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Cited by 280

The DOI matches its Crossref record; 397 of the 397 references it cites were found in a registry or an index.

Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives

Open access
Fang, Zengli, Meng, Qingcai, Xu, Jin, Wang, Wei, Zhang, Bo, Liu, Jiang, Liang, Chen, Hua, Jie, Zhao, Yingjun, Yu, Xianjun, Shi, Si·2023·Cancer Communications

Abstract

As a critical component of the tumor microenvironment (TME), cancer‐associated fibroblasts (CAFs) play important roles in cancer initiation and progression. Well‐known signaling pathways, including the transforming growth factor‐β (TGF‐β), Hedgehog (Hh), Notch, Wnt, Hippo, nuclear factor kappa‐B (NF‐κB), Janus kinase (JAK)/signal transducer and activator of transcription (STAT), mitogen‐activated protein kinase (MAPK), and phosphoinositide 3‐kinase (PI3K)/AKT pathways, as well as transcription factors, including hypoxia‐inducible factor (HIF), heat shock transcription factor 1 (HSF1), P53, Snail, and Twist, constitute complex regulatory networks in the TME to modulate the formation, activation, heterogeneity, metabolic characteristics and malignant phenotype of CAFs. Activated CAFs remodel the TME and influence the malignant biological processes of cancer cells by altering the transcriptional and secretory characteristics, and this modulation partially depends on the regulation of signaling cascades. The results of preclinical and clinical trials indicated that therapies targeting signaling pathways in CAFs demonstrated promising efficacy but were also accompanied by some failures (e.g., NCT01130142 and NCT01064622). Hence, a comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the development of more efficient and safer stroma‐targeted cancer therapies. Here, we review recent advances in studies of signaling pathways in CAFs and briefly discuss some future perspectives on CAF research.

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Crossref · 10.1002/cac2.12392

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Metadata

Authors
Fang, Z., Meng, Q., Xu, J., Wang, W., Zhang, B., Liu, J., Liang, C., Hua, J., Zhao, Y., Yu, X., & Shi, S.
Venue
Cancer Communications
Published
2022-11-24
Volume
43
Issue
1
Pages
3-41
ISSN
  • 1000-467X (ISSN-L)
  • 2523-3548
OpenAlex
W4310079132
Cited by
280
References
397
FWCI
14.22
Type
journal article
Language
en
Open access
gold

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