Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

Piccialli, Ilaria, Tedeschi, Valentina, Caputo, Lucia, D’Errico, Stefano, Ciccone, Roselia, De Feo, Vincenzo, Secondo, Agnese, Pannaccione, Anna·2022·Frontiers in Pharmacology

DOI 10.3389/fphar.2022.876614

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Genipin inhibits lipopolysaccharide-induced acute systemic inflammation in mice as evidenced by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis
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Neuroprotection by Genipin against Reactive Oxygen and Reactive Nitrogen Species-Mediated Injury in Organotypic Hippocampal Slice Cultures
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Effects of Catalpol on Mitochondrial Function and Working Memory in Mice after Lipopolysaccharide-Induced Acute Systemic Inflammation
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BACE1 Inhibition by Genistein: Biological Evaluation, Kinetic Analysis, and Molecular Docking Simulation
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Geniposide Attenuates Insulin-Deficiency-Induced Acceleration of β-amyloidosis in an APP/PS1 Transgenic Model of Alzheimer's Disease
Zhang, Yonglan, Yin, Fei, Liu, Jianhui, Liu, Zixuan, Guo, Lixia, Xia, Zhining, Zidichouski, Jeffrey · 2015 · Neurochemistry International
Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 β and protein expression in spinal cord of mice
Ana Cláudia Piccinelli, Priscila Neder Morato, Marcelo dos Santos Barbosa, Júlio Croda, Jared M. Sampson, Xiang‐Peng Kong, Elisabete Castelon Konkiewitz, Edward Benjamin Ziff, Jaime Amaya‐Farfán, Cândida Aparecida Leite Kassuya · 2016 · Life Sciences
The Role of β-Amyloid Protein in Synaptic Function: Implications for Alzheimers Disease Therapy
Fernando Peña‐Ortega, Armando I. Gutiérrez-Lerma, Ricardo Quiroz‐Baez, Clorinda Arias · 2006 · Current Neuropharmacology
Anti-amyloidoGenic Effects of Soybean Isoflavones In Vitro: Fluorescence Spectroscopy Demonstrating Direct Binding to Aβ Monomers, Oligomers and Fibrils
Hirohata, Mie, Ono, Kenjiro, Takasaki, Jun-ichi, Takahashi, Ryoichi, Ikeda, Tokuhei, Morinaga, Akiyoshi, Yamada, Masahito · 2012 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Therapeutic Potential of Genipin in Central Neurodegenerative Diseases
Yanwei Li, Lin Li, Christian Hölscher · 2016 · CNS Drugs
Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers
Zahra Najarzadeh, Hossein Mohammad‐Beigi, Jannik Nedergaard Pedersen, Gunna Christiansen, Thorbjørn Vincent Sønderby, Seyed Abbas Shojaosadati, Dina Morshedi, Kristian Strømgaard, Georg Meisl, Duncan S. Sutherland et al. · 2019 · Biomolecules
GLP-1 receptor plays a critical role in geniposide-induced expression of heme oxygenase-1 in PC12 cells
Fei Yin, Jianhui Liu, Xuxu Zheng, Lixia Guo · 2010 · Acta Pharmacologica Sinica
Catalpol provides a protective effect on fibrillary Aβ1–42‐induced barrier disruption in an in vitro model of the blood–brain barrier
Chenyang Liu, Kang Chen, Yunwei Lu, Zhuyuan Fang, Guran Yu · 2018 · Phytotherapy Research
Synergistic effects of quercetin and regular exercise on the recovery of spatial memory and reduction of parameters of oxidative stress in an animal model of Alzheimer's disease
Molaei, Amin, Hatami, Homeira, Dehghan, Gholamreza, Sadeghian, Reihaneh, Khajehnasiri, Nazli · 2020 · IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Mitochondria and Cellular Redox State on the Route from Ageing to Alzheimer's Disease
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Insoluble Vascular Amyloid Deposits Trigger Disruption of the Neurovascular Unit in Alzheimer’s Disease Brains
Luis Oskar Soto-Rojas, B. Berenice Campa-Córdoba, Charles R. Harrington, Andrés Salas‐Casas, Mario Hernándes‐Alejandro, Ignacio Villanueva‐Fierro, Marely Bravo-Muñoz, Linda Garcés‐Ramírez, Fidel de la Cruz‐López, Miguel Ángel Ontiveros‐Torres et al. · 2021 · International Journal of Molecular Sciences
The protective effect of geniposide on human neuroblastoma cells in the presence of formaldehyde
Ping Sun, Jinyan Chen, Jiao Li, Mengru Sun, Weichuan Mo, Kai-li Liu, Yanyan Meng, Ying Min Liu, Feng Wang, Rongqiao He et al. · 2013 · BMC Complementary and Alternative Medicine
Lyophilized Powder of Catalpol and Puerarin Protects Neurovascular Unit from Stroke
Qiang XUE, Yang Liu, Ran He, Sheng Yang, Jie Tong, Li Xu, Yi Chen, Xiaoyu Xu · 2016 · International Journal of Biological Sciences
Geniposide Protects Primary Cortical Neurons against Oligomeric Aβ1-42-Induced Neurotoxicity through a Mitochondrial Pathway
Chunhui Zhao, Cui Lv, Hang Li, Shijing Du, Xiaoli Liu, Zhi Li, Wenfeng Xin, Wensheng Zhang · 2016 · PLoS ONE
Terpenes and Phenylpropanoids as Acetyl- and Butyrylcholinesterase Inhibitors: A Comparative Study
Szwajgier, Dominik, Baranowska-Wójcik, Ewa · 2019 · Current Alzheimer Research
The role of mitochondrial oxidative stress in the metabolic alterations in diet‐induced obesity in rats
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Biological and Computational Evaluation of Resveratrol Inhibitors against Alzheimer's Disease
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Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice
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Systemic administration of catalpol prevents d-galactose induced mitochondrial dysfunction in mice
Xiuli Zhang, Weidong Liu, Xinhua Niu, Lijia An · 2010 · Neuroscience Letters
Curcumin derivatives as new ligands of Aβ peptides
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Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells
Zhuo Wang, Xueshi Huang, Pu Zhao, Limei Zhao, Zhan‐You Wang · 2018 · Frontiers in Aging Neuroscience
Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure
Feng Xu, Ziao Fu, Sharmila Dass, AnnMarie E. Kotarba, Judianne Davis, Steven O. Smith, William E. Van Nostrand · 2016 · Nature Communications
Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease
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Geniposide decreases the level of Aβ1−42 in the hippocampus of streptozotocin-induced diabetic rats
Jianhui Liu, Yonglan Zhang, Xiaohong Deng, Fei Yin · 2013 · Acta Biochimica et Biophysica Sinica
Genipin Attenuates Tau Phosphorylation and Aβ Levels in Cellular Models of Alzheimer’s Disease
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Genipin Attenuates Lipopolysaccharide-Induced Persistent Changes of Emotional Behaviors and Neural Activation in the Hypothalamic Paraventricular Nucleus and the central Amygdala Nucleus
Araki, Ryota, Hiraki, Yosuke, Yabe, Takeshi · 2014 · European Journal of Pharmacology
Screening Assay for Metal-Catalyzed Oxidation Inhibitors Using Liquid Chromatography−Mass Spectrometry with an N-Terminal β-Amyloid Peptide
Inoue, Koichi, Nakagawa, Ako, Hino, Tomoaki, Oka, Hisao · 2009 · Analytical Chemistry
Regulation of NF-Κb Activity in Astrocytes: Effects of Flavonoids at Dietary-Relevant Concentrations
Spilsbury, Alison, Vauzour, David, Spencer, Jeremy P.E., Rattray, Marcus · 2012 · Biochemical and Biophysical Research Communications
Catalpol ameliorates diabetic atherosclerosis in diabetic rabbits.
Jiangyue Liu, Chen-Zhao Zheng, Xin-Ping Hao, Daijuan Zhang, An-Wei Mao, Ping Yuan · 2016 · PubMed Central
Biophysical and In Vivo Studies Identify a New Natural-Based Polyphenol, Counteracting Aβ Oligomerization In Vitro and Aβ Oligomer-Mediated Memory Impairment and Neuroinflammation in an Acute Mouse Model of Alzheimer's Disease
Tomaselli, Simona, La Vitola, Pietro, Pagano, Katiuscia, Brandi, Edoardo, Santamaria, Giulia, Galante, Denise, D’Arrigo, Cristina, Moni, Lisa, Lambruschini, Chiara, Banfi, Luca et al. · 2019 · ACS Chemical Neuroscience
Resveratrol Rescues the Impairments of Hippocampal Neurons Stimulated by Microglial Over-Activation In Vitro
Feng Wang, Na Cui, Lijun Yang, Lin Shi, Qian Li, Gengshen Zhang, Jianliang Wu, Jun Qi Zheng, Baohua Jiao · 2015 · Cellular and Molecular Neurobiology
Geniposide Regulates Insulin-Degrading Enzyme Expression to Inhibit the Cytotoxicity of Aβ1-42 in Cortical Neurons
Fei Yin, Yonglan Zhang, Lixia Guo, Shuzhen Kong, Jianhui Liu · 2013 · CNS & Neurological Disorders - Drug Targets
Geniposide Alleviates Amyloid-Induced Synaptic Injury by Protecting Axonal Mitochondrial Trafficking
Haijing Zhang, Chunhui Zhao, Cui Lv, Xiaoli Liu, Shijing Du, Zhi Li, Yongyan Wang, Wensheng Zhang · 2017 · Frontiers in Cellular Neuroscience
Research Progress on Catalpol as Treatment for Atherosclerosis
Lei He, Rusheng Zhao, Youheng Wang, Huibing Liu, Xuehui Wang · 2021 · Frontiers in Pharmacology
A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder
Mark Frederick McCarty, James J. DiNicolantonio, Aaron Lerner · 2021 · International Journal of Molecular Sciences
Catalpol Protects Pre-myelinating Oligodendrocytes against Ischemia-Induced Oxidative Injury through ERK1/2 Signaling Pathway
Cai, Qiyan, Ma, Teng, Li, Chengren, Tian, Yanping, Li, Hongli · 2016 · International Journal of Biological Sciences
Structure-Activity Relationship of Clovamide and its Related Compounds for the Inhibition of Amyloid β Aggregation
Tsunoda, Tatsuhiko, Takase, Mio, Shigemori, Hideyuki · 2018 · Bioorganic & Medicinal Chemistry
Epigallocatechin-3-Gallate Plus Omega-3 Restores the Mitochondrial Complex I and F0F1-ATP Synthase Activities in PBMCs of Young Children with Down Syndrome: A Pilot Study of Safety and Efficacy
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Unusual Bioactive Compounds with Antioxidant Properties in Adjuvant Therapy Supporting Cognition Impairment in Age-Related Neurodegenerative Disorders
Natalia Cichoń, Angela Dziedzic, Leslaw Gorniak, Elżbieta Dorota Miller, Michał Bijak, Michał Starosta, Joanna Saluk · 2021 · International Journal of Molecular Sciences
p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function
Juan Ramón Perea, Marta Bolós, Raquel Cuadros, Esther García, Vega García‐Escudero, Félix Hernández, Róisín M. McManus, Michael Thomas Heneka, Jesús Ávila · 2022 · Molecular Neurobiology
Genistein Prevents Cadmium-Induced Neurotoxic Effects through its Antioxidant Mechanisms
Gong, D.-k., Liu, B.-h., Tan, X.-h. · 2014 · Drug Research
Geniposide Attenuates the Level of Aβ1-42 via Enhancing Leptin Signaling in Cellular and APP/PS1 Transgenic Mice
Liu, Zixuan, Zhang, Yonglan, Liu, Jianhui, Yin, Fei · 2017 · Archives of Pharmacal Research
Neuroprotective Effects of Geniposide in SH-SY5Y Cells and Primary Hippocampal Neurons Exposed to Aβ42
Ping Sun, Haimin Ding, Mi Liang, Xiaojing Li, Weichuan Mo, Xu Wang, Ying Min Liu, Rongqiao He, Qian Hua · 2014 · BioMed Research International
GLP-1 receptor regulates cell growth through regulating IDE expression level in Aβ1–42-treated PC12 cells
Huajie Li, Liping Cao, Yi Ren, Ying Jiang, Wei Xie, Dawen Li · 2017 · Bioscience Reports
Quercetin Prevents Body Weight Loss Due to the Using of Superparamagnetic Iron Oxide Nanoparticles in Rat
Najafabadi, Rezvan Enteshari, Kazemipour, Nasrin, Esmaeili, Abolghasem, Beheshti, Siamak, Nazifi, Saeed · 2018 · Advanced Biomedical Research
The complex relationship between genotype, pathology and phenotype in familial dementia
John B. Kwok, Clement T. Loy, Carol Dobson‐Stone, Glenda Margaret Halliday · 2020 · Neurobiology of Disease
Unravelling the disease process
Peter St George‐Hyslop, Martin N. Rossor · 2001 · The Lancet
Geniposide, the component of the Chinese herbal formula Tongluojiunao, protects amyloid-β (Aβ)1-42-mediated death of hippocampal neurons via the non-classical estrogen signaling pathway
Jiao Li, Qian Hua, Feng Wang, Haimin Ding, Chunyan Jin, Jinyan Chen, Yanan Zhao, Xiaojing Li, Wenju Chen, Ping Sun et al. · 2014 · Neural Regeneration Research
The Anemonia Sulcata Toxin BDS-I Protects Astrocytes Exposed to Aβ1-42 Oligomers by Restoring [Ca2+]i Transients and ER Ca2+ Signaling
Piccialli, Ilaria, Tedeschi, Valentina, Boscia, Francesca, Ciccone, Roselia, Casamassa, Antonella, de Rosa, Valeria, Grieco, Paolo, Secondo, Agnese, Pannaccione, Anna · 2020 · Toxins
Design and Microwave-Assisted Synthesis of Aza-Resveratrol Analogs with Potent Cholinesterase Inhibition
Brunella Biscussi, Victoria Richmond, Carlos Javier Baier · 2020 · CNS & Neurological Disorders - Drug Targets
Leptin Signaling Plays a Critical Role in the Geniposide-Induced Decrease of Tau Phosphorylation
Liu, Jianhui, Liu, Zixuan, Zhang, Yonglan, Yin, Fei · 2015 · Acta Biochimica et Biophysica Sinica
Exploring new avenues for modifying course of progression of Alzheimer's disease: The rise of natural medicine
Sarah Lye, Caitlin E. Aust, Lyn Robyn Griffiths, Francesca Fernandez · 2021 · Journal of the Neurological Sciences