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Cited by 24,451

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants

Dermyshi, Elda, Wang, Yizhong, Yan, Chongbin, Hong, Wenchao, Qiu, Gang, Gong, Xiaohui, Zhang, Ting·2017·Neonatology
DOI 10.1159/000454668
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Abstract

Background: Over the last few years, probiotics have been one of the most studied interventions in neonatal medicine. Objectives: The aim of this work was to analyse all studies (randomized controlled trials, RCTs, and observational studies) assessing the use of probiotics in very low birth weight (VLBW) preterm infants. Search Methods: A systematic literature search was conducted using PubMed, Embase, Cochrane Library, and Web of Science. The data from RCTs and observational studies were pooled and analysed separately. Selection Criteria: RCTs and observational studies that enrolled VLBW infants with enteral administration of probiotics were considered. Extracted study data included probiotic characteristics and at least 1 clinical outcome (necrotizing enterocolitis [NEC], late-onset sepsis or all-cause mortality). Data Collection and Analysis: Forty-four studies were eligible for our review: 30 RCTs and 14 observational studies. Severe NEC rates (stage II or more) and all-cause mortality were reduced among the probiotic groups in both the RCTs (RR 0.57, 95% CI 0.47-0.70, and RR 0.77, 95% CI 0.65-0.92, respectively) and the observational studies (RR 0.51, 95% CI 0.37-0.70, and RR 0.71, 95% CI 0.62-0.81, respectively). Furthermore, there was a 12% reduction in the risk of sepsis in RCTs and a 19% reduction in observational studies. The meta-analysis of observational studies showed a reduction in the risk of NEC in extremely low birth weight infants. However, this was not statistically significant. Conclusions: This meta-analysis of RCT and observational studies found that the use of probiotics was beneficial for the prevention of severe NEC, late-onset sepsis, and all-cause mortality in VLBW infants.

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Cited by

Items 701–800 of 1,270

Metadata

Authors
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T.
Venue
Neonatology
Publisher
S. Karger AG
Published
2017
Volume
112
Issue
1
Pages
9-23
ISSN
  • 1661-7800 (ISSN-L)
  • 1661-7819
DOI
10.1159/000454668
OpenAlex
W2588681363
Cited by
24,451
References
12
FWCI
200.65
Type
journal article
Language
en
Open access
closed
Licence

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