Cited by 34Child Abuse and TraumaNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

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The influence of stress and early life adversity on addiction: Psychobiological mechanisms of risk and resilience

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Mustafa Al’Absi·2020·International review of neurobiology

DOI 10.1016/bs.irn.2020.03.012PMC PMC9188362

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Abstract

Preclinical, clinical, and population research demonstrates that stress and early life adversity (ELA) increase vulnerability to initiate, maintain, and relapse in addiction. Individuals with addiction problems have higher prevalence of trauma exposure than nondrug users; and this association extends to young populations (e.g., adolescents). Mechanisms for these associations likely involve multiple systems, including changes in the mesolimbic reward functions, HPA axis stress response, and other stress- and reward-related pathways. Other brain morphological and functional changes are also likely involved and directly contribute to the neurohormonal and behavioral alterations observed during adulthood in those exposed to ELA. Stress-related risk is influenced by sex, genetic factors, and resilience, among other factors. Our heuristic model proposes that long-term effects of stress and ELA on the brain contribute to dysregulation of the stress response, emotional reactivity, reward systems, cognitive dysregulation, and delay discounting that lead to impulsive and high-risk behaviors, such as drug use and relapse.

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“These blunted stress responses among nicotine users may reflect long-term effects of nicotine use on stress response systems, leading to increased risk for maintaining use (to compensate for such dysregulation) and to increased vulnerability to stressrelated disorders, such as depression (al’Absi 2020; al’Absi et al.…”
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Authors: Al’Absi, M.
Affiliations: University of Minnesota (US)
Corresponding author: Mustafa Al’Absi
ORCID: Mustafa Al’Absi
Venue: International review of neurobiology
Publisher: Elsevier
Published: 2020
Volume: 152
Pages: 71-100
ISSN: 0074-7742 (ISSN-L)
DOI: 10.1016/bs.irn.2020.03.012
PMC: PMC9188362
OpenAlex: W3021998954
Cited by: 34
References: 249
Citations by year: 2026: 6 · 2025: 6 · 2024: 8 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 1
FWCI: 24.93
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: International review of neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (R01DA027232, R01DA016351)
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: childhood adversity, stress, addiction, resilience, trauma exposure, hypothalamic-pituitary-adrenal axis, mesolimbic reward system, stress response dysregulation, emotional reactivity, delay discounting, impulsivity, drug relapse, sex differences, genetic factors, brain structural changes, cognitive dysregulation, adolescents
MeSH terms: Adolescent, Adult, Child, Child, Preschool, Female, Humans, Male, Neural Pathways, Stress, Psychological, Behavior, Addictive, Adult Survivors of Child Abuse, Resilience, Psychological

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The influence of stress and early life adversity on addiction: Psychobiological mechanisms of risk and resilience

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