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Genetic Dissection of Complex Traits

Lander, Eric S., Schork, Nicholas J.·1994·Science
DOI 10.1126/science.8091226
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Abstract

Medical genetics was revolutionized during the 1980s by the application of genetic mapping to locate the genes responsible for simple Mendelian diseases. Most diseases and traits, however, do not follow simple inheritance patterns. Geneticists have thus begun taking up the even greater challenge of the genetic dissection of complex traits. Four major approaches have been developed: linkage analysis, allele-sharing methods, association studies, and polygenic analysis of experimental crosses. This article synthesizes the current state of the genetic dissection of complex traits—describing the methods, limitations, and recent applications to biological problems.

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200 of 247 shown

Cited by

Metadata

Authors
Lander, E. S., & Schork, N. J.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1994-09-30
Volume
265
Issue
5181
Pages
2037-2048
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8091226
OpenAlex
W2123466824
Cited by
3,413
References
12
FWCI
85.15
Type
journal article
Language
en
Open access
closed

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