Cited by 1,824

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Disordered Microbial Communities in Asthmatic Airways

Open access

Hilty, Markus, Burke, Conor, Pedro, Helder, Cardenas, Paul, Bush, Andy, Bossley, Cara, Davies, Jane, Ervine, Aaron, Poulter, Len, Pachter, Lior, Moffatt, Miriam F., Cookson, William O. C.·2010·PLoS ONE

DOI 10.1371/journal.pone.0008578

Open this paper in CoChat — free account

Abstract

BACKGROUND: A rich microbial environment in infancy protects against asthma [1], [2] and infections precipitate asthma exacerbations [3]. We compared the airway microbiota at three levels in adult patients with asthma, the related condition of COPD, and controls. We also studied bronchial lavage from asthmatic children and controls. PRINCIPAL FINDINGS: We identified 5,054 16S rRNA bacterial sequences from 43 subjects, detecting >70% of species present. The bronchial tree was not sterile, and contained a mean of 2,000 bacterial genomes per cm(2) surface sampled. Pathogenic Proteobacteria, particularly Haemophilus spp., were much more frequent in bronchi of adult asthmatics or patients with COPD than controls. We found similar highly significant increases in Proteobacteria in asthmatic children. Conversely, Bacteroidetes, particularly Prevotella spp., were more frequent in controls than adult or child asthmatics or COPD patients. SIGNIFICANCE: The results show the bronchial tree to contain a characteristic microbiota, and suggest that this microbiota is disturbed in asthmatic airways.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0008578

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An ecological and evolutionary perspective on human–microbe mutualism and disease
Dethlefsen, L., McFall-Ngai, M., & Relman, D. A. (2007) · Nature · doi:10.1038/nature06245 · Cited by 1,660
Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness
Morens, D. M., Taubenberger, J. K., & Fauci, A. S. (2008) · The Journal of Infectious Diseases · doi:10.1086/591708 · Cited by 1,625 · cited 2×
“Significantly, death in the 1918–1919, 1957 and 1968 influenza pandemics resulted most commonly from secondary bacterial pneumonia caused by organisms presumed to be previously present in the respiratory tract [10,11].”
Background
The asthma epidemic
Eder, W., Ege, M. J., & von Mutius, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054308 · Cited by 1,621
Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
Artis, D. (2008) · Nature reviews. Immunology · doi:10.1038/nri2316 · Cited by 1,136

Show all 4 references

Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00202013 · Cited by 3,926
Self-citation
Microbiota in health and diseases
Hou, K., Wu, Z.-X., Chen, X.-Y., Wang, J.-Q., Zhang, D., Xiao, C., Zhu, D., Koya, J. B., Wei, L., Li, J., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00974-4 · Cited by 3,171
Gut Microbiota Metabolism of Dietary Fiber Influences Allergic Airway Disease and Hematopoiesis
Trompette, A., Gollwitzer, E. S., Yadava, K., Sichelstiel, A. K., Sprenger, N., Ngom-Bru, C., Blanchard, C., Junt, T., Nicod, L. P., Harris, N. L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3444 · Cited by 2,862
The healthy human microbiome
Lloyd-Price, J., Abu-Ali, G., & Huttenhower, C. (2016) · Genome Medicine · doi:10.1186/s13073-016-0307-y · Cited by 1,891
The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment
Zhang, X., Zhang, D., Jia, H., Feng, Q., Wang, D., Liang, D., Wu, X., Li, J., Tang, L., Li, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3914 · Cited by 1,690
Exposure to Environmental Microorganisms and Childhood Asthma
Ege, M. J., Mayer, M., Normand, A.-C., Genuneit, J., Cookson, W. O. C. M., Braun-Fahrländer, C., Heederik, D., Piarroux, R., & von Mutius, E. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1007302 · Cited by 1,529
Self-citation
The immune response to Prevotella bacteria in chronic inflammatory disease
Larsen, J. M. (2017) · Immunology · doi:10.1111/imm.12760 · Cited by 1,343
Topographical Continuity of Bacterial Populations in the Healthy Human Respiratory Tract
Charlson, E. S., Bittinger, K., Haas, A. R., Fitzgerald, A. S., Frank, I., Yadav, A., Bushman, F. D., & Collman, R. G. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201104-0655oc · Cited by 1,144
Analysis of the lung microbiome in the “healthy” smoker and in COPD.
Erb-Downward, J. R., Thompson, D. L., Han, M. K., Freeman, C. M., McCloskey, L., Schmidt, L. A., Young, V. B., Toews, G. B., Curtis, J. L., Sundaram, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016384 · Cited by 973
The Microbiome and the Respiratory Tract
Dickson, R. P., Erb-Downward, J. R., Martinez, F. J., & Huffnagle, G. B. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105238 · Cited by 953
The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development
Teo, S. M., Mok, D., Pham, K., Kusel, M., Serralha, M., Troy, N., Holt, B. J., Hales, B. J., Walker, M. L., Hollams, E., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.008 · Cited by 953
Obesity and asthma
Peters, U., Dixon, A. E., & Forno, E. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.02.004 · Cited by 934
Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals
Bassis, C. M., Erb-Downward, J. R., Dickson, R. P., Freeman, C. M., Schmidt, T. M., Young, V. B., Beck, J. M., Curtis, J. L., & Huffnagle, G. B. (2015) · mBio · doi:10.1128/mbio.00037-15 · Cited by 839
“During states of ill health, such as viral upper respiratory tract infections, allergies, or sinus infections, the liquid flow from the nasal cavity increases, and this clearly has the potential to affect the lung microbiome, consistent with studies of rhinovirus infection and asthmatics that highlighted changes in th…”
Background
Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers
Morris, A., Beck, J. M., Schloss, P. D., Campbell, T. B., Crothers, K., Curtis, J. L., Flores, S. C., Fontenot, A. P., Ghedin, E., Huang, L., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201210-1913oc · Cited by 822
Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age
Bisgaard, H., Li, N., Bonnelykke, K., Chawes, B. L. K., Skov, T., Paludan-Müller, G., Stokholm, J., Smith, B., & Krogfelt, K. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.04.060 · Cited by 786
Asthma: Definitions and Pathophysiology
Mims, J. W. (2015) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21609 · Cited by 711
Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome
Dickson, R. P., Singer, B. H., Newstead, M. W., Falkowski, N. R., Erb-Downward, J. R., Standiford, T. J., & Huffnagle, G. B. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.113 · Cited by 724
The Microbiota of Breast Tissue and Its Association with Breast Cancer
Urbaniak, C., Gloor, G. B., Brackstone, M., Scott, L., Tangney, M., & Reid, G. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.01235-16 · Cited by 625
Lung microbiota promotes tolerance to allergens in neonates via PD-L1
Gollwitzer, E. S., Saglani, S., Trompette, A., Yadava, K., Sherburn, R., McCoy, K. D., Nicod, L. P., Lloyd, C. M., & Marsland, B. J. (2014) · Nature Medicine · doi:10.1038/nm.3568 · Cited by 596
The influence of the microbiome on respiratory health
Wypych, T. P., Wickramasinghe, L. C., & Marsland, B. J. (2019) · Nature Immunology · doi:10.1038/s41590-019-0451-9 · Cited by 611
The role of bacteria in the pathogenesis and progression of idiopathic pulmonary fibrosis
Molyneaux, P. L., Cox, M. J., Willis-Owen, S. A. G., Mallia, P., Russell, K. E., Russell, A.-M., Murphy, E., Johnston, S. L., Schwartz, D. A., Wells, A. U., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201403-0541oc · Cited by 567
Self-citation
Bacterial topography of the healthy human lower respiratory tract
Dickson, R. P., Erb-Downward, J. R., Freeman, C. M., McCloskey, L., Falkowski, N. R., Huffnagle, G. B., & Curtis, J. L. (2017) · mBio · doi:10.1128/mbio.02287-16 · Cited by 548
Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology
Akdis, C. A., Bachert, C., Cingi, C., Dykewicz, M. S., Hellings, P. W., Naclerio, R. M., Schleimer, R. P., & Ledford, D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.036 · Cited by 538
The respiratory tract microbiome and lung inflammation: a two-way street.
Huffnagle, G. B., Dickson, R. P., & Lukacs, N. W. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.108 · Cited by 535
The role of the microbiome in exacerbations of chronic lung diseases
Dickson, R. P., Martinez, F. J., & Huffnagle, G. B. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61136-3 · Cited by 495
Analysis of Gut Microbiota in Patients with Parkinson’s Disease
Petrov, V. A., Saltykova, I. V., Zhukova, I. A., Alifirova, V. M., Zhukova, N. G., Dorofeeva, Y. B., Tyakht, A. V., Kovarsky, B. A., Alekseev, D. G., Kostryukova, E. S., et al. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3700-7 · Cited by 487
Role of Probiotics in Human Gut Microbiome-Associated Diseases
Kim, S.-K., Guevarra, R. B., Kim, Y.-T., Kwon, J., Kim, H., Cho, J. H., Kim, H. B., & Lee, J.-H. (2019) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1906.06064 · Cited by 519
Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease
Bloom, S. M., Bijanki, V. N., Nava, G. M., Sun, L., Malvin, N. P., Donermeyer, D. L., Dunne, W. M., Allen, P. M., & Stappenbeck, T. S. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.009 · Cited by 488
Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation
Segal, L. N., Alekseyenko, A. V., Clemente, J. C., Kulkarni, R., Wu, B., Chen, H., Berger, K. I., Goldring, R. M., Rom, W. N., Blaser, M. J., et al. (2013) · Microbiome · doi:10.1186/2049-2618-1-19 · Cited by 482
Interaction between the microbiome and TP53 in human lung cancer
Greathouse, K. L., White, J. R., Vargas, A. J., Bliskovsky, V. V., Beck, J. A., von Muhlinen, N., Polley, E. C., Bowman, E. D., Khan, M. A., Robles, A. I., et al. (2018) · Genome Biology · doi:10.1186/s13059-018-1501-6 · Cited by 446
The role of the lung microbiota and the gut–lung axis in respiratory infectious diseases
Dumas, A., Bernard, L., Poquet, Y., Lugo-Villarino, G., & Neyrolles, O. (2018) · Cellular Microbiology · doi:10.1111/cmi.12966 · Cited by 444
Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization
Herbst, T., Sichelstiel, A., Schär, C., Yadava, K., Bürki, K., Cahenzli, J., McCoy, K., Marsland, B. J., & Harris, N. L. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1574oc · Cited by 440
The lung microbiome in moderate and severe chronic obstructive pulmonary disease
Pragman, A. A., Kim, H. B., Reilly, C. S., Wendt, C., & Isaacson, R. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047305 · Cited by 437
Disordered Microbial Communities in the Upper Respiratory Tract of Cigarette Smokers
Charlson, E. S., Chen, J., Custers-Allen, R., Bittinger, K., Li, H., Sinha, R., Hwang, J., Bushman, F. D., & Collman, R. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015216 · Cited by 437
The biodiversity hypothesis and allergic disease: world allergy organization position statement
Haahtela, T., Holgate, S., Pawankar, R., Akdis, C. A., Benjaponpitak, S., Caraballo, L., Demain, J., Portnoy, J., & von Hertzen, L. (2013) · World Allergy Organization Journal · doi:10.1186/1939-4551-6-3 · Cited by 426
A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies
Calder, P. C., Ahluwalia, N., Albers, R., Bosco, N., Bourdet-Sicard, R., Haller, D., Holgate, S. T., Jönsson, L. S., Latulippe, M. E., Marcos, A., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512005119 · Cited by 425
Sinus Microbiome Diversity Depletion and Corynebacterium tuberculostearicum Enrichment Mediates Rhinosinusitis
Abreu, N. A., Nagalingam, N. A., Song, Y., Roediger, F. C., Pletcher, S. D., Goldberg, A. N., & Lynch, S. V. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003783 · Cited by 415
Outgrowth of the bacterial airway microbiome after rhinovirus exacerbation of chronic obstructive pulmonary disease
Molyneaux, P. L., Mallia, P., Cox, M. J., Footitt, J., Willis-Owen, S. A. G., Homola, D., Trujillo-Torralbo, M.-B., Elkin, S., Kon, O. M., Cookson, W. O. C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201302-0341oc · Cited by 390
Compartmentalized and systemic control of tissue immunity by commensals
Belkaid, Y., & Naik, S. (2013) · Nature Immunology · doi:10.1038/ni.2604 · Cited by 382
Structural changes in the gut microbiome of constipated patients
Zhu, L., Liu, W., Alkhouri, R., Baker, R. D., Bard, J. E., Quigley, E. M., & Baker, S. S. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00082.2014 · Cited by 381
The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease
O’Dwyer, D. N., Dickson, R. P., & Moore, B. B. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600279 · Cited by 362
Towards an ecology of the lung: new conceptual models of pulmonary microbiology and pneumonia pathogenesis
Dickson, R. P., Erb-Downward, J. R., & Huffnagle, G. B. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70028-1 · Cited by 371
The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma
Goleva, E., Jackson, L. P., Harris, J. K., Robertson, C. E., Sutherland, E. R., Hall, C. F., Good, J. T., Gelfand, E. W., Martin, R. J., & Leung, D. Y. M. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201304-0775oc · Cited by 363
Fungal allergy in asthma-state of the art and research needs
Denning, D. W., Pashley, C., Hartl, D., Wardlaw, A., Godet, C., Del Giacco, S., Delhaes, L., & Sergejeva, S. (2014) · Clinical and Translational Allergy · doi:10.1186/2045-7022-4-14 · Cited by 357
Characterization of microbiome in bronchoalveolar lavage fluid of patients with lung cancer comparing with benign mass like lesions
Lee, S. H., Sung, J. Y., Yong, D., Chun, J., Kim, S. Y., Song, J. H., Chung, K. S., Kim, E. Y., Jung, J. Y., Kang, Y. A., et al. (2016) · Lung Cancer · doi:10.1016/j.lungcan.2016.10.016 · Cited by 354
Lung-enriched Organisms and Aberrant Bacterial and Fungal Respiratory Microbiota after Lung Transplant
Charlson, E. S., Diamond, J. M., Bittinger, K., Fitzgerald, A. S., Yadav, A., Haas, A. R., Bushman, F. D., & Collman, R. G. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0693oc · Cited by 348
The microbiome in allergic disease: Current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology
Huang, Y. J., Marsland, B. J., Bunyavanich, S., O'Mahony, L., Leung, D. Y. M., Muraro, A., & Fleisher, T. A. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.02.007 · Cited by 330
Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation
Tunney, M. M., Einarsson, G. G., Wei, L., Drain, M., Klem, E. R., Cardwell, C., Ennis, M., Boucher, R. C., Wolfgang, M. C., & Elborn, J. S. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201210-1937oc · Cited by 316
Gut-Lung Axis: The Microbial Contributions and Clinical Implications
He, Y., Wen, Q., Yao, F., Xu, D., Huang, Y., & Wang, J. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1176988 · Cited by 301
Natural immunity: Biodiversity loss and inflammatory diseases are two global megatrends that might be related
von Hertzen, L., Hanski, I., & Haahtela, T. (2011) · The EMBO Reports · doi:10.1038/embor.2011.195 · Cited by 304
Smoking and microbiome in oral, airway, gut and some systemic diseases
Huang, C., & Shi, G. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1971-7 · Cited by 288
Microbiome effects on immunity, health and disease in the lung
Shukla, S. D., Budden, K. F., Neal, R., & Hansbro, P. M. (2017) · Clinical & Translational Immunology · doi:10.1038/cti.2017.6 · Cited by 287
Epithelial barrier repair and prevention of allergy
Goleva, E., Berdyshev, E., & Leung, D. Y. M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124608 · Cited by 251
The microbiome in respiratory medicine: current challenges and future perspectives
Faner, R., Sibila, O., Agustí, A., Bernasconi, E., Chalmers, J. D., Huffnagle, G. B., Manichanh, C., Molyneaux, P. L., Paredes, R., Pérez Brocal, V., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.02086-2016 · Cited by 247
Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients
de Steenhuijsen Piters, W. A. A., Huijskens, E. G. W., Wyllie, A. L., Biesbroek, G., van den Bergh, M. R., Veenhoven, R. H., Wang, X., Trzciński, K., Bonten, M. J., Rossen, J. W. A., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2015.99 · Cited by 235
Difference of lower airway microbiome in bilateral protected specimen brush between lung cancer patients with unilateral lobar masses and control subjects
Liu, H., Tao, L., Zhang, J., Zhu, Y., Zheng, Y., Liu, D., Zhou, M., Ke, H., Shi, M., & Qu, J. (2018) · International Journal of Cancer · doi:10.1002/ijc.31098 · Cited by 235
The microbiology of asthma
Edwards, M. R., Bartlett, N. W., Hussell, T., Openshaw, P., & Johnston, S. L. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2801 · Cited by 205
Chronic obstructive pulmonary disease and asthma‐associated Proteobacteria, but not commensal Prevotella spp., promote Toll‐like receptor 2‐independent lung inflammation and pathology
Larsen, J. M., Musavian, H. S., Butt, T. M., Ingvorsen, C., Thysen, A. H., & Brix, S. (2015) · Immunology · doi:10.1111/imm.12376 · Cited by 200
Occurrence and Dynamism of Lactic Acid Bacteria in Distinct Ecological Niches: A Multifaceted Functional Health Perspective
George, F., Daniel, C., Thomas, M., Singer, E., Guilbaud, A., Tessier, F. J., Revol-Junelles, A.-M., Borges, F., & Foligné, B. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02899 · Cited by 198
The microbial environment and its influence on asthma prevention in early life
von Mutius, E. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.12.1301 · Cited by 188
Microbiota Promotes Chronic Pulmonary Inflammation by Enhancing IL-17A and Autoantibodies
Yadava, K., Pattaroni, C., Sichelstiel, A. K., Trompette, A., Gollwitzer, E. S., Salami, O., von Garnier, C., Nicod, L. P., & Marsland, B. J. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201504-0779oc · Cited by 184
Inflammation and Airway Microbiota during Cystic Fibrosis Pulmonary Exacerbations
Zemanick, E. T., Harris, J. K., Wagner, B. D., Robertson, C. E., Sagel, S. D., Stevens, M. J., Accurso, F. J., & Laguna, T. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062917 · Cited by 180
Differences in fungi present in induced sputum samples from asthma patients and non-atopic controls: a community based case control study
van Woerden, H. C., Gregory, C., Brown, R., Marchesi, J. R., Hoogendoorn, B., & Matthews, I. P. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-69 · Cited by 177
The role of infection in the pathogenesis of idiopathic pulmonary fibrosis
Molyneaux, P. L., & Maher, T. M. (2013) · European Respiratory Review · doi:10.1183/09059180.00000713 · Cited by 171
Increased Risk of Pneumonia and Bronchiolitis after Bacterial Colonization of the Airways as Neonates
Vissing, N. H., Chawes, B. L. K., & Bisgaard, H. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201302-0215oc · Cited by 170
Environmentally Determined Differences in the Murine Lung Microbiota and Their Relation to Alveolar Architecture
Yun, Y., Srinivas, G., Kuenzel, S., Linnenbrink, M., Alnahas, S., Bruce, K. D., Steinhoff, U., Baines, J. F., & Schaible, U. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113466 · Cited by 168
The Role of the Lung Microbiome in Health and Disease. A National Heart, Lung, and Blood Institute Workshop Report
Huang, Y. J., Charlson, E. S., Collman, R. G., Colombini-Hatch, S., Martinez, F. D., & Senior, R. M. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201303-0488ws · Cited by 156
Multicenter comparison of lung and oral microbiomes of HIV-infected and HIV-uninfected individuals.
Beck, J. M., Schloss, P. D., Venkataraman, A., Twigg, H., Jablonski, K. A., Bushman, F. D., Campbell, T. B., Charlson, E. S., Collman, R. G., Crothers, K., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201501-0128oc · Cited by 150
The lung tissue microbiota of mild and moderate chronic obstructive pulmonary disease
Pragman, A. A., Lyu, T., Baller, J. A., Gould, T. J., Kelly, R. F., Reilly, C. S., Isaacson, R. E., & Wendt, C. H. (2018) · Microbiome · doi:10.1186/s40168-017-0381-4 · Cited by 150
The airway microbiome of intubated premature infants: characteristics and changes that predict the development of bronchopulmonary dysplasia
Lohmann, P., Luna, R. A., Hollister, E. B., Devaraj, S., Mistretta, T.-A., Welty, S. E., & Versalovic, J. (2014) · Pediatric Research · doi:10.1038/pr.2014.85 · Cited by 146
Bronchial microbiome of severe COPD patients colonised by Pseudomonas aeruginosa
Millares, L., Ferrari, R., Gallego, M., Garcia-Nuñez, M., Pérez-Brocal, V., Espasa, M., Pomares, X., Monton, C., Moya, A., & Monsó, E. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-013-2044-0 · Cited by 136
Repertoire of intensive care unit pneumonia microbiota
Bousbia, S., Papazian, L., Saux, P., Forel, J. M., Auffray, J.-P., Martin, C., Raoult, D., & La Scola, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032486 · Cited by 118
Mechanistic insight into the function of the microbiome in lung diseases
Ubags, N. D. J., & Marsland, B. J. (2017) · European Respiratory Journal · doi:10.1183/13993003.02467-2016 · Cited by 109
Nasopharyngeal Microbiota in Infants With Acute Otitis Media
Hilty, M., Qi, W., Brugger, S. D., Frei, L., Agyeman, P., Frey, P. M., Aebi, S., & Mühlemann, K. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis024 · Cited by 106
Self-citation
Microbiota abnormalities in inflammatory airway diseases — Potential for therapy
Gollwitzer, E. S., & Marsland, B. J. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.08.002 · Cited by 100
Severe asthma in children
Bush, A., Fleming, L., & Saglani, S. (2017) · Respirology · doi:10.1111/resp.13085 · Cited by 106
Self-citation
The respiratory microbiome: an underappreciated player in the human response to inhaled pollutants?
Adar, S. D., Huffnagle, G. B., & Curtis, J. L. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.03.010 · Cited by 88
Microbiome and Asthma: Microbial Dysbiosis and the Origins, Phenotypes, Persistence, and Severity of Asthma
Valverde-Molina, J., & García-Marcos, L. (2023) · Nutrients · doi:10.3390/nu15030486 · Cited by 92
Analysis of the association between host genetics, smoking, and sputum microbiota in healthy humans
Lim, M. Y., Yoon, H. S., Rho, M., Sung, J., Song, Y.-M., Lee, K., & Ko, G. (2016) · Scientific Reports · doi:10.1038/srep23745 · Cited by 89
Airway Microbial Diversity is Inversely Associated with Mite-Sensitized Rhinitis and Asthma in Early Childhood
Chiu, C.-Y., Chan, Y.-L., Tsai, Y.-S., Chen, S.-A., Wang, C.-J., Chen, K.-F., & Chung, I.-F. (2017) · Scientific Reports · doi:10.1038/s41598-017-02067-7 · Cited by 84
Molecular Identification of Bacteria in Tracheal Aspirate Fluid from Mechanically Ventilated Preterm Infants
Mourani, P. M., Harris, J. K., Sontag, M. K., Robertson, C. E., & Abman, S. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025959 · Cited by 78
Taxa of the nasal microbiome are associated with influenza-specific IgA response to live attenuated influenza vaccine
Salk, H. M., Simon, W. L., Lambert, N. D., Kennedy, R. B., Grill, D. E., Kabat, B. F., & Poland, G. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162803 · Cited by 75
Exposure to common respiratory bacteria alters the airway epithelial response to subsequent viral infection
Bellinghausen, C., Gulraiz, F., Heinzmann, A. C. A., Dentener, M. A., Savelkoul, P. H. M., Wouters, E. F., Rohde, G. G., & Stassen, F. R. (2016) · Respiratory Research · doi:10.1186/s12931-016-0382-z · Cited by 71
Selective pressures during chronic infection drive microbial competition and cooperation
Baishya, J., & Wakeman, C. A. (2019) · npj Biofilms and Microbiomes · doi:10.1038/s41522-019-0089-2 · Cited by 70
Modulation of potential respiratory pathogens by pH1N1 viral infection.
Leung, R. K.-K., Zhou, J.-W., Guan, W., Li, S.-K., Yang, Z.-F., & Tsui, S. K.-W. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12054 · Cited by 66
Nasopharyngeal microbiome diversity changes over time in children with asthma
Pérez-Losada, M., Alamri, L., Crandall, K. A., & Freishtat, R. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170543 · Cited by 63
Asthma in the Precision Medicine Era: Biologics and Probiotics
Chiu, C.-J., & Huang, M.-T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094528 · Cited by 60
Addressing unmet needs in understanding asthma mechanisms: From the European Asthma Research and Innovation Partnership (EARIP) Work Package (WP)2 collaborators
Edwards, M. R., Saglani, S., Schwarze, J., Skevaki, C., Smith, J. A., Ainsworth, B., Almond, M., Andreakos, E., Belvisi, M. G., Chung, K. F., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.02448-2016 · Cited by 55
Self-citation
Microbiome influences on allergy in mice and humans
Marsland, B. J., & Salami, O. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.07.005 · Cited by 49
The microbiome of the human lower airways: a next generation sequencing perspective
Aho, V. T. E., Pereira, P. A. B., Haahtela, T., Pawankar, R., Auvinen, P., & Koskinen, K. (2015) · World Allergy Organization Journal · doi:10.1186/s40413-015-0074-z · Cited by 47
The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges
Tang, H. H. F., Teo, S. M., Sly, P. D., Holt, P. G., & Inouye, M. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.08.026 · Cited by 43
Microbiome: paediatricians’ perspective
Arora, S., Dewan, P., & Gupta, P. (2015) · Indian Journal of Medical Research · doi:10.4103/0971-5916.171275 · Cited by 39
Oral Microbiomes in Children with Asthma and Dental Caries
Cherkasov, S. V., Popova, L. Y., Vivtanenko, T. V., Demina, R. R., Khlopko, Y. A., Balkin, A. S., & Plotnikov, A. O. (2019) · Oral Diseases · doi:10.1111/odi.13020 · Cited by 26

Authors: Hilty, M., Burke, C., Pedro, H., Cardenas, P., Bush, A., Bossley, C., Davies, J., Ervine, A., Poulter, L., Pachter, L., Moffatt, M. F., & Cookson, W. O. C.
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2010-01-05
Volume: 5
Issue: 1
Pages: e8578
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0008578
OpenAlex: W2050591900
Cited by: 1,824
References: 4
FWCI: 47.37
Type: journal article
Language: en
Open access: gold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Disordered Microbial Communities in Asthmatic Airways

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks

Data sources