Cited by 488Neuroendocrine regulation and behaviorAnimal Behavior and ReproductionNeurotransmitter Receptor Influence on Behavior

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Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole

Young, Larry J., Nilsen, Roger, Waymire, Katrina G., MacGregor, Grant R., Insel, Thomas R.·1999·Nature

DOI 10.1038/23475

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Abstract

Arginine vasopressin influences male reproductive and social behaviours in several vertebrate taxa through its actions at the V1a receptor in the brain. The neuroanatomical distribution of vasopressin V1a receptors varies greatly between species with different forms of social organization. Here we show that centrally administered arginine vasopressin increases affiliative behaviour in the highly social, monogamous prairie vole, but not in the relatively asocial, promiscuous montane vole. Molecular analyses indicate that gene duplication and/or changes in promoter structure of the prairie vole receptor gene may contribute to the species differences in vasopressin-receptor expression. We further show that mice that are transgenic for the prairie vole receptor gene have a neuroanatomical pattern of receptor binding that is similar to that of the prairie vole, and exhibit increased affiliative behaviour after injection with arginine vasopressin. These data indicate that the pattern of V1a-receptor gene expression in the brain may be functionally associated with species-typical social behaviours in male vertebrates.

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Authors: Young, L. J., Nilsen, R., Waymire, K. G., MacGregor, G. R., & Insel, T. R.
Affiliations: Emory University (US)
Corresponding author: Nilsen, Roger
ORCID: Young, Larry J.
MacGregor, Grant R.
Insel, Thomas R.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1999-08
Volume: 400
Issue: 6746
Pages: 766-768
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/23475
OpenAlex: W1556396873
Cited by: 488
References: 19
Citations by year: 2026: 9 · 2025: 13 · 2024: 13 · 2023: 5 · 2022: 13 · 2021: 11 · 2020: 11 · 2019: 11 · 2018: 13 · 2017: 21 · 2016: 12 · 2015: 17 · 2014: 24 · 2013: 23 · 2012: 18
FWCI: 39.13
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: vasopressin, V1a receptor, Microtus ochrogaster, montane vole, affiliative behavior, social behavior, monogamy, gene duplication, promoter structure, transgenic mice, receptor gene expression, species differences, social organization
MeSH terms: Animals, Arginine Vasopressin, Brain, Arvicolinae, Female, Male, Mice, Transgenic, Molecular Sequence Data, Pair Bond, Social Behavior, Species Specificity, Gene Expression, Receptors, Vasopressin, Mice

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Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole

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