Cited by 124Posttraumatic Stress Disorder ResearchNeuroendocrine regulation and behaviorStress Responses and Cortisol

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Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: Salience processing and fear inhibition processes

Koch, Saskia B.J., van Zuiden, Mirjam, Nawijn, Laura, Frijling, Jessie L., Veltman, Dick J., Olff, Miranda·2014·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2013.11.018

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Abstract

About ten percent of people experiencing a traumatic event will subsequently develop post-traumatic stress disorder (PTSD). PTSD is characterized by an exaggerated fear response which fails to extinguish over time and cannot be inhibited in safe contexts. The neurobiological correlates of PTSD involve enhanced salience processing (i.e. amygdala, dorsal anterior cingulate cortex (dACC) and anterior insula (AI) hyperactivity), and reduced top-down inhibitory control over this fear response (i.e. dorsal and ventromedial prefrontal cortex (vmPFC) hypoactivity and diminished structural and functional connectivity between the vmPFC, hippocampus and amygdala). Therefore, dampening the exaggerated fear response (i.e. by reducing amygdala hyperactivity) and enhancing top-down inhibitory control (i.e. by promoting prefrontal control over the amygdala) during psychotherapy is an important target for medication-enhanced psychotherapy (MEP) in PTSD patients. Since the neuropeptide oxytocin (OT) has been found to act on these two processes, we propose that OT is a promising pharmacological agent to boost treatment response in PTSD. Human fMRI studies indicate that intranasal OT attenuates amygdala (hyper)activity and enhances connectivity of the amygdala with the vmPFC and hippocampus, resulting in increased top-down control over the fear response. In addition, intranasal OT was found to attenuate amygdala-brainstem connectivity and to change activity and connectivity in nodes of the salience network (i.e. AI and dACC). Furthermore, OT administration may modulate hypothalamus-pituitary-adrenal (HPA) axis and autonomic nervous system (ANS) function and may enhance social behaviour, which could be beneficial in the therapeutic alliance. We also discuss contextual and interindividual factors (e.g. gender and social context) which may influence the effectiveness of OT in MEP. In all, we propose that intranasal OT given prior to each psychotherapy session may be an effective additive treatment to boost treatment response in PTSD.

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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,842
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426
Large-scale brain networks and psychopathology: a unifying triple network model
Menon, V. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.08.003 · Cited by 4,168
Biobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight.
Taylor, S. E., Klein, L. C., Lewis, B. P., Gruenewald, T. L., Gurung, R. A. R., & Updegraff, J. A. (2000) · Psychological Review · doi:10.1037/0033-295x.107.3.411 · Cited by 3,308
Rethinking feelings: an fMRI study of the cognitive regulation of emotion
Ochsner, K. N., Bunge, S. A., Gross, J. J., & Gabrieli, J. D. E. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902760807212 · Cited by 2,520
Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980
A Multidimensional Meta-Analysis of Psychotherapy for PTSD
Bradley, R., Greene, J., Russ, E., Dutra, L., & Westen, D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.214 · Cited by 1,938
Extinction Learning in Humans
Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
Gilbertson, M. W., Shenton, M. E., Ciszewski, A., Kasai, K., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2002) · Nature Neuroscience · doi:10.1038/nn958 · Cited by 1,635
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,581
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356
Recall of Fear Extinction in Humans Activates the Ventromedial Prefrontal Cortex and Hippocampus in Concert
Milad, M. R., Wright, C. I., Orr, S. P., Pitman, R. K., Quirk, G. J., & Rauch, S. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.011 · Cited by 1,197
Gender differences in posttraumatic stress disorder.
Olff, M., Langeland, W., Draijer, N., & Gersons, B. P. R. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.2.183 · Cited by 1,058
Self-citation
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941
A meta-analysis of structural brain abnormalities in PTSD
KARL, A., SCHAEFER, M., MALTA, L., DORFEL, D., ROHLEDER, N., & WERNER, A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.03.004 · Cited by 881
The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety
Kim, M. J., Loucks, R. A., Palmer, A. L., Brown, A. C., Solomon, K. M., Marchante, A. N., & Whalen, P. J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.025 · Cited by 838
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774
Neural circuitry underlying the regulation of conditioned fear and its relation to extinction
Delgado, M. R., Nearing, K. I., LeDoux, J. E., & Phelps, E. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.029 · Cited by 716
The safety and efficacy of ±3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study
Mithoefer, M. C., Wagner, M. T., Mithoefer, A. T., Jerome, L., & Doblin, R. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110378371 · Cited by 674
The Neural Bases of Distraction and Reappraisal
McRae, K., Hughes, B., Chopra, S., Gabrieli, J. D. E., Gross, J. J., & Ochsner, K. N. (2010) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21243 · Cited by 642
The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences
Olff, M., Frijling, J. L., Kubzansky, L. D., Bradley, B., Ellenbogen, M. A., Cardoso, C., Bartz, J. A., Yee, J. R., & van Zuiden, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.019 · Cited by 620
Self-citation
The Influence of Stress Hormones on Fear Circuitry
Rodrigues, S. M., LeDoux, J. E., & Sapolsky, R. M. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135620 · Cited by 556
Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder
Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., Stout, J. C., & Nathan, P. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.123 · Cited by 549 · cited 2×
“Notably, in this study no effect of OT on amygdala reactivity was found in healthy controls, suggesting that OT might be most effective in dampening amygdala responsiveness in pathological states, for example when the amygdala is hyperresponsive (Labuschagne et al., 2010), as in PTSD.”
Background
Neurocircuitry models of posttraumatic stress disorder and beyond: A meta-analysis of functional neuroimaging studies
Patel, R., Spreng, R. N., Shin, L. M., & Girard, T. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.003 · Cited by 546
Effective treatments for PTSD: practice guidelines from the International Society for Traumatic Stress Studies
Hudson, P. (2011) · British Journal of Guidance and Counselling · doi:10.1080/03069885.2010.550798 · Cited by 526
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521
Presence and acquired origin of reduced recall for fear extinction in PTSD: Results of a twin study
Milad, M. R., Orr, S. P., Lasko, N. B., Chang, Y., Rauch, S. L., & Pitman, R. K. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.01.017 · Cited by 512
Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.003 · Cited by 511
Context-Dependent Human Extinction Memory Is Mediated by a Ventromedial Prefrontal and Hippocampal Network
Kalisch, R., Korenfeld, E., Stephan, K. E., Weiskopf, N., Seymour, B., & Dolan, R. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2021-06.2006 · Cited by 493
A Role for the Human Dorsal Anterior Cingulate Cortex in Fear Expression
Milad, M. R., Quirk, G. J., Pitman, R. K., Orr, S. P., Fischl, B., & Rauch, S. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.032 · Cited by 485
Effective Treatments for PTSD
Ursano, R. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1805-a · Cited by 462
How the Neurocircuitry and Genetics of Fear Inhibition May Inform Our Understanding of PTSD
Jovanović, T., & Ressler, K. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09071074 · Cited by 457
Applying Learning Principles to the Treatment of Post‐Trauma Reactions
ROTHBAUM, B. O., & DAVIS, M. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1301.012 · Cited by 454
Oxytocin can hinder trust and cooperation in borderline personality disorder
Bartz, J., Simeon, D., Hamilton, H., Kim, S., Crystal, S., Braun, A., Vicens, V., & Hollander, E. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq085 · Cited by 452
Quantitative meta-analysis of neural activity in posttraumatic stress disorder
Hayes, J. P., Hayes, S. M., & Mikedis, A. M. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-9 · Cited by 452
Impaired fear inhibition is a biomarker of PTSD but not depression
Jovanovic, T., Norrholm, S. D., Blanding, N. Q., Davis, M., Duncan, E., Bradley, B., & Ressler, K. J. (2010) · Depression and Anxiety · doi:10.1002/da.20663 · Cited by 444
The structural integrity of an amygdala-prefrontal pathway predicts trait anxiety
Kim, M. J., & Whalen, P. J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2335-09.2009 · Cited by 433 · cited 1×
“In addition, the strength of the amygdala—vmPFC pathway, as expressed by structural integrity (measured with diffusion tensor imaging, DTI) is lower in individuals with high trait anxiety (Kim and Whalen, 2009).”
Background
Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity
Petrovic, P., Kalisch, R., Singer, T., & Dolan, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4572-07.2008 · Cited by 424 · cited 3×
“In addition, OT administered after fear conditioning was found to attenuate amygdala and dACC activity to pre-conditioned faces as well as affective ratings of these faces (Petrovic et al., 2008).”
BackgroundInfluential
Fear is only as deep as the mind allows
Diekhof, E. K., Geier, K., Falkai, P., & Gruber, O. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.05.073 · Cited by 413
Neural Dysregulation in Posttraumatic Stress Disorder: Evidence for Disrupted Equilibrium Between Salience and Default Mode Brain Networks
Sripada, R. K., King, A. P., Welsh, R. C., Garfinkel, S. N., Wang, X., Sripada, C. S., & Liberzon, I. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318273bf33 · Cited by 412
Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory
Milad, M. R., Quinn, B. T., Pitman, R. K., Orr, S. P., Fischl, B., & Rauch, S. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502441102 · Cited by 412
The neuropeptide oxytocin facilitates pro-social behavior and prevents social avoidance in rats and mice
Lukas, M., Toth, I., Reber, S. O., Slattery, D. A., Veenema, A. H., & Neumann, I. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.95 · Cited by 403
The lifetime prevalence of traumatic events and posttraumatic stress disorder in the Netherlands
de Vries, G., & Olff, M. (2009) · Journal of Traumatic Stress · doi:10.1002/jts.20429 · Cited by 390
Self-citation
Anxiety Dissociates Dorsal and Ventral Medial Prefrontal Cortex Functional Connectivity with the Amygdala at Rest
Kim, M. J., Gee, D. G., Loucks, R. A., Davis, F. C., & Whalen, P. J. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq237 · Cited by 388
Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala
Viviani, D., Charlet, A., van den Burg, E., Robinet, C., Hurni, N., Abatis, M., Magara, F., & Stoop, R. (2011) · Science · doi:10.1126/science.1201043 · Cited by 381
A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder
Guastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.005 · Cited by 366
Oxytocin modulates amygdala, insula, and inferior frontal gyrus responses to infant crying: a randomized controlled trial
Riem, M. M. E., Bakermans-Kranenburg, M. J., Pieper, S., Tops, M., Boksem, M. A. S., Vermeiren, R. R. J. M., van IJzendoorn, M. H., & Rombouts, S. A. R. B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.006 · Cited by 366
A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research
MacDonald, E., Dadds, M. R., Brennan, J. L., Williams, K., Levy, F., & Cauchi, A. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.02.015 · Cited by 359 · cited 1×
“Besides its easy application, a recent review showed that short-term use of intranasal OT up to doses of 40 IU results in minimal side effects and is equally safe to use in psychiatric patients as in healthy individuals (MacDonald et al., 2011).”
Background
Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research
Guastella, A. J., Hickie, I. B., McGuinness, M. M., Otis, M., Woods, E. A., Disinger, H. M., Chan, H.-K., Chen, T. F., & Banati, R. B. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.019 · Cited by 357
Intranasal oxytocin versus placebo in the treatment of adults with Autism Spectrum Disorders: A randomized controlled trial
Anagnostou, E., Soorya, L., Chaplin, W., Bartz, J., Halpern, D., Wasserman, S., Wang, A. T., Pepa, L., Tanel, N., Kushki, A., et al. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-16 · Cited by 350
Posttraumatic stress disorder may be associated with impaired fear inhibition: Relation to symptom severity
Jovanovic, T., Norrholm, S. D., Fennell, J. E., Keyes, M., Fiallos, A. M., Myers, K. M., Davis, M., & Duncan, E. J. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2007.12.014 · Cited by 315
Magnetic Resonance Imaging of Hippocampal Subfields in Posttraumatic Stress Disorder
Wang, Z., Neylan, T. C., Mueller, S. G., Lenoci, M., Truran, D., Marmar, C. R., Weiner, M. W., & Schuff, N. W. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.205 · Cited by 307
Intranasal oxytocin reduces psychotic symptoms and improves Theory of Mind and social perception in schizophrenia
Pedersen, C. A., Gibson, C. M., Rau, S. W., Salimi, K., Smedley, K. L., Casey, R. L., Leserman, J., Jarskog, L. F., & Penn, D. L. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.07.027 · Cited by 305
Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Thompson, R., Ditzen, B., Patel, R., & Pagnoni, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.013 · Cited by 303
Amygdala Volume Changes in Posttraumatic Stress Disorder in a Large Case-Controlled Veterans Group
Morey, R. A., Gold, A. L., LaBar, K. S., Beall, S. K., Brown, V. M., Haswell, C. C., Nasser, J. D., Wagner, H. R., McCarthy, G., & Mid-Atlantic MIRECC Workgroup, F. T. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.50 · Cited by 289
Anticipation of Aversive Visual Stimuli Is Associated With Increased Insula Activation in Anxiety-Prone Subjects
Simmons, A., Strigo, I., Matthews, S. C., Paulus, M. P., & Stein, M. B. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.038 · Cited by 287
Default mode network connectivity as a predictor of post‐traumatic stress disorder symptom severity in acutely traumatized subjects
Lanius, R. A., Bluhm, R. L., Coupland, N. J., Hegadoren, K. M., Rowe, B., Théberge, J., Neufeld, R. W. J., Williamson, P. C., & Brimson, M. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01391.x · Cited by 273
Gray Matter Correlates of Posttraumatic Stress Disorder: A Quantitative Meta-Analysis
Kühn, S., & Gallinat, J. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.029 · Cited by 259
Focal brain damage protects against post-traumatic stress disorder in combat veterans
Koenigs, M., Huey, E. D., Raymont, V., Cheon, B., Solomon, J., Wassermann, E. M., & Grafman, J. (2008) · Nature Neuroscience · doi:10.1038/nn2032 · Cited by 255
In Search of the Trauma Memory: A Meta-Analysis of Functional Neuroimaging Studies of Symptom Provocation in Posttraumatic Stress Disorder (PTSD)
Sartory, G., Cwik, J. C., Knuppertz, H., Schürholt, B., Lebens, M., Seitz, R. J., & Schulze, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058150 · Cited by 252
Oxytocin facilitates protective responses to aversive social stimuli in males
Striepens, N., Scheele, D., Kendrick, K. M., Becker, B., Schäfer, L., Schwalba, K., Reul, J., Maier, W., & Hurlemann, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208852109 · Cited by 242
Effects of oxytocin on recollections of maternal care and closeness
Bartz, J. A., Zaki, J., Ochsner, K. N., Bolger, N., Kolevzon, A., Ludwig, N., & Lydon, J. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012669107 · Cited by 238 · cited 2×
“Bohus et al., 1978; Toth et al., 2012). Several rodent studies have shown that intraventricular administration of OT facilitated the extinction of passive avoidance behaviour, measured as the latency to enter a compartment previously associated with an aversive stimulus (e.g. Bohus et al., 1978). Importantly, Toth and…”
Background
Opposite effects of oxytocin and vasopressin on avoidance behaviour and hippocampal theta rhythm in the rat
BOHUS, B., URBAN, I., VANWIMERSMAGREIDANUS, T., & DEWIED, D. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90107-7 · Cited by 231
A Randomized Placebo-Controlled Trial of d-Cycloserine to Enhance Exposure Therapy for Posttraumatic Stress Disorder
de Kleine, R. A., Hendriks, G.-J., Kusters, W. J. C., Broekman, T. G., & van Minnen, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.02.033 · Cited by 220
Oxytocin and Reduction of Social Threat Hypersensitivity in Women With Borderline Personality Disorder
Bertsch, K., Gamer, M., Schmidt, B., Schmidinger, I., Walther, S., Kästel, T., Schnell, K., Büchel, C., Domes, G., & Herpertz, S. C. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13020263 · Cited by 214
Oxytocin buffers cortisol responses to stress in individuals with impaired emotion regulation abilities
Quirin, M., Kuhl, J., & Düsing, R. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.12.005 · Cited by 204
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Sripada, C. S., Phan, K. L., Labuschagne, I., Welsh, R., Nathan, P. J., & Wood, A. G. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000533 · Cited by 197
Oxytocin increases amygdala reactivity to threatening scenes in females
Lischke, A., Gamer, M., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.01.011 · Cited by 194 · cited 2×
“Several human neuroimaging studies have shown that OT administration in healthy females resulted in enhanced, rather than attenuated, amygdala reactivity towards threatening scenes (Lischke et al., 2012) and fearful faces (Bertsch et al.”
Background
Oxytocin increases anxiety to unpredictable threat
Grillon, C., Krimsky, M., Charney, D. R., Vytal, K., Ernst, M., & Cornwell, B. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.156 · Cited by 192 · cited 2×
“electric shocks) was increased after OTadministration compared to AVP and placebo administration (Grillon et al., 2012).”
BackgroundResult
No Laughing Matter: Intranasal Oxytocin Administration Changes Functional Brain Connectivity during Exposure to Infant Laughter
Riem, M. M. E., van IJzendoorn, M. H., Tops, M., Boksem, M. A. S., Rombouts, S. A. R. B., & Bakermans-Kranenburg, M. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.313 · Cited by 191
Oxytocin plasma concentrations after single intranasal oxytocin administration–a study in healthy men
Gossen, A., Hahn, A., Westphal, L., Prinz, S., Schultz, R. T., Gründer, G., & Spreckelmeyer, K. N. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.07.001 · Cited by 189
Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study
Cardoso, C., Ellenbogen, M. A., Orlando, M. A., Bacon, S. L., & Joober, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.07.013 · Cited by 187
Helping oxytocin deliver: considerations in the development of oxytocin-based therapeutics for brain disorders
MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181
Differences between effects of psychological versus pharmacological treatments on functional and morphological brain alterations in anxiety disorders and major depressive disorder: A systematic review
Quidé, Y., Witteveen, A. B., El‐Hage, W., Veltman, D. J., & Olff, M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.09.004 · Cited by 180
Self-citation
Effective psychotherapies for posttraumatic stress disorder: a review and critique.
Cloître, M. (2009) · PubMed · Cited by 171
Exaggerated Activation of Dorsal Anterior Cingulate Cortex During Cognitive Interference: A Monozygotic Twin Study of Posttraumatic Stress Disorder
Shin, L. M., Bush, G., Milad, M. R., Lasko, N. B., Brohawn, K. H., Hughes, K. C., Macklin, M. L., Gold, A. L., Karpf, R. D., Orr, S. P., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.09121812 · Cited by 170
Sex differences in vasopressin and oxytocin innervation of the brain
DEVRIES, G. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00402-0 · Cited by 169
Pre-trauma individual differences in extinction learning predict posttraumatic stress
Lommen, M. J. J., Engelhard, I. M., Sijbrandij, M., van den Hout, M. A., & Hermans, D. (2013) · Behaviour Research and Therapy · doi:10.1016/j.brat.2012.11.004 · Cited by 167
Oxytocin causes a sustained decrease in plasma levels of corticosterone in rats
Petersson, M., Hulting, A., & Uvnäs‐Moberg, K. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00159-7 · Cited by 156
Anxiolytic-like effect of oxytocin in the simulated public speaking test
de Oliveira, D. C., Zuardi, A. W., Graeff, F. G., Queiroz, R. H., & Crippa, J. A. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111400642 · Cited by 154
Effects of intranasal vasopressin and oxytocin on physiologic responding during personal combat imagery in Vietnam veterans with posttraumatic stress disorder
Pitman, R. K., Orr, S. P., & Lasko, N. B. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90035-f · Cited by 150
Reduced neural activation during an inhibition task is associated with impaired fear inhibition in a traumatized civilian sample
Jovanovic, T., Ely, T., Fani, N., Glover, E. M., Gutman, D., Tone, E. B., Norrholm, S. D., Bradley, B., & Ressler, K. J. (2013) · Cortex · doi:10.1016/j.cortex.2012.08.011 · Cited by 146
Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin
Labuschagne, I., Phan, K. L., WOOD, A. G., Angstadt, M., Chua, P. M.-L., Heinrichs, M., Stout, J. C., & Nathan, P. J. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001489 · Cited by 144
A heartfelt response: oxytocin effects on response to social stress in men and women
Kubzansky, L. D., Mendes, W. B., Appleton, A. A., Block, J., & Adler, G. K. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.02.010 · Cited by 142
The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample
Acheson, D., Feifel, D., de Wilde, S., Mckinney, R., Lohr, J., & Risbrough, V. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3099-4 · Cited by 141
Oxytocin and psychotherapy: a pilot study of its physiological, behavioral and subjective effects in males with depression
MacDonald, K., MacDonald, T. M., Brüne, M., Lamb, K., Wilson, M. P., Golshan, S., & Feifel, D. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.05.014 · Cited by 140
Elevated salivary levels of oxytocin persist more than 7 h after intranasal administration
van IJzendoorn, M. H., Bhandari, R., van der Veen, R., Grewen, K. M., & Bakermans-Kranenburg, M. J. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00174 · Cited by 137
Amygdala Volume in Combat-Exposed Veterans With and Without Posttraumatic Stress Disorder: A Cross-sectional Study
Kuo, J. R., Kaloupek, D. G., & Woodward, S. H. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.73 · Cited by 136
White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder
Fani, N., King, T. Z., Jovanovic, T., Glover, E. M., Bradley, B., Choi, K., Ely, T., Gutman, D. A., & Ressler, K. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.146 · Cited by 135
A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder
Olff, M., Langeland, W., Witteveen, A., & Denys, D. (2010) · CNS Spectrums · doi:10.1017/s109285290000047x · Cited by 135
Self-citation
Amygdala Volume in Adults with Posttraumatic Stress Disorder: A Meta-Analysis
Woon, F. L., & Hedges, D. W. (2009) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.2009.21.1.5 · Cited by 120
Central administration of oxytocin receptor ligands affects cued fear extinction in rats and mice in a timepoint-dependent manner
Toth, I., Neumann, I. D., & Slattery, D. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2702-4 · Cited by 107
Intranasal Oxytocin as an Adjunct to Risperidone in Patients with Schizophrenia
Modabbernia, A., Rezaei, F., Salehi, B., Jafarinia, M., Ashrafi, M., Tabrizi, M. H., Hosseini, S. M. R., Tajdini, M., Ghaleiha, A., & Akhondzadeh, S. (2012) · CNS Drugs · doi:10.1007/s40263-012-0022-1 · Cited by 107
Increased anterior cingulate cortex and hippocampus activation in Complex PTSD during encoding of negative words
Thomaes, K., Dorrepaal, E., Draijer, N., de Ruiter, M. B., Elzinga, B. M., Sjoerds, Z., van Balkom, A. J., Smit, J. H., & Veltman, D. J. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr084 · Cited by 103
Self-citation
Hippocampal microinfusion of oxytocin attenuates the behavioural response to stress by means of dynamic interplay with the glucocorticoid-catecholamine responses
Cohen, H., Kaplan, Z., Kozlovsky, N., Gidron, Y., Matar, M. A., & Zohar, J. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02003.x · Cited by 94
Learning About Oxytocin: Pharmacologic and Behavioral Issues
Chini, B., Leonzino, M., Braida, D., & Sala, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.029 · Cited by 91
Early Altered Resting-State Functional Connectivity Predicts the Severity of Post-Traumatic Stress Disorder Symptoms in Acutely Traumatized Subjects
Zhou, Y., Wang, Z., Qin, L.-D., Wan, J.-Q., Sun, Y.-W., Su, S.-S., Ding, W.-N., & Xu, J.-R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046833 · Cited by 89
An fMRI study of unconditioned responses in post-traumatic stress disorder
Linnman, C., Zeffiro, T. A., Pitman, R. K., & Milad, M. R. (2011) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-1-8 · Cited by 84
Block of glucocorticoid synthesis during re-activation inhibits extinction of an established fear memory
Blundell, J. J., Blaiss, C. A., Lagace, D. C., Eisch, A. J., & Powell, C. M. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.02.006 · Cited by 79
The Promise and Perils of Oxytocin
Miller, G. (2013) · Science · doi:10.1126/science.339.6117.267 · Cited by 76 · cited 1×
“longterm consequences of OT administration, difference in effects between acute and chronic OT administration and whether intranasal OT does enter the brain) (Macdonald and Feifel, 2013; Miller, 2013).”
Background
Hippocampal but not amygdalar volume affects contextual fear conditioning in humans
Pohlack, S. T., Nees, F., Liebscher, C., Cacciaglia, R., Diener, S. J., Ridder, S., Woermann, F. G., & Flor, H. (2011) · Human Brain Mapping · doi:10.1002/hbm.21224 · Cited by 75
Social anxiety modulates amygdala activation during social conditioning
Pejic, T., Hermann, A., Vaitl, D., & Stark, R. M. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr095 · Cited by 61
Different Regional Gray Matter Loss in Recent Onset PTSD and Non PTSD after a Single Prolonged Trauma Exposure
Chen, Y., Fu, K., Chen, F., Tang, L., Zhang, J., Huan, Y., Cui, J., Mu, Y., Qi, S., Xiong, L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048298 · Cited by 59
DecreasedN‐acetyl‐aspartate levels in anterior cingulate and hippocampus in subjects with post‐traumatic stress disorder: a proton magnetic resonance spectroscopy study
Ham, B., Chey, J., Yoon, S. J., Sung, Y., Jeong, D., Kim, S. J., Sim, M., Choi, N., Choi, I., Renshaw, P. F., et al. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05253.x · Cited by 55
Pharmacological Innovations for Posttraumatic Stress Disorder and Medication- Enhanced Psychotherapy
Dunlop, B. W., Mansson, E. E., & Gerardi, M. A. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212803530899 · Cited by 48
Amygdala response to negative images in postpartumvsnulliparous women and intranasal oxytocin
Rupp, H. A., James, T. W., Ketterson, E. D., Sengelaub, D. R., Ditzen, B., & Heiman, J. R. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss100 · Cited by 44
More vulnerability of left than right hippocampal damage in right-handed patients with post-traumatic stress disorder
Shu, X., Li, X., Liu, W. D., Chen, F.-Y., Zhu, C., Sun, X.-H., Wang, X., Liu, Z.-C., & Zhao, H. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.04.009 · Cited by 38
P.3.026 Intranasal oxytocin in patients with post traumatic stress disorder: a single dose, pilot double blind crossover study
Yatzkar, U., & Klein, E. (2010) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(10)70098-5 · Cited by 32

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Authors: Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Corresponding author: Koch, Saskia B.J.
ORCID: Koch, Saskia B.J.
Nawijn, Laura
Frijling, Jessie L.
Veltman, Dick J.
Olff, Miranda
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2014-02
Volume: 40
Pages: 242-256
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2013.11.018
OpenAlex: W1977778322
Cited by: 123
References: 114
Citations by year: 2026: 5 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 9 · 2018: 19 · 2017: 15 · 2016: 9 · 2015: 16 · 2014: 8
FWCI: 1.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: intranasal oxytocin, post-traumatic stress disorder, salience processing, fear inhibition, amygdala hyperactivity, salience network, anterior insula, dorsal anterior cingulate cortex, hypothalamic-pituitary-adrenal axis, autonomic nervous system, social behavior, therapeutic relationship, gender differences, treatment response
MeSH terms: Adaptation, Psychological, Administration, Intranasal, Animals, Combined Modality Therapy, Fear, Humans, Mental Processes, Oxytocin, Psychotherapy, Stress Disorders, Post-Traumatic

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Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: Salience processing and fear inhibition processes

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