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Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

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Vecsey, C. G., Hawk, J. D., Lattal, K. M., Stein, J. M., Fabian, S. A., Attner, M. A., Cabrera, S. M., McDonough, C. B., Brindle, P. K., Abel, T., Wood, M. A.·2007·Journal of Neuroscience

DOI 10.1523/jneurosci.0296-07.2007

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Abstract

Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both memory and synaptic plasticity. The current model for the action of HDAC inhibitors assumes that they alter gene expression globally and thus affect memory processes in a nonspecific manner. Here, we show that the enhancement of hippocampus-dependent memory and hippocampal synaptic plasticity by HDAC inhibitors is mediated by the transcription factor cAMP response element-binding protein (CREB) and the recruitment of the transcriptional coactivator and histone acetyltransferase CREB-binding protein (CBP) via the CREB-binding domain of CBP. Furthermore, we show that the HDAC inhibitor trichostatin A does not globally alter gene expression but instead increases the expression of specific genes during memory consolidation. Our results suggest that HDAC inhibitors enhance memory processes by the activation of key genes regulated by the CREB:CBP transcriptional complex.

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“, 2011), increase mucosal serotonin release and affect learning and memory function (Vecsey et al., 2007; Stefanko et al., 2009).”
Background
Histone Deacetylases 1 and 2 in Memory Function
Pao, P.-C., & Tsai, L.-H. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00775 · Cited by 34
Sodium butyrate as a selective cognitive enhancer for weak or impaired memory
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Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory
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Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons
Takamatsu, G., Katagiri, C., Tomoyuki, T., Shimizu-Okabe, C., Nakamura, W., Nakamura-Higa, M., Hayakawa, T., Wakabayashi, S., Kondo, T., Takayama, C., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.036 · Cited by 17
RETRACTED ARTICLE: Amelioration of obsessive-compulsive disorder in three mouse models treated with one epigenetic drug: unraveling the underlying mechanism
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Retracted
Enhancement of psychotherapy using epigenetic modulating drugs
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Authors: Vecsey, C. G., Hawk, J. D., Lattal, K. M., Stein, J. M., Fabian, S. A., Attner, M. A., Cabrera, S. M., McDonough, C. B., Brindle, P. K., Abel, T., & Wood, M. A.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2007-06-06
Volume: 27
Issue: 23
Pages: 6128-6140
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0296-07.2007
OpenAlex: W2042966900
Cited by: 831
References: 12
FWCI: 19.49
Type: journal article
Language: en
Open access: bronze

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

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