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Differential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exercise

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Moore, Daniel R., Tang, Jason E., Burd, Nicholas A., Rerecich, Tracy, Tarnopolsky, Mark A., Phillips, Stuart M.·2009·The Journal of Physiology

DOI 10.1113/jphysiol.2008.164087

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Abstract

We aimed to determine whether there is a differential stimulation of the contractile myofibrillar and the cellular sarcoplasmic proteins after ingestion of protein and how this is affected by resistance exercise. Fasted (FAST) muscle protein synthesis was measured in seven healthy young men with a primed constant infusion of l‐[ring‐13 C 6]phenylalanine. Participants then performed an intense bout of unilateral resistance exercise followed by the consumption of 25 g of whey protein to maximally stimulate protein synthesis. In the rested (FED) leg myofibrillar (MYO) protein synthesis was elevated (P < 0.01) above FAST at 3 h (∼163%) but not at 1 and 5 h (P > 0.05). In contrast, MYO protein synthesis in the exercised (FED‐EX) leg was stimulated above FAST at 1, 3 and 5 h (∼100, 216, and 229%, respectively; P < 0.01) with the increase at 5 h being greater than FED (P < 0.01). Thus, the synthesis of muscle contractile proteins is stimulated by both feeding and resistance exercise early (1 h) but has a greater duration and amplitude after resistance exercise. Sarcoplasmic (SARC) protein synthesis was similarly elevated (P < 0.01) above FAST by ∼104% at 3 h in both FED and FED‐EX suggesting SARC protein synthesis is stimulated by feeding but that this response is not augmented by resistance exercise. In conclusion, myofibrillar and sarcoplasmic protein synthesis are similarly, but transiently, stimulated with protein feeding. In contrast, resistance exercise rapidly stimulates and sustains the synthesis of only the myofibrillar protein fraction after protein ingestion. These data highlight the importance of measuring the synthetic response of specific muscle protein fractions when examining the effects of exercise and nutrition.

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The muscle protein synthetic response to the ingestion of a plant-derived protein blend does not differ from an equivalent amount of milk protein in healthy, young males
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Physical Activity Performed in the Evening Increases the Overnight Muscle Protein Synthetic Response to Presleep Protein Ingestion in Older Men
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“The effect of protein intake on MPS rates is further potentiated by resistance- (6, 7) or endurance-type (8, 9) exercise, resulting in MPS rates greater than those observed after protein ingestion or exercise only.”
Background
Targeting Anabolic Impairment in Response to Resistance Exercise in Older Adults with Mobility Impairments: Potential Mechanisms and Rehabilitation Approaches
Drummond, M. J., Marcus, R. L., & LaStayo, P. C. (2012) · Journal of Aging Research · doi:10.1155/2012/486930 · Cited by 28

Authors: Moore, D. R., Tang, J. E., Burd, N. A., Rerecich, T., Tarnopolsky, M. A., & Phillips, S. M.
Venue: The Journal of Physiology
Publisher: Wiley
Published: 2009-02-13
Volume: 587
Issue: 4
Pages: 897-904
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jphysiol.2008.164087
OpenAlex: W1593324935
Cited by: 324
References: 13
FWCI: 10.13
Type: journal article
Language: en
Open access: green

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Differential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exercise

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