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Basal lamina changes in neurodegenerative disorders
Open accessAbstract
Background: Neurodegenerative disorders are a group of age-associated diseases characterized by progressive degeneration of the structure and function of the CNS. Two key pathological features of these disorders are blood-brain barrier (BBB) breakdown and protein aggregation. Main body: The BBB is composed of various cell types and a non-cellular component---the basal lamina (BL). Although how different cells affect the BBB is well studied, the roles of the BL in BBB maintenance and function remain largely unknown. In addition, located in the perivascular space, the BL is also speculated to regulate protein clearance via the meningeal lymphatic/glymphatic system. Recent studies from our laboratory and others have shown that the BL actively regulates BBB integrity and meningeal lymphatic/glymphatic function in both physiological and pathological conditions, suggesting that it may play an important role in the pathogenesis and/or progression of neurodegenerative disorders. In this review, we focus on changes of the BL and its major components during aging and in neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). First, we introduce the vascular and lymphatic systems in the CNS. Next, we discuss the BL and its major components under homeostatic conditions, and summarize their changes during aging and in AD, PD, and ALS in both rodents and humans. The functional significance of these alterations and potential therapeutic targets are also reviewed. Finally, key challenges in the field and future directions are discussed. Conclusions: Understanding BL changes and the functional significance of these changes in neurodegenerative disorders will fill the gap of knowledge in the field. Our goal is to provide a clear and concise review of the complex relationship between the BL and neurodegenerative disorders to stimulate new hypotheses and further research in this field.
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“Breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive decline”
From ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease (2022) · cites this paper as Nguyen et al 2021
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Sorted by citations
ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease
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Metadata
- Authors
- Nguyen, B., Bix, G., & Yao, Y.
- Affiliations
- University of Georgia (US)
- Tulane University (US)
- Corresponding author
- Yao, Yao
- Venue
- Molecular Neurodegeneration
- Published
- 2021-12-07
- Volume
- 16
- Issue
- 1
- Pages
- 81-81
- ISSN
- 1750-1326 (ISSN-L)
- PMC
- PMC8650282
- OpenAlex
- W4200551731
- Cited by
- 75
- References
- 354
- Citations by year
- 2026: 9 · 2025: 23 · 2024: 16 · 2023: 13 · 2022: 14
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Molecular Neurodegeneration (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Heart, Lung, and Blood Institute (R01HL146574)
- National Institute on Aging (R21AG064422, R21AG073862, RF1AG065345)
- American Heart Association (16SDG29320001)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- basement membrane, neurodegenerative diseases, blood-brain barrier, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, aging, meningeal lymphatic system, glymphatic system, protein clearance, protein aggregation, perivascular spaces, therapeutic target
- MeSH terms
- Glymphatic System, Alzheimer Disease, Basement Membrane, Blood-Brain Barrier, Humans, Neurodegenerative Diseases
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