The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty

Frailty in Older Adults: Evidence for a Phenotype

Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907

The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons

Podsiadlo, D., & Richardson, S. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb01616.x · Cited by 14,418

A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission

Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792

Frailty in elderly people

Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503

Untitled work

(2014) · Medical Entomology and Zoology · Cited by 9,400

A global clinical measure of fitness and frailty in elderly people

Rockwood, K. (2005) · Canadian Medical Association Journal · doi:10.1503/cmaj.050051 · Cited by 8,968

Grading quality of evidence and strength of recommendations

(2004) · BMJ · doi:10.1136/bmj.328.7454.1490 · Cited by 8,477

Exercise and Physical Activity for Older Adults

Chodzko-Zajko, W. J., Proctor, D. N., Fiatarone Singh, M. A., Minson, C. T., Nigg, C. R., Salem, G. J., & Skinner, J. S. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181a0c95c · Cited by 5,153

Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia

Chen, L.-K., Liu, L.-K., Woo, J., Assantachai, P., Auyeung, T.-W., Bahyah, K. S., Chou, M.-Y., Chen, L.-Y., Hsu, P.-S., Krairit, O., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.11.025 · Cited by 4,051

Frailty Consensus: A Call to Action

Morley, J. E., Vellas, B., Abellan van Kan, G., Anker, S. D., Bauer, J. M., Bernabei, R., Cesari, M., Chumlea, W. C., Doehner, W., Evans, J., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.03.022 · Cited by 4,043

A standard procedure for creating a frailty index

Searle, S. D., Mitnitski, A., Gahbauer, E. A., Gill, T. M., & Rockwood, K. (2008) · BMC Geriatrics · doi:10.1186/1471-2318-8-24 · Cited by 3,568

The World report on ageing and health: a policy framework for healthy ageing

Beard, J. R., Officer, A., de Carvalho, I. A., Sadana, R., Pot, A. M., Michel, J.-P., Lloyd-Sherlock, P., Epping-Jordan, J. E., Peeters, G. M. E. E. (., Mahanani, W. R., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00516-4 · Cited by 3,287

Prevalence of frailty in community-dwelling older persons: a systematic review

Collard, R. M., Boter, H., Schoevers, R. A., & Oude Voshaar, R. C. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04054.x · Cited by 3,073

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

Hochberg, M. C., Altman, R. D., April, K. T., Benkhalti, M., Guyatt, G., McGowan, J., Towheed, T., Welch, V., Wells, G., & Tugwell, P. (2012) · Arthritis Care & Research · doi:10.1002/acr.21596 · Cited by 3,068

Accumulation of Deficits as a Proxy Measure of Aging

Mitnitski, A. B., Mogilner, A. J., & Rockwood, K. (2001) · The Scientific World JOURNAL · doi:10.1100/tsw.2001.58 · Cited by 2,893

Vitamin D deficiency: a worldwide problem with health consequences

Holick, M. F., & Chen, T. C. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.1080s · Cited by 2,689

Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group

Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553

STOPP/START criteria for potentially inappropriate prescribing in older people: version 2

O'Mahony, D., O'Sullivan, D., Byrne, S., O'Connor, M. N., Ryan, C., & Gallagher, P. (2014) · Age and Ageing · doi:10.1093/ageing/afu145 · Cited by 2,397

Validation of the Mini Nutritional Assessment short-form (MNA®-SF): A practical tool for identification of nutritional status

Kaiser, M. J., Bauer, J. M., Ramsch, C., Uter, W., Guigoz, Y., Cederholm, T., Thomas, D. R., Anthony, P., Charlton, K. E., Maggio, M., et al. (2009) · The Journal of nutrition, health and aging · doi:10.1007/s12603-009-0214-7 · Cited by 2,073

A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans

Morley, J. E., Malmstrom, T. K., & Miller, D. K. (2012) · The Journal of nutrition, health and aging · doi:10.1007/s12603-012-0084-2 · Cited by 1,987

Geriatric Syndromes: Clinical, Research, and Policy Implications of a Core Geriatric Concept: (See Editorial Comments by Dr. William Hazzard on pp 794–796)

Inouye, S. K., Studenski, S., Tinetti, M. E., & Kuchel, G. A. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01156.x · Cited by 1,874

Validity and reliability of the Edmonton Frail Scale

Rolfson, D. B., Majumdar, S. R., Tsuyuki, R. T., Tahir, A., & Rockwood, K. (2006) · Age and Ageing · doi:10.1093/ageing/afl041 · Cited by 1,643

STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation

Gallagher, P., Ryan, C., Byrne, S., Kennedy, J., & O’Mahony, D. (2008) · Int. Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp46072 · Cited by 1,506

Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial

Pahor, M., Guralnik, J. M., Ambrosius, W. T., Blair, S., Bonds, D. E., Church, T. S., Espeland, M. A., Fielding, R. A., Gill, T. M., Groessl, E. J., et al. (2014) · JAMA · doi:10.1001/jama.2014.5616 · Cited by 1,427

Annual High-Dose Oral Vitamin D and Falls and Fractures in Older Women: A Randomized Controlled Trial

Sanders, K. M., Stuart, A. L., Williamson, E. J., Simpson, J. A., Kotowicz, M. A., Young, D., & Nicholson, G. C. (2010) · JAMA · doi:10.1001/jama.2010.594 · Cited by 1,381

ACSM's guidelines for exercise testing and prescription

Franklin, B. A., WHALEY, M. H., Howley, E. T., Balady, G. J., & Grais, I. M. (2006) · Medical Entomology and Zoology · Cited by 1,344

GRADE guidelines: 15. Going from evidence to recommendation—determinants of a recommendation's direction and strength

Andrews, J. C., Schünemann, H. J., Oxman, A. D., Pottie, K., Meerpohl, J. J., Coello, P. A., Rind, D., Montori, V. M., Brito, J. P., Norris, S., et al. (2013) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2013.02.003 · Cited by 1,315

Frailty measurement in research and clinical practice: A review

Dent, E., Kowal, P., & Hoogendijk, E. O. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.03.007 · Cited by 1,292

Malnutrition in hospital outpatients and inpatients: prevalence, concurrent validity and ease of use of the ‘malnutrition universal screening tool’ (‘MUST’) for adults

Stratton, R. J., Hackston, A., Longmore, D., Dixon, R., Price, S., Stroud, M., King, C., & Elia, M. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041258 · Cited by 1,239

Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes

Gnjidic, D., Hilmer, S. N., Blyth, F. M., Naganathan, V., Waite, L., Seibel, M. J., McLachlan, A. J., Cumming, R. G., Handelsman, D. J., & Le Couteur, D. G. (2012) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2012.02.018 · Cited by 1,176

Transitions between frailty states among community-living older persons

Gill, T. M., Gahbauer, E. A., Allore, H. G., & Han, L. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.4.418 · Cited by 1,141

The Tilburg Frailty Indicator: Psychometric Properties

Gobbens, R. J. J., van Assen, M. A. L. M., Luijkx, K. G., Wijnen-Sponselee, M. T., & Schols, J. M. G. A. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2009.11.003 · Cited by 1,106

Prevalence and 10‐Year Outcomes of Frailty in Older Adults in Relation to Deficit Accumulation

Song, X., Mitnitski, A., & Rockwood, K. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02764.x · Cited by 1,104

The I.A.N.A. task force on frailty assessment of older people in clinical practice

Van Kan, G. A., Rolland, Y., Bergman, H., Morley, J. E., Kritchevsky, S. B., & Vellas, B. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982161 · Cited by 1,099

Low Vitamin D and High Parathyroid Hormone Levels as Determinants of Loss of Muscle Strength and Muscle Mass (Sarcopenia): The Longitudinal Aging Study Amsterdam

Visser, M., Deeg, D. J. H., & Lips, P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030604 · Cited by 1,099

Vitamin D–Binding Protein and Vitamin D Status of Black Americans and White Americans

Powe, C. E., Evans, M. K., Wenger, J., Zonderman, A. B., Berg, A. H., Nalls, M., Tamez, H., Zhang, D., Bhan, I., Karumanchi, S. A., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1306357 · Cited by 1,087

Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials

Ellis, G., Whitehead, M. A., Robinson, D., O'Neill, D., & Langhorne, P. (2011) · BMJ · doi:10.1136/bmj.d6553 · Cited by 1,068

Frailty syndrome: an overview

Leng, S., Chen, X., & Mao, G. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s45300 · Cited by 991

Prevalence of Frailty in Middle-Aged and Older Community-Dwelling Europeans Living in 10 Countries

Santos-Eggimann, B., Cuenoud, P., Spagnoli, J., & Junod, J. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp012 · Cited by 963

Interventions for preventing falls in older people in care facilities and hospitals

Cameron, I. D., Gillespie, L. D., Robertson, M. C., Murray, G. R., Hill, K. D., Cumming, R. G., & Kerse, N. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005465.pub3 · Cited by 928

Grading quality of evidence and strength of recommendations in clinical practice guidelines: Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions

Brożek, J. L., Akl, E. A., Alonso‐Coello, P., Lang, D., Jaeschke, R., Williams, J. W., Phillips, B., Lelgemann, M., Lethaby, A., Bousquet, J., et al. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.01973.x · Cited by 894

A systematic review of the emerging definition of ‘deprescribing’ with network analysis: implications for future research and clinical practice.

Reeve, E., Gnjidic, D., Long, J., & Hilmer, S. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12732 · Cited by 855

Protein and energy supplementation in elderly people at risk from malnutrition

Milne, A. C., Potter, J., Vivanti, A., & Avenell, A. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003288.pub3 · Cited by 849

The frailty phenotype and the frailty index: different instruments for different purposes

Cesari, M., Gambassi, G., Abellan van Kan, G., & Vellas, B. (2014) · Age and Ageing · doi:10.1093/ageing/aft160 · Cited by 817

Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents

Wilson, M.-M. G., Thomas, D. R., Rubenstein, L. Z., Chibnall, J. T., Anderson, S., Baxi, A., Diebold, M. R., & Morley, J. E. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.1074 · Cited by 809

Frailty and Risk of Falls, Fracture, and Mortality in Older Women: The Study of Osteoporotic Fractures

Ensrud, K. E., Ewing, S. K., Taylor, B. C., Fink, H. A., Stone, K. L., Cauley, J. A., Tracy, J. K., Hochberg, M. C., Rodondi, N., Cawthon, P. M., et al. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.7.744 · Cited by 760

Frailty: An Emerging Public Health Priority

Cesari, M., Prince, M., Thiyagarajan, J. A., De Carvalho, I. A., Bernabei, R., Chan, P., Gutierrez-Robledo, L. M., Michel, J.-P., Morley, J. E., Ong, P., et al. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.12.016 · Cited by 726

Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial

Ng, T. P., Feng, L., Nyunt, M. S. Z., Feng, L., Niti, M., Tan, B. Y., Chan, G., Khoo, S. A., Chan, S. M., Yap, P., et al. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.06.017 · Cited by 725

Effects of physical exercise interventions in frail older adults: a systematic review of randomized controlled trials

de Labra, C., Guimaraes-Pinheiro, C., Maseda, A., Lorenzo, T., & Millán-Calenti, J. C. (2015) · BMC Geriatrics · doi:10.1186/s12877-015-0155-4 · Cited by 709

Validity of the Kihon Checklist for assessing frailty status

Satake, S., Senda, K., Hong, Y., Miura, H., Endo, H., Sakurai, T., Kondo, I., & Toba, K. (2016) · Geriatrics & Gerontology International · doi:10.1111/ggi.12543 · Cited by 691

Interventions for preventing falls in older people in nursing care facilities and hospitals

Cameron, I. D., Murray, G. R., Gillespie, L. D., Robertson, M. C., Hill, K. D., Cumming, R. G., & Kerse, N. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005465.pub2 · Cited by 682

Updating the Evidence for Physical Activity: Summative Reviews of the Epidemiological Evidence, Prevalence, and Interventions to Promote “Active Aging”

Bauman, A., Merom, D., Bull, F. C., Buchner, D. M., & Fiatarone Singh, M. A. (2016) · The Gerontologist · doi:10.1093/geront/gnw031 · Cited by 679

Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report

Turner, G., & Clegg, A. (2014) · Age and Ageing · doi:10.1093/ageing/afu138 · Cited by 678

Effects of a Vitamin D and Leucine-Enriched Whey Protein Nutritional Supplement on Measures of Sarcopenia in Older Adults, the PROVIDE Study: A Randomized, Double-Blind, Placebo-Controlled Trial

Bauer, J. M., Verlaan, S., Bautmans, I., Brandt, K., Donini, L. M., Maggio, M., McMurdo, M. E. T., Mets, T., Seal, C., Wijers, S. L., et al. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.05.021 · Cited by 670

Nutritional recommendations for the management of sarcopenia

Morley, J. E., Argiles, J. M., Evans, W. J., Bhasin, S., Cella, D., Deutz, N. E. P., Doehner, W., Fearon, K. C. H., Ferrucci, L., Hellerstein, M. K., et al. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.04.014 · Cited by 664

Detection of Older People at Increased Risk of Adverse Health Outcomes After an Emergency Visit: The ISAR Screening Tool

McCusker, J., Bellavance, F., Cardin, S., Trepanier, S., Verdon, J., & Ardman, O. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb05204.x · Cited by 653

The effectiveness of exercise interventions for the management of frailty: a systematic review

Theou, O., Stathokostas, L., Roland, K. P., Jakobi, J. M., Patterson, C., Vandervoort, A. A., & Jones, G. R. (2011) · Journal of Aging Research · doi:10.4061/2011/569194 · Cited by 652

Frailty screening methods for predicting outcome of a comprehensive geriatric assessment in elderly patients with cancer: a systematic review

Hamaker, M. E., Jonker, J. M., de Rooij, S. E., Vos, A. G., Smorenburg, C. H., & van Munster, B. C. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70259-0 · Cited by 643

A Comparison of Frailty Indexes for the Prediction of Falls, Disability, Fractures, and Mortality in Older Men

Ensrud, K. E., Ewing, S. K., Cawthon, P. M., Fink, H. A., Taylor, B. C., Cauley, J. A., Dam, T., Marshall, L. M., Orwoll, E. S., Cummings, S. R., et al. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02137.x · Cited by 636

Worldwide vitamin D status

van Schoor, N. M., & Lips, P. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.06.007 · Cited by 634

Effect of Exercise on Physical Function, Daily Living Activities, and Quality of Life in the Frail Older Adults: A Meta-Analysis

Chou, C.-H., Hwang, C.-L., & Wu, Y.-T. (2012) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2011.08.042 · Cited by 629

Vitamin D Deficiency in India: Prevalence, Causalities and Interventions

G, R., & Gupta, A. (2014) · Nutrients · doi:10.3390/nu6020729 · Cited by 581

Potentially Inappropriate Medications Defined by STOPP Criteria and the Risk of Adverse Drug Events in Older Hospitalized Patients

Hamilton, H., Gallagher, P., Ryan, C., Byrne, S., & O’Mahony, D. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.215 · Cited by 566

Association between frailty and short- and long-term outcomes among critically ill patients: a multicentre prospective cohort study

Bagshaw, S. M., Stelfox, H. T., McDermid, R. C., Rolfson, D. B., Tsuyuki, R. T., Baig, N., Artiuch, B., Ibrahim, Q., Stollery, D. E., Rokosh, E., et al. (2014) · Canadian Medical Association Journal · doi:10.1503/cmaj.130639 · Cited by 555

Effects of Exercise and Amino Acid Supplementation on Body Composition and Physical Function in Community‐Dwelling Elderly Japanese Sarcopenic Women: A Randomized Controlled Trial

Kim, H. K., Suzuki, T., Saito, K., Yoshida, H., Kobayashi, H., Kato, H., & Katayama, M. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03776.x · Cited by 551

Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial

Bischoff-Ferrari, H. A., Dawson-Hughes, B., Orav, E. J., Staehelin, H. B., Meyer, O. W., Theiler, R., Dick, W., Willett, W. C., & Egli, A. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.7148 · Cited by 511

Development and Validation of a Multidimensional Prognostic Index for One-Year Mortality from Comprehensive Geriatric Assessment in Hospitalized Older Patients

Pilotto, A., Ferrucci, L., Franceschi, M., D'Ambrosio, L. P., Scarcelli, C., Cascavilla, L., Paris, F., Placentino, G., Seripa, D., Dallapiccola, B., et al. (2008) · Rejuvenation Research · doi:10.1089/rej.2007.0569 · Cited by 506

Frailty in Older Men: Prevalence, Progression, and Relationship with Mortality

Cawthon, P. M., Marshall, L. M., Michael, Y., Dam, T., Ensrud, K. E., Barrett‐Connor, E., Orwoll, E. S., & for the Osteoporotic Fractures in Men Research Group (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01259.x · Cited by 500

Defining inappropriate practices in prescribing for elderly people: a national consensus panel.

McLeod, P. J., Huang, A. R., Tamblyn, R. M., & Gayton, D. (1997) · Europe PMC (PubMed Central) · Cited by 486

Initial Manifestations of Frailty Criteria and the Development of Frailty Phenotype in the Women's Health and Aging Study II

Xue, Q.-L., Bandeen-Roche, K., Varadhan, R., Zhou, J., & Fried, L. P. (2008) · The Journals of Gerontology: Series A · doi:10.1093/gerona/63.9.984 · Cited by 484

Effect of Vitamin D Supplementation on Muscle Strength, Gait and Balance in Older Adults: A Systematic Review and Meta‐Analysis

Muir, S. W., & Montero‐Odasso, M. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03733.x · Cited by 470

Sarcopenia and Physical Frailty: Two Sides of the Same Coin

Cesari, M., Landi, F., Vellas, B., Bernabei, R., & Marzetti, E. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00192 · Cited by 468

Protein Supplementation Improves Physical Performance in Frail Elderly People: A Randomized, Double-Blind, Placebo-Controlled Trial

Tieland, M., van de Rest, O., Dirks, M. L., van der Zwaluw, N., Mensink, M., van Loon, L. J. C., & de Groot, L. C. P. G. M. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.07.005 · Cited by 446

A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial

Cameron, I. D., Fairhall, N., Langron, C., Lockwood, K., Monaghan, N., Aggar, C., Sherrington, C., Lord, S. R., & Kurrle, S. E. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-65 · Cited by 429

The Study of Mental and Resistance Training (SMART) Study-Resistance Training and/or cognitive Training in mild cognitive impairment: a randomized, double-blind, double-sham controlled trial

Fiatarone Singh, M. A., Gates, N., Saigal, N., Wilson, G. C., Meiklejohn, J., Brodaty, H., Wen, W., Singh, N., Baune, B. T., Suo, C., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.09.010 · Cited by 424

Role of dietary protein in the sarcopenia of aging

Paddon-Jones, D., Short, K. R., Campbell, W. W., Volpi, E., & Wolfe, R. R. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1562s · Cited by 401

Depression in the Elderly

Taylor, W. D. (2014) · New England Journal of Medicine · doi:10.1056/nejmcp1402180 · Cited by 394

Comparison of Frailty Indicators Based on Clinical Phenotype and the Multiple Deficit Approach in Predicting Mortality and Physical Limitation

Woo, J., Leung, J., & Morley, J. E. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04074.x · Cited by 385

Diagnostic test accuracy of simple instruments for identifying frailty in community-dwelling older people: a systematic review

Clegg, A., Rogers, L., & Young, J. (2015) · Age and Ageing · doi:10.1093/ageing/afu157 · Cited by 380

Dose-Response Relationship of Resistance Training in Older Adults: A Meta-Analysis

STEIB, S., SCHOENE, D., & PFEIFER, K. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181c34465 · Cited by 378

Frailty Screening in the Community Using the FRAIL Scale

Woo, J., Yu, R., Wong, M., Yeung, F., Wong, M., & Lum, C. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.01.087 · Cited by 374

Meta-Analysis: Protein and Energy Supplementation in Older People

Milne, A. C., Avenell, A., & Potter, J. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-1-200601030-00008 · Cited by 344

Cobalamin Deficiency: Clinical Picture and Radiological Findings

Briani, C., Dalla Torre, C., Citton, V., Manara, R., Pompanin, S., Binotto, G., & Adami, F. (2013) · Nutrients · doi:10.3390/nu5114521 · Cited by 339

Does the 'Otago exercise programme' reduce mortality and falls in older adults?: a systematic review and meta-analysis

Thomas, S., Mackintosh, S., & Halbert, J. (2010) · Age and Ageing · doi:10.1093/ageing/afq102 · Cited by 335

Measuring frailty: Developing and testing the GFI (Groningen frailty indicator).

Steverink, N., Slaets, J., Schuurmans, H., & Lis, M. (2001) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 327

Transitions in Frailty States Among Community-Living Older Adults and Their Associated Factors

Lee, J. S. W., Auyeung, T.-W., Leung, J., Kwok, T., & Woo, J. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.12.002 · Cited by 324

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Nowson, C. A., McGrath, J. J., Ebeling, P. R., Haikerwal, A., Daly, R. M., Sanders, K. M., Seibel, M. J., & Mason, R. S. (2012) · Medical Journal of Australia · doi:10.5694/mja11.10301 · Cited by 311

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Makizako, H., Shimada, H., Doi, T., Tsutsumimoto, K., & Suzuki, T. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-008462 · Cited by 304

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Artaza-Artabe, I., Sáez-López, P., Sánchez-Hernández, N., Fernández-Gutierrez, N., & Malafarina, V. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.04.009 · Cited by 295

PRISMA-7: A case-finding tool to identify older adults with moderate to severe disabilities

Raîche, M., Hébert, R., & Dubois, M.-F. (2008) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2007.06.004 · Cited by 294

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Landi, F., Calvani, R., Cesari, M., Tosato, M., Martone, A. M., Bernabei, R., Onder, G., & Marzetti, E. (2015) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2015.04.005 · Cited by 288

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Morley, J. E., Malmstrom, T. K., Rodriguez-Mañas, L., & Sinclair, A. J. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.10.001 · Cited by 277

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Singh, N. A., Quine, S., Clemson, L. M., Williams, E. J., Williamson, D. A., Stavrinos, T. M., Grady, J. N., Perry, T. J., Lloyd, B. D., Smith, E. U. R., et al. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.08.005 · Cited by 274

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de Souto Barreto, P., Morley, J. E., Chodzko-Zajko, W., H. Pitkala, K., Weening-Djiksterhuis, E., Rodriguez-Mañas, L., Barbagallo, M., Rosendahl, E., Sinclair, A., Landi, F., et al. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.01.021 · Cited by 274

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Goggins, W. B., Woo, J., Sham, A., & Ho, S. C. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.8.1046 · Cited by 267

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Halfon, M., Phan, O., & Teta, D. (2015) · BioMed Research International · doi:10.1155/2015/953241 · Cited by 261

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Bock, J.-O., König, H.-H., Brenner, H., Haefeli, W. E., Quinzler, R., Matschinger, H., Saum, K.-U., Schöttker, B., & Heider, D. (2016) · BMC Health Services Research · doi:10.1186/s12913-016-1360-3 · Cited by 259

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Landi, F., Marzetti, E., Martone, A. M., Bernabei, R., & Onder, G. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000018 · Cited by 255

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Rockwood, K., Abeysundera, M. J., & Mitnitski, A. (2007) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2007.07.012 · Cited by 249

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Potter, K., Flicker, L., Page, A., & Etherton-Beer, C. (2016) · PLOS ONE · doi:10.1371/journal.pone.0149984 · Cited by 246

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Bauer, J. M., Kaiser, M. J., Anthony, P., Guigoz, Y., & Sieber, C. C. (2008) · Nutrition in Clinical Practice · doi:10.1177/0884533608321132 · Cited by 240

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Flaherty, J. H., Perry, H. M., Lynchard, G. S., & Morley, J. E. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.10.m554 · Cited by 236

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Theou, O., Rockwood, M. R. H., Mitnitski, A., & Rockwood, K. (2012) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2012.03.001 · Cited by 232

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Woolf, S., Schünemann, H. J., Eccles, M. P., Grimshaw, J. M., & Shekelle, P. (2012) · Implementation Science · doi:10.1186/1748-5908-7-61 · Cited by 232

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and the members of the Guidelines International Network Implementation Working Group, Gagliardi, A. R., & Alhabib, S. (2015) · Implementation Science · doi:10.1186/s13012-015-0247-8 · Cited by 229

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Flicker, L., Mead, K., MacInnis, R. J., Nowson, C., Scherer, S., Stein, M. S., Thomasx, J., Hopper, J. L., & Wark, J. D. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51510.x · Cited by 228

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Morley, J. E. (2012) · Family Practice · doi:10.1093/fampra/cmr063 · Cited by 218

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Vellas, B., Balardy, L., Gillette-Guyonnet, S., Abellan Van Kan, G., Ghisolfi-Marque, A., Subra, J., Bismuth, S., Oustric, S., & Cesari, M. (2013) · The Journal of nutrition, health and aging · doi:10.1007/s12603-013-0363-6 · Cited by 208

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van de Pol, M. H. J., Fluit, C. R. M. G., Lagró, J., Slaats, Y. H. P., Rikkert, M. G. M. O., & Lagro-Janssen, A. L. M. (2015) · Patient Education and Counseling · doi:10.1016/j.pec.2015.12.014 · Cited by 160

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Rockwood, K. J., Rockwood, M. R. H., & Mitnitski, A. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02667.x · Cited by 159

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Cadore, E. L., Moneo, A. B. B., Mensat, M. M., Muñoz, A. R., Casas-Herrero, A., Rodriguez-Mañas, L., & Izquierdo, M. (2014) · AGE · doi:10.1007/s11357-013-9599-7 · Cited by 151

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Holroyd-Leduc, J. M., Resin, J., Ashley, L. A., Barwich, D., Elliott, J. B., Huras, P., Légaré, F., Mahoney, M., Maybee, A., McNeil, H., et al. (2016) · Research Involvement and Engagement · doi:10.1186/s40900-016-0038-7 · Cited by 147

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Rosendahl-Riise, H., Spielau, U., Ranhoff, A. H., Gudbrandsen, O. A., & Dierkes, J. (2016) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12394 · Cited by 147

Measuring factors affecting grip strength in a Taiwan Chinese population and a comparison with consolidated norms

Wu, S.-W., Wu, S.-F., Liang, H.-W., Wu, Z.-T., & Huang, S. (2008) · Applied Ergonomics · doi:10.1016/j.apergo.2008.08.006 · Cited by 146

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Gregorevic, K. J., Hubbard, R. E., Katz, B., & Lim, W. K. (2016) · BMC Geriatrics · doi:10.1186/s12877-016-0292-4 · Cited by 146

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Lopez, D. G., Flicker, L. A., & Dobson, A. J. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03746.x · Cited by 142

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Kim, H., Suzuki, T., Kim, M., Kojima, N., Yoshida, Y., Hirano, H., Saito, K., Iwasa, H., Shimada, H., Hosoi, E., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.10.006 · Cited by 139

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Lakey, S. L., LaCroix, A. Z., Gray, S. L., Soo Borson, B., Williams, C. D., Calhoun, D., Goveas, J. S., Smoller, J. W., Ockene, J. K., Masaki, K., et al. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.03940.x · Cited by 137

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Baitar, A., Fraeyenhove, F. V., Vandebroek, A., Droogh, E. D., Galdermans, D., Mebis, J., & Schrijvers, D. L. A. L. (2012) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2012.08.001 · Cited by 134

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Liu, L.-K., Lee, W., Chen, L., Hwang, A., Lin, M.-H., Peng, L., & Chen, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136968 · Cited by 132

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HáBERT, R., Bravo, G., Korner-Bitensky, N. A., & Voyer, L. (1996) · Age and Ageing · doi:10.1093/ageing/25.2.159 · Cited by 130

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Jung, H., Jang, I., Lee, Y. S., Lee, C. K., Cho, E.-I., Kang, W. Y., Chae, J. H., Lee, E., & Kim, D. H. (2016) · Journal of Korean Medical Science · doi:10.3346/jkms.2016.31.3.345 · Cited by 130

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Hawley-Hague, H., Horne, M., Campbell, M., Demack, S., Skelton, D. A., & Todd, C. J. (2013) · The Gerontologist · doi:10.1093/geront/gnt075 · Cited by 129

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Chung, C. L. H., Thilarajah, S., & Tan, D. M. L. (2015) · Clinical Rehabilitation · doi:10.1177/0269215515570381 · Cited by 127

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Jung, H., Kim, S., Ahn, S., Lim, J., Han, J.-W., Kim, T. H., Kim, K., Kim, K.-I., & Kim, C.-H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087958 · Cited by 126

High prevalence of vitamin D deficiency among middle-aged and elderly individuals in northwestern China: Its relationship to osteoporosis and lifestyle factors

Zhen, D., Liu, L., Guan, C., Zhao, N., & Tang, X. (2014) · Bone · doi:10.1016/j.bone.2014.09.024 · Cited by 126

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Basger, B., Chen, T. F., & Moles, R. J. (2008) · Drugs & Aging · doi:10.2165/00002512-200825090-00004 · Cited by 124

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Scott, I. A., Anderson, K., Freeman, C. R., & Stowasser, D. A. (2014) · The Medical Journal of Australia · doi:10.5694/mja14.00146 · Cited by 123

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Psychosocial factors modify the association of frailty with adverse outcomes: a prospective study of hospitalised older people

Dent, E., & Hoogendijk, E. O. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-108 · Cited by 119

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Fried, L. P. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025916 · Cited by 119

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Bronskill, S. E., Gill, S. S., Paterson, J. M., Bell, C. M., Anderson, G., & Rochon, P. A. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.07.001 · Cited by 115

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Almeida, O. P., Hankey, G. J., Yeap, B. B., Golledge, J., Norman, P. E., & Flicker, L. A. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.10.023 · Cited by 115

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Moreira, V. G., & Lourenço, R. A. (2013) · Clinics · doi:10.6061/clinics/2013(07)15 · Cited by 115

Association of vitamin D deficiency and frailty: A systematic review and meta-analysis

Zhou, J., Huang, P., Liu, P., Hao, Q., Chen, S., Dong, B., & Wang, J. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.09.003 · Cited by 114

Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people

Tieland, M., Brouwer-Brolsma, E. M., Nienaber‐Rousseau, C., van Loon, L. J. C., & de Groot, C. P. G. M. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.144 · Cited by 111

A limit to frailty in very old, community-dwelling people: a secondary analysis of the Chinese longitudinal health and longevity study

Bennett, S. L., Song, X., Mitnitski, A., & Rockwood, K. J. (2012) · Age and Ageing · doi:10.1093/ageing/afs180 · Cited by 111

Deprescribing for older patients

Frank, C., & Weir, E. L. (2014) · Canadian Medical Association Journal · doi:10.1503/cmaj.131873 · Cited by 108

Frailty and Body Mass Index as Predictors of 3-Year Mortality in Older Adults Living in the Community

Lee, Y., Kim, J., Han, E. S., Ryu, M., Cho, Y., & Chae, S. (2014) · Gerontology · doi:10.1159/000362330 · Cited by 107

Resistance training improves fatigue and quality of life in previously sedentary breast cancer survivors: a randomised controlled trial

Hagstrom, A. D., Marshall, P. W., Lonsdale, C., Cheema, B. S., Singh, M. A. F., & Green, S. (2015) · European Journal of Cancer Care · doi:10.1111/ecc.12422 · Cited by 107

Home-based resistance training for older adults: a systematic review.

Thiebaud, R. S., Funk, M. D., & Abe, T. (2014) · Geriatrics & Gerontology International · doi:10.1111/ggi.12326 · Cited by 105

A Pilot Study of the FRAIL Scale on Predicting Outcomes in Chinese Elderly People With Type 2 Diabetes

Li, Y., Zou, Y., Wang, S., Li, J., Jing, X., Yang, M., Wang, L., Cao, L., Yang, X., Xu, L., et al. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.05.019 · Cited by 104

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Santanasto, A. J., Glynn, N. W., Lovato, L. C., Blair, S. N., Fielding, R. A., Gill, T. M., Guralnik, J. M., Hsu, F., King, A. C., Strotmeyer, E. S., et al. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14804 · Cited by 103

Detection and treatment of medical inpatients with or at-risk of malnutrition: Suggested procedures based on validated guidelines

Bounoure, L., Gomes, F., Stanga, Z., Keller, U., Meier, R., Ballmer, P., Fehr, R., Mueller, B., Genton, L., Bertrand, P. C., et al. (2016) · Nutrition · doi:10.1016/j.nut.2016.01.019 · Cited by 103

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Wong, Y. Y., McCaul, K. A., Yeap, B. B., Hankey, G. J., & Flicker, L. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1702 · Cited by 102

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Zheng, Z., Guan, S., Ding, H., Wang, Z., Zhang, J., Zhao, J., Ma, J., & Chan, P. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14135 · Cited by 102

Simple self‐report FRAIL scale might be more closely associated with dialysis complications than other frailty screening instruments in rural chronic dialysis patients

Chao, C., Hsu, Y.-S., Chang, P.-Y., He, Y., Ueng, R., Lai, C., Chiang, C., Huang, J., & Huang, S. (2015) · Nephrology · doi:10.1111/nep.12401 · Cited by 101

Can progressive resistance strength training reduce physical disability in older adults? A meta-analysis study

Liu, C.-J., & Latham, N. K. (2010) · Disability and Rehabilitation · doi:10.3109/09638288.2010.487145 · Cited by 101

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Chang, C.-I., Chan, D., Kuo, K.-N., Hsiung, C. A., & Chen, C. (2011) · Journal of the Formosan Medical Association · doi:10.1016/s0929-6646(11)60037-5 · Cited by 98

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Yang, F., & Gu, D. (2016) · BMC Geriatrics · doi:10.1186/s12877-016-0317-z · Cited by 67

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