Chemistry, Pharmacology and Health Benefits of Anthocyanins

Inflammation and cancer

Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219

Determination of Total Monomeric Anthocyanin Pigment Content of Fruit Juices, Beverages, Natural Colorants, and Wines by the pH Differential Method: Collaborative Study

Lee, J., Durst, R. W., Wrolstad, R. E., Collaborators:, Eisele, T., Giusti, M. M., Hach�, J., Hofsommer, H., Koswig, S., Krueger, D. A., et al. (2005) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/88.5.1269 · Cited by 3,012

Chemical studies of anthocyanins: A review

Castañeda-Ovando, A., Pacheco-Hernández, M. D. L., Páez-Hernández, M. E., Rodríguez, J. A., & Galán-Vidal, C. A. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2008.09.001 · Cited by 2,552

Dietary phenolics: chemistry, bioavailability and effects on health

Crozier, A., Jaganath, I. B., & Clifford, M. N. (2009) · Natural Product Reports · doi:10.1039/b802662a · Cited by 1,988

Goodman and Gilman's the Pharmacological Basis of Therapeutics

Thompson Coon, J. (2002) · Focus on Alternative and Complementary Therapies · doi:10.1111/j.2042-7166.2002.tb05480.x · Cited by 1,744

FLAVONOIDS: Chemistry, Biochemistry and Applications

Andersen, Ø. M., & Markham, K. R. (2018) · Cited by 1,717

Analysis and biological activities of anthocyanins

Kong, J.-M., Chia, L.-S., Goh, N.-K., Chia, T.-F., & Brouillard, R. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00438-2 · Cited by 1,682

Assessing Antioxidant and Prooxidant Activities of Phenolic Compounds

Fukumoto, L. R., & Mazza, G. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000220w · Cited by 1,660

Anthocyanins: Natural Colorants with Health-Promoting Properties

He, J., & Giusti, M. M. (2010) · Annual Review of Food Science and Technology · doi:10.1146/annurev.food.080708.100754 · Cited by 1,637

Phenol-Explorer: an online comprehensive database on polyphenol contents in foods

Neveu, V., Perez-Jimenez, J., Vos, F., Crespy, V., du Chaffaut, L., Mennen, L., Knox, C., Eisner, R., Cruz, J., Wishart, D., et al. (2010) · Database · doi:10.1093/database/bap024 · Cited by 1,439

Oxygen Radical Absorbing Capacity of Anthocyanins

Wang, H., Cao, G., & Prior, R. L. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf960421t · Cited by 1,365

Oxidative stress and gene regulation

Allen, R. G., & Tresini, M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00242-7 · Cited by 1,302

Induction of phase I, II and III drug metabolism/transport by xenobiotics

Xu, C., Li, C. Y.-T., & Kong, A.-N. T. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02977789 · Cited by 1,279

Concentrations of Anthocyanins in Common Foods in the United States and Estimation of Normal Consumption

Wu, X., Beecher, G. R., Holden, J. M., Haytowitz, D. B., Gebhardt, S. E., & Prior, R. L. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060300l · Cited by 1,191

Anthocyanins and their role in cancer prevention

Wang, L.-S., & Stoner, G. D. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.020 · Cited by 1,038

Acylated anthocyanins from edible sources and their applications in food systems

Giusti, M. M., & Wrolstad, R. E. (2003) · Biochemical Engineering Journal · doi:10.1016/s1369-703x(02)00221-8 · Cited by 954

Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women

Mink, P. J., Scrafford, C. G., Barraj, L. M., Harnack, L., Hong, C.-P., Nettleton, J. A., & Jacobs, D. R. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.895 · Cited by 945

Quantification of Polyphenolics and Their Antioxidant Capacity in Fresh Plums

Kim, D.-O., Chun, O. K., Kim, Y. J., Moon, H.-Y., & Lee, C. Y. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0343074 · Cited by 913

Berry anthocyanins as novel antioxidants in human health and disease prevention

Zafra‐Stone, S., Yasmin, T., Bagchi, M., Chatterjee, A., Vinson, J. A., & Bagchi, D. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700002 · Cited by 884

Antioxidant Activity of Anthocyanins and Their Aglycons

Kähkönen, M. P., & Heinonen, M. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf025551i · Cited by 862

Dietary Cyanidin 3-O-β-D-Glucoside-Rich Purple Corn Color Prevents Obesity and Ameliorates Hyperglycemia in Mice

Tsuda, T., Horio, F., Uchida, K., Aoki, H., & Osawa, T. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.7.2125 · Cited by 818

Anthocyanins - nature, occurrence and dietary burden

Clifford, M. N. (2000) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(20000515)80:7<1063::aid-jsfa605>3.0.co;2-q · Cited by 800

Tracking color and pigment changes in anthocyanin products

Wrolstad, R. E., Durst, R. W., & Lee, J. (2005) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2005.03.019 · Cited by 782

Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?

Halliwell, B. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.01.028 · Cited by 759

α-glucosidase inhibitors from plants: A natural approach to treat diabetes

Kumar, V., Prakash, O., Kumar, S., & Narwal, S. (2011) · Pharmacognosy Reviews · doi:10.4103/0973-7847.79096 · Cited by 729

The Case for Anthocyanin Consumption to Promote Human Health: A Review

Pojer, E., Mattivi, F., Johnson, D., & Stockley, C. S. (2013) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12024 · Cited by 633

The bioavailability and absorption of anthocyanins: Towards a better understanding

McGhie, T. K., & Walton, M. C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700092 · Cited by 605

Anthocyanins: Structural characteristics that result in unique metabolic patterns and biological activities

Prior, R. L., & Wu, X. (2006) · Free Radical Research · doi:10.1080/10715760600758522 · Cited by 585

Berry Phenolics: Antimicrobial Properties and Mechanisms of Action Against Severe Human Pathogens

Nohynek, L. J., Alakomi, H.-L., Kähkönen, M. P., Heinonen, M., Helander, I. M., Oksman-Caldentey, K.-M., & Puupponen-Pimiä, R. H. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5401_4 · Cited by 537

Dietary anthocyanin‐rich plants: Biochemical basis and recent progress in health benefits studies

Tsuda, T. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100526 · Cited by 535

Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women

Cao, G., Russell, R. M., Lischner, N., & Prior, R. L. (1998) · The Journal of Nutrition · doi:10.1093/jn/128.12.2383 · Cited by 502

Protocatechuic Acid Is the Major Human Metabolite of Cyanidin-Glucosides3

Vitaglione, P., Donnarumma, G., Napolitano, A., Galvano, F., Gallo, A., Scalfi, L., & Fogliano, V. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.9.2043 · Cited by 495

Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries

SEERAM, N. (2001) · Phytomedicine · doi:10.1078/0944-7113-00053 · Cited by 492

Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects

Mazza, G., Kay, C. D., Cottrell, T., & Holub, B. J. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020690l · Cited by 484

The Arabidopsis MATE Transporter TT12 Acts as a Vacuolar Flavonoid/H+-Antiporter Active in Proanthocyanidin-Accumulating Cells of the Seed Coat

Marinova, K., Pourcel, L., Weder, B., Schwarz, M., Barron, D., Routaboul, J.-M., Debeaujon, I., & Klein, M. (2007) · The Plant Cell · doi:10.1105/tpc.106.046029 · Cited by 482

Select Flavonoids and Whole Juice From Purple Grapes Inhibit Platelet Function and Enhance Nitric Oxide Release

Freedman, J. E., Parker, C., Li, L., Perlman, J. A., Frei, B., Ivanov, V., Deak, L. R., Iafrati, M. D., & Folts, J. D. (2001) · Circulation · doi:10.1161/01.cir.103.23.2792 · Cited by 475

Wine Phenolics

WATERHOUSE, A. L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02903.x · Cited by 472

Anthocyanins in Cardiovascular Disease

Wallace, T. C. (2011) · Advances in Nutrition · doi:10.3945/an.110.000042 · Cited by 471

Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer

Pantuck, A. J., Leppert, J. T., Zomorodian, N., Aronson, W., Hong, J., Barnard, R. J., Seeram, N., Liker, H., Wang, H., Elashoff, R., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2290 · Cited by 461

In vitro metabolism of anthocyanins by human gut microflora

Aura, A.-M., Martin-Lopez, P., O’Leary, K. A., Williamson, G., Oksman-Caldentey, K.-M., Poutanen, K., & Santos-Buelga, C. (2005) · European Journal of Nutrition · doi:10.1007/s00394-004-0502-2 · Cited by 459

Tree nut phytochemicals: composition, antioxidant capacity, bioactivity, impact factors. A systematic review of almonds, Brazils, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios and walnuts

Bolling, B. W., Chen, C.-Y. O., McKay, D. L., & Blumberg, J. B. (2011) · Nutrition Research Reviews · doi:10.1017/s095442241100014x · Cited by 454

Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol

Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., & Jula, A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.323 · Cited by 445

Potential Mechanisms of Cancer Chemoprevention by Anthocyanins

Hou, D.-X. (2003) · Current Molecular Medicine · doi:10.2174/1566524033361555 · Cited by 443

Anthocyanin‐ and hydrolyzable tannin‐rich pomegranate fruit extract modulates MAPK and NF‐κB pathways and inhibits skin tumorigenesis in CD‐1 mice

Afaq, F., Saleem, M., Krueger, C. G., Reed, J. D., & Mukhtar, H. (2005) · International Journal of Cancer · doi:10.1002/ijc.20587 · Cited by 439

Dietary Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic Mice

Takikawa, M., Inoue, S., Horio, F., & Tsuda, T. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.118216 · Cited by 439

A Multidrug Resistance–Associated Protein Involved in Anthocyanin Transport in Zea mays

Goodman, C. D., Casati, P., & Walbot, V. (2004) · The Plant Cell · doi:10.1105/tpc.022574 · Cited by 433

Anti-angiogenic, Antioxidant, and Anti-carcinogenic Properties of a Novel Anthocyanin-Rich Berry Extract Formula

Bagchi, D., Sen, C. K., Bagchi, M., & Atalay, M. (2004) · Biochemistry (Moscow) · doi:10.1023/b:biry.0000016355.19999.93 · Cited by 404

Absorption and Metabolism of Anthocyanins in Elderly Women after Consumption of Elderberry or Blueberry

Prior, R. L., Wu, X., & Cao, G. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.7.1865 · Cited by 392

Natural Colorants for Food and Nutraceutical Uses

Delgado-Vargas, F., & Paredes-Lopez, O. (2002) · CRC Press eBooks · doi:10.1201/9781420031713 · Cited by 385

Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies

Wang, X., Ouyang, Y. Y., Liu, J., & Zhao, G. (2014) · British Journal of Nutrition · doi:10.1017/s000711451300278x · Cited by 384

Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function.

GHOSH, D. K., & Konishi, T. (2007) · PubMed · Cited by 379

Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora

Keppler, K., & Humpf, H.-U. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.05.003 · Cited by 376

Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L

Tsuda, T., Shiga, K., Ohshima, K., Kawakishi, S., & Osawa, T. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00421-2 · Cited by 366

Isolation and Identification of Strawberry Phenolics with Antioxidant and Human Cancer Cell Antiproliferative Properties

Zhang, Y., Seeram, N. P., Lee, R., Feng, L., & Heber, D. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071989c · Cited by 365

Blueberry Supplementation Enhances Signaling and Prevents Behavioral Deficits in an Alzheimer Disease Model

Joseph, J. A., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D., & Denisova, N. A. (2003) · Nutritional Neuroscience · doi:10.1080/1028415031000111282 · Cited by 362

The impact of fruit flavonoids on memory and cognition

Spencer, J. P. E. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510003934 · Cited by 358

Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment

Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., & Joseph, J. A. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114509992364 · Cited by 353

Carbohydrate and fiber recommendations for individuals with diabetes: a quantitative assessment and meta-analysis of the evidence

Anderson, J. W., Randles, K. M., Kendall, C. W. C., & Jenkins, D. J. A. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719338 · Cited by 350

Tart cherry anthocyanins inhibit tumor development in ApcMin mice and reduce proliferation of human colon cancer cells

Kang, S.-Y., Seeram, N. P., Nair, M. G., & Bourquin, L. D. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00583-9 · Cited by 349

Orally Administered Delphinidin 3-Rutinoside and Cyanidin 3-Rutinoside Are Directly Absorbed in Rats and Humans and Appear in the Blood as the Intact Forms

Matsumoto, H., Inaba, H., Kishi, M., Tominaga, S., Hirayama, M., & Tsuda, T. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf001246q · Cited by 342

Strawberry Anthocyanins Are Recovered in Urine as Glucuro- and Sulfoconjugates in Humans

Felgines, C., Talavéra, S., Texier, O., Lamaison, J.-L., Gonthier, M.-P., Scalbert, A., & Rémésy, C. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.5.1296 · Cited by 340

Identification of Anthocyanins in the Liver, Eye, and Brain of Blueberry-Fed Pigs

Kalt, W., Blumberg, J. B., McDonald, J. E., Vinqvist-Tymchuk, M. R., Fillmore, S. A. E., Graf, B. A., O’Leary, J. M., & Milbury, P. E. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071998l · Cited by 336

Antioxidant activity and phenolic profile of pistachio (Pistacia vera L., variety Bronte) seeds and skins

Tomaino, A., Martorana, M., Arcoraci, T., Monteleone, D., Giovinazzo, C., & Saija, A. (2010) · Biochimie · doi:10.1016/j.biochi.2010.03.027 · Cited by 335

Anthocyanins Induce the Activation of Phase II Enzymes through the Antioxidant Response Element Pathway against Oxidative Stress-Induced Apoptosis

Shih, P.-H., Yeh, C.-T., & Yen, G.-C. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071933i · Cited by 334

Anthocyanin Metabolism in Rats and Their Distribution to Digestive Area, Kidney, and Brain

Talavéra, S., Felgines, C., Texier, O., Besson, C., Gil-Izquierdo, A., Lamaison, J.-L., & Rémésy, C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050145v · Cited by 333

The stomach as a site for anthocyanins absorption from food1

Passamonti, S., Vrhovsek, U., Vanzo, A., & Mattivi, F. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00504-0 · Cited by 322

Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress

Youdim, K. A., Martin, A., & Joseph, J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00329-4 · Cited by 312

Effects of Commercial Anthocyanin-Rich Extracts on Colonic Cancer and Nontumorigenic Colonic Cell Growth

Zhao, C., Giusti, M. M., Malik, M., Moyer, M. P., & Magnuson, B. A. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049517a · Cited by 302

Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice

Sasaki, R., Nishimura, N., Hoshino, H., Isa, Y., Kadowaki, M., Ichi, T., Tanaka, A., Nishiumi, S., Fukuda, I., Ashida, H., et al. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.008 · Cited by 298

Anthocyanins Are Efficiently Absorbed from the Stomach in Anesthetized Rats

Talavéra, S., Felgines, C., Texier, O., Lamaison, J.-L., Besson, C., & Rémésy, C. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.12.4178 · Cited by 296

Identification and quantification of phenolic compounds and their effects on antioxidant activity in pomegranate juices of eight Iranian cultivars

Mousavinejad, G., Emam-Djomeh, Z., Rezaei, K., & Khodaparast, M. H. H. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.01.044 · Cited by 288

Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy

González-Barrio, R., Borges, G., Mullen, W., & Crozier, A. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf100315d · Cited by 284

Antioxidant Activities and Antitumor Screening of Extracts from Cranberry Fruit (Vaccinium macrocarpon)

Yan, X., Murphy, B. T., Hammond, G. B., Vinson, J. A., & Neto, C. C. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0202234 · Cited by 282

Phenolic Compounds from Blueberries Can Inhibit Colon Cancer Cell Proliferation and Induce Apoptosis

Yi, W., Fischer, J., Krewer, G., & Akoh, C. C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051333o · Cited by 282

Anthocyanins as Antimicrobial Agents of Natural Plant Origin

Cisowska, A., Wojnicz, D., & Hendrich, A. B. (2011) · Natural Product Communications · doi:10.1177/1934578x1100600136 · Cited by 267

Structure−Function Relationships of Anthocyanins from Various Anthocyanin-Rich Extracts on the Inhibition of Colon Cancer Cell Growth

Jing, P., Bomser, J. A., Schwartz, S. J., He, J., Magnuson, B. A., & Giusti, M. M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8005917 · Cited by 266

Whole Berries versus Berry Anthocyanins: Interactions with Dietary Fat Levels in the C57BL/6J Mouse Model of Obesity

Prior, R. L., Wu, X., Gu, L., Hager, T. J., Hager, A., & Howard, L. R. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071993o · Cited by 265

Anti-hyperglycemic Effect of Diacylated Anthocyanin Derived from Ipomoea batatas Cultivar Ayamurasaki Can Be Achieved through the α-Glucosidase Inhibitory Action

Matsui, T., Ebuchi, S., Kobayashi, M., Fukui, K., Sugita, K., Terahara, N., & Matsumoto, K. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf025913m · Cited by 264

Low intake of fruits, berries and vegetables is associated with excess mortality in men: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study

Rissanen, T. H., Voutilainen, S., Virtanen, J. K., Venho, B., Vanharanta, M., Mursu, J., & Salonen, J. T. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.1.199 · Cited by 260

Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti‐Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects

Asgary, S., Sahebkar, A., Afshani, M. R., Keshvari, M., Haghjooyjavanmard, S., & Rafieian‐Kopaei, M. (2014) · Phytotherapy Research · doi:10.1002/ptr.4977 · Cited by 257

Anthocyanin metabolites in human urine and serum

Kay, C. D., Mazza, G., Holub, B. J., & Wang, J. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041126 · Cited by 254

Anthocyanin-Rich Extracts Inhibit Multiple Biomarkers of Colon Cancer in Rats

Lala, G., Malik, M., Zhao, C., He, J., Kwon, Y., Giusti, M. M., & Magnuson, B. A. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5401_10 · Cited by 254

Red wine, dealcoholized red wine, and especially grape juice, inhibit atherosclerosis in a hamster model

Vinson, J. A., Teufel, K., & Wu, N. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00625-0 · Cited by 253

Anthocyanins and heart health.

Mazza, G. (2007) · PubMed · Cited by 251

Chronic Dietary Intake of Plant-Derived Anthocyanins Protects the Rat Heart against Ischemia-Reperfusion Injury3

Toufektsian, M.-C., de Lorgeril, M., Nagy, N., Salen, P., Donati, M. B., Giordano, L., Mock, H.-P., Peterek, S., Matros, A., Petroni, K., et al. (2008) · The Journal of Nutrition · doi:10.1093/jn/138.4.747 · Cited by 251

Antibacterial Activity Directed Isolation of Compounds from Punica granatum

Naz, S., Siddiqi, R., Ahmad, S., Rasool, S. A., & Sayeed, S. A. (2007) · Journal of Food Science · doi:10.1111/j.1750-3841.2007.00533.x · Cited by 247

Cyanidin-3-rutinoside, a Natural Polyphenol Antioxidant, Selectively Kills Leukemic Cells by Induction of Oxidative Stress

Feng, R., Ni, H.-M., Wang, S. Y., Tourkova, I. L., Shurin, M. R., Harada, H., & Yin, X.-M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610616200 · Cited by 238

Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity

Kimura, Y., Ito, H., Ohnishi, R., & Hatano, T. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.10.041 · Cited by 233

Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved

Hou, D.-X., Yanagita, T., Uto, T., Masuzaki, S., & Fujii, M. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.05.003 · Cited by 231

The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides

Arts, I. C. W., Sesink, A. L. A., Faassen-Peters, M., & Hollman, P. C. H. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041123 · Cited by 227

Regulation of Adipocyte Function by Anthocyanins; Possibility of Preventing the Metabolic Syndrome

Tsuda, T. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf073113b · Cited by 225

The interaction of anthocyanins with bilitranslocase

Passamonti, S., Vrhovsek, U., & Mattivi, F. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00927-0 · Cited by 221

Anthocyans from fruits and vegetables – Does bright colour signal cancer chemopreventive activity?

Cooke, D., Steward, W. P., Gescher, A. J., & Marczylo, T. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.06.009 · Cited by 221

Purified Blueberry Anthocyanins and Blueberry Juice Alter Development of Obesity in Mice Fed an Obesogenic High-Fat Diet

Prior, R. L., E. Wilkes, S., R. Rogers, T., Khanal, R. C., Wu, X., & Howard, L. R. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902852d · Cited by 218

Anthocyanins Exist in the Circulation Primarily as Metabolites in Adult Men

Kay, C. D., Mazza, G. (., & Holub, B. J. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.11.2582 · Cited by 218

Anthocyanins Are Efficiently Absorbed from the Small Intestine in Rats

Talavéra, S., Felgines, C., Texier, O., Besson, C., Manach, C., Lamaison, J.-L., & Rémésy, C. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.9.2275 · Cited by 216

Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells

LAZZE, M. (2003) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(02)00285-1 · Cited by 214

Blueberry Supplemented Diet: Effects on Object Recognition Memory and Nuclear Factor-kappa B Levels in Aged Rats

Goyarzu, P., Malin, D. H., Lau, F. C., Taglialatela, G., Moon, W. D., Jennings, R., Moy, E., Moy, D., Lippold, S., Shukitt-Hale, B., et al. (2004) · Nutritional Neuroscience · doi:10.1080/10284150410001710410 · Cited by 213

Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans

Kay, C. D. (2006) · Nutrition Research Reviews · doi:10.1079/nrr2005116 · Cited by 210

Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells

Shih, P.-H., Yeh, C.-T., & Yen, G.-C. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.05.001 · Cited by 205

Antimicrobial action of the American cranberry constituents; phenolics, anthocyanins, and organic acids, against Escherichia coli O157:H7

Lacombe, A., Wu, V. C. H., Tyler, S., & Edwards, K. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.01.035 · Cited by 199

Anthocyanin Stability and Recovery: Implications for the Analysis of Clinical and Experimental Samples

Woodward, G., Kroon, P., Cassidy, A., & Kay, C. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900602b · Cited by 198

Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment

Xu, J.-W., Ikeda, K., & Yamori, Y. (2004) · Hypertension · doi:10.1161/01.hyp.0000135868.38343.c6 · Cited by 197

Systematic Review of Anthocyanins and Markers of Cardiovascular Disease

Wallace, T., Slavin, M., & Frankenfeld, C. (2016) · Nutrients · doi:10.3390/nu8010032 · Cited by 197

Protective Effects of Anthocyanins from Blackberry in a Rat Model of Acute Lung Inflammation

Rossi, A., Serraino, I., Dugo, P., Di Paola, R., Mondello, L., Genovese, T., Morabito, D., Dugo, G., Sautebin, L., Caputi, A. P., et al. (2003) · Free Radical Research · doi:10.1080/1071576031000112690 · Cited by 195

Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients

Castilla, P., Dávalos, A., Teruel, J. L., Cerrato, F., Fernández-Lucas, M., Merino, J. L., Sánchez-Martín, C. C., Ortuño, J., & Lasunción, M. A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.1053 · Cited by 194

Absorption, Bioavailability, and Metabolism of Flavonoids

Hollman, P. C. H. (2004) · Archives Of Physiology And Biochemistry · doi:10.1080/13880200490893492 · Cited by 193

Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFkappaB by edible berry juice.

Boivin, D., Blanchette, M., Barrette, S., Moghrabi, A., & Béliveau, R. (2007) · PubMed · Cited by 192

Bioavailability of Flavonoids: A Review of Their Membrane Transport and the Function of Bilitranslocase in Animal and Plant Organisms

Passamonti, S., Terdoslavich, M., Franca, R., Vanzo, A., Tramer, F., Braidot, E., Petrussa, E., & Vianello, A. (2009) · Current Drug Metabolism · doi:10.2174/138920009788498950 · Cited by 191

Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure

Serraino, I., Dugo, L., Dugo, P., Mondello, L., Mazzon, E., Dugo, G., Caputi, A. P., & Cuzzocrea, S. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00356-4 · Cited by 186

A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer

Paller, C. J., Ye, X., Wozniak, P. J., Gillespie, B. K., Sieber, P. R., Greengold, R. H., Stockton, B. R., Hertzman, B. L., Efros, M. D., Roper, R. P., et al. (2013) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2012.20 · Cited by 184

α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins. 2. α-Glucosidase Inhibition by Isolated Acylated Anthocyanins

Matsui, T., Ueda, T., Oki, T., Sugita, K., Terahara, N., & Matsumoto, K. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0012502 · Cited by 183

Potential Risks Resulting from Fruit/Vegetable–Drug Interactions: Effects on Drug‐Metabolizing Enzymes and Drug Transporters

Rodríguez‐Fragoso, L., Martínez‐Arismendi, J. L., Orozco‐Bustos, D., Reyes‐Esparza, J., Torres, E., & Burchiel, S. W. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2011.02155.x · Cited by 179

Blackberry Anthocyanins Are Mainly Recovered from Urine as Methylated and Glucuronidated Conjugates in Humans

Felgines, C., Talavera, S., Texier, O., Gil-Izquierdo, A., Lamaison, J.-L., & Remesy, C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051092k · Cited by 177

Anthocyanins are Bioavailable in Humans following an Acute Dose of Cranberry Juice

Milbury, P. E., Vita, J. A., & Blumberg, J. B. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.117168 · Cited by 175

Plasma and Urine Responses Are Lower for Acylated vs Nonacylated Anthocyanins from Raw and Cooked Purple Carrots

Kurilich, A. C., Clevidence, B. A., Britz, S. J., Simon, P. W., & Novotny, J. A. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050570o · Cited by 173

Mechanisms Linking Diet and Colorectal Cancer: The Possible Role of Insulin Resistance

Bruce, W. R., Wolever, T. M. S., & Giacca, A. (2000) · Nutrition and Cancer · doi:10.1207/s15327914nc3701_2 · Cited by 172

Xenobiotic Metabolism and Berry Flavonoid Transport across the Blood−Brain Barrier

Milbury, P. E., & Kalt, W. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903529m · Cited by 171

Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract

Pergola, C., Rossi, A., Dugo, P., Cuzzocrea, S., & Sautebin, L. (2006) · Nitric Oxide · doi:10.1016/j.niox.2005.10.003 · Cited by 168

Red wine anthocyanins are rapidly absorbed in humans and affect monocyte chemoattractant protein 1 levels and antioxidant capacity of plasma

Garcia-Alonso, M., Minihane, A.-M., Rimbach, G., Rivas-Gonzalo, J. C., & de Pascual-Teresa, S. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.05.011 · Cited by 165

An anthocyanin/polyphenolic‐rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands

Weisel, T., Baum, M., Eisenbrand, G., Dietrich, H., Will, F., Stockis, J., Kulling, S., Rüfer, C., Johannes, C., & Janzowski, C. (2006) · Biotechnology Journal · doi:10.1002/biot.200600004 · Cited by 163

Antimutagenicity of Deacylated Anthocyanins in Purple-fleshed Sweetpotato

YOSHIMOTO, M., Okuno, S., YAMAGUCHI, M., & Yamakawa, O. (2001) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.65.1652 · Cited by 163

Extracts Enriched in Different Polyphenolic Families Normalize Increased Cardiac NADPH Oxidase Expression while Having Differential Effects on Insulin Resistance, Hypertension, and Cardiac Hypertrophy in High-Fructose-Fed Rats

Al-Awwadi, N. A., Araiz, C., Bornet, A., Delbosc, S., Cristol, J.-P., Linck, N., Azay, J., Teissedre, P.-L., & Cros, G. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048919f · Cited by 163

Microarray profiling of gene expression in human adipocytes in response to anthocyanins

Tsuda, T., Ueno, Y., Yoshikawa, T., Kojo, H., & Osawa, T. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.042 · Cited by 163

Methods of Analysis for Anthocyanins in Plants and Biological Fluids

Mazza, G., Cacace, J. E., & Kay, C. D. (2004) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/87.1.129 · Cited by 160

Urinary metabolites as biomarkers of polyphenol intake in humans—a systematic review

Pérez-Jiménez, J., Hubert, J., Hooper, L., Cassidy, A., Manach, C., Williamson, G., & Scalbert, A. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29924 · Cited by 159

Bioavailability and Tissue Distribution of Anthocyanins in Bilberry (Vaccinium myrtillus L.) Extract in Rats

Ichiyanagi, T., Shida, Y., Rahman, M. M., Hatano, Y., & Konishi, T. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0602370 · Cited by 159

Anthocyanin Composition and Antioxidant Activity of the Crowberry (Empetrum nigrum) and Other Berries

Ogawa, K., Sakakibara, H., Iwata, R., Ishii, T., Sato, T., Goda, T., Shimoi, K., & Kumazawa, S. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf800406v · Cited by 159

Cyanidin and cyanidin 3-O-β-D-glucoside as DNA cleavage protectors and antioxidants

Acquaviva, R., Russo, A., Galvano, F., Galvano, G., Barcellona, M. L., Volti, G. L., & Vanella, A. (2003) · Cell Biology and Toxicology · doi:10.1023/b:cbto.0000003974.27349.4e · Cited by 156

Comparative study of anthocyanin composition, antimicrobial and antioxidant activity in bilberry (Vaccinium myrtillus L.) and blueberry (Vaccinium corymbosum L.) fruits.

Burdulis, D., Šarkinas, A., Jasutienė, I., Stackevicené, E., Nikolajevas, L., & Janulis, V. (2009) · PubMed · Cited by 155

Food Matrix Affecting Anthocyanin Bioavailability: Review

Yang, M., Koo, S. I., Song, W., & Chun, O. K. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711794088380 · Cited by 152

Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus

Shukitt‐Hale, B., Lau, F. C., Carey, A. N., Galli, R. L., Spangler, E. L., Ingram, D. K., & Joseph, J. A. (2008) · Nutritional Neuroscience · doi:10.1179/147683008x301487 · Cited by 148

Short-Term Dietary Supplementation of Blueberry Polyphenolics: Beneficial Effects on Aging Brain Performance and Peripheral Tissue Function

Youdim, K. A., Shukitt‐Hale, B., Martin-Marco, A., Wang, H., Denisova, N., Bickford, P. C., & Joseph, J. A. (2000) · Nutritional Neuroscience · doi:10.1080/1028415x.2000.11747338 · Cited by 148

anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells

Chang, Y., Huang, H., HSU, J., Yang, S., & Wang, C. C. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.10.014 · Cited by 146

Estimation of the intake of anthocyanidins and their food sources in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Zamora‐Ros, R., Knaze, V., Luján‐Barroso, L., Slimani, N., Romieu, I., Touillaud, M. S., Kaaks, R., Teucher, B., Mattiello, A., Grioni, S., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511001437 · Cited by 146

A Systematic Review on the Health Effects of Plums ( Prunus domestica and Prunus salicina )

Igwe, E. O., & Charlton, K. E. (2016) · Phytotherapy Research · doi:10.1002/ptr.5581 · Cited by 143

Effects of anthocyanins on cardiovascular risk factors and inflammation in pre-hypertensive men: a double-blind randomized placebo-controlled crossover study

Hassellund, S. S., Flaa, A., Kjeldsen, S. E., Seljeflot, I., Karlsen, A. S., Erlund, I., & Rostrup, M. (2012) · Journal of Human Hypertension · doi:10.1038/jhh.2012.4 · Cited by 142

Oxidative stress-based cytotoxicity of delphinidin and cyanidin in colon cancer cells

Čvorović, J., Tramer, F., Granzotto, M., Candussio, L., Decorti, G., & Passamonti, S. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.05.019 · Cited by 139

Interindividual differences in phytochemical metabolism and disposition

Lampe, J. W., & Chang, J. H. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.05.003 · Cited by 139

Effect of cyanidin‐3‐glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis—Relationship with tissue anthocyanin levels

Cooke, D. N., Schwarz, M., Boocock, D. J., Winterhalter, P., Steward, W. P., Gescher, A. J., & Marczylo, T. H. (2006) · International Journal of Cancer · doi:10.1002/ijc.22090 · Cited by 137

Dietary Anthocyanins as Nutritional Therapy for Nonalcoholic Fatty Liver Disease

Valenti, L. V. C., Riso, P., Mazzocchi, A., Porrini, M., Fargion, S. R., & Agostoni, C. V. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/145421 · Cited by 137

Dietary Antioxidants and Paraoxonases Against LDL Oxidation and Atherosclerosis Development

Aviram, M., Kaplan, M., Rosenblat, M., & Fuhrman, B. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-27661-0_9 · Cited by 135

Antibacterial effects of American cranberry (Vaccinium macrocarpon) concentrate on foodborne pathogens

Wu, V. C. H., Qiu, X., Bushway, A. A., & Harper, L. (2008) · LWT · doi:10.1016/j.lwt.2008.01.001 · Cited by 134

Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials

Serban, C., Sahebkar, A., Ursoniu, S., Andrica, F., & Banach, M. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000585 · Cited by 133

Comparative assessment of distribution of blackcurrant anthocyanins in rabbit and rat ocular tissues

Matsumoto, H., Nakamura, Y., Iida, H., Ito, K., & Ohguro, H. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2005.12.019 · Cited by 131

Effect of lyophilised berries on memory, anxiety and locomotion in adult rats

RAMIREZ, M., Izquierdo, I., Raseira, M. D. C. B., Zuanazzi, J. Â. S., Barros, D. M., & Henriques, A. T. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2005.07.003 · Cited by 130

The 1.8-Å Crystal Structure of a Matrix Metalloproteinase 8-Barbiturate Inhibitor Complex Reveals a Previously Unobserved Mechanism for Collagenase Substrate Recognition

Brandstetter, H., Grams, F., Glitz, D., Lang, A., Huber, R., Bode, W., Krell, H., & Engh, R. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007475200 · Cited by 129

New insight into the structures and formation of anthocyanic vacuolar inclusions in flower petals.

Zhang, H., Wang, L., Deroles, S. C., Bennett, R., & Davies, K. M. (2006) · BMC Plant Biology · doi:10.1186/1471-2229-6-29 · Cited by 125

Effect of Anthocyanin Fractions from Selected Cultivars of Georgia-Grown Blueberries on Apoptosis and Phase II Enzymes

Srivastava, A., Akoh, C. C., Fischer, J. G., & Krewer, G. W. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062915o · Cited by 122

Fractionation of Blue Wheat Anthocyanin Compounds and Their Contribution to Antioxidant Properties

Abdel‐Aal, E. M., Abou-Arab, A. A., Gamel, T. H., Hucl, P., Young, J. C., & Rabalski, I. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf802168c · Cited by 121

α-Glucosidase Inhibitory and Antihyperglycemic Effects of Polyphenols in the Fruit of Viburnum dilatatum Thunb.

Iwai, K., Kim, M., Onodera, A., & Matsue, H. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0606353 · Cited by 120

Identification of Cabernet Sauvignon Anthocyanin Gut Microflora Metabolites

Forester, S. C., & Waterhouse, A. L. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801309n · Cited by 120

Scientific Opinion on the re‐evaluation of anthocyanins (E 163) as a food additive

(ANS), E. P. O. F. A. A. N. S. A. T. F. (2013) · EFSA Journal · doi:10.2903/j.efsa.2013.3145 · Cited by 119

Anthocyanidins induce apoptosis in human promyelocytic leukemia cells: Structure-activity relationship and mechanisms involved

Hou, D., Ose, T., Lin, S., Harazoro, K., Imamura, I., Kubo, M., Uto, T., Terahara, N., Yoshimoto, M., & Fujii, M. (2003) · International Journal of Oncology · doi:10.3892/ijo.23.3.705 · Cited by 118

Enhanced Anthocyanin Extraction from Red Cabbage Using Pulsed Electric Field Processing

Gachovska, T. K., Cassada, D. A., Subbiah, J., et al. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01699.x · Cited by 118

Urinary excretion of cyanidin glycosides

Mülleder, U., Murkovic, M., & Pfannhauser, W. (2002) · Journal of Biochemical and Biophysical Methods · doi:10.1016/s0165-022x(02)00093-3 · Cited by 117

Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort

Zamora‐Ros, R., Knaze, V., Luján‐Barroso, L., Slimani, N., Romieu, I., Fedirko, V., de Magistris, M. S., Ericson, U., Amiano, P., Trichopoulou, A., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451100239x · Cited by 117

Flower colour and cytochromes P450

Tanaka, Y. (2006) · Phytochemistry Reviews · doi:10.1007/s11101-006-9003-7 · Cited by 116

Long-term antioxidant supplementation attenuates oxidative stress markers and cognitive deficits in senescent-accelerated OXYS rats

Kolosova, N. G., Shcheglova, T. V., Sergeeva, S. V., & Лоскутова, Л. В. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.07.022 · Cited by 116

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

Rendeiro, C., Guerreiro, J. D. T., Williams, C. M., & Spencer, J. P. E. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000146 · Cited by 114

Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?

Thomasset, S. C., Teller, N., Cai, H., Marko, D., Berry, D. P., Steward, W. P., & Gescher, A. J. (2009) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-009-0976-y · Cited by 113

Anthocyanin-Rich Grape Extract Blocks Breast Cell DNA Damage

Singletary, K. W., Jung, K.-J., & Giusti, M. M. (2007) · Journal of Medicinal Food · doi:10.1089/jmf.2006.258 · Cited by 113

Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection

Galli, R. L., Bielinski, D. F., Szprengiel, A., Shukitt‐Hale, B., & JOSEPH, J. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.017 · Cited by 113

Affinity Purification of Copper-Chelating Peptides from Sunflower Protein Hydrolysates

Megías, C., Pedroche, J., Yust, M. D. M., Girón‐Calle, J., Alaiz, M., Millán, F., & Vioque, J. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0712705 · Cited by 112

Action of pelargonidin on hyperglycemia and oxidative damage in diabetic rats: Implication for glycation-induced hemoglobin modification

Roy, M., Sen, S., & Chakraborti, A. S. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.03.011 · Cited by 112

Inhibition of Helicobacter pylori in vitro by various berry extracts, with enhanced susceptibility to clarithromycin

Chatterjee, A., Yasmin, T., Bagchi, D., & STOHS, S. J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000044310.92444.ec · Cited by 109

Stability of Black Raspberry Anthocyanins in the Digestive Tract Lumen and Transport Efficiency into Gastric and Small Intestinal Tissues in the Rat

He, J., Wallace, T. C., Keatley, K. E., Failla, M. L., & Giusti, M. M. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900567t · Cited by 108

Gene expression profile of isolated rat adipocytes treated with anthocyanins

Tsuda, T., Ueno, Y., Kojo, H., Yoshikawa, T., & Osawa, T. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2004.12.014 · Cited by 106

Effects of black current anthocyanoside intake on dark adaptation and VDT work-induced transient refractive alteration in healthy humans.

Nakaishi, H., Matsumoto, H., Tominaga, S., & Hirayama, M. (2000) · PubMed · Cited by 105

Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice

Mauray, A., Felgines, C., Morand, C., Mazur, A., Scalbert, A., & Milenković, D. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.04.011 · Cited by 103

Long-term wine consumption is related to cardiovascular mortality and life expectancy independently of moderate alcohol intake: the Zutphen Study

Streppel, M. T., Ocké, M. C., Boshuizen, H. C., Kok, F. J., & Kromhout, D. (2009) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2008.082198 · Cited by 101

Photoprotective Potential of Strawberry ( Fragaria × ananassa ) Extract against UV-A Irradiation Damage on Human Fibroblasts

Giampieri, F., Álvarez-Suárez, J. M., Tulipani, S., Gonzaléz‐Paramás, A. M., Santos‐Buelga, C., Bompadre, S., Quiles, J. L., Mezzetti, B., & Battino, M. A. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf205065x · Cited by 101

Purple grape juice inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation

Jung, K.-J., Wallig, M. A., & Singletary, K. W. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.03.020 · Cited by 100

Pelargonidin Is Absorbed and Metabolized Differently than Cyanidin after Marionberry Consumption in Pigs

Wu, X., Pittman, H. E., & Prior, R. L. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2603 · Cited by 100

Flavonoids and the Risk of Oral and Pharyngeal Cancer: A Case-Control Study from Italy

Rossi, M., Garavello, W., Talamini, R., Negri, E., Bosetti, C., Maso, L. D., Λάγιου, Π., Tavani, A., Polesel, J., Barzan, L., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0168 · Cited by 99

Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion‐induced injury

Scarabelli, T. M., Mariotto, S., Abdel‐Azeim, S., Shoji, K., Darra, E., Stephanou, A., Chen-Scarabelli, C. A., Maréchal, J., Knight, R. A., Ciampa, A. R., et al. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.12.037 · Cited by 97

Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis

Favot, L., Martin, S., Keravis, T. M., Andriantsitohaina, R., & Lugnier, C. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00433-4 · Cited by 96

Flavonoid Biosynthesis in Barley Primary Leaves Requires the Presence of the Vacuole and Controls the Activity of Vacuolar Flavonoid Transport

Marinova, K., Kleinschmidt, K., Weissenböck, G., et al. (2007) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.094748 · Cited by 93

Two-Year Randomized, Placebo-Controlled Study of Black Currant Anthocyanins on Visual Field in Glaucoma

Ohguro, H., Ohguro, I., Katai, M., & Tanaka, S. (2012) · Ophthalmologica · doi:10.1159/000335961 · Cited by 90

Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins

Renis, M., Calandra, L., Scifo, C., Tomasello, B., Cardile, V., Vanella, L., Bei, R., Fauci, L. L., & Galvano, F. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507876239 · Cited by 89

Lifestyle modification, nutritional and vitamins supplements for age‐related macular degeneration

Sin, H. P. Y., Liu, D. T. L., & Lam, D. S. C. (2012) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2011.02357.x · Cited by 89

Cyanidin-3-O-β-glucopyranoside, a natural free-radical scavenger against aflatoxin B1- and ochratoxin A-induced cell damage in a human hepatoma cell line (Hep G2) and a human colonic adenocarcinoma cell line (CaCo-2)

Guerra, M., Galvano, F., Bonsi, L., et al. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051425 · Cited by 87

Inhibition of Rat Mammary Tumorigenesis by Concord Grape Juice Constituents

Singletary, K. W., Stansbury, M. J., Giusti, M. M., van Breemen, R. B., Wallig, M. A., & Rimando, A. M. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030278l · Cited by 86

First evidence of C- and O-glycosyl flavone in blood orange (Citrus sinensis (L.) Osbeck) juice and their influence on antioxidant properties

Barreca, D., Bellocco, E., Leuzzi, U., & Gattuso, G. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.10.096 · Cited by 84

Cyanidin‐3‐glucoside regulates phosphorylation of endothelial nitric oxide synthase

Xu, J., Ikeda, K., & Yamori, Y. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.08.027 · Cited by 83

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