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Cited by 3,122

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Tolerogenic Dendritic Cells

Steinman, Ralph M., Hawiger, Daniel, Nussenzweig, Michel C.·2003·Annual Review of Immunology
DOI 10.1146/annurev.immunol.21.120601.141040
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Abstract

▪ Abstract Dendritic cells (DCs) have several functions in innate and adaptive immunity. In addition, there is increasing evidence that DCs in situ induce antigen-specific unresponsiveness or tolerance in central lymphoid organs and in the periphery. In the thymus DCs generate tolerance by deleting self-reactive T cells. In peripheral lymphoid organs DCs also induce tolerance to antigens captured by receptors that mediate efficient uptake of proteins and dying cells. Uptake by these receptors leads to the constitutive presentation of antigens on major histocompatibility complex (MHC) class I and II products. In the steady state the targeting of DC antigen capture receptors with low doses of antigens leads to deletion of the corresponding T cells and unresponsiveness to antigenic rechallenge with strong adjuvants. In contrast, if a stimulus for DC maturation is coadministered with the antigen, the mice develop immunity, including interferon-γ-secreting effector T cells and memory T cells. There is also new evidence that DCs can contribute to the expansion and differentiation of T cells that regulate or suppress other immune T cells. One possibility is that distinct developmental stages and subsets of DCs and T cells can account for the different pathways to peripheral tolerance, such as deletion or suppression. We suggest that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs.

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Metadata

Authors
Steinman, R. M., Hawiger, D., & Nussenzweig, M. C.
Venue
Annual Review of Immunology
Publisher
Annual Reviews
Published
2003-04
Volume
21
Issue
1
Pages
685-711
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
DOI
10.1146/annurev.immunol.21.120601.141040
OpenAlex
W2161354474
Cited by
3,122
References
3
FWCI
10.12
Type
journal article
Language
en
Open access
closed

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