Nicotine and Hippocampus-Dependent Learning: Implications for Addiction

Gould, Thomas J.

doi:10.1385/mn:34:2:93

Cited by 61Memory and Neural MechanismsNicotinic Acetylcholine Receptors StudySmoking Behavior and Cessation

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Nicotine and Hippocampus-Dependent Learning: Implications for Addiction

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Gould, Thomas J.·2006·Molecular Neurobiology

DOI 10.1385/mn:34:2:93PMC PMC2716133

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Abstract

Addiction is a complex disorder because many factors contribute to the development and maintenance of addiction. One factor is learning. For example, drug-context associations that develop during drug use could facilitate drug craving upon re-exposure to contexts previously associated with drugs. Additionally, deficits in cognitive processes associated with withdrawal could precipitate relapse in attempts to ameliorate those deficits. Because addiction and learning involve common neural areas and cell signaling cascades, addiction-related changes in processes underlying plasticity may contribute to addiction. This article examines similarities between addiction and learning at the behavioral, neural, and cellular levels, with emphasis on the neural substrates underlying the effects of acute nicotine, chronic nicotine, and withdrawal from chronic nicotine on hippocampus-dependent contextual learning.

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Cigarette smoke has been shown to affect the autonomic nervous system via its influence on fear learning.
“cigarette smoke (CS) has been shown to affect the ANS via its influence on fear learning (Gould, 2006).”
From Effectiveness of a Novel Qigong Meditative Movement Practice for Impaired Health in Flight Attendants Exposed to Second-Hand Cigarette Smoke (2017) · cites this paper as Gould, 2006

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Nicotine enhances trace cued fear conditioning but not delay cued fear conditioning in C57BL/6 mice
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Nicotine recruits a local glutamatergic circuit to excite septohippocampal GABAergic neurons
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MK-801 disrupts acquisition of contextual fear conditioning but enhances memory consolidation of cued fear conditioning
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Acute and chronic nicotine exposure reverse age-related declines in the induction of long-term potentiation in the rat hippocampus
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Nicotine increases intracellular calcium in rat hippocampal neurons via voltage-gated calcium channels
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Neuronal MEK is important for normal fear conditioning in mice
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Functional characterization of mouse α4β2 nicotinic acetylcholine receptors stably expressed in HEK293T cells
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NMDA and AMPA Receptors Contribute to the Nicotinic Cholinergic Excitation of CA1 Interneurons in the Rat Hippocampus
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Effects of Prolonged Nicotinic Ligand Exposure on Function of Heterologously Expressed, Human α4β2- and α4β4-Nicotinic Acetylcholine Receptors
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Nicotine produces a within-subject enhancement of contextual fear conditioning in C57BL/6 mice independent of sex
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Nicotine withdrawal syndrome: behavioural distress and selective up‐regulation of the cyclic AMP pathway in the amygdala
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Repetitive exposures to nicotine induce a hyper‐responsiveness via the cAMP/PKA/CREB signal pathway in Drosophila
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Memory formation requires p38MAPK activity in the rat hippocampus
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Coantagonism of glutamate receptors and nicotinic acetylcholinergic receptors disrupts fear conditioning and latent inhibition of fear conditioningPreprint
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Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction
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Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?: Figure 1.
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Modulation of Hippocampus-Dependent Learning and Synaptic Plasticity by Nicotine
Kenney, J. W., & Gould, T. J. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8037-9 · Cited by 242
Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses
Miwa, J. M., Freedman, R., & Lester, H. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.014 · Cited by 205
Tobacco addiction and the dysregulation of brain stress systems
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The pharmacology of the endocannabinoid system: functional and structural interactions with other neurotransmitter systems and their repercussions in behavioral addiction
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Hippocampal α4β2 nicotinic acetylcholine receptor involvement in the enhancing effect of acute nicotine on contextual fear conditioning
Davis, J. A., Kenney, J. W., & Gould, T. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3242-07.2007 · Cited by 107
Self-citation
Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction
Olive, M. F. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.01.029 · Cited by 80
β2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice
Davis, J. A., & Gould, T. J. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0624-8 · Cited by 72
“These nAChR subtypes are critically involved in some hippocampus-dependent tasks (Barros et al. 2004; Curzon et al. 1996; Felix and Levin 1997; Levin et al. 2002) and have a modulatory role in other hippocampus-dependent tasks (Davis and Gould 2006; Wehner et al. 2004).”
BackgroundMethodResultInfluentialSelf-citation
Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research
Portugal, G. S., & Gould, T. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.05.006 · Cited by 73
Hippocampal Long-Term Potentiation Is Disrupted during Expression and Extinction But Is Restored after Reinstatement of Morphine Place Preference
Portugal, G. S., Al‐Hasani, R., Fakira, A. K., González-Romero, J. L., Melyan, Z., McCall, J. G., Bruchas, M. R., & Morón, J. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2838-13.2014 · Cited by 70
β2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning
Portugal, G. S., Kenney, J. W., & Gould, T. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.05.002 · Cited by 66
Varenicline ameliorates nicotine withdrawal-induced learning deficits in C57BL/6 mice.
Raybuck, J. D., Portugal, G. S., Lerman, C., & Gould, T. J. (2008) · Behavioral Neuroscience · doi:10.1037/a0012601 · Cited by 62
Self-citation
Age-associated changes in nicotine dependence
Park, S., Lee, J.-Y., Song, T. M., & Cho, S. (2012) · Public Health · doi:10.1016/j.puhe.2012.02.007 · Cited by 62
“Interestingly, a significant decrease in high-affinity nicotinic binding in the hippocampus, a brain region involved in addiction, has been shown to occur around 40 years of age.(26,27) Reduced nicotinic binding affinity has been shown in patients with neurodegenerative diseases and in aged individuals.”
Background
Substance abuse, memory, and post-traumatic stress disorder
Tipps, M. E., Raybuck, J. D., & Lattal, K. M. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.002 · Cited by 62
“This effect has been replicated across many studies and suggests that chronic exposure to nicotine produces tolerance to its enhancing effects on learning and memory (Gould, 2006).”
BackgroundResult
Hippocampal nAChRs mediate nicotine withdrawal-related learning deficits
Davis, J. A., & Gould, T. J. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.02.003 · Cited by 60
Self-citation
Ryanodine receptor‐2 upregulation and nicotine‐mediated plasticity
Ziviani, E., Lippi, G., Bano, D., Munarriz, E. R., Guiducci, S., Zoli, M., Young, K. W., & Nicotera, P. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.279 · Cited by 59
“In the central nervous system, nicotine has a multitude of effects ranging from enhanced cognitive function to neuro- protection and addiction (Gotti and Clementi, 2004; Gould, 2006; Levin et al, 2006; Rose, 2007; Picciotto and Zoli, 2008).”
Background
Nicotine withdrawal‐induced deficits in trace fear conditioning in C57BL / 6 mice – a role for high‐affinity β2 subunit‐containing nicotinic acetylcholine receptors
Raybuck, J. D., & Gould, T. J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06580.x · Cited by 53
Atomoxetine Reverses Nicotine Withdrawal-Associated Deficits in Contextual Fear Conditioning
Davis, J. A., & Gould, T. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301315 · Cited by 52
“The results of our research (Davis and Gould, 2006; Davis et al, 2005, 2006; Gould, 2003; Gould et al, 2004; Gould and Higgins, 2003; Gould and Lommock, 2003; Gould and Wehner, 1999) and the research of others (Wehner et al, 2004) indicate that acute nicotine dose dependently enhances contextual…”
BackgroundResult
Nicotine facilitates long‐term potentiation induction in oriens‐lacunosum moleculare cells via Ca2+ entry through non‐α7 nicotinic acetylcholine receptors
Jia, Y., Yamazaki, Y., Nakauchi, S., Ito, K., & Sumikawa, K. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07058.x · Cited by 51
Hippocampal and striatal gray matter volume are associated with a smoking cessation treatment outcome: results of an exploratory voxel-based morphometric analysis
Froeliger, B., Kozink, R. V., Rose, J. E., Behm, F. M., Salley, A. N., & McClernon, F. J. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1862-3 · Cited by 49
“Nicotine withdrawal impairs hippocampaldependent memory processes, whereas acute nicotine administration restores it, and these effects are thought to occur via nicotine’s modulation of multiple neurotransmitter systems including acetylcholine, norepinephrine, glutamate, and dopamine (Gould 2006; Levin et al. 2006).”
Background
Associative Learning, the Hippocampus, and Nicotine Addiction
Gould, T. J., & Davis, J. A. (2008) · Current Drug Abuse Reviews · doi:10.2174/1874473710801010009 · Cited by 49
Nicotine withdrawal disrupts new contextual learning
Portugal, G. S., & Gould, T. J. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.11.001 · Cited by 43
“Investigations into the neurobiologyof addictionhave revealed that drugs of abuse can alter learning and memory and that many of the neural substrates disrupted by drug addiction also play an important role in learning and memory (Davis and Gould, 2008; Gould, 2006; Hyman, 2005; Kelley, 2004).”
Background
Patterns and Characteristics of Nicotine Dependence Among Adults With Cigarette Use in the US, 2006-2019
Han, B., Einstein, E. B., & Compton, W. M. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.19602 · Cited by 41
α2 Nicotine receptors function as a molecular switch to continuously excite a subset of interneurons in rat hippocampal circuits
Jia, Y., Yamazaki, Y., Nakauchi, S., & Sumikawa, K. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06706.x · Cited by 39
Nicotine withdrawal disrupts both foreground and background contextual fear conditioning but not pre-pulse inhibition of the acoustic startle response in C57BL/6 mice
André, J. M., Gulick, D., Portugal, G. S., & Gould, T. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.018 · Cited by 38
Varenicline ameliorates ethanol-induced deficits in learning in C57BL/6 mice
Gulick, D., & Gould, T. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.03.002 · Cited by 37
“…diverse neuronal processes (Davis & De Fiebre, 2006) such as those involved in reward/reinforcement (Jerlhag, Grotli, Luthman, Svensson, & Engel, 2006; Walters, Brown, Changeux, Martin, & Damaj, 2006) and learning/memory (Chan, Wong, & Sheu, 2007; Davis, Kenney, & Gould, 2007; Gould, 2006).”
Nicotine and extinction of fear conditioning
Elias, G. A., Gulick, D., Wilkinson, D. S., & Gould, T. J. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.022 · Cited by 36
Nicotine ameliorates NMDA receptor antagonist-induced deficits in contextual fear conditioning through high-affinity nicotinic acetylcholine receptors in the hippocampus
André, J. M., Leach, P. T., & Gould, T. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.004 · Cited by 32
“It is possible that nicotine ameliorates NMDAR antagonist-induced deficits in contextual fear conditioning by gating a sufficient amount of calcium to directly activate learning-related cell signaling cascades (Dajas-Bailador and Wonnacott, 2004; Gould, 2006; Tinsley et al., 2004).”
Background
Heterogeneity of Reward Mechanisms
Lajtha, Á., & Sershen, H. W. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0096-4 · Cited by 32
Nicotine enhances contextual fear memory reconsolidation in rats
Tian, S., Huang, F., Li, P., Zhen-bang, L. I., Zhou, S., Deng, H., & Yang, Y. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.10.058 · Cited by 34
Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits
Sey, N. Y. A., Hu, B., Iskhakova, M., Lee, S., Sun, H., Shokrian, N., Hutta, G. B., Marks, J. A., Quach, B. C., Johnson, E. O., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01558-y · Cited by 28
“We also found strong expression in the hippocampus for ND risk genes, highlighting the role of hippocampus-dependent learning in ND [54].”
Background
Thyroid hormone signaling: Contribution to neural function, cognition, and relationship to nicotine
Leach, P. T., & Gould, T. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.001 · Cited by 24
The effects of galantamine on nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6 mice
Wilkinson, D. S., & Gould, T. J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.010 · Cited by 26
Immediate and persisting effect of toluene chronic exposure on hippocampal cell loss in adolescent and adult rats
Zhvania, M. G., Chilachava, L., Japaridze, N. J., Gelazonia, L., & Lordkipanidze, T. G. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.10.021 · Cited by 20
Neuroactive effects of cotinine on the hippocampus: Behavioral and biochemical parameters
Aguiar, R. B., Parfitt, G. M., Jaboinski, J., & Barros, D. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.032 · Cited by 20
“Nicotine also stimulates changes in calcium influx and in the release of calcium internal stores, which can activate not only kinases but also transcription factors such as CREB (reviewed by Gould, 2006).”
Vulnerability to nicotine self-administration in adolescent mice correlates with age-specific expression of α4* nicotinic receptors
Renda, A., Penty, N., Komal, P., & Nashmi, R. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.019 · Cited by 17
α2-Null mutant mice have altered levels of neuronal activity in restricted midbrain and limbic brain regions during nicotine withdrawal as demonstrated by cfos expression
Upton, M. K., & Lotfipour, S. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.06.015 · Cited by 16
Involvement of neuronal β 2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: Implications for pharmacotherapies
Simmons, S. J., & Gould, T. J. (2014) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12171 · Cited by 18
Neuroanatomical circuitry mediating the sensory impact of nicotine in the central nervous system
Dehkordi, O., Rose, J. E., Asadi, S., Manaye, K. F., Millis, R. M., & Jayam‐Trouth, A. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23477 · Cited by 17
Chronic fluoxetine ameliorates adolescent chronic nicotine exposure-induced long-term adult deficits in trace conditioning
Connor, D. A., & Gould, T. J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.07.033 · Cited by 15
“In contrast, immediate abstinence (withdrawal) from chronic nicotine elicits deficits in hippocampusdependent learning in adult mice (Davis et al., 2005; Davis and Gould, 2009; Gould et al., 2012; Raybuck and Gould, 2009).”
Background
ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice
Yildirim, E., Connor, D. A., & Gould, T. J. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000111 · Cited by 13
Neuropeptide CART prevents memory loss attributed to withdrawal of nicotine following chronic treatment in mice
Borkar, C. D., Sagarkar, S., Sakharkar, A. J., Subhedar, N. K., & Kokare, D. M. (2017) · Addiction Biology · doi:10.1111/adb.12579 · Cited by 13
Effectiveness of a Novel Qigong Meditative Movement Practice for Impaired Health in Flight Attendants Exposed to Second-Hand Cigarette Smoke
Payne, P., Fiering, S., Leiter, J. C., Zava, D. T., & Crane-Godreau, M. A. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00067 · Cited by 12
“In addition to its role as a principal cause of COPD (Moritsugu, 2007), cigarette smoke (CS) has been shown to affect the ANS via its influence on fear learning (Gould, 2006).”
Background
Converging action of alcohol consumption and cannabinoid receptor activation on adult hippocampal neurogenesis
Alén, F., Mouret, A., Viveros, M., Llorente, R., Lepousez, G., Lledo, P., & López‐Moreno, J. A. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709991118 · Cited by 11
Donepezil reverses nicotine withdrawal-induced deficits in contextual fear conditioning in c57bl/6j mice.
Poole, R. L., Connor, D. A., & Gould, T. J. (2014) · Behavioral Neuroscience · doi:10.1037/bne0000003 · Cited by 11
“, & Gould, T. J. (2009). Nicotine withdrawal disrupts new contextual learning.”
BackgroundInfluential
Effect of 4-Fluoro-N-(4-sulfamoylbenzyl) Benzene Sulfonamide on cognitive deficits and hippocampal plasticity during nicotine withdrawal in rats
Rehman, N. U., Esmaeilpour, K., Joushi, S., Abbas, M., al‐Rashida, M., Rauf, K., & Masoumi‐Ardakani, Y. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110783 · Cited by 10
Cognitive mechanisms underlying relapse to nicotine
Lester, R. A. J. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.038 · Cited by 10
“…c to the hippocampus, a study of the cellular and molecular actions of nicotine in the hippocampus, particularly its plasticity inducing effects (Gould, 2006) may move the fi eld towards a neuronal explanation for the context-dependent behavioral changes, just as hippocampal synaptic long-term…”
Background
Age-dependent and pathway-specific bimodal action of nicotine on synaptic plasticity in the hippocampus of mice lacking the miR-132/212 genes
Stojanovic, T., Velarde Gamez, D., Schuld, G. J., Bormann, D., Cabatic, M., Uhrin, P., Lubec, G., & Monje, F. J. (2022) · Cells · doi:10.3390/cells11020261 · Cited by 8
Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice
Molas, S., Gener, T., Güell‐Bosch, J., Martı́n, M., Ballesteros‐Yáñez, I., Sanchez-Vives, M. V., & Dierssen, M. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0147-1 · Cited by 9
“Drugs of abuse, including nicotine, induce neuroplasticity in areas involved in cognitive function, such as the hippocampus, a neuroadaptation assumed to contribute to the development of addiction by favoring associative memories [2-6].”
Background
Single nucleotide polymorphisms rs148582811 regulates its host gene ARVCF expression to affect nicotine-associated hippocampus-dependent memory
Yang, Z., Chen, J., Han, H., Wang, Y., Shi, X., Zhang, B., Mao, Y. Q., Li, A. N., Yuan, W., Yao, J., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108335 · Cited by 6
Thyroid receptor β involvement in the effects of acute nicotine on hippocampus-dependent memory
Leach, P. T., Kenney, J. W., Connor, D. A., & Gould, T. J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.026 · Cited by 6
Neural Mechanisms of Stress and Addiction
Seo, D., & Sinha, R. (2011) · Wiley eBooks · doi:10.1002/9781119998938.ch9 · Cited by 6
Tobacco Smoking and Brain Endogenous Opioid Release: More Than Nicotine Alone
Domino, E. F., & Hirasawa-Fujita, M. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty039 · Cited by 6
The Effects of Nicotine on Learning and Memory
Gould, T. J. (2014) · The Receptors · doi:10.1007/978-1-4939-1167-7_11 · Cited by 5
Chronic Toluene Exposure and the Hippocampal Structure in Adolescent and Adult Brains
Zhvania, M. G., Japaridze, N. J., Chilachava, L., Gelazonia, L., & Pochkhidze, N. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800212-4.00093-5 · Cited by 5
Addressing altered anticipation as a transdiagnostic target through computational psychiatry
Sepúlveda, P., Aitsahalia, I., Kumar, K., Atkin, T., & Iigaya, K. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.02.014 · Cited by 3
The impact of adolescent stress on nicotine use and affective disorders in rodent models
Mooney‐Leber, S. M., Caruso, M. J., Gould, T. J., Cavigelli, S. A., & Kamens, H. M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15421 · Cited by 3
Chromatin architecture in addiction circuitry elucidates biological mechanisms underlying cigarette smoking and alcohol use traitsPreprint
Sey, N. Y. A., Hu, B., Iskhakova, M., Sun, H., Shokrian, N., Hutta, G. B., Marks, J. A., Quach, B. C., Johnson, E. O., Hancock, D. B., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.18.436046 · Cited by 1
EFFECTS OF ADMINISTRATION OF PERINATAL BUPROPION ON THE POPULATION SPIKE AMPLITUDE IN NEONATAL RAT HIPPOCAMPAL SLICES
Heysieattalab, S., Zare, S., Pakdel, F. G., & Hashtjini, M. M. (2010) · Iranian journal of basic medical sciences. · doi:10.22038/ijbms.2010.5114
“Over years of smoking, neuroadaptations occur and long term synaptic changes redound in the learned behaviors (15, 16).”
Background
Effect of miRNA-138 Injected into the Medial Habenula on Nicotine Intake and Preference
Fitzgerald, K. (2015) · CU Scholar (University of Colorado Boulder)

Associative Learning, the Hippocampus, and Nicotine Addiction
Gould, T. J., & Davis, J. A. (2008) · Current Drug Abuse Reviews · doi:10.2174/1874473710801010009 · Cited by 49
Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning
Gould, T. J., & Leach, P. T. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.004 · Cited by 72
Current Drug Abuse Reviews, 2008, 1, 9-19 9 Associative Learning, the Hippocampus, and Nicotine Addiction
Davis, J. A., & Gould, T. J. (2013)
Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addictionPreprint
Kutlu, M. G., & Gould, T. J. (2016) · Learning & Memory · doi:10.1101/lm.042192.116 · Cited by 345
Modulation of Hippocampus-Dependent Learning and Synaptic Plasticity by Nicotine
Kenney, J. W., & Gould, T. J. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8037-9 · Cited by 242

Authors: Gould, T. J.
Affiliations: Temple University (US)
Corresponding author: Gould, Thomas J.
ORCID: Gould, Thomas J.
Venue: Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2006
Volume: 34
Issue: 2
Pages: 93-108
ISSN: 0893-7648 (ISSN-L)
DOI: 10.1385/mn:34:2:93
PMC: PMC2716133
OpenAlex: W2093132337
Cited by: 61
References: 167
Citations by year: 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 2 · 2012: 2
FWCI: 3.08
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Molecular Neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (DA017949, R01DA017949)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords: nicotine, hippocampus, contextual learning, addiction, drug craving, withdrawal, relapse, neuroplasticity, chronic nicotine exposure, signal transduction
MeSH terms: Acetylcholine, Animals, Conditioning, Psychological, Hippocampus, Humans, Learning, Neuronal Plasticity, Substance Withdrawal Syndrome, Tobacco Use Disorder, Cyclic AMP Response Element-Binding Protein, MAP Kinase Signaling System

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Nicotine and Hippocampus-Dependent Learning: Implications for Addiction

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