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Immunochemical characterization of inhibitory mouse cortical neurons: Three chemically distinct classes of inhibitory cells

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Xu, Xiangmin, Roby, Keith D., Callaway, Edward M.·2010·Journal of Comparative Neurology

DOI 10.1002/cne.22229PMC PMC2804902

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Abstract

The cerebral cortex has diverse types of inhibitory neurons. In rat cortex, past research has shown that parvalbumin (PV), somatostatin (SOM), calretinin (CR), and cholecystokinin (CCK) label four distinct chemical classes of GABAergic interneurons. However, in contrast to rat cortex, previous studies indicate that there is significant colocalization of SOM and CR in mouse cortical inhibitory neurons. In the present study we further characterized immunochemical distinctions among mouse inhibitory cortical neurons by double immunochemical labeling with chemical markers. We found that, PV, SOM, and vasointenstinal peptide (VIP) reliably identify three nonoverlapping distinct subpopulations, as there was no overlap of immunoreactivity between PV and all the other chemical markers tested, and SOM and VIP did not show any overlap in labeled neurons in all the cortical areas. In comparison, there was significant overlap in combinations of other chemical markers. With some laminar and regional variations, the average overlap of SOM/CR (percentage of SOM+ cells expressing CR) and SOM/neuropeptide tyrosine (NPY) across all examined layers and cortical regions was 21.6% and 7.1%, respectively. The average overlap of VIP/CR, VIP/NPY, and CR/NPY was 34.2%, 9.5%, and 10%, respectively. We quantified and assessed the percentages of marker-positive GABAergic cells, and showed that the nonoverlapping subpopulations (i.e., PV+, SOM+ and VIP+ cells) accounted for about 60% of the GABAergic cell population. Taken together, our data reveal important chemical distinctions between mouse inhibitory cortical neurons and indicate that PV, SOM, and VIP can differentially label a majority of mouse inhibitory cortical neurons.

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Self-citation

Authors: Xu, X., Roby, K. D., & Callaway, E. M.
Affiliations: Salk Institute for Biological Studies (US)
Corresponding author: Callaway, Edward M.
ORCID: Xu, Xiangmin
Callaway, Edward M.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 2009-11-30
Volume: 518
Issue: 3
Pages: 389-404
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.22229
PMC: PMC2804902
OpenAlex: W2066101989
Cited by: 429
References: 23
Citations by year: 2026: 10 · 2025: 25 · 2024: 18 · 2023: 15 · 2022: 30 · 2021: 23 · 2020: 39 · 2019: 29 · 2018: 32 · 2017: 32 · 2016: 32 · 2015: 31 · 2014: 27 · 2013: 29 · 2012: 23
FWCI: 7.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH063912, R01MH063912)
National Institute on Drug Abuse (R00DA023700, K99DA023700, DA023700)
National Eye Institute (EY-010742, R01EY010742)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: GABAergic interneurons, parvalbumin, somatostatin, vasoactive intestinal peptide, neuropeptide tyrosine, calretinin, cholecystokinin, neuropeptide co-localization, mouse cortex, interneuron subpopulations
MeSH terms: Animals, Brain Chemistry, Cerebral Cortex, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Immunohistochemistry, Interneurons, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Synaptic Transmission, Neuropeptide Y, Neuropeptides, Parvalbumins, Phenotype, Recombinant Fusion Proteins, Somatostatin, Vasoactive Intestinal Peptide, Biomarkers, Green Fluorescent Proteins, Mice, S100 Calcium Binding Protein G, Calbindin 2

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Immunochemical characterization of inhibitory mouse cortical neurons: Three chemically distinct classes of inhibitory cells

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