationship between functional capacity and body mass index with plasma coenzyme Q10 and oxidative damage in community-dwelling elderly-people
del Pozo-Cruz, J., Rodríguez-Bies, E., Navas‐Enamorado, I., Cruz, B. D. P., Navas, P., & López‐Lluch, G. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.026 · Cited by 40
Self-citation
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast
Jiménez‐Hidalgo, M., Santos‐Ocaña, C., Padilla, S., Villalba, J. M., López‐Lluch, G., Martín‐Montalvo, A., Minor, R. K., Sinclair, D. A., de Cabo, R., & Navas, P. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00461.x · Cited by 40
Self-citation
Effects of Long-Term Caloric Restriction on Early Steps of the Insulin-Signaling System in Mouse Skeletal Muscle
Argentino, D. P., Dominici, F. P., Al-Regaiey, K., Bonkowski, M. S., Bartke, A., & Turyn, D. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.1.28 · Cited by 40
The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice
Lopez-Dominguez, J. A., Ramsey, J. J., Tran, D., Imai, D. M., Koehne, A. L., Laing, S. T., Griffey, S. M., Kim, K., Taylor, S. L., Hagopian, K., et al. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu177 · Cited by 39
Self-citation
Role of PGC-1α in exercise training- and resveratrol-induced prevention of age-associated inflammation
Olesen, J., Ringholm, S., Nielsen, M. M., Brandt, C. T., Pedersen, J. T., Halling, J. F., Goodyear, L. J., & Pilegaard, H. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.07.015 · Cited by 38
Age-dependent effect of every-other-day feeding and aerobic exercise in ubiquinone levels and related antioxidant activities in mice muscle
Rodríguez-Bies, E., Navas, P., & López-Lluch, G. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu002 · Cited by 36
Self-citation
Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats
Khraiwesh, H. M., Lopez-Dominguez, J. A., Fernández-del-Río, L., Gutiérrez-Casado, E., López‐Lluch, G., Navas, P., de Cabo, R., Ramsey, J. J., Burón, M. I., Villalba, J. M., et al. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.023 · Cited by 36
Self-citation
Aging and TOR: interwoven in the fabric of life
Sharp, Z. D. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0542-0 · Cited by 36
Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae
Falcón, A. A., Chen, S., Wood, M. S., & Aris, J. P. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0209-z · Cited by 35
The Influence of Dietary Lipid Composition on Skeletal Muscle Mitochondria From Mice Following 1 Month of Calorie Restriction
Chen, Y., Hagopian, K., McDonald, R. B., Bibus, D. M., López‐Lluch, G., Villalba, J. M., Navas, P., & Ramsey, J. J. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls113 · Cited by 34
Self-citation
Mitohormesis in muscle cells: a morphological, molecular, and proteomic approach
Berberi, E., Sestili, P., Vallorani, L., Guescini, M., Calcabrini, C., Gioacchini, A. M., Annibalini, G., Lucertini, F., Piccoli, G., & Stocchi, V. (2019) · Muscles Ligaments and Tendons Journal · doi:10.32098/mltj.04.2013.05 · Cited by 32
The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress
Hyun, D. H., Kim, J., Moon, C., Lim, C. J., de Cabo, R., & Mattson, M. P. (2011) · AGE · doi:10.1007/s11357-011-9245-1 · Cited by 31
The influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction
Chen, Y., Hagopian, K., Bibus, D. M., Villalba, J. M., López‐Lluch, G., Navas, P., Kim, K., McDonald, R. B., & Ramsey, J. J. (2012) · Bioscience Reports · doi:10.1042/bsr20120060 · Cited by 30
Self-citation
Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie-restricted mice
Lopez-Dominguez, J. A., Khraiwesh, H. M., González-Reyes, J. A., López‐Lluch, G., Navas, P., Ramsey, J. J., de Cabo, R., Burón, M. I., & Villalba, J. M. (2012) · AGE · doi:10.1007/s11357-012-9492-9 · Cited by 30
Self-citation
Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD+ level, SIRT1 activity and replicative lifespan of human Hs68 cells
Yang, N.-C., Song, T., Chen, M.-Y., & Hu, M. (2011) · Biogerontology · doi:10.1007/s10522-011-9342-7 · Cited by 28
Muscle Physiology Changes Induced by Every Other Day Feeding and Endurance Exercise in Mice: Effects on Physical Performance
Rodríguez-Bies, E., Calvo, S. S.-C., Fontán‐Lozano, Á., Peña, J., de la Rosa, F. J. B., Carrión, Á. M., Navas, P., & López‐Lluch, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013900 · Cited by 28
Self-citation
Plasma membrane electron transport in pancreatic β-cells is mediated in part by NQO1
Gray, J. P., Eisen, T. J., Cline, G. W., Smith, P. J., & Heart, E. A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00673.2010 · Cited by 27
Erythrocyte plasma membrane redox system may determine maximum life span
Rizvi, S. I., Kumar, D., Chakravarty, S., & Singh, P. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2010.12.014 · Cited by 26
Transcriptional Role of FOXO1 in Drug Resistance through Antioxidant Defense Systems
Gotō, T., & Takano, M. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1599-3_13 · Cited by 24
Increased vulnerability to β-cell destruction and diabetes in mice lacking NAD(P)H:quinone oxidoreductase 1
Yeo, S.-H., Noh, J., Kim, Y., Gang, G., Kim, S. W., Kim, K., Hwang, J. H., Shong, M., & Lee, C. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.02.013 · Cited by 24
The Ongoing Saga of Sirtuins and Aging
Kaeberlein, M. R. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.004 · Cited by 22
Dietary Manipulation of Mouse Metabolism
Feige, J. N., Lagouge, M., & Auwerx, J. (2008) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb29b05s84 · Cited by 18
The Influence of Dietary Lipid Composition on Skeletal Muscle Mitochondria From Mice Following Eight Months of Calorie Restriction
Chen, Y., Hagopian, K., Bibus, D. M., Villalba, J. M., López‐Lluch, G., Navas, P., Kim, K., & Ramsey, J. J. (2014) · Physiological Research · doi:10.33549/physiolres.932529 · Cited by 18
Self-citation
Coenzyme Q-dependent functions of plasma membrane in the aging process
Navas, P., Villalba, J. M., & Lenaz, G. (2005) · AGE · doi:10.1007/s11357-005-1632-z · Cited by 16
Self-citation
IGF Type 1 Receptor: A Cell Cycle Progression Factor That Regulates Aging
Dupont, J., & Holzenberger, M. (2003) · Cell Cycle · doi:10.4161/cc.2.4.408 · Cited by 16
Calorie-restriction and longevity. End of a dream, at least for primates?
Robert, L. (2013) · European Geriatric Medicine · doi:10.1016/j.eurger.2013.02.005 · Cited by 11
Plasma membrane redox and control of sirtuin
Crane, F. L., & Löw, H. (2005) · AGE · doi:10.1007/s11357-005-1631-0 · Cited by 8

Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990
Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes
Kolb, H., & Martin, S. (2017) · BMC Medicine · doi:10.1186/s12916-017-0901-x · Cited by 717
Ageing, age-related diseases and oxidative stress: What to do next?
Luo, J., Mills, K., le Cessie, S., Noordam, R., & van Heemst, D. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100982 · Cited by 581
Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging
Ma, S., Sun, S., Geng, L., Song, M., Wang, W., Ye, Y., Ji, Q., Zou, Z., Wang, S., He, X., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.008 · Cited by 349
Molecular mechanisms of renal aging
Schmitt, R., & Melk, A. (2017) · Kidney International · doi:10.1016/j.kint.2017.02.036 · Cited by 235

See all 288

Authors: López‐Lluch, G., & Navas, P.
Venue: The Journal of Physiology
Publisher: Wiley
Published: 2016-01-03
Volume: 594
Issue: 8
Pages: 2043-2060
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jp270543
OpenAlex: W2172818274
Cited by: 288
References: 192
FWCI: 6.15
Type: journal article
Language: en
Open access: hybrid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Calorie restriction as an intervention in ageing

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks

Data sources