CoChat
Sign Up
Cited by 4,794

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, Jay D., Goldstein, Joseph L., Brown, Michael S.·2002·Journal of Clinical Investigation
DOI 10.1172/jci15593
Open this paper in CoChat — free account

Abstract

Lipid homeostasis in vertebrate cells is regulated by a family of membrane-bound transcription factors designated sterol regulatory element-binding proteins (SREBPs).SREBPs directly activate the expression of more than 30 genes dedicated to the synthesis and uptake of cholesterol, fatty acids, triglycerides, and phospholipids, as well as the NADPH cofactor required to synthesize these molecules (1-4).In the liver, three SREBPs regulate the production of lipids for export into the plasma as lipoproteins and into the bile as micelles.The complex, interdigitated roles of these three SREBPs have been dissected through the study of ten different lines of gene-manipulated mice.These studies form the subject of this review.

Overview

Integrity signals

Registry

Crossref · 10.1172/jci0215593

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 4 references

Research works printed but not linked: 44

  1. Brown, 1997, Cell, 89, 331, 10.1016/S0092-8674(00)80213-5 · DOI · Paper page
  2. Horton, 1999, Curr Opin Lipidol, 10, 143, 10.1097/00041433-199904000-00008 · DOI
  3. Edwards, 2000, Biochim Biophys Acta, 1529, 103, 10.1016/S1388-1981(00)00140-2 · DOI
  4. Sakakura, 2001, Biochem Biophys Res Commun, 286, 176, 10.1006/bbrc.2001.5375 · DOI
  5. Goldstein, 2002, Arch Biochem Biophys, 397, 139, 10.1006/abbi.2001.2615 · DOI · Paper page
  6. Shimomura, 1997, J Clin Invest, 99, 838, 10.1172/JCI119247 · DOI
  7. Moon, 2001, J Biol Chem, 276, 45358, 10.1074/jbc.M108413200 · DOI
  8. Shimomura, 1998, J Biol Chem, 273, 35299, 10.1074/jbc.273.52.35299 · DOI · Paper page
  9. Shimano, 1996, J Clin Invest, 98, 1575, 10.1172/JCI118951 · DOI
  10. Shimano, 1997, J Clin Invest, 99, 846, 10.1172/JCI119248 · DOI · Paper page
  11. Horton, 1998, J Clin Invest, 101, 2331, 10.1172/JCI2961 · DOI
  12. Korn, 1998, J Clin Invest, 102, 2050, 10.1172/JCI5341 · DOI · Paper page
  13. Shimano, 1997, J Clin Invest, 100, 2115, 10.1172/JCI119746 · DOI · Paper page
  14. Matsuda, 2001, Genes Dev, 15, 1206, 10.1101/gad.891301 · DOI · Paper page
  15. Yang, 2001, Proc Natl Acad Sci USA, 98, 13607, 10.1073/pnas.201524598 · DOI · Paper page
  16. Mitchell, 2001, Nat Genet, 28, 241, 10.1038/90074 · DOI · Paper page
  17. Hua, 1996, Cell, 87, 415, 10.1016/S0092-8674(00)81362-8 · DOI · Paper page
  18. Shimomura, 1997, Proc Natl Acad Sci USA, 94, 12354, 10.1073/pnas.94.23.12354 · DOI · Paper page
  19. Sato, 1996, J Biol Chem, 271, 26461, 10.1074/jbc.271.43.26461 · DOI
  20. Amemiya-Kudo, 2000, J Biol Chem, 275, 31078, 10.1074/jbc.M005353200 · DOI · Paper page
  21. Janowski, 1999, Proc Natl Acad Sci USA, 96, 266, 10.1073/pnas.96.1.266 · DOI
  22. Repa, 2000, Genes Dev, 14, 2819, 10.1101/gad.844900 · DOI
  23. DeBose-Boyd, 2001, Proc Natl Acad Sci USA, 98, 1477, 10.1073/pnas.98.4.1477 · DOI · Paper page
  24. Xu, 1999, J Biol Chem, 274, 23577, 10.1074/jbc.274.33.23577 · DOI · Paper page
  25. Ou, 2001, Proc Natl Acad Sci USA, 98, 6027, 10.1073/pnas.111138698 · DOI
  26. Xu, 2001, J Biol Chem, 276, 9800, 10.1074/jbc.M008973200 · DOI
  27. Foretz, 1999, Proc Natl Acad Sci USA, 96, 12737, 10.1073/pnas.96.22.12737 · DOI
  28. Shimomura, 1999, Proc Natl Acad Sci USA, 96, 13656, 10.1073/pnas.96.24.13656 · DOI
  29. Foretz, 1999, Mol Cell Biol, 19, 3760, 10.1128/MCB.19.5.3760 · DOI
  30. Shimomura, 2000, Mol Cell, 6, 77, 10.1016/S1097-2765(05)00010-9 · DOI
  31. Horton, 1998, Proc Natl Acad Sci USA, 95, 5987, 10.1073/pnas.95.11.5987 · DOI · Paper page
  32. Kim, 1998, J Clin Invest, 101, 1, 10.1172/JCI1411 · DOI
  33. Shimano, 1999, J Biol Chem, 274, 35832, 10.1074/jbc.274.50.35832 · DOI · Paper page
  34. Becard, 2001, Diabetes, 50, 2425, 10.2337/diabetes.50.11.2425 · DOI
  35. Chakravarty, 2001, J Biol Chem, 276, 34816, 10.1074/jbc.M103310200 · DOI
  36. Marchesini, 2001, Diabetes, 50, 1844, 10.2337/diabetes.50.8.1844 · DOI · Paper page
  37. Shimomura, 1999, J Biol Chem, 274, 30028, 10.1074/jbc.274.42.30028 · DOI
  38. Lin, 2000, Nat Med, 6, 998, 10.1038/79697 · DOI · Paper page
  39. Gillian-Daniel, 2002, Proc Natl Acad Sci USA, 99, 4337, 10.1073/pnas.072557199 · DOI · Paper page
  40. Horton, 1999, J Clin Invest, 103, 1067, 10.1172/JCI6246 · DOI
  41. Pai, 1998, J Biol Chem, 273, 26138, 10.1074/jbc.273.40.26138 · DOI
  42. Latasa, 2000, Proc Natl Acad Sci USA, 97, 10619, 10.1073/pnas.180306597 · DOI
  43. Joseph, 2002, J Biol Chem, 277, 11019, 10.1074/jbc.M111041200 · DOI
  44. Hannah, 2001, J Biol Chem, 276, 4365, 10.1074/jbc.M007273200 · DOI · Paper page

Cited by

Sorted by citations

Items 101–174 of 174

Metadata

Authors
Horton, J. D., Goldstein, J. L., & Brown, M. S.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2002-05-01
Volume
109
Issue
9
Pages
1125-1131
ISSN
0021-9738
DOI
10.1172/jci15593
Cited by
4,794
References
4
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review