The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,551
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
Gasparini, F., Lingenhöhl, K., Stoehr, N., Flor, P. J., Heinrich, M., Vranesic, I., Biollaz, M., Allgeier, H., Heckendorn, R., Urwyler, S., et al. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00082-9 · Cited by 725 · cited 1×
“mGluR antagonists reduce dilation of arterioles In the next series of experiments, we stimulated neuronal afferents in the absence or in the presence of LY367385 and MPEP, antagonists of subtypes 1 and 5, respectively, of group I metabotropic glutamate receptors (mGluRs”
Method
Cited by
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280
The blood-brain barrier/neurovascular unit in health and disease
Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661
Zhang, Y., Sloan, S. A., Clarke, L. E., Caneda, C., Plaza, C. A., Blumenthal, P. D., Vogel, H., Steinberg, G. K., Edwards, M. S. B., Li, G., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.013 · Cited by 2,295
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
Iadecola, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.030 · Cited by 2,480
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313
Neurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease
Barres, B. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.013 · Cited by 1,352
New roles for astrocytes: redefining the functional architecture of the brain.
Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.008 · Cited by 1,334
Gliotransmitters Travel in Time and Space
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308
Self-citationCerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.48 · Cited by 1,243
Glial regulation of the cerebral microvasculature
Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153
Bidirectional control of CNS capillary diameter by pericytes
Peppiatt, C. M., Howarth, C., Mobbs, P., & Attwell, D. (2006) · Nature · doi:10.1038/nature05193 · Cited by 1,150
Neuroinflammation and depression: A review
Troubat, R., Barone, P., Leman, S., Desmidt, T., Cressant, A., Atanasova, B., Brizard, B., El Hage, W., Surget, A., Belzung, C., et al. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14720 · Cited by 1,107
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934
The tripartite synapse: roles for gliotransmission in health and disease
Halassa, M. M., Fellin, T., & Haydon, P. G. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.12.005 · Cited by 852
An astrocytic basis of epilepsy
Tian, G.-F., Azmi, H., Takano, T., Xu, Q., Peng, W., Lin, J., Oberheim, N., Lou, N., Wang, X., Zielke, H. R., et al. (2005) · Nature Medicine · doi:10.1038/nm1277 · Cited by 806
Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
Nimmerjahn, A., Kirchhoff, F., Kerr, J. N. D., & Helmchen, F. (2004) · Nature Methods · doi:10.1038/nmeth706 · Cited by 784
Neurovascular mechanisms of Alzheimer's neurodegeneration
Zlokovic, B. V. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.02.001 · Cited by 770
Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior
Halassa, M. M., & Haydon, P. G. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135843 · Cited by 763
Astrocytic complexity distinguishes the human brain
Oberheim, N. A., Wang, X., Goldman, S., & Nedergaard, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.08.004 · Cited by 739
Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
Wang, X., Lou, N., Xu, Q., Tian, G.-F., Peng, W. G., Han, X., Kang, J., Takano, T., & Nedergaard, M. (2006) · Nature Neuroscience · doi:10.1038/nn1703 · Cited by 685
The blood-brain barrier: an engineering perspective
Wong, A. D., Ye, M., Levy, A. F., Rothstein, J. D., Bergles, D. E., & Searson, P. C. (2013) · Frontiers in Neuroengineering · doi:10.3389/fneng.2013.00007 · Cited by 662
Glial responses to implanted electrodes in the brain
Salatino, J. W., Ludwig, K. A., Kozai, T. D. Y., & Purcell, E. K. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0154-1 · Cited by 642
Wilhelmsson, U., Bushong, E. A., Price, D. L., Smarr, B. L., Phung, V., Terada, M., Ellisman, M. H., & Pekny, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602841103 · Cited by 643
Heterogeneity of astrocytic form and function.
Oberheim, N. A., Goldman, S. A., & Nedergaard, M. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-452-0_3 · Cited by 638
Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue
Rajkowska, G., & Stockmeier, C. (2013) · Current Drug Targets · doi:10.2174/13894501113149990156 · Cited by 603
Signaling at the Gliovascular Interface
Simard, M., Arcuino, G., Takano, T., Liu, Q. S., & Nedergaard, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09254.2003 · Cited by 586
The neurovascular unit - concept review
Muoio, V., Persson, P. B., & Sendeski, M. M. (2014) · Acta Physiologica · doi:10.1111/apha.12250 · Cited by 564
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature
Ayata, C., & Lauritzen, M. (2015) · Physiological Reviews · doi:10.1152/physrev.00027.2014 · Cited by 555
Hamilton, N. B. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00005 · Cited by 513
Perea, G., & Araque, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3965-04.2005 · Cited by 488
Wilhelmsson, U., Li, L., Pekna, M., Berthold, C.-H., Blom, S., Eliasson, C., Renner, O., Bushong, E., Ellisman, M., Morgan, T. E., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0820-04.2004 · Cited by 455
Tarantini, S., Tran, C. H. T., Gordon, G. R., Ungvari, Z., & Csiszar, A. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2016.11.004 · Cited by 411
Role of Astrocytes in Neurovascular Coupling
Petzold, G. C., & Murthy, V. N. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.009 · Cited by 409
Devor, A., Dunn, A. K., Andermann, M. L., Ulbert, I., Boas, D. A., & Dale, A. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00403-3 · Cited by 387
The Translational Significance of the Neurovascular Unit
McConnell, H. L., Kersch, C. N., Woltjer, R. L., & Neuwelt, E. A. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.760215 · Cited by 314
Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease
Osborn, L. M., Kamphuis, W., Wadman, W. J., & Hol, E. M. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.001 · Cited by 312
Cerebral Blood Flow Response to Functional Activation
Paulson, O. B., Hasselbalch, S. G., Rostrup, E., Knudsen, G. M., & Pelligrino, D. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.188 · Cited by 264
Nicolakakis, N., Aboulkassim, T., Ongali, B., Lecrux, C., Fernandes, P., Rosa-Neto, P., Tong, X.-K., & Hamel, E. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3348-08.2008 · Cited by 262
Loaiza, A., Porras, O. H., & Barros, L. F. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07337.2003 · Cited by 254
Neuronal and vascular interactions
Andreone, B. J., Lacoste, B., & Gu, C. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033835 · Cited by 256
The capillary bed offers the largest hemodynamic resistance to the cortical blood supply
Gould, I. G., Tsai, P., Kleinfeld, D., & Linninger, A. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16671146 · Cited by 252
The neurovascular unit in brain function and disease: The neurovascular unit function
Lecrux, C., & Hamel, E. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02256.x · Cited by 251
A Novel Transwell Blood Brain Barrier Model Using Primary Human Cells
Stone, N. L., England, T. J., & O’Sullivan, S. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00230 · Cited by 251
Bazan, N. G. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r300013-jlr200 · Cited by 247
Fellin, T. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05830.x · Cited by 245
Inflammation and the neurovascular unit in the setting of focal cerebral ischemia
del Zoppo, G. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.028 · Cited by 243
Astrocyte Endfeet in Brain Function and Pathology: Open Questions
Díaz-Castro, B., Robel, S., & Mishra, A. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-091922-031205 · Cited by 238
Stratification of astrocytes in healthy and diseased brain
Verkhratsky, A., Zorec, R., & Parpura, V. (2017) · Brain Pathology · doi:10.1111/bpa.12537 · Cited by 236
Endothelial influences on cerebrovascular tone
Andresen, J., Shafi, N. I., & Bryan, R. M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00937.2005 · Cited by 235
Cerebral Hemodynamics and Vascular Risk Factors: Setting the Stage for Alzheimer's Disease
de la Torre, J. C. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-120793 · Cited by 219
Evaluating the gray and white matter energy budgets of human brain function
Yu, Y., Herman, P., Rothman, D. L., Agarwal, D., & Hyder, F. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17708691 · Cited by 211
Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone
Filosa, J. A., Morrison, H. W., Iddings, J. A., Du, W., & Kim, K. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.064 · Cited by 222
Winship, I. R., Plaa, N., & Murphy, T. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4801-06.2007 · Cited by 221
The energetic brain—A review from students to students
Bordone, M. P., Salman, M. M., Titus, H. E., Amini, E., Andersen, J. V., Chakraborti, B., Diuba, A. V., Dubouskaya, T. G., Ehrke, E., Espindola de Freitas, A., et al. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14829 · Cited by 205
“supply to meet neuronal energy demand (Zonta et al. 2003; Takano et al. 2006; Gordon et al. 2008).”
High-Resolution In Vivo Imaging of the Neurovascular Unit during Spreading Depression
Chuquet, J., Hollender, L., & Nimchinsky, E. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0721-07.2007 · Cited by 203
The role of neuronal signaling in controlling cerebral blood flow
DRAKE, C., & IADECOLA, C. (2007) · Brain and Language · doi:10.1016/j.bandl.2006.08.002 · Cited by 177
Calcium signaling and gliotransmission in normal vs. reactive astrocytes
Agulhon, C., Sun, M.-Y., Murphy, T., Myers, T., Lauderdale, K., & Fiacco, T. A. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00139 · Cited by 167
Ballistic labeling and dynamic imaging of astrocytes in organotypic hippocampal slice cultures.
Benediktsson, A. M., Schachtele, S. J., Green, S. H., & Dailey, M. E. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.05.013 · Cited by 166
Glutamate‐mediated neuronal–glial transmission
Verkhratsky, A., & Kirchhoff, F. (2007) · Journal of Anatomy · doi:10.1111/j.1469-7580.2007.00734.x · Cited by 156
PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells
Harraz, O. F., Longden, T. A., Hill-Eubanks, D., & Nelson, M. T. (2018) · eLife · doi:10.7554/elife.38689 · Cited by 149
The physiology of developmental changes in BOLD functional imaging signals
Harris, J. J., Reynell, C., & Attwell, D. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.04.001 · Cited by 142
Glutamate mediates acute glucose transport inhibition in hippocampal neurons
Porras, O. H., Loaiza, A., & Barros, L. F. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1882-04.2004 · Cited by 139
Ion channel networks in the control of cerebral blood flow
Longden, T. A., Hill-Eubanks, D. C., & Nelson, M. T. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15616138 · Cited by 137
Torkamani, A., Dean, B., Schork, N. J., & Thomas, E. A. (2010) · Genome Research · doi:10.1101/gr.101956.109 · Cited by 134
Liu, C.-Y., Yang, Y., Ju, W.-N., Wang, X., & Zhang, H.-L. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00193 · Cited by 131
Paris, D., Humphrey, J., Quadros, A., Patel, N., Crescentini, R., Crawford, F., & Mullan, M. (2003) · Neurological Research · doi:10.1179/016164103101201940 · Cited by 127
Heterogeneity of Astrocytes in Grey and White Matter
Köhler, S., Winkler, U., & Hirrlinger, J. (2021) · Neurochemical Research · doi:10.1007/s11064-019-02926-x · Cited by 123
Tobinick, E. (2009) · CNS Drugs · doi:10.2165/11310810-000000000-00000 · Cited by 117
Neurovascular coupling is impaired in slow walkers: the MOBILIZE Boston Study
Sorond, F. A., Kiely, D. K., Galica, A., Moscufo, N., Serrador, J. M., Iloputaife, I., Egorova, S., Dell'Oglio, E., Meier, D. S., Newton, E., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22433 · Cited by 111
Stobart, J. L. L., Lu, L., Anderson, H. D. I., Mori, H., & Anderson, C. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215929110 · Cited by 113
Nehlig, A., Wittendorp-Rechenmann, E., & Dao Lam, C. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000128533.84196.d8 · Cited by 111
Ungvari, Z., Tarantini, S., Hertelendy, P., Valcarcel-Ares, M. N., Fülöp, G. A., Logan, S., Kiss, T., Farkas, E., Csiszar, A., & Yabluchanskiy, A. (2017) · GeroScience · doi:10.1007/s11357-017-9964-z · Cited by 101
Chapter 14 Cerebral vascular dysregulation in the ischemic brain
(2008) · Handbook of Clinical Neurology · doi:10.1016/s0072-9752(08)01914-3 · Cited by 98
Astrocytes in the regulation of cerebrovascular functions
Cohen‐Salmon, M., Slaoui, L., Mazaré, N., Gilbert, A., Oudart, M., Alvear‐Perez, R., Elorza‐Vidal, X., Chever, O., & Boulay, A. (2021) · Glia · doi:10.1002/glia.23924 · Cited by 93
Caffeine and the Control of Cerebral Hemodynamics
Pelligrino, D. A., Xu, H.-L., & Vetri, F. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091261 · Cited by 93
Liang, Z., Wang, X., Hao, Y., Qiu, L., Lou, Y., Zhang, Y., Ma, D., & Feng, J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00703 · Cited by 84
Sonnay, S., Gruetter, R., & Duarte, J. M. N. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00288 · Cited by 74
Glial Cells and Integrity of the Nervous System
von Bernhardi, R., Eugenín-von Bernhardi, J., Flores, B., & Eugenín León, J. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-40764-7_1 · Cited by 67
Lechuga-Sancho, A. M., Arroba, A. I., Frago, L. M., García-Cáceres, C., de Célix, A. D.-R., Argente, J., & Chowen, J. A. (2006) · Endocrinology · doi:10.1210/en.2006-0766 · Cited by 64
Blood vessels and Parkinsonism
Barcia, C. (2004) · Frontiers in Bioscience · doi:10.2741/1145 · Cited by 41
Takuwa, H., Autio, J., Nakayama, H., Matsuura, T., Obata, T., Okada, E., Masamoto, K., & Kanno, I. (2011) · Brain Research · doi:10.1016/j.brainres.2010.11.007 · Cited by 41
Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders
Kaminsky, N., Bihari, O., Kanner, S., & Barzilai, A. (2016) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2016.04.003 · Cited by 38
Komaki, Y., Debacker, C., Djemai, B., Ciobanu, L., Tsurugizawa, T., & Bihan, D. L. (2020) · PLOS ONE · doi:10.1371/journal.pone.0228759 · Cited by 20
Henao‐Restrepo, J., López‐Murillo, C., Valderrama‐Carmona, P., Orozco‐Santa, N., Gomez, J., Gutiérrez‐Vargas, J., Moraga, R., Toledo, J., Littau, J. L., Härtel, S., et al. (2023) · Brain Pathology · doi:10.1111/bpa.13119 · Cited by 11
(2024) · Journal of Addiction Psychiatry · doi:10.17756/jap.2024-045 · Cited by 3
Metadata
- Authors
- Zonta, M., Angulo, M. C., Gobbo, S., Rosengarten, B., Hossmann, K.-A., Pozzan, T., & Carmignoto, G.
- Venue
- Nature Neuroscience
- Published
- 2002-11-25
- Volume
- 6
- Issue
- 1
- Pages
- 43-50
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2068400560
- Cited by
- 1,455
- References
- 4
- FWCI
- 18.87
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.