The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Central nervous system control of food intake
Abstract
New information regarding neuronal circuits that control food intake and their hormonal regulation has extended our understanding of energy homeostasis, the process whereby energy intake is matched to energy expenditure over time. The profound obesity that results in rodents (and in the rare human case as well) from mutation of key signalling molecules involved in this regulatory system highlights its importance to human health. Although each new signalling pathway discovered in the hypothalamus is a potential target for drug development in the treatment of obesity, the growing number of such signalling molecules indicates that food intake is controlled by a highly complex process. To better understand how energy homeostasis can be achieved, we describe a model that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function.
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In the citing paper
“Individual populations of neurons within a given hypothalamic nucleus may have opposing effects, as with POMC and AGRP neurons in the arcuate nucleus52.”
From IDOL regulates systemic energy balance through control of neuronal VLDLR expression (2019) · cites this paper as [52]
In the citing paper
“In addition to its critical role in regulating glucose, lipid and protein metabolism, insulin also has important central nervous system effects, where its action in the hypothalamus reduces food intake and increases energy expenditure [155].”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [155]
In the citing paper
“Two major feeding-related neuronal populations are involved: the medially located, orexigenic neurons that synthesize neuropeptide Y (NPY), AGRP, and ␥-amino butyric acid (GABA); and laterally located anorexigenic neurons that produce ␣-MSH and CART (56).”
From Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions (2014) · cites this paper as [56]
In the citing paper
“Two antagonistic, neuronal populations in the arcuate nucleus, the orexigenic NPY/AGRP/GABA neurons and the anorexigenic ␣-MSH/CART neurons, are primarily responsible for sensing and relaying information to hypophysiotropic TRH neurons about the concentration of leptin in the bloodstream (56)”
From Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions (2014) · cites this paper as [56]
In the citing paper
“Because the fasting-induced fall of leptin stimulates NPY/AGRP neurons and inhibits ␣-MSH/CART neurons (56)”
From Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions (2014) · cites this paper as [56]
In the citing paper
“in lean healthy individuals, peripheral and even central infusion of insulin suppresses appetite and feeding”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Schwartz, Woods, Porte, Seeley, & Baskin, 2000
In the citing paper
“The adipose tissue-derived hormone, leptin, is crucial to integrate the melanocortin neuronal circuit of the hypothalamus with the energy stores of the body [34-36].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [36]
In the citing paper
“The neurotransmitters norepinephrine, dopamine and serotonin are also important in central energy balance [34, 36]”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [36]
In the citing paper
“POMC neurons are depolarized by leptin, leading to release of α-melanocyte stimulating hormone (α-MSH), a POMC-derived neuropeptide that mediates its anorexigenic effects through activation of melanocortin receptors (Cone, 2005; Cowley et al., 2001; Schwartz et al., 2000).”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Schwartz et al., 2000
In the citing paper
“In addition, these meal-related humeral signals can be modulated by the more tonic, or long-term, homeostatic signals which are influenced by body energy stores, namely leptin, insulin [11,12], and ghrelin [13].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [12]
In the citing paper
“Leptin is a hormone that is produced mainly by adipocytes and has been implicated in a wide variety of physiological functions, especially in the regulation of energy balance119,120.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [120]
In the citing paper
“In contrast to adiponectin, leptin is secreted in increasing amounts as adipocytes enlarge119,120.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [120]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346
Flagged first, then by citations
Research works printed but not linked: 3
- Edholm, O. G. Energy balance in man. J. Human Nutr. 31, 413–431 (1977).
- Bray, G. A., Fisler, J. & York, D. A. Neuroendocrine control of the development of obesity: understanding gained from studies of experimental animal models. Front. Neuroendocrinol. 11, 128–181 (1990).
- Hagan, M. et al. Effect of agouti-related peptide (83-132) on food intake: competitive melanocortin-receptor antagonism on short but not long term effects. Am. J. Physiol. (in the press).
Cited by
Sorted by citations
Items 201–300 of 328
Ott, V., Benedict, C., Schultes, B., Born, J., & Hallschmid, M. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01490.x · Cited by 139
Autoantibodies against α-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients
Fetissov, S. O., Hallman, J., Oreland, L., af Klinteberg, B., Grenbäck, E., Hulting, A.-L., & Hökfelt, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222658699 · Cited by 140
Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice
Brown, L. M., Clegg, D. J., Benoit, S. C., & Woods, S. C. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.08.008 · Cited by 139
Self-citationFekete, C., & Lechan, R. M. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.04.002 · Cited by 137
Mechanisms of Weight Loss After Obesity Surgery
Akalestou, E., Miras, A. D., Rutter, G. A., & le Roux, C. W. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab022 · Cited by 136
Fedewa, M. V., Hathaway, E. D., Ward-Ritacco, C. L., Williams, T. D., & Dobbs, W. C. (2018) · Sports Medicine · doi:10.1007/s40279-018-0897-1 · Cited by 135
Zheng, H., Corkern, M., Stoyanova, I., Patterson, L. M., Tian, R., & Berthoud, H.-R. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00781.2002 · Cited by 135
Melanocortin-4 Receptor Mediates Chronic Cardiovascular and Metabolic Actions of Leptin
Tallam, L. S., da Silva, A. A., & Hall, J. E. (2006) · Hypertension · doi:10.1161/01.hyp.0000227966.36744.d9 · Cited by 133
Fekete, C., Sarkar, S., Rand, W. M., Harney, J. W., Emerson, C. H., Bianco, A. C., & Lechan, R. M. (2002) · Endocrinology · doi:10.1210/en.2002-220338 · Cited by 131
Signals that influence food intake and body weight
WOODS, S. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.060 · Cited by 131
Self-citationLamy, C. M., Sanno, H., Labouèbe, G., Picard, A., Magnan, C., Chatton, J.-Y., & Thorens, B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.003 · Cited by 130
Benedict, C., Brede, S., Schiöth, H. B., Lehnert, H., Schultes, B., Born, J., & Hallschmid, M. (2011) · Diabetes · doi:10.2337/db10-0329 · Cited by 129
The role of hypothalamic estrogen receptors in metabolic regulation
Frank, A., Brown, L. M., & Clegg, D. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.002 · Cited by 128
“NPY increases following OVX with concomitant reduction of E2, and administration of E2 to the ARC reverses this increase [84; 127].”
InfluentialNeural melanocortin receptors in obesity and related metabolic disorders
Girardet, C., & Butler, A. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.004 · Cited by 128
Holsen, L. M., Savage, C. R., Martin, L. E., Bruce, A. S., Lepping, R. J., Ko, E., Brooks, W. M., Butler, M. G., Zarcone, J. R., & Goldstein, J. M. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.204 · Cited by 128
Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei
Currie, P. J., Mirza, A., Fuld, R., Park, D., & Vasselli, J. R. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00756.2004 · Cited by 125
Weight gain and metabolic changes during treatment with antipsychotics and antidepressants
Himmerich, H., Minkwitz, J., & Kirkby, K. (2015) · Endocrine, Metabolic & Immune Disorders-Drug Targets · doi:10.2174/1871530315666150623092031 · Cited by 122
Behavior therapy for obesity: where are we now?
Sarwer, D. B., von Sydow Green, A., Vetter, M. L., & Wadden, T. A. (2009) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e32832f5a79 · Cited by 120
In vivo characterization of high Basal signaling from the ghrelin receptor
Petersen, P. S., Woldbye, D. P. D., Madsen, A. N., Egerod, K. L., Jin, C., Lang, M., Rasmussen, M., Beck-Sickinger, A. G., & Holst, B. (2009) · Endocrinology · doi:10.1210/en.2008-1638 · Cited by 121
Intracellular Mechanisms Involved in Leptin Regulation of Sympathetic Outflow
Rahmouni, K., Haynes, W. G., Morgan, D. A., & Mark, A. L. (2003) · Hypertension · doi:10.1161/01.hyp.0000048342.54392.40 · Cited by 120
Psychopharmacological advances in eating disorders
Himmerich, H., & Treasure, J. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1383895 · Cited by 119
da Silva, A. A., Kuo, J. J., & Hall, J. E. (2004) · Hypertension · doi:10.1161/01.hyp.0000128421.23499.b9 · Cited by 117
The drive to eat in homo sapiens: Energy expenditure drives energy intake
Blundell, J. E., Gibbons, C., Beaulieu, K., Casanova, N., Duarte, C., Finlayson, G., Stubbs, R. J., & Hopkins, M. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112846 · Cited by 115
Heiss, C. N., Mannerås-Holm, L., Lee, Y. S., Serrano-Lobo, J., Håkansson Gladh, A., Seeley, R. J., Drucker, D. J., Bäckhed, F., & Olofsson, L. E. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109163 · Cited by 114
Self-citationLadyman, S. R., & Grattan, D. R. (2005) · Endocrinology · doi:10.1210/en.2005-0194 · Cited by 115
Melanocortin-independent Effects of Leptin on Hepatic Glucose Fluxes
Gutiérrez-Juárez, R., Obici, S., & Rossetti, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408665200 · Cited by 115
Central Nervous System Regulation of Energy Metabolism: Ghrelin versus Leptin
Nogueiras, R., Tschöp, M. H., & Zigman, J. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1433.054 · Cited by 115
The Glucostatic Theory of Appetite Control and the Risk of Obesity and Diabetes
Chaput, J.-P., & Tremblay, A. (2009) · International Journal of Obesity · doi:10.1038/ijo.2008.221 · Cited by 111
A functional neuroimaging review of obesity, appetitive hormones and ingestive behavior
Burger, K. S., & Berner, L. A. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.025 · Cited by 110
Leptin and the Cardiovascular System
Rahmouni, K. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.225 · Cited by 110
Kullmann, S., Frank, S., Heni, M., Ketterer, C., Veit, R., Häring, H.-U., Fritsche, A., & Preissl, H. (2013) · Neuroendocrinology · doi:10.1159/000341406 · Cited by 110
Role of oxytocin signaling in the regulation of body weight
Blevins, J. E., & Ho, J. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9260-x · Cited by 108
Adage, T., Scheurink, A. J. W., de Boer, S. F., de Vries, K., Konsman, J. P., Kuipers, F., Adan, R. A. H., Baskin, D. G., Schwartz, M. W., & van Dijk, G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03639.2001 · Cited by 106
Self-citationThe role of PYY in feeding regulation
Ueno, H., Yamaguchi, H., Mizuta, M., & Nakazato, M. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2007.09.011 · Cited by 105
Changes in gut hormones after bariatric surgery
Vincent, R. P., & Le Roux, C. W. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03164.x · Cited by 100
Food for Thought: Reward Mechanisms and Hedonic Overeating in Obesity
Lee, P. C., & Dixon, J. B. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0280-9 · Cited by 97
Glucagon-like peptides 1 and 2 in health and disease: A review
Marathe, C. S., Rayner, C. K., Jones, K. L., & Horowitz, M. (2013) · Peptides · doi:10.1016/j.peptides.2013.01.014 · Cited by 100
Chemical Sensing at the Robot Fingertips: Toward Automated Taste Discrimination in Food Samples
Ciui, B., Martin, A., Mishra, R. K., Nakagawa, T., Dawkins, T. J., Lyu, M., Cristea, C., Sandulescu, R., & Wang, J. (2018) · ACS Sensors · doi:10.1021/acssensors.8b00778 · Cited by 98
Fekete, C., Singru, P. S., Sanchez, E., Sarkar, S., Christoffolete, M. A., Riberio, R. S., Rand, W. M., Emerson, C. H., Bianco, A. C., & Lechan, R. M. (2006) · Endocrinology · doi:10.1210/en.2005-0956 · Cited by 97
Gali Ramamoorthy, T., Allen, T.-J., Davies, A., Harno, E., Sefton, C., Murgatroyd, C., & White, A. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0094-1 · Cited by 97
Altered brain response to drinking glucose and fructose in obese adolescents
Jastreboff, A. M., Sinha, R., Arora, J., Giannini, C., Kubat, J., Malik, S., Van Name, M. A., Santoro, N., Savoye, M., Duran, E. J., et al. (2016) · Diabetes · doi:10.2337/db15-1216 · Cited by 97
Obesity-Related Hypertension and the Role of Insulin and Leptin in High-Fat–Fed Rabbits
Lim, K., Burke, S. L., & Head, G. A. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00705 · Cited by 95
Schwartz, M. W., & Niswender, K. D. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0906 · Cited by 93
Self-citationGut adaptation after metabolic surgery and its influences on the brain, liver and cancer
Sinclair, P., Brennan, D. J., & le Roux, C. W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0057-y · Cited by 91
Burst-like control of lipolysis by the sympathetic nervous system in vivo
Hücking, K., Hamilton-Wessler, M., Ellmerer, M., & Bergman, R. N. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14466 · Cited by 89
Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure
KASAHARA, Y., TAKAYANAGI, Y., KAWADA, T., ITOI, K., & NISHIMORI, K. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70498 · Cited by 89
Vagal control of satiety and hormonal regulation of appetite
Owyang, C., & Heldsinger, A. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.4.338 · Cited by 87
Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production
Yang, C. S., Lam, C. K. L., Chari, M., Cheung, G. W. C., Kokorovic, A., Gao, S., Leclerc, I., Rutter, G. A., & Lam, T. K. T. (2010) · Diabetes · doi:10.2337/db10-0221 · Cited by 86
Cardiovascular risk of adipokines: a review
Dutheil, F., Gordon, B. A., Naughton, G., Crendal, E., Courteix, D., Chaplais, E., Thivel, D., Lac, G., & Benson, A. C. (2018) · Journal of International Medical Research · doi:10.1177/0300060517706578 · Cited by 87
Koban, M., Le, W. W., & Hoffman, G. E. (2006) · Endocrinology · doi:10.1210/en.2005-0695 · Cited by 85
Beck, B., & Pourié, G. (2013) · Nutrition Reviews · doi:10.1111/nure.12045 · Cited by 86
Wisse, B. E., Ogimoto, K., Tang, J., Harris, M. K., Raines, E. W., & Schwartz, M. W. (2007) · Endocrinology · doi:10.1210/en.2007-0394 · Cited by 85
Self-citationSexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis
Shi, H., Strader, A. D., Sorrell, J. E., Chambers, J. B., Woods, S. C., & Seeley, R. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00704.2007 · Cited by 85
Linoleic acid rescues microglia inflammation triggered by saturated fatty acid
Tu, T. H., Kim, H., Yang, S., Kim, J. K., & Kim, J. G. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.047 · Cited by 84
Jastreboff, A. M., Lacadie, C., Seo, D., Kubat, J., Van Name, M. A., Giannini, C., Savoye, M., Constable, R. T., Sherwin, R. S., Caprio, S., et al. (2014) · Diabetes Care · doi:10.2337/dc14-0525 · Cited by 83
Lee, A. W. S., Hengstler, H., Schwald, K., Berriel-Diaz, M., Loreth, D., Kirsch, M., Kretz, O., Haas, C. A., de Angelis, M. H., Herzig, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041537 · Cited by 84
The vagus nerve in thermoregulation and energy metabolism
Székely, M. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00217-4 · Cited by 84
Maejima, Y., Rita, R. S., Santoso, P., Aoyama, M., Hiraoka, Y., Nishimori, K., Gantulga, D., Shimomura, K., & Yada, T. (2015) · Neuroendocrinology · doi:10.1159/000371636 · Cited by 81
Minireview: How Peptide Hormone Vesicles Are Transported to the Secretion Site for Exocytosis
Park, J. J., & Loh, Y. P. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0209 · Cited by 81
Fekete, C., Sarkar, S., Rand, W. M., Harney, J. W., Emerson, C. H., Bianco, A. C., Beck-Sickinger, A., & Lechan, R. M. (2002) · Endocrinology · doi:10.1210/en.2002-220574 · Cited by 79
Fekete, C., Marks, D. L., Sarkar, S., Emerson, C. H., Rand, W. M., Cone, R. D., & Lechan, R. M. (2004) · Endocrinology · doi:10.1210/en.2004-0476 · Cited by 79
M ETABOLIC L ESSONS FROM G ENETICALLY L EAN M ICE
Reitman, M. L. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102849 · Cited by 75
Metabolic Phenotyping Guidelines: studying eating behaviour in humans
Gibbons, C., Finlayson, G., Dalton, M., Caudwell, P., & Blundell, J. E. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0020 · Cited by 74
Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration
van Dijk, G., van Heijningen, S., Reijne, A. C., Nyakas, C., van der Zee, E. A., & Eisel, U. L. M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00173 · Cited by 75
Perello, M., Stuart, R. C., & Nillni, E. A. (2006) · Endocrinology · doi:10.1210/en.2005-1533 · Cited by 74
The Role of Leptin in the Regulation of Energy Balance and Adiposity
Van Dijk, G. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00707.x · Cited by 75
A common biological basis of obesity and nicotine addiction
Thorgeirsson, T. E., Gudbjartsson, D. F., Sulem, P., Besenbacher, S., Styrkarsdottir, U., Thorleifsson, G., Walters, G. B., TAG Consortium, Oxford-GSK Consortium, ENGAGE consortium, et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.81 · Cited by 71
Huang, H., Xu, Y., & van den Pol, A. N. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00740.2010 · Cited by 70
Roman, E. A. F. R., Reis, D., Romanatto, T., Maimoni, D., Ferreira, E. A., Santos, G. A., Torsoni, A. S., Velloso, L. A., & Torsoni, M. A. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.007 · Cited by 71
Boccia, L., Gamakharia, S., Coester, B., Whiting, L., Lutz, T. A., & Le Foll, C. (2020) · Peptides · doi:10.1016/j.peptides.2020.170366 · Cited by 70
Why weight loss maintenance is difficult
Evert, A. B., & Franz, M. J. (2017) · Diabetes Spectrum · doi:10.2337/ds017-0025 · Cited by 63
Orexin-A Hyperphagia: Hindbrain Participation in Consummatory Feeding Responses
Baird, J.-P., Choe, A., Loveland, J. L., Beck, J., Mahoney, C. E., Lord, J. S., & Grigg, L. A. (2009) · Endocrinology · doi:10.1210/en.2008-0293 · Cited by 65
Cheng, Y., Zhang, Q., Meng, Q., Xia, T., Huang, Z., Wang, C., Liu, B., Chen, S., Xiao, F., Du, Y., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-0028 · Cited by 65
Rivera, P., Pérez-Martín, M., Pavón, F. J., Serrano, A., Crespillo, A., Cifuentes, M., López-Ávalos, M.-D., Grondona, J. M., Vida, M., Fernández-Llebrez, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064750 · Cited by 65
Association of Body Mass and Brain Activation during Gastric Distention: Implications for Obesity
Tomasi, D., Wang, G.-J., Wang, R., Backus, W., Geliebter, A., Telang, F., Jayne, M. C., Wong, C., Fowler, J. S., & Volkow, N. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006847 · Cited by 64
Sibutramine effects on central mechanisms regulating energy homeostasis
R. Araujo, J., & Martel, F. (2012) · Current Neuropharmacology · doi:10.2174/157015912799362788 · Cited by 64
Role of leptin and central nervous system melanocortins in obesity hypertension
da Silva, A. A., Carmo, J. M. D., & Hall, J. E. (2013) · Current Opinion in Nephrology and Hypertension · doi:10.1097/mnh.0b013e32835d0c05 · Cited by 63
Menyhért, J., Wittmann, G., Lechan, R. M., Keller, E., Liposits, Z., & Fekete, C. (2007) · Endocrinology · doi:10.1210/en.2007-0390 · Cited by 62
Central inhibitory effects on feeding induced by the adipo-myokine irisin
Ferrante, C., Orlando, G., Recinella, L., Leone, S., Chiavaroli, A., Di Nisio, C., Shohreh, R., Manippa, F., Ricciuti, A., Vacca, M., et al. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.09.011 · Cited by 62
Hallschmid, M., Jauch-Chara, K., Korn, O., Mölle, M., Rasch, B., Born, J., Schultes, B., & Kern, W. (2010) · Diabetes · doi:10.2337/db09-1493 · Cited by 61
Himmerich, H., Koethe, D., Schuld, A., Yassouridis, A., & Pollm�cher, T. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2038-9 · Cited by 60
Programming of mouse obesity by maternal exposure to concentrated ambient fine particles
Chen, M., Wang, X., Hu, Z., Zhou, H., Xu, Y., Qiu, L., Qin, X., Zhang, Y., & Ying, Z. (2017) · Particle and Fibre Toxicology · doi:10.1186/s12989-017-0201-9 · Cited by 59
Young, C. N., Morgan, D. A., Butler, S. D., Mark, A. L., & Davisson, R. L. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00405 · Cited by 58
Weigt, C., Hertrampf, T., Zoth, N., Fritzemeier, K. H., & Diel, P. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.12.013 · Cited by 56
Learning and the motivation to eat: forebrain circuitry.
Petrovich, G. D. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.059 · Cited by 57
LRb signals act within a distributed network of leptin‐responsive neurones to mediate leptin action
Leinninger, G. M., & Myers, M. G. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01784.x · Cited by 56
Glucose-Sensing in the Reward System
Koekkoek, L. L., Mul, J. D., & la Fleur, S. E. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00716 · Cited by 51
Wiss, D. A., Criscitelli, K., Gold, M., & Avena, N. (2017) · Appetite · doi:10.1016/j.appet.2016.12.019 · Cited by 53
If Body Fatness is Under Physiological Regulation, Then How Come We Have an Obesity Epidemic?
Speakman, J. R. (2014) · Physiology · doi:10.1152/physiol.00053.2013 · Cited by 53
da Silva, A. A., Tallam, L. S., Liu, J., & Hall, J. E. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00187.2006 · Cited by 51
Estradiol‐Induced Anorexia Is Independent of Leptin and Melanin‐Concentrating Hormone
Tritos, N. A., Segal‐Lieberman, G., Vezeridis, P. S., & Maratos‐Flier, E. (2004) · Obesity Research · doi:10.1038/oby.2004.84 · Cited by 47
Monnier, L., Schlienger, J.-L., Colette, C., & Bonnet, F. (2021) · Diabetes & Metabolism · doi:10.1016/j.diabet.2020.09.002 · Cited by 47
Mihály, E., Fekete, C., Légrádi, G., & Lechan, R. M. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03094-8 · Cited by 47
Molecular Targets for Obesity Therapy in the Brain
Obici, S. (2009) · Endocrinology · doi:10.1210/en.2009-0409 · Cited by 45
Leptin, neuroinflammation and obesity
Dragano, N. R. V., Haddad-Tovolli, R., & Velloso, L. A. (2017) · Frontiers of hormone research · doi:10.1159/000452908 · Cited by 45
Dagbasi, A., Lett, A. M., Murphy, K., & Frost, G. (2020) · Proceedings of the Nutrition Society · doi:10.1017/s0029665120006941 · Cited by 44
Primary Cilia as a Signaling Platform for Control of Energy Metabolism
Song, D. K., Choi, J. H., & Kim, M.-S. (2018) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2018.42.2.117 · Cited by 42
Heijboer, A. C., van den Hoek, A. M., Pijl, H., Voshol, P. J., Havekes, L. M., Romijn, J. A., & Corssmit, E. P. M. (2005) · Diabetologia · doi:10.1007/s00125-005-1838-8 · Cited by 43
Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice
CHAOLU, H., ASAKAWA, A., USHIKAI, M., LI, Y.-X., CHENG, K.-C., LI, J.-B., ZOSHIKI, T., TERASHI, M., TANAKA, C., ATSUCHI, K., et al. (2011) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2011.199 · Cited by 43
Distribution of NPY Y5-like immunoreactivity in the rat brain
Morin, S. M., & Gehlert, D. R. (2006) · Journal of Molecular Neuroscience · doi:10.1385/jmn:29:2:109 · Cited by 39
Metadata
- Authors
- Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G.
- Affiliations
- University of Washington (US)
- University of Cincinnati (US)
- Venue
- Nature
- Published
- 2000-04
- Volume
- 404
- Issue
- 6778
- Pages
- 661-671
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1561443084
- Cited by
- 6,451
- References
- 123
- Citations by year
- 2026: 87 · 2025: 126 · 2024: 138 · 2023: 123 · 2022: 153 · 2021: 210 · 2020: 184 · 2019: 206 · 2018: 223 · 2017: 255 · 2016: 292 · 2015: 316 · 2014: 305 · 2013: 367 · 2012: 339
- FWCI
- 22.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- food intake regulation, energy homeostasis, hypothalamus, neuropeptides, hormone signaling, obesity, neural circuits, energy expenditure
- MeSH terms
- Central Nervous System, Eating, Energy Metabolism, Homeostasis, Humans, Hypothalamus, Insulin, Models, Biological, Neuropeptides, Obesity, Satiation, Biogenic Monoamines, Signal Transduction, Leptin
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