The underappreciated role of muscle in health and disease

Exercise training and nutritional supplementation for physical frailty in very elderly people

Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857

Skeletal muscle triglyceride levels are inversely related to insulin action

Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179

Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action

Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss

Kelley, D. E., Goodpaster, B., Wing, R. R., & Simoneau, J.-A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1130 · Cited by 1,096

Postexercise net protein synthesis in human muscle from orally administered amino acids

Tipton, K. D., Ferrando, A. A., Phillips, S. M., Doyle, D., & Wolfe, R. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.4.e628 · Cited by 616

Testosterone administration to older men improves muscle function: molecular and physiological mechanisms

Ferrando, A. A., Sheffield-Moore, M., Yeckel, C. W., Gilkison, C., Jiang, J., Achacosa, A., Lieberman, S. A., Tipton, K., Wolfe, R. R., & Urban, R. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00362.2001 · Cited by 522

THE INSULIN RESISTANCE SYNDROME: Definition and Dietary Approaches to Treatment

Reaven, G. M. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132155 · Cited by 516

Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study

Bohé, J., Low, A., Wolfe, R. R., & Rennie, M. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.050674 · Cited by 496

Amino acid ingestion improves muscle protein synthesis in the young and elderly

Paddon-Jones, D., Sheffield-Moore, M., Zhang, X.-J., Volpi, E., Wolf, S. E., Aarsland, A., Ferrando, A. A., & Wolfe, R. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00368.2003 · Cited by 467

Essential Amino Acid and Carbohydrate Supplementation Ameliorates Muscle Protein Loss in Humans during 28 Days Bedrest

Paddon-Jones, D., Sheffield-Moore, M., Urban, R. J., Sanford, A. P., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032159 · Cited by 338

Skeletal muscle: A brief review of structure and function

Frontera, W. R., & Ochala, J. (2015) · Calcified Tissue International · doi:10.1007/s00223-014-9915-y · Cited by 1,758

Dietary protein recommendations and the prevention of sarcopenia

Paddon-Jones, D., & Rasmussen, B. B. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831cef8b · Cited by 823

Association between muscular strength and mortality in men: prospective cohort study

Ruiz, J. R., Sui, X., Lobelo, F., Morrow, J. R., Jackson, A. W., Sjostrom, M., & Blair, S. N. (2008) · BMJ · doi:10.1136/bmj.a439 · Cited by 815

Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants

Celis-Morales, C. A., Welsh, P., Lyall, D. M., Steell, L., Petermann, F., Anderson, J., Iliodromiti, S., Sillars, A., Graham, N., Mackay, D. F., et al. (2018) · BMJ · doi:10.1136/bmj.k1651 · Cited by 772

Dietary protein intake and human health

Wu, G. (2016) · Food & Function · doi:10.1039/c5fo01530h · Cited by 748

Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms

Booth, F. W., Roberts, C. K., Thyfault, J. P., Ruegsegger, G. N., & Toedebusch, R. G. (2017) · Physiological Reviews · doi:10.1152/physrev.00019.2016 · Cited by 696

The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein Consumption

van Vliet, S., Burd, N. A., & van Loon, L. J. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.204305 · Cited by 651

Insulin resistance and sarcopenia: mechanistic links between common co-morbidities

Cleasby, M. E., Jamieson, P. M., & Atherton, P. J. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0533 · Cited by 596

Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials

Wycherley, T. P., Moran, L. J., Clifton, P. M., Noakes, M., & Brinkworth, G. D. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.044321 · Cited by 606

Skeletal Muscle Regulates Metabolism via Interorgan Crosstalk: Roles in Health and Disease

Argilés, J. M., Campos, N., Lopez-Pedrosa, J. M., Rueda, R., & Rodriguez-Mañas, L. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.04.019 · Cited by 581

Protein, weight management, and satiety

Paddon-Jones, D., Westman, E., Mattes, R. D., Wolfe, R. R., Astrup, A., & Westerterp-Plantenga, M. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1558s · Cited by 549

Effects of Nutritional Prehabilitation, With and Without Exercise, on Outcomes of Patients Who Undergo Colorectal Surgery: A Systematic Review and Meta-analysis

Gillis, C., Buhler, K., Bresee, L., Carli, F., Gramlich, L., Culos-Reed, N., Sajobi, T. T., & Fenton, T. R. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.05.012 · Cited by 541

Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exercise

Witard, O. C., Jackman, S. R., Breen, L., Smith, K., Selby, A., & Tipton, K. D. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.055517 · Cited by 517

Muscle, Bone, and Fat Crosstalk: The Biological Role of Myokines, Osteokines, and Adipokines

Kirk, B., Feehan, J., Lombardi, G., & Duque, G. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00599-y · Cited by 510

Optimal protein intake in the elderly

Wolfe, R. R., Miller, S. L., & Miller, K. B. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.008 · Cited by 456

Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion

Glover, E. I., Phillips, S. M., Oates, B. R., Tang, J. E., Tarnopolsky, M. A., Selby, A., Smith, K., & Rennie, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.160333 · Cited by 414

Strengths and Limitations of BMI in the Diagnosis of Obesity: What is the Path Forward?

Sweatt, K., Garvey, W. T., & Martins, C. (2024) · Current Obesity Reports · doi:10.1007/s13679-024-00580-1 · Cited by 398

The danger of weight loss in the elderly

Miller, S. L., & Wolfe, R. R. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982710 · Cited by 384

Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise

Wackerhage, H., Schoenfeld, B. J., Hamilton, D. L., Lehti, M., & Hulmi, J. J. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00685.2018 · Cited by 357

Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?

Wolfe, R. R. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0184-9 · Cited by 337

International society of sports nutrition position stand: diets and body composition

Aragon, A. A., Schoenfeld, B. J., Wildman, R., Kleiner, S., VanDusseldorp, T., Taylor, L., Earnest, C. P., Arciero, P. J., Wilborn, C., Kalman, D. S., et al. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0174-y · Cited by 301

Skeletal muscle aging: influence of oxidative stress and physical exercise

Gomes, M. J., Martinez, P. F., Pagan, L. U., Damatto, R. L., Mariano Cezar, M. D., Ruiz Lima, A. R., Okoshi, K., & Okoshi, M. P. (2017) · Oncotarget · doi:10.18632/oncotarget.14670 · Cited by 285

Mechanism of increased risk of insulin resistance in aging skeletal muscle

Shou, J., Chen, P.-J., & Xiao, W.-H. (2020) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-020-0523-x · Cited by 283

Diet and its relationship with grip strength in community-dwelling older men and women: The Hertfordshire cohort study

Robinson, S. M., Jameson, K. A., Batelaan, S. F., Martin, H. J., Syddall, H. E., Dennison, E. M., Cooper, C., Sayer, A. A., & the Hertfordshire Cohort Study Group (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01478.x · Cited by 282

Live strong and prosper: the importance of skeletal muscle strength for healthy ageing

McLeod, M., Breen, L., Hamilton, D. L., & Philp, A. (2016) · Biogerontology · doi:10.1007/s10522-015-9631-7 · Cited by 274

Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults

Nunes, E. A., Colenso‐Semple, L., McKellar, S. R., Yau, T., Ali, M. U., Fitzpatrick‐Lewis, D., Sherifali, D., Gaudichon, C., Tomé, D., Atherton, P. J., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12922 · Cited by 280

Recent Perspectives Regarding the Role of Dietary Protein for the Promotion of Muscle Hypertrophy with Resistance Exercise Training

Stokes, T., Hector, A., Morton, R., McGlory, C., & Phillips, S. (2018) · Nutrients · doi:10.3390/nu10020180 · Cited by 263

Resistance Training in the Treatment of the Metabolic Syndrome: A Systematic Review and Meta-Analysis of the Effect of Resistance Training on Metabolic Clustering in Patients with Abnormal Glucose Metabolism

Strasser, B., Siebert, U., & Schobersberger, W. (2010) · Sports Medicine · doi:10.2165/11531380-000000000-00000 · Cited by 258

The Role of Milk- and Soy-Based Protein in Support of Muscle Protein Synthesis and Muscle Protein Accretion in Young and Elderly Persons

Phillips, S. M., Tang, J. E., & Moore, D. R. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10718096 · Cited by 243

Muscle loss: The new malnutrition challenge in clinical practice

Landi, F., Camprubi-Robles, M., Bear, D. E., Cederholm, T., Malafarina, V., Welch, A. A., & Cruz-Jentoft, A. J. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.11.021 · Cited by 235

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

Demontis, F., Piccirillo, R., Goldberg, A. L., & Perrimon, N. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.012559 · Cited by 238

A high whey protein-, leucine-, and vitamin D–enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial

Verreijen, A. M., Verlaan, S., Engberink, M. F., Swinkels, S., de Vogel-van den Bosch, J., & Weijs, P. J. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.090290 · Cited by 237

Nutritional interventions to augment resistance training-induced skeletal muscle hypertrophy

Morton, R. W., McGlory, C., & Phillips, S. M. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00245 · Cited by 234

The magnitude and progress of lean body mass, fat-free mass, and skeletal muscle mass loss following bariatric surgery: a systematic review and meta-analysis

Nuijten, M. A. H., Eijsvogels, T. M. H., Monpellier, V. M., Janssen, I. M. C., Hazebroek, E. J., & Hopman, M. T. E. (2022) · Obesity Reviews · doi:10.1111/obr.13370 · Cited by 236

Associations Between Dietary Nutrient Intake and Muscle Mass and Strength in Community‐Dwelling Older Adults: The Tasmanian Older Adult Cohort Study

Scott, D., Blizzard, L., Fell, J., Giles, G., & Jones, G. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.03147.x · Cited by 228

Increasing Dietary Protein Requirements in Elderly People for Optimal Muscle and Bone Health

Gaffney‐Stomberg, E., Insogna, K. L., Rodriguez, N. R., & Kerstetter, J. E. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02285.x · Cited by 226

Evidence for Resistance Training as a Treatment Therapy in Obesity

Strasser, B., & Schobersberger, W. (2011) · Journal of Obesity · doi:10.1155/2011/482564 · Cited by 220

Characterising the muscle anabolic potential of dairy, meat and plant-based protein sources in older adults

Gorissen, S. H. M., & Witard, O. C. (2018) · Proceedings of the Nutrition Society · doi:10.1017/s002966511700194x · Cited by 221

Malnutrition-Sarcopenia Syndrome: Is This the Future of Nutrition Screening and Assessment for Older Adults?

Vandewoude, M. F. J., Alish, C. J., Sauer, A. C., & Hegazi, R. A. (2012) · Journal of Aging Research · doi:10.1155/2012/651570 · Cited by 214

Association of sarcopenic obesity with the risk of all-cause mortality among adults over a broad range of different settings: a updated meta-analysis

Zhang, X., Xie, X., Dou, Q., Liu, C., Zhang, W., Yang, Y., Deng, R., & Cheng, A. S. K. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1195-y · Cited by 209

Effect of proteins from different sources on body composition

Gilbert, J.-A., Bendsen, N. T., Tremblay, A., & Astrup, A. (2011) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.12.008 · Cited by 207

Omega-3 Fatty Acids and Skeletal Muscle Health

Jeromson, S., Gallagher, I., Galloway, S., & Hamilton, D. (2015) · Marine Drugs · doi:10.3390/md13116977 · Cited by 203

A validation of the application of D2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans

Wilkinson, D. J., Franchi, M. V., Brook, M. S., Narici, M. V., Williams, J. P., Mitchell, W. K., Szewczyk, N. J., Greenhaff, P. L., Atherton, P. J., & Smith, K. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00650.2013 · Cited by 195

Development and validation of anthropometric prediction equations for lean body mass, fat mass and percent fat in adults using the National Health and Nutrition Examination Survey (NHANES) 1999–2006

Lee, D. H., Keum, N., Hu, F. B., Orav, E. J., Rimm, E. B., Sun, Q., Willett, W. C., & Giovannucci, E. L. (2017) · British Journal of Nutrition · doi:10.1017/s0007114517002665 · Cited by 191

Rehabilitation for Hospital-Associated Deconditioning

Kortebein, P. (2009) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0b013e3181838f70 · Cited by 190

Whey and casein labeled with l-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion

Reitelseder, S., Agergaard, J., Doessing, S., Helmark, I. C., Lund, P., Kristensen, N. B., Frystyk, J., Flyvbjerg, A., Schjerling, P., van Hall, G., et al. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00513.2010 · Cited by 190

Diabetes, Sarcopenia, and Frailty

Morley, J. E. (2008) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2008.03.004 · Cited by 186

Increased consumption of dairy foods and protein during diet- and exercise-induced weight loss promotes fat mass loss and lean mass gain in overweight and obese premenopausal women

Josse, A. R., Atkinson, S. A., Tarnopolsky, M. A., & Phillips, S. M. (2011) · The Journal of Nutrition · doi:10.3945/jn.111.141028 · Cited by 187

Minimal-dose resistance training for improving muscle mass, strength, and function: A narrative review of current evidence and practical considerations

Fyfe, J. J., Hamilton, D. L., & Daly, R. M. (2022) · Sports Medicine · doi:10.1007/s40279-021-01605-8 · Cited by 172

Maximizing muscle protein anabolism: the role of protein quality

Tang, J. E., & Phillips, S. M. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831cef75 · Cited by 178

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

Pak, H. H., Haws, S. A., Green, C. L., Koller, M., Lavarias, M. T., Richardson, N. E., Yang, S. E., Dumas, S. N., Sonsalla, M., Bray, L., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00466-9 · Cited by 171

Characterization of Dietary Protein among Older Adults in the United States: Amount, Animal Sources, and Meal Patterns

Berner, L. A., Becker, G., Wise, M., & Doi, J. (2013) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2013.01.014 · Cited by 171

Animal Protein versus Plant Protein in Supporting Lean Mass and Muscle Strength: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Lim, M. T., Pan, B. J., Toh, D. W. K., Sutanto, C. N., & Kim, J. E. (2021) · Nutrients · doi:10.3390/nu13020661 · Cited by 164

The macronutrients, appetite, and energy intake

Carreiro, A. L., Dhillon, J., Gordon, S., Higgins, K. A., Jacobs, A. G., McArthur, B. M., Redan, B. W., Rivera, R. L., Schmidt, L. R., & Mattes, R. D. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-121415-112624 · Cited by 159

Effects of protein supplementation on lean body mass, muscle strength, and physical performance in nonfrail community-dwelling older adults: a systematic review and meta-analysis

ten Haaf, D. S. M., Nuijten, M. A. H., Maessen, M. F. H., Horstman, A. M. H., Eijsvogels, T. M. H., & Hopman, M. T. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy192 · Cited by 152

Assessing the role of muscle protein breakdown in response to nutrition and exercise in humans.

Tipton, K. D., Hamilton, D. L., & Gallagher, I. J. (2018) · Sports Medicine · doi:10.1007/s40279-017-0845-5 · Cited by 152

Dietary Guidelines should reflect new understandings about adult protein needs

Layman, D. K. (2009) · Nutrition & Metabolism · doi:10.1186/1743-7075-6-12 · Cited by 146

Incretin-Based Weight Loss Pharmacotherapy: Can Resistance Exercise Optimize Changes in Body Composition?

Locatelli, J. C., Costa, J. G., Haynes, A., Naylor, L. H., Fegan, P. G., Yeap, B. B., & Green, D. J. (2024) · Diabetes Care · doi:10.2337/dci23-0100 · Cited by 152

Nutritional Support for Exercise-Induced Injuries

Tipton, K. D. (2015) · Sports Medicine · doi:10.1007/s40279-015-0398-4 · Cited by 147

Protein recommendations for weight loss in elite athletes: a focus on body composition and performance

Hector, A. J., & Phillips, S. M. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2017-0273 · Cited by 137

Skeletal muscle and resistance exercise training; the role of protein synthesis in recovery and remodeling

McGlory, C., Devries, M. C., & Phillips, S. M. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00613.2016 · Cited by 135

Protein Considerations for Optimising Skeletal Muscle Mass in Healthy Young and Older Adults

Witard, O., Wardle, S., Macnaughton, L., Hodgson, A., & Tipton, K. (2016) · Nutrients · doi:10.3390/nu8040181 · Cited by 132

Human insulinotropic response to oral ingestion of native and hydrolysed whey protein

Power, O., Hallihan, A., & Jakeman, P. (2009) · Amino Acids · doi:10.1007/s00726-008-0156-0 · Cited by 128

Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise–Induced Muscle Protein Anabolism

Reidy, P. T., & Rasmussen, B. B. (2016) · The Journal of Nutrition · doi:10.3945/jn.114.203208 · Cited by 128

Systemic Nutrient and Stress Signaling via Myokines and Myometabolites

Rai, M., & Demontis, F. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105305 · Cited by 123

Whey protein supplementation preserves postprandial myofibrillar protein synthesis during short-term energy restriction in overweight and obese adults

Hector, A. J., Marcotte, G. R., Churchward-Venne, T. A., Murphy, C. H., Breen, L., von Allmen, M., Baker, S. K., & Phillips, S. M. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.200832 · Cited by 119

Where frailty meets diabetes

Perkisas, S., & Vandewoude, M. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2743 · Cited by 120

Dose–response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials

Tagawa, R., Watanabe, D., Ito, K., Ueda, K., Nakayama, K., Sanbongi, C., & Miyachi, M. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuaa104 · Cited by 118

Perioperative oral nutritional supplements in normally or mildly undernourished geriatric patients submitted to surgery for hip fracture: A randomized clinical trial

Botella-Carretero, J. I., Iglesias, B., Balsa, J. A., Arrieta, F., Zamarrón, I., & Vázquez, C. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2010.01.012 · Cited by 116

Training to Fatigue: The Answer for Standardization When Assessing Muscle Hypertrophy?

Dankel, S. J., Jessee, M. B., Mattocks, K. T., Mouser, J. G., Counts, B. R., Buckner, S. L., & Loenneke, J. P. (2017) · Sports Medicine · doi:10.1007/s40279-016-0633-7 · Cited by 115

Protective role of Parkin in skeletal muscle contractile and mitochondrial function

Gouspillou, G., Godin, R., Piquereau, J., Picard, M., Mofarrahi, M., Mathew, J., Purves‐Smith, F. M., Sgarioto, N., Hepple, R. T., Burelle, Y., et al. (2018) · The Journal of Physiology · doi:10.1113/jp275604 · Cited by 115

Protein leucine content is a determinant of shorter- and longer-term muscle protein synthetic responses at rest and following resistance exercise in healthy older women: a randomized, controlled trial

Devries, M. C., McGlory, C., Bolster, D. R., Kamil, A., Rahn, M., Harkness, L., Baker, S. K., & Phillips, S. M. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqx028 · Cited by 112

Influence of Amino Acids, Dietary Protein, and Physical Activity on Muscle Mass Development in Humans

Dideriksen, K., Reitelseder, S., & Holm, L. (2013) · Nutrients · doi:10.3390/nu5030852 · Cited by 110

The Recommended Dietary Allowance of Protein: A Misunderstood Concept

Wolfe, R. R., & Miller, S. L. (2008) · JAMA · doi:10.1001/jama.299.24.2891 · Cited by 107

Anabolic sensitivity of postprandial muscle protein synthesis to the ingestion of a protein-dense food is reduced in overweight and obese young adults

Beals, J. W., Sukiennik, R. A., Nallabelli, J., Emmons, R. S., van Vliet, S., Young, J. R., Ulanov, A. V., Li, Z., Paluska, S. A., De Lisio, M., et al. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.130385 · Cited by 99

Bigger weights may not beget bigger muscles: Evidence from acute muscle protein synthetic responses after resistance exercise

Burd, N. A., Mitchell, C. J., Churchward-Venne, T. A., & Phillips, S. M. (2012) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h2012-022 · Cited by 99

Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation

Dulac, M., Leduc‐Gaudet, J., Reynaud, O., Ayoub, M., Guérin, A., Finkelchtein, M., Hussain, S. N., & Gouspillou, G. (2020) · The Journal of Physiology · doi:10.1113/jp279802 · Cited by 90

Handgrip strength is positively related to blood pressure and hypertension risk: results from the National Health and nutrition examination survey

Ji, C., Zheng, L., Zhang, R., Wu, Q., & Zhao, Y. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0734-4 · Cited by 89

Assessment of protein requirement in octogenarian women with use of the indicator amino acid oxidation technique

Tang, M., McCabe, G. P., Elango, R., Pencharz, P. B., Ball, R. O., & Campbell, W. W. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.042325 · Cited by 92

Whey protein and essential amino acids promote the reduction of adipose tissue and increased muscle protein synthesis during caloric restriction-induced weight loss in elderly, obese individuals

Coker, R. H., Miller, S., Schutzler, S., Deutz, N., & Wolfe, R. R. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-105 · Cited by 92

A systematic review of the effect of semaglutide on lean mass: insights from clinical trials

Bikou, A., Dermiki-Gkana, F., Penteris, M., Constantinides, T. K., & Kontogiorgis, C. (2024) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2024.2343092 · Cited by 97

Pronounced energy restriction with elevated protein intake results in no change in proteolysis and reductions in skeletal muscle protein synthesis that are mitigated by resistance exercise

Hector, A. J., McGlory, C., Damas, F., Mazara, N., Baker, S. K., & Phillips, S. M. (2018) · The FASEB Journal · doi:10.1096/fj.201700158rr · Cited by 91

Role of protein and amino acids in promoting lean mass accretion with resistance exercise and attenuating lean mass loss during energy deficit in humans

Churchward-Venne, T. A., Murphy, C. H., Longland, T. M., & Phillips, S. M. (2013) · Amino Acids · doi:10.1007/s00726-013-1506-0 · Cited by 90

Rate and determinants of excessive fat-free mass loss after bariatric surgery

Nuijten, M. A. H., Monpellier, V. M., Eijsvogels, T. M. H., Janssen, I. M. C., Hazebroek, E. J., & Hopman, M. T. E. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04654-6 · Cited by 87

Obesity Alters the Muscle Protein Synthetic Response to Nutrition and Exercise

Beals, J. W., Burd, N. A., Moore, D. R., & van Vliet, S. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00087 · Cited by 88

Concurrent exercise incorporating high-intensity interval or continuous training modulates mTORC1 signaling and microRNA expression in human skeletal muscle

Fyfe, J. J., Bishop, D. J., Zacharewicz, E., Russell, A. P., & Stepto, N. K. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00479.2015 · Cited by 87

Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia

Börsch, A., Ham, D. J., Mittal, N., Tintignac, L. A., Migliavacca, E., Feige, J. N., Rüegg, M. A., & Zavolan, M. (2021) · Communications Biology · doi:10.1038/s42003-021-01723-z · Cited by 85

The time course of disuse muscle atrophy of the lower limb in health and disease

Hardy, E. J. O., Inns, T. B., Hatt, J., Doleman, B., Bass, J. J., Atherton, P. J., Lund, J. N., & Phillips, B. E. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.13067 · Cited by 83

Inflammatory Proteins and Muscle Strength in Adolescents: The AVENA Study

Ruiz, J. R., Ortega, F. B., Wärnberg, J., Moreno, L. A., Carrero, J. J., Gonzalez-Gross, M., Marcos, A., Gutierrez, A., & Sjöström, M. (2008) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.162.5.462 · Cited by 78

“Nutraceuticals” in relation to human skeletal muscle and exercise

Deane, C. S., Wilkinson, D. J., Phillips, B. E., Smith, K., Etheridge, T., & Atherton, P. J. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00230.2016 · Cited by 73

Mapping ongoing nutrition intervention trials in muscle, sarcopenia, and cachexia: a scoping review of future research

Orsso, C. E., Montes‐Ibarra, M., Findlay, M., van der Meij, B. S., de van der Schueren, M. A. E., Landi, F., Laviano, A., & Prado, C. M. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12954 · Cited by 73

Protein-Amino Acid Metabolism Disarrangements: The Hidden Enemy of Chronic Age-Related Conditions

Pasini, E., Corsetti, G., Aquilani, R., Romano, C., Picca, A., Calvani, R., & Dioguardi, F. (2018) · Nutrients · doi:10.3390/nu10040391 · Cited by 71

β-Hydroxy-β-methylbutyrate, mitochondrial biogenesis, and skeletal muscle health

He, X., Duan, Y., Yao, K., Li, F., Hou, Y., Wu, G., & Yin, Y. (2016) · Amino Acids · doi:10.1007/s00726-015-2126-7 · Cited by 70

Improving muscle mass: Response of muscle metabolism to exercise, nutrition and anabolic agents

Tipton, K. D., & Ferrando, A. A. (2008) · Essays in Biochemistry · doi:10.1042/bse0440085 · Cited by 66

Resistance training variables for optimization of muscle hypertrophy: an umbrella review.

Bernárdez-Vázquez, R., Raya-González, J., Castillo, D., & Beato, M. (2022) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2022.949021 · Cited by 67

A focus on leucine in the nutritional regulation of human skeletal muscle metabolism in ageing, exercise and unloading states

Ely, I. A., Phillips, B. E., Smith, K., Wilkinson, D. J., Piasecki, M., Breen, L., Larsen, M. S., & Atherton, P. J. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.08.010 · Cited by 64

The effects of whey protein with or without carbohydrates on resistance training adaptations

Hulmi, J. J., Laakso, M., Mero, A. A., Häkkinen, K., Ahtiainen, J. P., & Peltonen, H. (2015) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0109-4 · Cited by 61

Resistance Training Combined With Diet Decreases Body Fat While Preserving Lean Mass Independent of Resting Metabolic Rate: A Randomized Trial

Miller, T., Mull, S., Aragon, A. A., Krieger, J., & Schoenfeld, B. J. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2017-0221 · Cited by 59

A Life History Perspective on Athletes with Low Energy Availability

Shirley, M. K., Longman, D. P., Elliott-Sale, K. J., Hackney, A. C., Sale, C., & Dolan, E. (2022) · Sports Medicine · doi:10.1007/s40279-022-01643-w · Cited by 57

Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review

Verbrugge, S. A. J., Schönfelder, M., Becker, L., Yaghoob Nezhad, F., Hrabě de Angelis, M., & Wackerhage, H. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00553 · Cited by 56