Cited by 1,132Muscle metabolism and nutritionMuscle Physiology and DisordersCardiovascular and exercise physiology

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Mixed muscle protein synthesis and breakdown after resistance exercise in humans

Phillips, S. M., Tipton, K. D., Aarsland, A., Wolf, S. E., Wolfe, R. R.·1997·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.1997.273.1.e99

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Abstract

Mixed muscle protein fractional synthesis rate (FSR) and fractional breakdown rate (FBR) were examined after an isolated bout of either concentric or eccentric resistance exercise. Subjects were eight untrained volunteers (4 males, 4 females). Mixed muscle protein FSR and FBR were determined using primed constant infusions of [2H5]phenylalanine and 15N-phenylalanine, respectively. Subjects were studied in the fasted state on four occasions: at rest and 3, 24, and 48 h after a resistance exercise bout. Exercise was eight sets of eight concentric or eccentric repetitions at 80% of each subject's concentric 1 repetition maximum. There was no significant difference between contraction types for either FSR, FBR, or net balance (FSR minus FBR). Exercise resulted in significant increases above rest in muscle FSR at all times: 3 h = 112%, 24 h = 65%, 48 h = 34% (P < 0.01). Muscle FBR was also increased by exercise at 3 h (31%; P < 0.05) and 24 h (18%; P < 0.05) postexercise but returned to resting levels by 48 h. Muscle net balance was significantly increased after exercise at all time points [(in %/h) rest = -0.0573 +/- 0.003 (SE), 3 h = -0.0298 +/- 0.003, 24 h = -0.0413 +/- 0.004, and 48 h = -0.0440 +/- 0.005], and was significantly different from zero at all time points (P < 0.05). There was also a significant correlation between FSR and FBR (r = 0.88, P < 0.001). We conclude that exercise resulted in an increase in muscle net protein balance that persisted for up to 48 h after the exercise bout and was unrelated to the type of muscle contraction performed.

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Authors: Phillips, S. M., Tipton, K. D., Aarsland, A., Wolf, S. E., & Wolfe, R. R.
Affiliations: Shriners Hospitals for Children - Galveston (US)
ORCID: Phillips, S. M.
Tipton, K. D.
Wolf, S. E.
Wolfe, R. R.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 1997-07-01
Volume: 273
Issue: 1
Pages: E99-E107
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.1997.273.1.e99
OpenAlex: W1952358281
Cited by: 1,132
References: 2
Citations by year: 2026: 16 · 2025: 33 · 2024: 34 · 2023: 38 · 2022: 27 · 2021: 59 · 2020: 51 · 2019: 58 · 2018: 70 · 2017: 71 · 2016: 48 · 2015: 55 · 2014: 54 · 2013: 62 · 2012: 52
FWCI: 3.10
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Stirling Online Research Repository (University of Stirling) (submittedVersion)
Funders: U.S. Public Health Service (M01-0073, 38010)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: muscle protein synthesis, muscle protein degradation, resistance training, eccentric contraction, concentric contraction, net protein balance, post-exercise recovery
MeSH terms: Adult, Biopsy, Creatine Kinase, Creatinine, Deuterium, Female, Humans, Male, Methylhistidines, Muscle Proteins, Nitrogen Isotopes, Phenylalanine, Rest, Time Factors, Urea, Biomarkers, Exercise, Muscle, Skeletal

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Mixed muscle protein synthesis and breakdown after resistance exercise in humans

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